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The map label for this gene is copR [H]

Identifier: 83311994

GI number: 83311994

Start: 3093414

End: 3094091

Strand: Reverse

Name: copR [H]

Synonym: amb2895

Alternate gene names: 83311994

Gene position: 3094091-3093414 (Counterclockwise)

Preceding gene: 83311995

Following gene: 83311993

Centisome position: 62.29

GC content: 66.81

Gene sequence:

>678_bases
ATGCGCATCCTTCTGATCGAGGACGACAGTGAAGCGGCGGCCTACATGGCCAAGGGCCTGCGCGAGGCCGGGCATGTGGT
CGATCACGCCGCCACCGGGACCGACGGGCTGTTCCTGGCCACCTCCGAGCGCTGGGACGCCATGATTATCGACCGCATGC
TGCCCGGCCTGGACGGGCTGGCCATCATCCAGGCGCTGCGCGCCGCCGGCAACACCACGCCGGTGCTGGTGCTGTCCGCC
CTGGGCAAGGTGGACGACCGGGTGCGCGGCCTGAAGGCGGGCGGCGACGATTATCTGGTCAAGCCCTATGCCTTCGCCGA
ATTGCTGGCCCGCATCGAGGCCCTGTCGCGCCGGGTGTCCAGCACCCAGCCCGAGACCCGCCTCAAGGTCGAGGACCTGG
AGATGGATCTGCTGGCCCGCACCGTGACCCGGGGCGGCCAGGAGATCGACCTGCAGCCGCGCGAATTCCGCCTGCTGGAA
TACCTCATGCGCCATGGCGGCCAGGTGGTGACCCGCACCATGCTGCTGGAGAATGTCTGGGAATACCATTTCGACCCGCA
GACCAATCTGATCGACGTGCATATCAGCCGGTTGCGCCAGAAGGTGGACAAGGATTTCGAACTGCCGCTGATCCATACGG
TTCGCGGCGCCGGATACACCCTTCGTGCGGCCCGCTAG

Upstream 100 bases:

>100_bases
ACCGGAAAAAGGCCCCCGCGTCGTCCCCCCTGGCGCGGGGGCTTTTCCGTGAGGGACGTTGCTTGTATGGTCCCCGGCAC
AACTTAGGTTATCGGACACG

Downstream 100 bases:

>100_bases
CCTCCTTCGCACCACCACCTTCCGGCTGGCGCTGAGCTATCTCGGCATTTTCACCGTCTCCGCCATCGCGCTGCTGGCGC
TGGTGTCGTGGAGCACCTCC

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRILLIEDDSEAAAYMAKGLREAGHVVDHAATGTDGLFLATSERWDAMIIDRMLPGLDGLAIIQALRAAGNTTPVLVLSA
LGKVDDRVRGLKAGGDDYLVKPYAFAELLARIEALSRRVSSTQPETRLKVEDLEMDLLARTVTRGGQEIDLQPREFRLLE
YLMRHGGQVVTRTMLLENVWEYHFDPQTNLIDVHISRLRQKVDKDFELPLIHTVRGAGYTLRAAR

Sequences:

>Translated_225_residues
MRILLIEDDSEAAAYMAKGLREAGHVVDHAATGTDGLFLATSERWDAMIIDRMLPGLDGLAIIQALRAAGNTTPVLVLSA
LGKVDDRVRGLKAGGDDYLVKPYAFAELLARIEALSRRVSSTQPETRLKVEDLEMDLLARTVTRGGQEIDLQPREFRLLE
YLMRHGGQVVTRTMLLENVWEYHFDPQTNLIDVHISRLRQKVDKDFELPLIHTVRGAGYTLRAAR
>Mature_225_residues
MRILLIEDDSEAAAYMAKGLREAGHVVDHAATGTDGLFLATSERWDAMIIDRMLPGLDGLAIIQALRAAGNTTPVLVLSA
LGKVDDRVRGLKAGGDDYLVKPYAFAELLARIEALSRRVSSTQPETRLKVEDLEMDLLARTVTRGGQEIDLQPREFRLLE
YLMRHGGQVVTRTMLLENVWEYHFDPQTNLIDVHISRLRQKVDKDFELPLIHTVRGAGYTLRAAR

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=48.868778280543, Blast_Score=223, Evalue=6e-60,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=44.4444444444444, Blast_Score=193, Evalue=8e-51,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.7239819004525, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=37.6681614349776, Blast_Score=135, Evalue=1e-33,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=35.2941176470588, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=36.5296803652968, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=32.4200913242009, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.3612334801762, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=32.15859030837, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=32.7354260089686, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=37.6623376623377, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=31.4410480349345, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.0701754385965, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.4336283185841, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=30.6451612903226, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25189; Mature: 25189

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLIEDDSEAAAYMAKGLREAGHVVDHAATGTDGLFLATSERWDAMIIDRMLPGLDGL
CEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCHH
AIIQALRAAGNTTPVLVLSALGKVDDRVRGLKAGGDDYLVKPYAFAELLARIEALSRRVS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHH
STQPETRLKVEDLEMDLLARTVTRGGQEIDLQPREFRLLEYLMRHGGQVVTRTMLLENVW
CCCCCCEEEHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EYHFDPQTNLIDVHISRLRQKVDKDFELPLIHTVRGAGYTLRAAR
HHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHEEECCCCEEEEECC
>Mature Secondary Structure
MRILLIEDDSEAAAYMAKGLREAGHVVDHAATGTDGLFLATSERWDAMIIDRMLPGLDGL
CEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCHH
AIIQALRAAGNTTPVLVLSALGKVDDRVRGLKAGGDDYLVKPYAFAELLARIEALSRRVS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHH
STQPETRLKVEDLEMDLLARTVTRGGQEIDLQPREFRLLEYLMRHGGQVVTRTMLLENVW
CCCCCCEEEHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EYHFDPQTNLIDVHISRLRQKVDKDFELPLIHTVRGAGYTLRAAR
HHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]