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The map label for this gene is nadC [H]

Identifier: 83312984

GI number: 83312984

Start: 4292856

End: 4293716

Strand: Reverse

Name: nadC [H]

Synonym: amb3885

Alternate gene names: 83312984

Gene position: 4293716-4292856 (Counterclockwise)

Preceding gene: 83312985

Following gene: 83312983

Centisome position: 86.44

GC content: 69.69

Gene sequence:

>861_bases
ATGCGGCCTGAGGCGGAGCTTGACTGGGACGACGCGCGGCGGGTCATCCTCGCCGCGCTGGCCGAGGACACGGGGGCGGA
CAAGGGCGGCGAAGGCGAGGACATCACCTCGGCCTCGGTGATCCCTGCCGATCTGCGCTTCACCGGAATCATGGCGGCGC
GCCATACCATGGTGGTGGCCGGCATGCCGGTGGCCCAGGAGGTCTTTCGCCTGGTGGTGCCCGAAGCCCGCTTCACAGCC
CGCGTGGCCGATGGCGACACGGTGGAGGCCGGCACGGTGCTGGCCGAGATGGAGGGCCCGGCCCGTGGCCTGCTGACCGC
CGAGCGCACGGCGCTGAACCTGCTGCAATTGCTGTCGGGCATCGCCACACTGACCAGTCAGTATGCCAAGCGCATCCAGG
GCACAGGCTGCACCCTGCTCGATACCAGGAAGACCATTCCGGGCCTGCGGCGCCTGTCCAAATACGCTACGCGGTGCGGC
GGCGCCAAGAACCACCGCATGGGCCTTTATGACGGCGTGCTGATCAAGGACAACCACATCGCCGTGTGCGGCGGGGTGGG
CGAGGCGGTGCGCCGCGCCAAGGCCGAGGGCCGCCCCAATATCGAAGCCGAATGCGACACCCTGGAACAGGTGGCCGAGG
CGGTGGAGGCCGGGGCCGACATCGTGCTGCTGGACAATATGGGCCCCGACGTGCTGCGCCGGGCGGTGGCCATCGTGGCC
GGACGGGCCAAGACCGAGGCGTCGGGCGGCGTGACGCTGGACACCATCCGCGCCATCGCCGAGACCGGAGTCGACTTCGT
CTCGGTGGGACGCATCACCCAATCGGCCCCGGCGGTCGATATCGGGCTGGACTGGAGCTGA

Upstream 100 bases:

>100_bases
GCCATCACCGTGCCCGAGGATCTGCGCGTCGCGGCCCTGAAGCCGCTGGAGCGCATGCTGGAGATGAGCAAGTCGGTCCC
CATGTCCGGAGACAAGCCCA

Downstream 100 bases:

>100_bases
GATGAGCAAGGCGGCGAATCCTTACGATCTGCTGGTCATCGGCTCGGGGGCCGCCGGCCTCTCGGTGGCGCTGGGCGTGC
TGGCGGCCAATCCCAAGGCC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MRPEAELDWDDARRVILAALAEDTGADKGGEGEDITSASVIPADLRFTGIMAARHTMVVAGMPVAQEVFRLVVPEARFTA
RVADGDTVEAGTVLAEMEGPARGLLTAERTALNLLQLLSGIATLTSQYAKRIQGTGCTLLDTRKTIPGLRRLSKYATRCG
GAKNHRMGLYDGVLIKDNHIAVCGGVGEAVRRAKAEGRPNIEAECDTLEQVAEAVEAGADIVLLDNMGPDVLRRAVAIVA
GRAKTEASGGVTLDTIRAIAETGVDFVSVGRITQSAPAVDIGLDWS

Sequences:

>Translated_286_residues
MRPEAELDWDDARRVILAALAEDTGADKGGEGEDITSASVIPADLRFTGIMAARHTMVVAGMPVAQEVFRLVVPEARFTA
RVADGDTVEAGTVLAEMEGPARGLLTAERTALNLLQLLSGIATLTSQYAKRIQGTGCTLLDTRKTIPGLRRLSKYATRCG
GAKNHRMGLYDGVLIKDNHIAVCGGVGEAVRRAKAEGRPNIEAECDTLEQVAEAVEAGADIVLLDNMGPDVLRRAVAIVA
GRAKTEASGGVTLDTIRAIAETGVDFVSVGRITQSAPAVDIGLDWS
>Mature_286_residues
MRPEAELDWDDARRVILAALAEDTGADKGGEGEDITSASVIPADLRFTGIMAARHTMVVAGMPVAQEVFRLVVPEARFTA
RVADGDTVEAGTVLAEMEGPARGLLTAERTALNLLQLLSGIATLTSQYAKRIQGTGCTLLDTRKTIPGLRRLSKYATRCG
GAKNHRMGLYDGVLIKDNHIAVCGGVGEAVRRAKAEGRPNIEAECDTLEQVAEAVEAGADIVLLDNMGPDVLRRAVAIVA
GRAKTEASGGVTLDTIRAIAETGVDFVSVGRITQSAPAVDIGLDWS

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=240, Percent_Identity=37.5, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1786299, Length=268, Percent_Identity=43.6567164179104, Blast_Score=194, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6321162, Length=288, Percent_Identity=34.7222222222222, Blast_Score=145, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30118; Mature: 30118

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPEAELDWDDARRVILAALAEDTGADKGGEGEDITSASVIPADLRFTGIMAARHTMVVA
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEE
GMPVAQEVFRLVVPEARFTARVADGDTVEAGTVLAEMEGPARGLLTAERTALNLLQLLSG
CCCHHHHHHHHHCCCCHHEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
IATLTSQYAKRIQGTGCTLLDTRKTIPGLRRLSKYATRCGGAKNHRMGLYDGVLIKDNHI
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCE
AVCGGVGEAVRRAKAEGRPNIEAECDTLEQVAEAVEAGADIVLLDNMGPDVLRRAVAIVA
EEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
GRAKTEASGGVTLDTIRAIAETGVDFVSVGRITQSAPAVDIGLDWS
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCHHCCCCEEEECCCCC
>Mature Secondary Structure
MRPEAELDWDDARRVILAALAEDTGADKGGEGEDITSASVIPADLRFTGIMAARHTMVVA
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEE
GMPVAQEVFRLVVPEARFTARVADGDTVEAGTVLAEMEGPARGLLTAERTALNLLQLLSG
CCCHHHHHHHHHCCCCHHEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
IATLTSQYAKRIQGTGCTLLDTRKTIPGLRRLSKYATRCGGAKNHRMGLYDGVLIKDNHI
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCE
AVCGGVGEAVRRAKAEGRPNIEAECDTLEQVAEAVEAGADIVLLDNMGPDVLRRAVAIVA
EEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
GRAKTEASGGVTLDTIRAIAETGVDFVSVGRITQSAPAVDIGLDWS
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]