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The map label for this gene is uvrC

Identifier: 83312899

GI number: 83312899

Start: 4195840

End: 4197714

Strand: Reverse

Name: uvrC

Synonym: amb3800

Alternate gene names: 83312899

Gene position: 4197714-4195840 (Counterclockwise)

Preceding gene: 83312900

Following gene: 83312898

Centisome position: 84.51

GC content: 67.63

Gene sequence:

>1875_bases
TTGACCGAAGCGGACAGTTCCGCCACGCCGCTGGCCCGGGGGGTGGAGGTTATCGCCCAAGTGGTGGCGACCCTGCCGCT
CAGCCCCGGCGTCTACCGCATGCTGAGCGGCAAGGGCGACGTGCTCTATGTGGGCAAGGCCAAGAGCCTGAAGAAGCGGG
TGGTGGCCTATACCAGGCCCGACCGCATGCCGCTGCGCATCCAGCGCATGATCGCCGAGACCGCCTCCATGGAGGTGGTG
ACCACCCGCACCGAGGTCGAGGCGCTGCTGCTGGAAAGCAACCTGATCAAGAGCCTGGGGCCGCGTTACAACATCCTCCT
CAAGGATGACAAGACCTTCCCCCACATCCTGATCACCGCCGACCATGACTGGCCGCAGGTGCTGAAACATCGCGGCGCCC
GCAACCGCAAGGGCGAGTATTTCGGCCCCTTCGCCTCGGCAGGGGCGGTGAACCAGACCCTGGCGGCGCTGCAGCGGGCC
TTCCTGCTGCGCTCATGCTCGGATTCGGTGTTCGCCTCGCGGACCCGGCCCTGCCTGCTGTTCCAGATCAAGCGCTGCTC
GGCGCCTTGCGTCGAGCGCATCGACCGCGACGAGTATCTGGCGCTGGTGGAGGAGGCGAGGGCCTTTCTCTCGGGCCAGA
GCCGCCGCGTCCAGCACGACCTCACCGCCCGCATGGAAAGCGCGGCCGAGGCCATGGAATACGAGGCGGCGGCGGTGTTC
CGCGACCGTATCCGGGCGCTGACCCGTATCCAGGCCCATCAGGACATCAACCCTGCCGAGGTGGAGGAGGCCGACGTGGT
CGCCCTGCATCAGGCCGGCGACGGGGTGTGCATCCAGGTGTTTTTTTTCCGCTCGGGCTGCAATTACGGCAACCGCGCCT
ATTTCCCGGTCCACGCTCAGGGCGAGGAGGCGCCGCAGATCATGGCGGCCTTCCTGGGGCAGTTCTATGCCGACAAGACG
CCGCCGCGCGAGATCCTGCTGTCGCTGGAGCCCGACGAGGTCGCCATCGTCGCCCAGGCCCTGTCGGAAAAGGCCGGGCG
CAAGGTGACCCTGTCCGTCCCTAAGCGCGGCGACCGCAAGCGGCTGGTGGAGCATGCGCACGACAATGCCCGCGACGCGC
TGGGCCGCCGCATGGCGGAAAGCGGGGCGCAGCGCAAATTGCTGGAAGGGGTGGCCGAACTGTTCGGGATGGAGTCGGCG
CCCGAGCGCATCGAGGTCTACGACAACTCCCACATCCAGGGCTCGGACGCGGTGGGGGCGATGATCGTCGCCGGTCCCGA
CGGGCTGATGAAATCGGCTTACCGGAAGTTCAACATCCGCTCGACCGATCTCACCCCCGGCGACGATTTCGGCATGATGC
GCGAGGTTCTGACCCGGCGCTTCGCCCGCGCCCAGAAGGAGGATCCCGACCGCGACCGGGGGCTGTGGCCCGACCTGGCG
CTGATCGACGGCGGACGGGGGCAGCTCAACGCCGCCCTGGGCGTGCTGGCCGAACTGGGCATCGACGACGTCATGCTGGT
GGGCATCGCCAAGGGCCCCGACCGCAATGCCGGGCGCGAGCGCTTTTTCCTGGCGGGCAAGGAGCCCATCAGCCTGGAAT
CCCGCCACCCGGTGCTGTACTTCCTGCAGCGTCTCAGGGACGAGGCCCACCGCTTCGCCATCGGCACCCACCGGGCCCGG
CGGTCCAAGGGATTGGTTCAATCCACCCTGGACGCTCTGCCCGGGATCGGGCCAAAGCGCAAGAAGGCCCTGCTGCACCA
TTTCGGCTCGGCCCGCGCCGTGGCCGAGGCCGGTCTGCCCGATCTGGAAAGCGTCGAGGGAATCAGCCACGCCATGGCCA
AAAAGATTCATGACTACTTCCATCCCGAGGGTTAG

Upstream 100 bases:

>100_bases
TCCACAGCTTTCGTGGATATCCCGGGATGCAAGGGAAATTCTGCTGCCCCTGCGAAGTAGATAGGGTAAACCGGTGCCCT
GACATCGCGGGAGGCGCGCC

Downstream 100 bases:

>100_bases
TATCCCGGCGTTATGCTGACCAGCCTTCCCAACCTGCTGACACTGTCGCGGATCGTCGTGATTCCGTTGGTGGTCGGCCT
GTTCTACGTGGACGGCGACG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MTEADSSATPLARGVEVIAQVVATLPLSPGVYRMLSGKGDVLYVGKAKSLKKRVVAYTRPDRMPLRIQRMIAETASMEVV
TTRTEVEALLLESNLIKSLGPRYNILLKDDKTFPHILITADHDWPQVLKHRGARNRKGEYFGPFASAGAVNQTLAALQRA
FLLRSCSDSVFASRTRPCLLFQIKRCSAPCVERIDRDEYLALVEEARAFLSGQSRRVQHDLTARMESAAEAMEYEAAAVF
RDRIRALTRIQAHQDINPAEVEEADVVALHQAGDGVCIQVFFFRSGCNYGNRAYFPVHAQGEEAPQIMAAFLGQFYADKT
PPREILLSLEPDEVAIVAQALSEKAGRKVTLSVPKRGDRKRLVEHAHDNARDALGRRMAESGAQRKLLEGVAELFGMESA
PERIEVYDNSHIQGSDAVGAMIVAGPDGLMKSAYRKFNIRSTDLTPGDDFGMMREVLTRRFARAQKEDPDRDRGLWPDLA
LIDGGRGQLNAALGVLAELGIDDVMLVGIAKGPDRNAGRERFFLAGKEPISLESRHPVLYFLQRLRDEAHRFAIGTHRAR
RSKGLVQSTLDALPGIGPKRKKALLHHFGSARAVAEAGLPDLESVEGISHAMAKKIHDYFHPEG

Sequences:

>Translated_624_residues
MTEADSSATPLARGVEVIAQVVATLPLSPGVYRMLSGKGDVLYVGKAKSLKKRVVAYTRPDRMPLRIQRMIAETASMEVV
TTRTEVEALLLESNLIKSLGPRYNILLKDDKTFPHILITADHDWPQVLKHRGARNRKGEYFGPFASAGAVNQTLAALQRA
FLLRSCSDSVFASRTRPCLLFQIKRCSAPCVERIDRDEYLALVEEARAFLSGQSRRVQHDLTARMESAAEAMEYEAAAVF
RDRIRALTRIQAHQDINPAEVEEADVVALHQAGDGVCIQVFFFRSGCNYGNRAYFPVHAQGEEAPQIMAAFLGQFYADKT
PPREILLSLEPDEVAIVAQALSEKAGRKVTLSVPKRGDRKRLVEHAHDNARDALGRRMAESGAQRKLLEGVAELFGMESA
PERIEVYDNSHIQGSDAVGAMIVAGPDGLMKSAYRKFNIRSTDLTPGDDFGMMREVLTRRFARAQKEDPDRDRGLWPDLA
LIDGGRGQLNAALGVLAELGIDDVMLVGIAKGPDRNAGRERFFLAGKEPISLESRHPVLYFLQRLRDEAHRFAIGTHRAR
RSKGLVQSTLDALPGIGPKRKKALLHHFGSARAVAEAGLPDLESVEGISHAMAKKIHDYFHPEG
>Mature_623_residues
TEADSSATPLARGVEVIAQVVATLPLSPGVYRMLSGKGDVLYVGKAKSLKKRVVAYTRPDRMPLRIQRMIAETASMEVVT
TRTEVEALLLESNLIKSLGPRYNILLKDDKTFPHILITADHDWPQVLKHRGARNRKGEYFGPFASAGAVNQTLAALQRAF
LLRSCSDSVFASRTRPCLLFQIKRCSAPCVERIDRDEYLALVEEARAFLSGQSRRVQHDLTARMESAAEAMEYEAAAVFR
DRIRALTRIQAHQDINPAEVEEADVVALHQAGDGVCIQVFFFRSGCNYGNRAYFPVHAQGEEAPQIMAAFLGQFYADKTP
PREILLSLEPDEVAIVAQALSEKAGRKVTLSVPKRGDRKRLVEHAHDNARDALGRRMAESGAQRKLLEGVAELFGMESAP
ERIEVYDNSHIQGSDAVGAMIVAGPDGLMKSAYRKFNIRSTDLTPGDDFGMMREVLTRRFARAQKEDPDRDRGLWPDLAL
IDGGRGQLNAALGVLAELGIDDVMLVGIAKGPDRNAGRERFFLAGKEPISLESRHPVLYFLQRLRDEAHRFAIGTHRARR
SKGLVQSTLDALPGIGPKRKKALLHHFGSARAVAEAGLPDLESVEGISHAMAKKIHDYFHPEG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=605, Percent_Identity=40, Blast_Score=446, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_MAGSA (Q2W0M1)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_423163.1
- ProteinModelPortal:   Q2W0M1
- STRING:   Q2W0M1
- GeneID:   3802443
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb3800
- NMPDR:   fig|342108.5.peg.3400
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q2W0M1
- ProtClustDB:   PRK00558
- BioCyc:   MMAG342108:AMB3800-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68968; Mature: 68837

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEADSSATPLARGVEVIAQVVATLPLSPGVYRMLSGKGDVLYVGKAKSLKKRVVAYTRP
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHCCC
DRMPLRIQRMIAETASMEVVTTRTEVEALLLESNLIKSLGPRYNILLKDDKTFPHILITA
CCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEC
DHDWPQVLKHRGARNRKGEYFGPFASAGAVNQTLAALQRAFLLRSCSDSVFASRTRPCLL
CCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEE
FQIKRCSAPCVERIDRDEYLALVEEARAFLSGQSRRVQHDLTARMESAAEAMEYEAAAVF
EEEHHCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RDRIRALTRIQAHQDINPAEVEEADVVALHQAGDGVCIQVFFFRSGCNYGNRAYFPVHAQ
HHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEEEECC
GEEAPQIMAAFLGQFYADKTPPREILLSLEPDEVAIVAQALSEKAGRKVTLSVPKRGDRK
CCCHHHHHHHHHHHHHCCCCCHHHEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHH
RLVEHAHDNARDALGRRMAESGAQRKLLEGVAELFGMESAPERIEVYDNSHIQGSDAVGA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCE
MIVAGPDGLMKSAYRKFNIRSTDLTPGDDFGMMREVLTRRFARAQKEDPDRDRGLWPDLA
EEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
LIDGGRGQLNAALGVLAELGIDDVMLVGIAKGPDRNAGRERFFLAGKEPISLESRHPVLY
EEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHH
FLQRLRDEAHRFAIGTHRARRSKGLVQSTLDALPGIGPKRKKALLHHFGSARAVAEAGLP
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCC
DLESVEGISHAMAKKIHDYFHPEG
CHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TEADSSATPLARGVEVIAQVVATLPLSPGVYRMLSGKGDVLYVGKAKSLKKRVVAYTRP
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHCCC
DRMPLRIQRMIAETASMEVVTTRTEVEALLLESNLIKSLGPRYNILLKDDKTFPHILITA
CCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEC
DHDWPQVLKHRGARNRKGEYFGPFASAGAVNQTLAALQRAFLLRSCSDSVFASRTRPCLL
CCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEE
FQIKRCSAPCVERIDRDEYLALVEEARAFLSGQSRRVQHDLTARMESAAEAMEYEAAAVF
EEEHHCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RDRIRALTRIQAHQDINPAEVEEADVVALHQAGDGVCIQVFFFRSGCNYGNRAYFPVHAQ
HHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEEEECC
GEEAPQIMAAFLGQFYADKTPPREILLSLEPDEVAIVAQALSEKAGRKVTLSVPKRGDRK
CCCHHHHHHHHHHHHHCCCCCHHHEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHH
RLVEHAHDNARDALGRRMAESGAQRKLLEGVAELFGMESAPERIEVYDNSHIQGSDAVGA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCE
MIVAGPDGLMKSAYRKFNIRSTDLTPGDDFGMMREVLTRRFARAQKEDPDRDRGLWPDLA
EEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
LIDGGRGQLNAALGVLAELGIDDVMLVGIAKGPDRNAGRERFFLAGKEPISLESRHPVLY
EEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHH
FLQRLRDEAHRFAIGTHRARRSKGLVQSTLDALPGIGPKRKKALLHHFGSARAVAEAGLP
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCC
DLESVEGISHAMAKKIHDYFHPEG
CHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA