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The map label for this gene is csgA [H]

Identifier: 83312930

GI number: 83312930

Start: 4231921

End: 4232589

Strand: Reverse

Name: csgA [H]

Synonym: amb3831

Alternate gene names: 83312930

Gene position: 4232589-4231921 (Counterclockwise)

Preceding gene: 83312931

Following gene: 83312929

Centisome position: 85.21

GC content: 69.81

Gene sequence:

>669_bases
ATGCCCACCATCCTGATCACCGGCGCCAATCGCGGCATGGGGCTTGAGTTCGCCCGGCAATATGCCGCCGAGGGCTGGCG
GGTGCTGGGCACGGTGCGCGATCCCATGGCGGGCCGCGCCTTGTCCGAGGCGGGCGGCGAGGTCTATGTCTGCGACGTGG
CCGACCCGGCCCAGGTGGCGCGGCTGAAAGCCTCGCTGGCCGGGGTGGGGCTGGACATCTTGCTGAACAATGCCGGCATC
TACGGCGAGAAGCAGGAGTTCGGCGCCGTCGACCCCGCCGCCTTCATGAAGGTGGTCGCCGTCGACACCCTGGCGCCGCT
GAAGCTGGCCGAAGCCTTCGCCGACCAGATGACCGGGGCCAGGATCATCGCGGCGGTGTCGTCCAAGATGGGCGCCATGT
CCGACAACACCTCGGGTGGGTCCTACGCCTACCGCGCCGCCAAGGCGGCCCTCAACATGGTGATCAAGGGGCTGGCGGTG
GATCTGGCGCCGCGCGGCATTCTCACCGTGGCGCTGTCGCCCGGCTGGGTGCGCACCGACATGGGCGGGGCCAACGCTCC
CCTGGATGCCGAGACCGCCGTGGCCGGCATGCGAAAGGTCATGGCCGGGCTGACGGCCGGGGACAGCGGCGCCTTCATCC
ATTACGATGGGTCTCGCCTGTCCTGGTAG

Upstream 100 bases:

>100_bases
ATCGAGGTCACCGCTCTCAAGGCGTAAAGAGCGGCGGGGACGGCCGCGCTCCGGGCATGGAGCGCGGGCATCCTGCCCGC
CAACCAACGGAGGACGCATC

Downstream 100 bases:

>100_bases
GGAGCAAAGCATGACCCAGCCGGTGGAGTTCTATTTCGATTTTGCCTCGCCTTACGGCTACTTCGCCTCCCTGGAGGTGG
ACGAGCTGGTGGCCGCCTTC

Product: dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MPTILITGANRGMGLEFARQYAAEGWRVLGTVRDPMAGRALSEAGGEVYVCDVADPAQVARLKASLAGVGLDILLNNAGI
YGEKQEFGAVDPAAFMKVVAVDTLAPLKLAEAFADQMTGARIIAAVSSKMGAMSDNTSGGSYAYRAAKAALNMVIKGLAV
DLAPRGILTVALSPGWVRTDMGGANAPLDAETAVAGMRKVMAGLTAGDSGAFIHYDGSRLSW

Sequences:

>Translated_222_residues
MPTILITGANRGMGLEFARQYAAEGWRVLGTVRDPMAGRALSEAGGEVYVCDVADPAQVARLKASLAGVGLDILLNNAGI
YGEKQEFGAVDPAAFMKVVAVDTLAPLKLAEAFADQMTGARIIAAVSSKMGAMSDNTSGGSYAYRAAKAALNMVIKGLAV
DLAPRGILTVALSPGWVRTDMGGANAPLDAETAVAGMRKVMAGLTAGDSGAFIHYDGSRLSW
>Mature_221_residues
PTILITGANRGMGLEFARQYAAEGWRVLGTVRDPMAGRALSEAGGEVYVCDVADPAQVARLKASLAGVGLDILLNNAGIY
GEKQEFGAVDPAAFMKVVAVDTLAPLKLAEAFADQMTGARIIAAVSSKMGAMSDNTSGGSYAYRAAKAALNMVIKGLAVD
LAPRGILTVALSPGWVRTDMGGANAPLDAETAVAGMRKVMAGLTAGDSGAFIHYDGSRLSW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Escherichia coli, GI1787335, Length=186, Percent_Identity=32.7956989247312, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI2367365, Length=192, Percent_Identity=34.8958333333333, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87082100, Length=235, Percent_Identity=30.6382978723404, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17558994, Length=240, Percent_Identity=30.4166666666667, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17558992, Length=240, Percent_Identity=30.8333333333333, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559962, Length=241, Percent_Identity=31.5352697095436, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17558990, Length=240, Percent_Identity=29.5833333333333, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI72001658, Length=237, Percent_Identity=29.535864978903, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI193207563, Length=238, Percent_Identity=28.9915966386555, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17559964, Length=239, Percent_Identity=28.8702928870293, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17558996, Length=250, Percent_Identity=26, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17532177, Length=238, Percent_Identity=27.3109243697479, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17541382, Length=246, Percent_Identity=25.609756097561, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17542178, Length=240, Percent_Identity=27.9166666666667, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24640547, Length=247, Percent_Identity=33.1983805668016, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 22868; Mature: 22736

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTILITGANRGMGLEFARQYAAEGWRVLGTVRDPMAGRALSEAGGEVYVCDVADPAQVA
CCEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCHHHHCCCEEEEEECCCHHHHH
RLKASLAGVGLDILLNNAGIYGEKQEFGAVDPAAFMKVVAVDTLAPLKLAEAFADQMTGA
HHHHHHHCCCEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCH
RIIAAVSSKMGAMSDNTSGGSYAYRAAKAALNMVIKGLAVDLAPRGILTVALSPGWVRTD
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEC
MGGANAPLDAETAVAGMRKVMAGLTAGDSGAFIHYDGSRLSW
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
PTILITGANRGMGLEFARQYAAEGWRVLGTVRDPMAGRALSEAGGEVYVCDVADPAQVA
CEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCHHHHCCCEEEEEECCCHHHHH
RLKASLAGVGLDILLNNAGIYGEKQEFGAVDPAAFMKVVAVDTLAPLKLAEAFADQMTGA
HHHHHHHCCCEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCH
RIIAAVSSKMGAMSDNTSGGSYAYRAAKAALNMVIKGLAVDLAPRGILTVALSPGWVRTD
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEC
MGGANAPLDAETAVAGMRKVMAGLTAGDSGAFIHYDGSRLSW
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]