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The map label for this gene is nqo2 [H]

Identifier: 83311882

GI number: 83311882

Start: 2970240

End: 2970848

Strand: Reverse

Name: nqo2 [H]

Synonym: amb2783

Alternate gene names: 83311882

Gene position: 2970848-2970240 (Counterclockwise)

Preceding gene: 83311883

Following gene: 83311881

Centisome position: 59.81

GC content: 65.19

Gene sequence:

>609_bases
ATGAGCAATCATTCCTACGAACCGGAAAGCTTCGCTTTCACCCCCGAATACCTGGAGAAGGCCAAGGCCTTCGTCGCCAA
GTACCCGGTTGGCCGCCAGCAGAGCGCGGTGATGCCGCTGCTCGATCTGGCCCAGCGCCAGGAAGGCTGGGTCAGCCGCG
CCGCCATGGAAGTCATCGCCGAGATGCTCGACATGGCTCCCATCCGGGTGGAGGAGGTGGCGACCTTCTACACCATGTAC
AACCGCAAGCCCGTGGGCACCTTCCACGTGCAGGTCTGCACCAATCTGCCGTGCATGCTGCGCGGCTCCGACGACGTGGT
GGCCGCCGCCAAGGCGGCGCTGGGCGTCGAGTTCGGCGACATGACCGCCGACGGCAAGTTCACCCTGTCCGAGGTGGAAT
GCCTGGGCGCCTGCGTCAACGCGCCCATGATGCAGATCAACGACGATTACTACGAGGACCTTACGCCTGAGACCACCAAG
GCGGTGCTCGAGGCCTTCAAGCGCGGCGAGACGCCGAAGCCCGGTCCCCAGAACGGTCGTCAGTTCTCGTGCCCGGCCGG
TGGCCCCACCAGCCTGACCGAGTTGAAGTTCGAGGGGGGGAAGGCCTGA

Upstream 100 bases:

>100_bases
TTCACCTGCAGGCGCTCGACATGATGTCCAAGGGACACATGCTGGCCGACGTGGTGGCCAATATCGGCTCCATCGACATC
GTTTTCGGCGAGATCGACCG

Downstream 100 bases:

>100_bases
TGCTGCGCGACTCCGATAGGATCTTCACCAATCTCTACGGCATCCATGACTGGCGCCTGAAGGGCGCCATGGCCCGTGGC
GACTGGAACGGCACCAAGGA

Product: NADH:ubiquinone oxidoreductase 24 kD subunit

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 2; NDH-1, chain 2 [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MSNHSYEPESFAFTPEYLEKAKAFVAKYPVGRQQSAVMPLLDLAQRQEGWVSRAAMEVIAEMLDMAPIRVEEVATFYTMY
NRKPVGTFHVQVCTNLPCMLRGSDDVVAAAKAALGVEFGDMTADGKFTLSEVECLGACVNAPMMQINDDYYEDLTPETTK
AVLEAFKRGETPKPGPQNGRQFSCPAGGPTSLTELKFEGGKA

Sequences:

>Translated_202_residues
MSNHSYEPESFAFTPEYLEKAKAFVAKYPVGRQQSAVMPLLDLAQRQEGWVSRAAMEVIAEMLDMAPIRVEEVATFYTMY
NRKPVGTFHVQVCTNLPCMLRGSDDVVAAAKAALGVEFGDMTADGKFTLSEVECLGACVNAPMMQINDDYYEDLTPETTK
AVLEAFKRGETPKPGPQNGRQFSCPAGGPTSLTELKFEGGKA
>Mature_201_residues
SNHSYEPESFAFTPEYLEKAKAFVAKYPVGRQQSAVMPLLDLAQRQEGWVSRAAMEVIAEMLDMAPIRVEEVATFYTMYN
RKPVGTFHVQVCTNLPCMLRGSDDVVAAAKAALGVEFGDMTADGKFTLSEVECLGACVNAPMMQINDDYYEDLTPETTKA
VLEAFKRGETPKPGPQNGRQFSCPAGGPTSLTELKFEGGKA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=197, Percent_Identity=57.3604060913706, Blast_Score=234, Evalue=4e-62,
Organism=Escherichia coli, GI1788621, Length=134, Percent_Identity=37.3134328358209, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17561328, Length=184, Percent_Identity=52.1739130434783, Blast_Score=206, Evalue=5e-54,
Organism=Drosophila melanogaster, GI18859877, Length=184, Percent_Identity=55.4347826086957, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21355353, Length=183, Percent_Identity=44.2622950819672, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 22107; Mature: 21976

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHSYEPESFAFTPEYLEKAKAFVAKYPVGRQQSAVMPLLDLAQRQEGWVSRAAMEVIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EMLDMAPIRVEEVATFYTMYNRKPVGTFHVQVCTNLPCMLRGSDDVVAAAKAALGVEFGD
HHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHCCCCCC
MTADGKFTLSEVECLGACVNAPMMQINDDYYEDLTPETTKAVLEAFKRGETPKPGPQNGR
CCCCCCEEHHHHHHHHHHHCCCCEEECCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
QFSCPAGGPTSLTELKFEGGKA
EEECCCCCCCCCEEEECCCCCC
>Mature Secondary Structure 
SNHSYEPESFAFTPEYLEKAKAFVAKYPVGRQQSAVMPLLDLAQRQEGWVSRAAMEVIA
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EMLDMAPIRVEEVATFYTMYNRKPVGTFHVQVCTNLPCMLRGSDDVVAAAKAALGVEFGD
HHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHCCCCCC
MTADGKFTLSEVECLGACVNAPMMQINDDYYEDLTPETTKAVLEAFKRGETPKPGPQNGR
CCCCCCEEHHHHHHHHHHHCCCCEEECCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
QFSCPAGGPTSLTELKFEGGKA
EEECCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1909571 [H]