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The map label for this gene is acdA [H]

Identifier: 83312330

GI number: 83312330

Start: 3491742

End: 3492920

Strand: Reverse

Name: acdA [H]

Synonym: amb3231

Alternate gene names: 83312330

Gene position: 3492920-3491742 (Counterclockwise)

Preceding gene: 83312335

Following gene: 83312329

Centisome position: 70.32

GC content: 64.72

Gene sequence:

>1179_bases
GTGCAGCATTTCAAGTGGGACGACCCCTTTCTCCTGGAAGACCAGCTTTCCGAAGACGAGAAGCTGATCCGCGACTCGGC
GCACGCCTATTGCCAGGAGAAGCTTCAGCCGCGCGTGATGAAGGCGTTCCGCGACGAGACCTTCGACCGCGAGATCATGA
ACGAGATGGGCGAGATGGGCCTGCTTGGCCCCACCATCCCCGAGGAATACGGCGGGCCGGGCGTCAACCACGTGGCCTAC
GGCCTGATCTCCCGCGAAGTGGAGCGGGTGGATTCCGGCTATCGCTCGGCCATGAGCGTGCAGTCGTCGCTGGTGATGCA
CCCCATCTTCAGCTACGGCACCGAGGAGCAGAAGAAGAAGTATCTGCCCCGTCTGGCCACCGGCGAGATCATCGGCTGTT
TCGGCCTGACCGAGCCCGACGCCGGCTCCGATCCGGGCGGCATGCGCACCCGCGCCAAGAAGGTGGACGGCGGCTATCTG
CTGACCGGTTCCAAGATGTGGATCACCAATTCCCCCATCTCGGACATCGCCATCGTCTGGGCCAAGTCCGACGCCCATGA
GGGCAAGATCAAGGGCTTCATCGTCGAGAAGGGTATCAAGGGCTTCACCACGCCGAAGATCGAGGGCAAGCTCTCCTTGC
GTGCCTCCATCACCGGCGAGATCGTGTTGGACGAGGCTTTCGTCCCCGACGAGGCGCTGATGCCCAACGCGTCCGGCCTG
GGTGGTCCGTTCGGCTGCCTCAACAAGGCCCGCTACGGCATCGCCTGGGGCGTCATCGGCGCCGCCGAGTTCTGCTGGCA
CGCGGCGCGCCAGTACATGCTGGACCGCAAGCAGTTCGGCCGCCCCCTGGCCGCCAACCAGATCCCCCAGCTGAAGCTGG
CCAACATGATGACCGAGATCACCCTGGGCCTGCAGGCCTGCGTGCGCGTCGGCCGCATGATGGACGACCACACCTGGGCG
CCCGAGGCCGTGTCGCTGATCAAGCGCAACAACTGCGGCAAGGCGCTGGACATCGCCCGCATGGCCCGCGACATGCACGG
CGGCAACGGCATCTCGGAAGAGTTCCACGTCATCCGCCACATGGTGAATCTGGAGACCGTGAACACCTACGAAGGTGCCC
ACGACGTCCATGCCCTGATCCTGGGTCGGGCCATGACCGGCATCCAGGCGTTCTCCTGA

Upstream 100 bases:

>100_bases
TGAAACGTTATGACATCCATAGAAAAGATATTTTTCTCATAATGGCTCCCATGGGCCATGGTGCGCCCAGTGCCATTCAT
CATCGTATGGGAGACATACC

Downstream 100 bases:

>100_bases
ACCTGAAGCCACGATACCGGCCGGGCAGCGATGCCCGGCCGAACTTCAAGAGGGTGATGCAGTCATGAAGGTGTTGGTCG
CGATCAAGCGTGTGATCGAT

Product: Acyl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MQHFKWDDPFLLEDQLSEDEKLIRDSAHAYCQEKLQPRVMKAFRDETFDREIMNEMGEMGLLGPTIPEEYGGPGVNHVAY
GLISREVERVDSGYRSAMSVQSSLVMHPIFSYGTEEQKKKYLPRLATGEIIGCFGLTEPDAGSDPGGMRTRAKKVDGGYL
LTGSKMWITNSPISDIAIVWAKSDAHEGKIKGFIVEKGIKGFTTPKIEGKLSLRASITGEIVLDEAFVPDEALMPNASGL
GGPFGCLNKARYGIAWGVIGAAEFCWHAARQYMLDRKQFGRPLAANQIPQLKLANMMTEITLGLQACVRVGRMMDDHTWA
PEAVSLIKRNNCGKALDIARMARDMHGGNGISEEFHVIRHMVNLETVNTYEGAHDVHALILGRAMTGIQAFS

Sequences:

>Translated_392_residues
MQHFKWDDPFLLEDQLSEDEKLIRDSAHAYCQEKLQPRVMKAFRDETFDREIMNEMGEMGLLGPTIPEEYGGPGVNHVAY
GLISREVERVDSGYRSAMSVQSSLVMHPIFSYGTEEQKKKYLPRLATGEIIGCFGLTEPDAGSDPGGMRTRAKKVDGGYL
LTGSKMWITNSPISDIAIVWAKSDAHEGKIKGFIVEKGIKGFTTPKIEGKLSLRASITGEIVLDEAFVPDEALMPNASGL
GGPFGCLNKARYGIAWGVIGAAEFCWHAARQYMLDRKQFGRPLAANQIPQLKLANMMTEITLGLQACVRVGRMMDDHTWA
PEAVSLIKRNNCGKALDIARMARDMHGGNGISEEFHVIRHMVNLETVNTYEGAHDVHALILGRAMTGIQAFS
>Mature_392_residues
MQHFKWDDPFLLEDQLSEDEKLIRDSAHAYCQEKLQPRVMKAFRDETFDREIMNEMGEMGLLGPTIPEEYGGPGVNHVAY
GLISREVERVDSGYRSAMSVQSSLVMHPIFSYGTEEQKKKYLPRLATGEIIGCFGLTEPDAGSDPGGMRTRAKKVDGGYL
LTGSKMWITNSPISDIAIVWAKSDAHEGKIKGFIVEKGIKGFTTPKIEGKLSLRASITGEIVLDEAFVPDEALMPNASGL
GGPFGCLNKARYGIAWGVIGAAEFCWHAARQYMLDRKQFGRPLAANQIPQLKLANMMTEITLGLQACVRVGRMMDDHTWA
PEAVSLIKRNNCGKALDIARMARDMHGGNGISEEFHVIRHMVNLETVNTYEGAHDVHALILGRAMTGIQAFS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=391, Percent_Identity=65.7289002557545, Blast_Score=555, Evalue=1e-158,
Organism=Homo sapiens, GI7669494, Length=370, Percent_Identity=64.8648648648649, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=31.758530183727, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=29.3010752688172, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=31.8840579710145, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI4501859, Length=365, Percent_Identity=29.041095890411, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=29.6, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=29.6, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4501857, Length=388, Percent_Identity=29.1237113402062, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI21361497, Length=393, Percent_Identity=28.2442748091603, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI76496475, Length=392, Percent_Identity=29.0816326530612, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4557235, Length=392, Percent_Identity=29.0816326530612, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=28.042328042328, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1786223, Length=345, Percent_Identity=25.2173913043478, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081958, Length=345, Percent_Identity=25.5072463768116, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081702, Length=170, Percent_Identity=30.5882352941176, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=64.1752577319588, Blast_Score=530, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=31.0344827586207, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=31.3984168865435, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=30.6010928961749, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=31.2169312169312, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17506239, Length=366, Percent_Identity=29.7814207650273, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71990804, Length=265, Percent_Identity=36.6037735849057, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71985184, Length=358, Percent_Identity=31.5642458100559, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=267, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=27.3684210526316, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=35.9307359307359, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=30.6273062730627, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17533517, Length=385, Percent_Identity=25.974025974026, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17551932, Length=301, Percent_Identity=24.5847176079734, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=289, Percent_Identity=24.9134948096886, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562446, Length=325, Percent_Identity=24.6153846153846, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI19920834, Length=393, Percent_Identity=62.3409669211196, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=30.8310991957105, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=30.4582210242588, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=29.6791443850267, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=30.3191489361702, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21355753, Length=395, Percent_Identity=28.8607594936709, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=31.3953488372093, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43322; Mature: 43322

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHFKWDDPFLLEDQLSEDEKLIRDSAHAYCQEKLQPRVMKAFRDETFDREIMNEMGEMG
CCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LLGPTIPEEYGGPGVNHVAYGLISREVERVDSGYRSAMSVQSSLVMHPIFSYGTEEQKKK
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YLPRLATGEIIGCFGLTEPDAGSDPGGMRTRAKKVDGGYLLTGSKMWITNSPISDIAIVW
HCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCEEEECCEEEEECCCCCCEEEEE
AKSDAHEGKIKGFIVEKGIKGFTTPKIEGKLSLRASITGEIVLDEAFVPDEALMPNASGL
ECCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCHHCCCCCCCC
GGPFGCLNKARYGIAWGVIGAAEFCWHAARQYMLDRKQFGRPLAANQIPQLKLANMMTEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
TLGLQACVRVGRMMDDHTWAPEAVSLIKRNNCGKALDIARMARDMHGGNGISEEFHVIRH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
MVNLETVNTYEGAHDVHALILGRAMTGIQAFS
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQHFKWDDPFLLEDQLSEDEKLIRDSAHAYCQEKLQPRVMKAFRDETFDREIMNEMGEMG
CCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LLGPTIPEEYGGPGVNHVAYGLISREVERVDSGYRSAMSVQSSLVMHPIFSYGTEEQKKK
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YLPRLATGEIIGCFGLTEPDAGSDPGGMRTRAKKVDGGYLLTGSKMWITNSPISDIAIVW
HCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCEEEECCEEEEECCCCCCEEEEE
AKSDAHEGKIKGFIVEKGIKGFTTPKIEGKLSLRASITGEIVLDEAFVPDEALMPNASGL
ECCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCHHCCCCCCCC
GGPFGCLNKARYGIAWGVIGAAEFCWHAARQYMLDRKQFGRPLAANQIPQLKLANMMTEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
TLGLQACVRVGRMMDDHTWAPEAVSLIKRNNCGKALDIARMARDMHGGNGISEEFHVIRH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
MVNLETVNTYEGAHDVHALILGRAMTGIQAFS
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]