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The map label for this gene is pepA [H]

Identifier: 83312774

GI number: 83312774

Start: 4036318

End: 4037916

Strand: Reverse

Name: pepA [H]

Synonym: amb3675

Alternate gene names: 83312774

Gene position: 4037916-4036318 (Counterclockwise)

Preceding gene: 83312775

Following gene: 83312772

Centisome position: 81.29

GC content: 70.42

Gene sequence:

>1599_bases
ATGCGCATCACCTTCCGCTCTCCCCCCGCCACCCTGGACGGCGCCATTGCCGTCGGGTTGTGGCGGGGGCGGCTTGCCAC
CCCATCCTTCACCGCCCTGGACGGCGACGGTTTGCTGGCCAAGGCGCTGAAGCGTCTGGGCTTCGACGGCGATGCCGAGG
AGACCGAGCTGCTGTTGGCGCCGCCGCGCCCGCTCTCGGCGCTGGTGGTGTTCGGGCTGGGCAAGGGGCGCAAGCTCGAT
GCCCGGCGTTTGCGCCGCATCGGCGGGGCCTTGCTCGATGAGCTGGACGAAAGCCGGGCCAAGGCGGTGACCGTTCTGCT
GGACCTGCCCGCCGGGCAGGCGGCGGAGATGGCCTATGGGCTGCGGCTCAAGGGCTATCGCCCGCTGTCCAAATACCGCA
CCAAATATGATCCCGACGACGAGGACGACATTCAGCCGGTGCTGGAATCGGTGATCGTCTGCTGTCCCGACCCGGACGAG
GCGGCGCGTCTGTTCCAGGCTCGCGAGGCGGTGGCCCAGGGGGTGTTCCTGGCCCGCGACCTGACGGACGAGCCCGCCAA
TGTGCTGGGGCCGGACGAGTTCGTCCGGCGCGCCCGCCTGCTGGAAGCGCTGGGTGTCGAGGTCACCGTGCTGGACGAGG
CCGCGCTGGCGGCCGAGGGCCTCAACCTGCTGGCGGCGGTGGGGCAGGGCAGCAAGCGGCCGCCCCGTCTGGTGCTGCTG
CGCTGGAAAGGCGCCGAGGGCAAGCCGCTGGTGCTGGTGGGCAAGGGCATCACCTTCGATACCGGCGGCATCACCATCAA
GGCCGATGACGAGGACATGGACGCCATGAAGGCCGACATGGCTGGGGCCGCCGCGGTGATCGGCGCCCTGCGCGCCGTGG
CGGGGCGACAGGCCAAGGCCCATGTCTGCGGCGTGCTGGCCCTGGCCGAGAACATGCCGTCGGGCGCGGCCCAGCGGCCC
GGCGACGTGGTCCGCTCTTTCTCGGGCCAGACCGTGGAGGTGATCGACACCGACGCCGAGGGCCGTCTGGTGCTGGCCGA
TGCCCTGGCCTGGGCGGCGGAGCGCCTGAAGCCCGCCGCCATGGTGGACATCGCCACCCTGACCGGCACCACCGAGGAAT
TGCTGGACGCCGAATACGCCGGCCTCTACGCCAATGACGATCTGCTGGCCAAGCGCCTGCTGAAGCACGCCAAGGCCGAG
GACGAGCCCTTGTGGCGGCTGCCGCTGACGGCGGCCTGCGACGAGGACATCAAGTCCGACATCGCCGACCTCAAGCACTG
CGCCTGGGGCGACGTCCCCGACAACGACGACGCGGCCCGCTTCCTGGAGCATTTCGTGCCCGAGGGGCTGCCCTGGGCTC
ATATCGACATGGCGGGGCGGGAATTTGCCGACGAGGACGATCCGCTGTGTCCCGAAACCGCGACGGGGTATGGAGTCAGG
CTGTTCGACGCCCTGGCGGGGGGGGGGGCTGACGGCGGGGCTGCCGCCCCGGTCCCCGCTTGGAGGCGACGCCTCCAAAC
CTCCATGCCGTTCATAAACAGGGACGAGGGGCAGGCGAGGCTTGGCCCCGGATGGGTTTGGGCGAGTGCCCAATCATGA

Upstream 100 bases:

>100_bases
GATCTCTGCCTGATCCGATGGTGCCGGTTCTGATCCGCCGGATCAGGATGAGATCCCTCCGCCCTTCGGTTGTCGGGATG
ACAGGTTTGATGGGGCGTTC

Downstream 100 bases:

>100_bases
AGGTGTGTTGCCGCTTCGCGCCTTGGGTGCCGTCTGGACGTCGTGGGCGATGGCTTGCAGCAGGAGCTGGAAGCCCAGGA
TGGTGGGCATGGCGGCCAGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MRITFRSPPATLDGAIAVGLWRGRLATPSFTALDGDGLLAKALKRLGFDGDAEETELLLAPPRPLSALVVFGLGKGRKLD
ARRLRRIGGALLDELDESRAKAVTVLLDLPAGQAAEMAYGLRLKGYRPLSKYRTKYDPDDEDDIQPVLESVIVCCPDPDE
AARLFQAREAVAQGVFLARDLTDEPANVLGPDEFVRRARLLEALGVEVTVLDEAALAAEGLNLLAAVGQGSKRPPRLVLL
RWKGAEGKPLVLVGKGITFDTGGITIKADDEDMDAMKADMAGAAAVIGALRAVAGRQAKAHVCGVLALAENMPSGAAQRP
GDVVRSFSGQTVEVIDTDAEGRLVLADALAWAAERLKPAAMVDIATLTGTTEELLDAEYAGLYANDDLLAKRLLKHAKAE
DEPLWRLPLTAACDEDIKSDIADLKHCAWGDVPDNDDAARFLEHFVPEGLPWAHIDMAGREFADEDDPLCPETATGYGVR
LFDALAGGGADGGAAAPVPAWRRRLQTSMPFINRDEGQARLGPGWVWASAQS

Sequences:

>Translated_532_residues
MRITFRSPPATLDGAIAVGLWRGRLATPSFTALDGDGLLAKALKRLGFDGDAEETELLLAPPRPLSALVVFGLGKGRKLD
ARRLRRIGGALLDELDESRAKAVTVLLDLPAGQAAEMAYGLRLKGYRPLSKYRTKYDPDDEDDIQPVLESVIVCCPDPDE
AARLFQAREAVAQGVFLARDLTDEPANVLGPDEFVRRARLLEALGVEVTVLDEAALAAEGLNLLAAVGQGSKRPPRLVLL
RWKGAEGKPLVLVGKGITFDTGGITIKADDEDMDAMKADMAGAAAVIGALRAVAGRQAKAHVCGVLALAENMPSGAAQRP
GDVVRSFSGQTVEVIDTDAEGRLVLADALAWAAERLKPAAMVDIATLTGTTEELLDAEYAGLYANDDLLAKRLLKHAKAE
DEPLWRLPLTAACDEDIKSDIADLKHCAWGDVPDNDDAARFLEHFVPEGLPWAHIDMAGREFADEDDPLCPETATGYGVR
LFDALAGGGADGGAAAPVPAWRRRLQTSMPFINRDEGQARLGPGWVWASAQS
>Mature_532_residues
MRITFRSPPATLDGAIAVGLWRGRLATPSFTALDGDGLLAKALKRLGFDGDAEETELLLAPPRPLSALVVFGLGKGRKLD
ARRLRRIGGALLDELDESRAKAVTVLLDLPAGQAAEMAYGLRLKGYRPLSKYRTKYDPDDEDDIQPVLESVIVCCPDPDE
AARLFQAREAVAQGVFLARDLTDEPANVLGPDEFVRRARLLEALGVEVTVLDEAALAAEGLNLLAAVGQGSKRPPRLVLL
RWKGAEGKPLVLVGKGITFDTGGITIKADDEDMDAMKADMAGAAAVIGALRAVAGRQAKAHVCGVLALAENMPSGAAQRP
GDVVRSFSGQTVEVIDTDAEGRLVLADALAWAAERLKPAAMVDIATLTGTTEELLDAEYAGLYANDDLLAKRLLKHAKAE
DEPLWRLPLTAACDEDIKSDIADLKHCAWGDVPDNDDAARFLEHFVPEGLPWAHIDMAGREFADEDDPLCPETATGYGVR
LFDALAGGGADGGAAAPVPAWRRRLQTSMPFINRDEGQARLGPGWVWASAQS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=316, Percent_Identity=35.7594936708861, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI47155554, Length=342, Percent_Identity=33.9181286549708, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1790710, Length=480, Percent_Identity=35.2083333333333, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI87082123, Length=338, Percent_Identity=39.3491124260355, Blast_Score=174, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=319, Percent_Identity=36.3636363636364, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=269, Percent_Identity=28.6245353159851, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355725, Length=294, Percent_Identity=36.734693877551, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24661038, Length=294, Percent_Identity=35.7142857142857, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20129969, Length=308, Percent_Identity=31.4935064935065, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI221379063, Length=329, Percent_Identity=35.258358662614, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI221379062, Length=329, Percent_Identity=35.258358662614, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21357381, Length=329, Percent_Identity=35.258358662614, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24662227, Length=301, Percent_Identity=30.5647840531561, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI161077148, Length=311, Percent_Identity=30.8681672025724, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI20130057, Length=311, Percent_Identity=30.8681672025724, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI20129963, Length=319, Percent_Identity=33.8557993730408, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922386, Length=302, Percent_Identity=32.1192052980132, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355645, Length=309, Percent_Identity=30.42071197411, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24662223, Length=309, Percent_Identity=30.42071197411, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646701, Length=237, Percent_Identity=32.9113924050633, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646703, Length=237, Percent_Identity=32.9113924050633, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358201, Length=237, Percent_Identity=32.9113924050633, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 56784; Mature: 56784

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITFRSPPATLDGAIAVGLWRGRLATPSFTALDGDGLLAKALKRLGFDGDAEETELLLA
CEEEECCCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCEEEEE
PPRPLSALVVFGLGKGRKLDARRLRRIGGALLDELDESRAKAVTVLLDLPAGQAAEMAYG
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHC
LRLKGYRPLSKYRTKYDPDDEDDIQPVLESVIVCCPDPDEAARLFQAREAVAQGVFLARD
EEECCCCCHHHHCCCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHC
LTDEPANVLGPDEFVRRARLLEALGVEVTVLDEAALAAEGLNLLAAVGQGSKRPPRLVLL
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEE
RWKGAEGKPLVLVGKGITFDTGGITIKADDEDMDAMKADMAGAAAVIGALRAVAGRQAKA
EECCCCCCEEEEEECCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
HVCGVLALAENMPSGAAQRPGDVVRSFSGQTVEVIDTDAEGRLVLADALAWAAERLKPAA
HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCHH
MVDIATLTGTTEELLDAEYAGLYANDDLLAKRLLKHAKAEDEPLWRLPLTAACDEDIKSD
HEEEHHHCCCHHHHHHHHHCCEECCHHHHHHHHHHHCCCCCCCEEECCCHHHCCHHHHHH
IADLKHCAWGDVPDNDDAARFLEHFVPEGLPWAHIDMAGREFADEDDPLCPETATGYGVR
HHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHH
LFDALAGGGADGGAAAPVPAWRRRLQTSMPFINRDEGQARLGPGWVWASAQS
HHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCC
>Mature Secondary Structure
MRITFRSPPATLDGAIAVGLWRGRLATPSFTALDGDGLLAKALKRLGFDGDAEETELLLA
CEEEECCCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCEEEEE
PPRPLSALVVFGLGKGRKLDARRLRRIGGALLDELDESRAKAVTVLLDLPAGQAAEMAYG
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHC
LRLKGYRPLSKYRTKYDPDDEDDIQPVLESVIVCCPDPDEAARLFQAREAVAQGVFLARD
EEECCCCCHHHHCCCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHC
LTDEPANVLGPDEFVRRARLLEALGVEVTVLDEAALAAEGLNLLAAVGQGSKRPPRLVLL
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEE
RWKGAEGKPLVLVGKGITFDTGGITIKADDEDMDAMKADMAGAAAVIGALRAVAGRQAKA
EECCCCCCEEEEEECCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
HVCGVLALAENMPSGAAQRPGDVVRSFSGQTVEVIDTDAEGRLVLADALAWAAERLKPAA
HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCHH
MVDIATLTGTTEELLDAEYAGLYANDDLLAKRLLKHAKAEDEPLWRLPLTAACDEDIKSD
HEEEHHHCCCHHHHHHHHHCCEECCHHHHHHHHHHHCCCCCCCEEECCCHHHCCHHHHHH
IADLKHCAWGDVPDNDDAARFLEHFVPEGLPWAHIDMAGREFADEDDPLCPETATGYGVR
HHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHH
LFDALAGGGADGGAAAPVPAWRRRLQTSMPFINRDEGQARLGPGWVWASAQS
HHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]