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The map label for this gene is hisZ

Identifier: 83312290

GI number: 83312290

Start: 3456822

End: 3457913

Strand: Reverse

Name: hisZ

Synonym: amb3191

Alternate gene names: 83312290

Gene position: 3457913-3456822 (Counterclockwise)

Preceding gene: 83312291

Following gene: 83312289

Centisome position: 69.62

GC content: 71.25

Gene sequence:

>1092_bases
ATGCTGCCCCCAGACGCGGAGTTCGAAGCCTCCGTCGTCCACAGCCTGATGAGCATGTTCGCCCGTCATGGCTATGATCG
TGTCAAGCCGCCGCTGATCGAATTCGAGGAAAGCCTGCTGGACGGCGCGGGGGGGGGGACCTCGTCCCAGACCTTCCGGG
TCATGGATCCCATGAGCCAGAAGATGATGGGCCTGCGCGCCGACATGACGCCGCAGGTGGCCCGCATCGCCGCCACCCGC
CTGGGATCCCAGCCCCGGCCGCTGCGCCTGTCCTATGCCGGTCAGGTGCTGCGGGTGAAGGGCACCCAGCTGCGCCCCGA
GCGGCAGTTCGGCCAGGCCGGAATCGAGCTGATCGGCTCGGATGATGCCGGCGCCGATGCCGAGGTCCTGGTGATGACCG
CCGAGGCGCTCGATGATCTCGGCGTGCCCGGGGTGTCCGCCGACCTGGCCCTGCCCACCCTGGTTCCGGCGGTGTTCGCC
GCCTATGGGATCAATGGCGAGACCGCCGATCGCCTGCGCGCCGCCCTCGACCACAAGGACAGCGCCACGGTTGCCGCCCA
GGGCGGAGCCGCCGCGCCGCTGCTGCAGGCGCTGATCGCCGCCGCCGGTCCGGCCGCCCGCGCCCTGGCCGAGCTGTGCG
CCCTGGACCTGCCCCCCGCCGCCGCCGCCGAGCGCGACCGTCTGGCCCGGGTGGTGGAACTGGCCGGTGCCGACCTGCCG
TCGCTGACCCTGACGGTCGATCCGGTGGAAAATCGCGGATTCGAGTATCATACCGGCCTCAGCTTCACCCTGTTCGCCCG
CAATATGGGTGCCGAACTGGGGCGCGGCGGGCGCTATCAGGGCGGAGGCGGCGAGCCGGCCACCGGCGCCACTCTGTTCA
TGGATTCCGTTCTGGCGGCGCTGCCCGGCCCCAAGCCGGCCAAGCGGCTGTTCGTTCCGGCGGGAACGCCCCGGGCCTGG
GCCCAGGCGTTCCGCGCCCAGGGCTGGGTGACGGTGTCGGGGCTGGACCCCGCCGCCGACCCGCAAGTGGAAGCAAAGCA
TCAGGGCTGCAGGCATCGCCTCGGTCCCGATGGTATCGTCGAAGTCGAATAG

Upstream 100 bases:

>100_bases
GAGCGGTCGTCATTGCGACGCCCGCCCTTGTTCCGGGTTGCGACACCAAGAGATGACCGAGTCCGCCAATCGGGCCCTGC
TGCCCGCCGGCCTGCGCGAC

Downstream 100 bases:

>100_bases
GTTAGGGGACTTAAAGGTATGGCGAACGTGGCTGTGGTCGGCGCCCAGTGGGGCGACGAGGGCAAGGGCAAGGTCGTCGA
TTGGCTCTCCGAGCGCGCCG

Product: ATP phosphoribosyltransferase

Products: AMP; diphosphate; L-histidyl-tRNA(His)

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MLPPDAEFEASVVHSLMSMFARHGYDRVKPPLIEFEESLLDGAGGGTSSQTFRVMDPMSQKMMGLRADMTPQVARIAATR
LGSQPRPLRLSYAGQVLRVKGTQLRPERQFGQAGIELIGSDDAGADAEVLVMTAEALDDLGVPGVSADLALPTLVPAVFA
AYGINGETADRLRAALDHKDSATVAAQGGAAAPLLQALIAAAGPAARALAELCALDLPPAAAAERDRLARVVELAGADLP
SLTLTVDPVENRGFEYHTGLSFTLFARNMGAELGRGGRYQGGGGEPATGATLFMDSVLAALPGPKPAKRLFVPAGTPRAW
AQAFRAQGWVTVSGLDPAADPQVEAKHQGCRHRLGPDGIVEVE

Sequences:

>Translated_363_residues
MLPPDAEFEASVVHSLMSMFARHGYDRVKPPLIEFEESLLDGAGGGTSSQTFRVMDPMSQKMMGLRADMTPQVARIAATR
LGSQPRPLRLSYAGQVLRVKGTQLRPERQFGQAGIELIGSDDAGADAEVLVMTAEALDDLGVPGVSADLALPTLVPAVFA
AYGINGETADRLRAALDHKDSATVAAQGGAAAPLLQALIAAAGPAARALAELCALDLPPAAAAERDRLARVVELAGADLP
SLTLTVDPVENRGFEYHTGLSFTLFARNMGAELGRGGRYQGGGGEPATGATLFMDSVLAALPGPKPAKRLFVPAGTPRAW
AQAFRAQGWVTVSGLDPAADPQVEAKHQGCRHRLGPDGIVEVE
>Mature_363_residues
MLPPDAEFEASVVHSLMSMFARHGYDRVKPPLIEFEESLLDGAGGGTSSQTFRVMDPMSQKMMGLRADMTPQVARIAATR
LGSQPRPLRLSYAGQVLRVKGTQLRPERQFGQAGIELIGSDDAGADAEVLVMTAEALDDLGVPGVSADLALPTLVPAVFA
AYGINGETADRLRAALDHKDSATVAAQGGAAAPLLQALIAAAGPAARALAELCALDLPPAAAAERDRLARVVELAGADLP
SLTLTVDPVENRGFEYHTGLSFTLFARNMGAELGRGGRYQGGGGEPATGATLFMDSVLAALPGPKPAKRLFVPAGTPRAW
AQAFRAQGWVTVSGLDPAADPQVEAKHQGCRHRLGPDGIVEVE

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISZ_MAGSA (Q2W2D0)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_422554.1
- ProteinModelPortal:   Q2W2D0
- STRING:   Q2W2D0
- GeneID:   3806316
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb3191
- NMPDR:   fig|342108.5.peg.2862
- eggNOG:   COG3705
- HOGENOM:   HBG616575
- OMA:   DLRGYHY
- ProtClustDB:   CLSK933083
- BioCyc:   MMAG342108:AMB3191-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00125
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004516
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549

Pfam domain/function: PF00587 tRNA-synt_2b

EC number: 6.1.1.21

Molecular weight: Translated: 37916; Mature: 37916

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPPDAEFEASVVHSLMSMFARHGYDRVKPPLIEFEESLLDGAGGGTSSQTFRVMDPMSQ
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCHHHH
KMMGLRADMTPQVARIAATRLGSQPRPLRLSYAGQVLRVKGTQLRPERQFGQAGIELIGS
HHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCHHHHCCCCEEEEEC
DDAGADAEVLVMTAEALDDLGVPGVSADLALPTLVPAVFAAYGINGETADRLRAALDHKD
CCCCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
SATVAAQGGAAAPLLQALIAAAGPAARALAELCALDLPPAAAAERDRLARVVELAGADLP
CCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
SLTLTVDPVENRGFEYHTGLSFTLFARNMGAELGRGGRYQGGGGEPATGATLFMDSVLAA
CEEEEECCCCCCCEEEECCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
LPGPKPAKRLFVPAGTPRAWAQAFRAQGWVTVSGLDPAADPQVEAKHQGCRHRLGPDGIV
CCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEE
EVE
ECC
>Mature Secondary Structure
MLPPDAEFEASVVHSLMSMFARHGYDRVKPPLIEFEESLLDGAGGGTSSQTFRVMDPMSQ
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCHHHH
KMMGLRADMTPQVARIAATRLGSQPRPLRLSYAGQVLRVKGTQLRPERQFGQAGIELIGS
HHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCHHHHCCCCEEEEEC
DDAGADAEVLVMTAEALDDLGVPGVSADLALPTLVPAVFAAYGINGETADRLRAALDHKD
CCCCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
SATVAAQGGAAAPLLQALIAAAGPAARALAELCALDLPPAAAAERDRLARVVELAGADLP
CCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
SLTLTVDPVENRGFEYHTGLSFTLFARNMGAELGRGGRYQGGGGEPATGATLFMDSVLAA
CEEEEECCCCCCCEEEECCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
LPGPKPAKRLFVPAGTPRAWAQAFRAQGWVTVSGLDPAADPQVEAKHQGCRHRLGPDGIV
CCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEE
EVE
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine; tRNA(His)

Specific reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA