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The map label for this gene is dxs1

Identifier: 83591394

GI number: 83591394

Start: 58117

End: 60054

Strand: Direct

Name: dxs1

Synonym: Rru_A0054

Alternate gene names: 83591394

Gene position: 58117-60054 (Clockwise)

Preceding gene: 83591386

Following gene: 83591396

Centisome position: 1.34

GC content: 68.73

Gene sequence:

>1938_bases
GTGACATCGAGACCGATAACGCCGCTTTTGGACACGATCCGCGGTCCTTCGGACACACGGGGTCTTTCGGTGGCGCAGCT
GGAGCAGCTGGCGCGCGAAGTGCGGGCGGAAATGATCGATGCGGTCTCGGTGACCGGCGGTCATCTGGGCTCGGGGCTTG
GGGTGGTCGAGCTGACGGTGGCCCTCCATCACGTGTTCGACACCCCCGACGACCGCATCATCTGGGATGTCGGCCATCAG
TGCTATCCCCACAAGATCCTGACCGGGCGGCGCGATCGCATCCGCACCCTGCGCCAGGGCGGCGGGCTGTCGGGCTTCAC
CCTGCGCGAGGAAAGCCCCTATGACCCCTTCGGCGCCGGGCATTCCTCGACCTCGATCTCGGCGGGTCTGGGCATGGCCA
TCGGCTCGGCCCTGGCCGGCGACGCCCGCGACGTGGTGGCGGTGATCGGCGACGGCTCGATGAGCGCGGGCATGGCCTAT
GAGGCGATGAACAATGCCGGGGCGGCCAAATCGCGGCTGATCGTCATCCTCAACGACAACGACATGTCGATCGCCCCGCC
GGTGGGGGCGATGAGCGCCTATCTGTCGCGGCTGCTCAGTTCGAAAAGCTGGCTGTCGATCCGCACCCTGGCCAAGGAGA
TCGTCGCCCGCCTGCCCGACGCCCTGGAGCGCACGGCCAAGCGGGCCGAGGAATACGCCCGCGGCATGGTGACGGGCGGC
GGCACGCTGTTCGAGGAGCTGGGCTTTTATTACGTCGGGCCGATCGACGGCCATCGCATGGACCATCTGGTGCCGGTGCT
GCGCAACGTGCGCGAGGCCGGGCGCGATGGTCCGGTGCTGATCCACGTGGTGACGCAAAAGGGCAAGGGCTATGCCCCGG
CCGAGAACGCGCCCGACAAATACCACGGCGTGTCGCGCTTCAACGTGGTGACCGGGGTTCAGGAAAAGGCCAAGCCGCAG
GCGCCGTCCTATACGGCGGTGTTTGGCAAGCAGCTGGTGGCGGCGGCGGCCAAGGACCATCGGATCGTCGGGGTGACGGC
GGCGATGCCCGGCGGCACCGGCCTTGACAAGCTGGCCACGGCCTATCCGCAGCGCTGCTTCGATGTCGGCATCGCCGAAC
AGCACGCCGTGACCTTCGCCGCCGGTCTGGCCTGCGAGGGGCTGAAGCCCTTCGTCGCCCTCTATTCCAGCTTTTTGCAG
CGCGGCTATGATCAGGTGGTCCACGACGTGGTCTTGCAGAAGCTGCCGGTGCGCTTCGCCATCGACCGCGCCGGGTTCGT
CGGCGCCGACGGGGCGACCCATGGCGGCGTCTTCGACATGGCCTTCCTCGGCTGCCTGCCCAATCTGGTGGTGATGTGCG
CCGCCGACGAGGCCGAGCTGGCGCGCATGGTGGTGACGGCGGCCGGCCATGACAGCGGCCCGATCGCCCTGCGCTATCCG
CGCGGCGAGGGCGTGGGGGTGGAGATCCCCGAGGATCCCCAACCTTTGGCGATCGGCAAGGGCCGCATCGTGCGCGAGGG
CAAGGGCGTGGCCCTGCTATCGATCGGCACCCGGCTGCAGTCGTGCCTGGAGGCTTGCGAGATCCTGGCGGCGCGCGGCC
TGACGCCGACGGTGGCCGACGCCCGCTTCCTCAAGCCCTTCGACGAGGAACTGGTGGCCGATCTCGCCGCCCGCCACGAG
GTGCTGATCGTCGTCGAGGAAGGCGCGATCGGCGGCTTCGGCGCCCATGTCGCCACTTGGCTGACCAACCAGGGCCTGCT
CGACGGCGGCCTCAAGCTGCGCGCCCTGCATATCCCCGACCGCTTCTTCGAGCACGACGCGCCCGAGGTCCAATGCGCCA
AGGCCGGCATCGACGCCCAGGCCATCACCACCGCCGTCCTCGACGCCCTCAAGCTTGAAACCAGCGCCACCATCGACGCC
GGCGCCCTGAAGGCGTAA

Upstream 100 bases:

>100_bases
GCGCGCCGTTGCCCGTTTCGTCGTCGACCGCAAAAGCTGAAGCCCCCCGGGGGTGTTTCCCCCCGTCAAGGGACGGTTTT
CATACGAGGAGAATTCCGCC

Downstream 100 bases:

>100_bases
AAATCACCCTTCGCTGTATTCATTAAGAAAAGGGCCGCATCCCGGGGATGCGGCCCTTTTCCAATTCAAGAAGGCTAAAA
CGCCTTACTGGGGATCGTCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 1; DXP synthase 1; DXPS 1

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MTSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTVALHHVFDTPDDRIIWDVGHQ
CYPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAGHSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAY
EAMNNAGAAKSRLIVILNDNDMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGG
GTLFEELGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDKYHGVSRFNVVTGVQEKAKPQ
APSYTAVFGKQLVAAAAKDHRIVGVTAAMPGGTGLDKLATAYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQ
RGYDQVVHDVVLQKLPVRFAIDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYP
RGEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVADARFLKPFDEELVADLAARHE
VLIVVEEGAIGGFGAHVATWLTNQGLLDGGLKLRALHIPDRFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDA
GALKA

Sequences:

>Translated_645_residues
MTSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTVALHHVFDTPDDRIIWDVGHQ
CYPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAGHSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAY
EAMNNAGAAKSRLIVILNDNDMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGG
GTLFEELGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDKYHGVSRFNVVTGVQEKAKPQ
APSYTAVFGKQLVAAAAKDHRIVGVTAAMPGGTGLDKLATAYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQ
RGYDQVVHDVVLQKLPVRFAIDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYP
RGEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVADARFLKPFDEELVADLAARHE
VLIVVEEGAIGGFGAHVATWLTNQGLLDGGLKLRALHIPDRFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDA
GALKA
>Mature_644_residues
TSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTVALHHVFDTPDDRIIWDVGHQC
YPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAGHSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAYE
AMNNAGAAKSRLIVILNDNDMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGGG
TLFEELGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDKYHGVSRFNVVTGVQEKAKPQA
PSYTAVFGKQLVAAAAKDHRIVGVTAAMPGGTGLDKLATAYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQR
GYDQVVHDVVLQKLPVRFAIDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYPR
GEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVADARFLKPFDEELVADLAARHEV
LIVVEEGAIGGFGAHVATWLTNQGLLDGGLKLRALHIPDRFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDAG
ALKA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=551, Percent_Identity=22.3230490018149, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4507521, Length=551, Percent_Identity=22.3230490018149, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI156564403, Length=219, Percent_Identity=27.3972602739726, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786622, Length=622, Percent_Identity=48.0707395498392, Blast_Score=568, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17539652, Length=431, Percent_Identity=24.1299303944316, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538422, Length=291, Percent_Identity=26.4604810996564, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45551847, Length=677, Percent_Identity=22.8951255539143, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45550715, Length=677, Percent_Identity=22.8951255539143, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24645119, Length=310, Percent_Identity=27.741935483871, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24666278, Length=264, Percent_Identity=28.4090909090909, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS1_RHORT (Q2RYD6)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_425146.1
- ProteinModelPortal:   Q2RYD6
- SMR:   Q2RYD6
- STRING:   Q2RYD6
- GeneID:   3834384
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0054
- NMPDR:   fig|1085.1.peg.1061
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- PhylomeDB:   Q2RYD6
- ProtClustDB:   PRK12571
- BioCyc:   RRUB269796:RRU_A0054-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68131; Mature: 68000

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTV
CCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALHHVFDTPDDRIIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAG
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCC
HSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAYEAMNNAGAAKSRLIVILNDN
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCEEEEEECCC
DMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGG
CCEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEECCC
GTLFEELGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDK
HHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHH
YHGVSRFNVVTGVQEKAKPQAPSYTAVFGKQLVAAAAKDHRIVGVTAAMPGGTGLDKLAT
HCCCCHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHH
AYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQRGYDQVVHDVVLQKLPVRFA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYP
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCEEEEEC
RGEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVAD
CCCCCEEECCCCCCCEEECCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHC
ARFLKPFDEELVADLAARHEVLIVVEEGAIGGFGAHVATWLTNQGLLDGGLKLRALHIPD
HHHCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCH
RFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDAGALKA
HHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TSRPITPLLDTIRGPSDTRGLSVAQLEQLAREVRAEMIDAVSVTGGHLGSGLGVVELTV
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALHHVFDTPDDRIIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTLREESPYDPFGAG
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCC
HSSTSISAGLGMAIGSALAGDARDVVAVIGDGSMSAGMAYEAMNNAGAAKSRLIVILNDN
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCEEEEEECCC
DMSIAPPVGAMSAYLSRLLSSKSWLSIRTLAKEIVARLPDALERTAKRAEEYARGMVTGG
CCEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEECCC
GTLFEELGFYYVGPIDGHRMDHLVPVLRNVREAGRDGPVLIHVVTQKGKGYAPAENAPDK
HHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHH
YHGVSRFNVVTGVQEKAKPQAPSYTAVFGKQLVAAAAKDHRIVGVTAAMPGGTGLDKLAT
HCCCCHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHH
AYPQRCFDVGIAEQHAVTFAAGLACEGLKPFVALYSSFLQRGYDQVVHDVVLQKLPVRFA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IDRAGFVGADGATHGGVFDMAFLGCLPNLVVMCAADEAELARMVVTAAGHDSGPIALRYP
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCEEEEEC
RGEGVGVEIPEDPQPLAIGKGRIVREGKGVALLSIGTRLQSCLEACEILAARGLTPTVAD
CCCCCEEECCCCCCCEEECCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHC
ARFLKPFDEELVADLAARHEVLIVVEEGAIGGFGAHVATWLTNQGLLDGGLKLRALHIPD
HHHCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCH
RFFEHDAPEVQCAKAGIDAQAITTAVLDALKLETSATIDAGALKA
HHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA