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The map label for this gene is folP [H]

Identifier: 83312303

GI number: 83312303

Start: 3471654

End: 3472082

Strand: Reverse

Name: folP [H]

Synonym: amb3204

Alternate gene names: 83312303

Gene position: 3472082-3471654 (Counterclockwise)

Preceding gene: 83312304

Following gene: 83312300

Centisome position: 69.9

GC content: 69.23

Gene sequence:

>429_bases
TTGCCTGATGCACATGCAGGGCGACGACCCGCGCACCATGCAGGCGGAGCCCCGCTATGCCTGCGCGCCACTCGACGTGT
TCGACCATCTGGCCCGACGGGTCCAGGACTGCGAAGCCTGGGCATTGCCCGTCAGCGGATCTGCCTCGATCCTGGTATCG
GCTTTGGCAAGACGCCCGGGCATTGTGCCCAGGTGCTGGGGAGTCTGGCTCTGCTGCACGGTCTGGGGCTGCCGCTGCTG
CTGGGAGTGTCGCGCAAGAGCTTCGTGGCCCGGCTGAGCCGGGACGAGGTTGCGACGGCCCGGCTGCCCGGCACCTTGGC
GGCCAATCTGGCCGGTCTGGATGCCGGGTTTCAGGTGCTGCGCGTCCACGACGTGCCCGAGACGGCCCAAGCCCTGGCCA
TCTGGACCGCCATGCGGAGCGGGGCTTAG

Upstream 100 bases:

>100_bases
ACGCGGCGGTCGAGGCGGGGGCGCGGATCATCAACGACGTCACCGCCCTGCTCGGCGATCCCGAGTCTCCCAAGGTGGCG
GCCCGAAGCGGCGCCGATCT

Downstream 100 bases:

>100_bases
CAGGCTGCGGATGGACGTCACTTCGGGGGCTTTTGCCCCCGATCCCCCAACCTGGAAGCCAGGCTTCCCGGACCCTTCTG
CTTTTTAGTCCATAGAAATA

Product: hypothetical protein

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MPDAHAGRRPAHHAGGAPLCLRATRRVRPSGPTGPGLRSLGIARQRICLDPGIGFGKTPGHCAQVLGSLALLHGLGLPLL
LGVSRKSFVARLSRDEVATARLPGTLAANLAGLDAGFQVLRVHDVPETAQALAIWTAMRSGA

Sequences:

>Translated_142_residues
MPDAHAGRRPAHHAGGAPLCLRATRRVRPSGPTGPGLRSLGIARQRICLDPGIGFGKTPGHCAQVLGSLALLHGLGLPLL
LGVSRKSFVARLSRDEVATARLPGTLAANLAGLDAGFQVLRVHDVPETAQALAIWTAMRSGA
>Mature_141_residues
PDAHAGRRPAHHAGGAPLCLRATRRVRPSGPTGPGLRSLGIARQRICLDPGIGFGKTPGHCAQVLGSLALLHGLGLPLLL
GVSRKSFVARLSRDEVATARLPGTLAANLAGLDAGFQVLRVHDVPETAQALAIWTAMRSGA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=100, Percent_Identity=42, Blast_Score=78, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 14684; Mature: 14553

Theoretical pI: Translated: 12.07; Mature: 12.07

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDAHAGRRPAHHAGGAPLCLRATRRVRPSGPTGPGLRSLGIARQRICLDPGIGFGKTPG
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
HCAQVLGSLALLHGLGLPLLLGVSRKSFVARLSRDEVATARLPGTLAANLAGLDAGFQVL
HHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEE
RVHDVPETAQALAIWTAMRSGA
EEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PDAHAGRRPAHHAGGAPLCLRATRRVRPSGPTGPGLRSLGIARQRICLDPGIGFGKTPG
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
HCAQVLGSLALLHGLGLPLLLGVSRKSFVARLSRDEVATARLPGTLAANLAGLDAGFQVL
HHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEE
RVHDVPETAQALAIWTAMRSGA
EEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]