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The map label for this gene is paaH [H]

Identifier: 83311695

GI number: 83311695

Start: 2782278

End: 2783798

Strand: Reverse

Name: paaH [H]

Synonym: amb2596

Alternate gene names: 83311695

Gene position: 2783798-2782278 (Counterclockwise)

Preceding gene: 83311696

Following gene: 83311694

Centisome position: 56.04

GC content: 68.44

Gene sequence:

>1521_bases
ATGAGTCTCGACGCCAATCGTTCCGACCTCATCCTCGGTCTCGTGGGCTCCGGCACCATGGGGCGCGGCATCGCCCAGAT
CGCCGTGGCCTCGGGCGTTACCGTCATCCTGGTTGACGCATTGCCCGGCGCCGCCGCCAAGGCCCGCGACGCCGTTTCCG
CCATGCTCGCCAAGCTGGCCGAGAAGGGCAAGCTGACCGCCGAGGCCTGCGCTAGCGCCACGGCGCGGCTCAAGCTGGGC
GAAAGCCTTGCCGATCTGGCTCCCTGCCATGTGGTGGTCGAGGCCATCGTCGAAGACATCAAGGTCAAGCAGGCCCTGAT
GAAGGATCTGGAGGCCATCGTCTCCAAGGACTGCCTGATTGCCAGCAATACCTCGTCGCTGTCGGTGACCTCCATCGCAG
CCGCCTGCCAGCACCCACAGCGGGTGGGCGGCTTTCATTTCTTCAATCCCGTTCCACTGATGAAAGTGGTGGAGGTCATC
GATGGCGTCATGACGGCGCCCTGGGTCGTCGAGACCCTGACGGCTCTGGCGCGGCGCATGGGGCATACCCCGGTCAAGGC
CAAGGACACCCCCGGCTTTGTGGTCAATCACGCCGGACGCGGCTATGGCACCGAGGCCCTGAAGCTGGTGGGCGAGGGGG
TGACCGACTTCTTCACCGCCGACCGCATCCTGAAGGGGGCCGCCGGCTTCCGCATGGGGCCGTTCGAACTGCTGGATCTC
ACCGCCCTGGACGTCTCCCACCCGGTGATGGAAAGCATCTACGACCAGTATTACCAGGAACCACGCTTCCGCCCGTCGCC
CATCACCCGCTCGCGCCTCGTCGCCGGCCTGCTGGGGCGCAAGACCGGGCGAGGCTTTTATGCCTATGAGGGCGACAAGG
CGGTGGTGCCGCCCGCGCCGCCGGTTCCCGCCGCCTGGCAAGGCCCTGTTTGGGTGGCTCCGGGCGAGGGCTCGCTGGCT
GTCGCCGCCCTGGTCACCAAATTGGGCGCCTCGCTGGAGACGGGTGAGAAGCCGGGCGAGACGGCCCTGATCCTCATCCC
CGTCCTGGGCGAGGACTGCACCACGGCGGTGGTGCGCCTCGGCCTCGACGCCGCCCGGTCCGTCGCCATCGACCCGCTGT
TCGGTCTGGACAGCCACCGTACCGTGATGACCAACCCGGTGACCCGGGCCGAGATCCGCGACGGCGCCCACGGCCTGCTG
GCCGGGGACGAGGTTGCCGTCTCGGTGATCGCCGACAGCCCCGGTCTGGTGGCGCAGCGGGTGGTGGCGACCATCGTCAA
TATCGGCTGCGACATCGCCCAGCAGCGCATCGCCACGCCGGACGACATCGACAAGGCGGTGACCCTGGGGCTCGGCTATC
CCGCCGGGCCGCTGTCCTGGGGCGACCGCATCGGCGCCGCCAAGGTGGTCGCCATCCTCGACACCGTGCTGGCCATCACC
GGCGATCCCCGCTACCGCGCCAGCCTGTGGCTGAAACGCCGCGCCGCTCTAGGCGTCTCTTTGCTGACTTCGGAGTCCTG
A

Upstream 100 bases:

>100_bases
AGCGCAAGGCCTTCCAACTGCTGTTCGCCAGCGCCGATCAGAAGGAAGGCATGAAGGCCTTCATCGAGAAGCGCAAGCCC
ACCTATCAGGGGAAATGATC

Downstream 100 bases:

>100_bases
TCCATGCTTGACGCCTATATCTACGACGGCCTGCGTTCCCCCATCGGCCGCCATGGCGGCGGCCTCGCCCCGGTGCGTTC
CGACGATCTGGCCGCCGAGG

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSLDANRSDLILGLVGSGTMGRGIAQIAVASGVTVILVDALPGAAAKARDAVSAMLAKLAEKGKLTAEACASATARLKLG
ESLADLAPCHVVVEAIVEDIKVKQALMKDLEAIVSKDCLIASNTSSLSVTSIAAACQHPQRVGGFHFFNPVPLMKVVEVI
DGVMTAPWVVETLTALARRMGHTPVKAKDTPGFVVNHAGRGYGTEALKLVGEGVTDFFTADRILKGAAGFRMGPFELLDL
TALDVSHPVMESIYDQYYQEPRFRPSPITRSRLVAGLLGRKTGRGFYAYEGDKAVVPPAPPVPAAWQGPVWVAPGEGSLA
VAALVTKLGASLETGEKPGETALILIPVLGEDCTTAVVRLGLDAARSVAIDPLFGLDSHRTVMTNPVTRAEIRDGAHGLL
AGDEVAVSVIADSPGLVAQRVVATIVNIGCDIAQQRIATPDDIDKAVTLGLGYPAGPLSWGDRIGAAKVVAILDTVLAIT
GDPRYRASLWLKRRAALGVSLLTSES

Sequences:

>Translated_506_residues
MSLDANRSDLILGLVGSGTMGRGIAQIAVASGVTVILVDALPGAAAKARDAVSAMLAKLAEKGKLTAEACASATARLKLG
ESLADLAPCHVVVEAIVEDIKVKQALMKDLEAIVSKDCLIASNTSSLSVTSIAAACQHPQRVGGFHFFNPVPLMKVVEVI
DGVMTAPWVVETLTALARRMGHTPVKAKDTPGFVVNHAGRGYGTEALKLVGEGVTDFFTADRILKGAAGFRMGPFELLDL
TALDVSHPVMESIYDQYYQEPRFRPSPITRSRLVAGLLGRKTGRGFYAYEGDKAVVPPAPPVPAAWQGPVWVAPGEGSLA
VAALVTKLGASLETGEKPGETALILIPVLGEDCTTAVVRLGLDAARSVAIDPLFGLDSHRTVMTNPVTRAEIRDGAHGLL
AGDEVAVSVIADSPGLVAQRVVATIVNIGCDIAQQRIATPDDIDKAVTLGLGYPAGPLSWGDRIGAAKVVAILDTVLAIT
GDPRYRASLWLKRRAALGVSLLTSES
>Mature_505_residues
SLDANRSDLILGLVGSGTMGRGIAQIAVASGVTVILVDALPGAAAKARDAVSAMLAKLAEKGKLTAEACASATARLKLGE
SLADLAPCHVVVEAIVEDIKVKQALMKDLEAIVSKDCLIASNTSSLSVTSIAAACQHPQRVGGFHFFNPVPLMKVVEVID
GVMTAPWVVETLTALARRMGHTPVKAKDTPGFVVNHAGRGYGTEALKLVGEGVTDFFTADRILKGAAGFRMGPFELLDLT
ALDVSHPVMESIYDQYYQEPRFRPSPITRSRLVAGLLGRKTGRGFYAYEGDKAVVPPAPPVPAAWQGPVWVAPGEGSLAV
AALVTKLGASLETGEKPGETALILIPVLGEDCTTAVVRLGLDAARSVAIDPLFGLDSHRTVMTNPVTRAEIRDGAHGLLA
GDEVAVSVIADSPGLVAQRVVATIVNIGCDIAQQRIATPDDIDKAVTLGLGYPAGPLSWGDRIGAAKVVAILDTVLAITG
DPRYRASLWLKRRAALGVSLLTSES

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=39.6491228070175, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=37.7049180327869, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=31.9148936170213, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=30.9278350515464, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=30.9278350515464, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI115430219, Length=243, Percent_Identity=27.5720164609054, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787661, Length=492, Percent_Identity=35.7723577235772, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1790281, Length=270, Percent_Identity=31.4814814814815, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788682, Length=233, Percent_Identity=32.618025751073, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17549919, Length=285, Percent_Identity=37.1929824561403, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17553560, Length=284, Percent_Identity=35.9154929577465, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=29.6551724137931, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=279, Percent_Identity=28.673835125448, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71985923, Length=298, Percent_Identity=30.2013422818792, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17508951, Length=280, Percent_Identity=32.5, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25144276, Length=302, Percent_Identity=31.4569536423841, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17508953, Length=280, Percent_Identity=32.5, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17558304, Length=285, Percent_Identity=31.2280701754386, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=30.8510638297872, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=30.8510638297872, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=30.8510638297872, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI45549573, Length=243, Percent_Identity=30.4526748971193, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129993, Length=237, Percent_Identity=28.6919831223629, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 52806; Mature: 52675

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDANRSDLILGLVGSGTMGRGIAQIAVASGVTVILVDALPGAAAKARDAVSAMLAKLA
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
EKGKLTAEACASATARLKLGESLADLAPCHVVVEAIVEDIKVKQALMKDLEAIVSKDCLI
HCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ASNTSSLSVTSIAAACQHPQRVGGFHFFNPVPLMKVVEVIDGVMTAPWVVETLTALARRM
ECCCCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GHTPVKAKDTPGFVVNHAGRGYGTEALKLVGEGVTDFFTADRILKGAAGFRMGPFELLDL
CCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
TALDVSHPVMESIYDQYYQEPRFRPSPITRSRLVAGLLGRKTGRGFYAYEGDKAVVPPAP
HHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEECCCCC
PVPAAWQGPVWVAPGEGSLAVAALVTKLGASLETGEKPGETALILIPVLGEDCTTAVVRL
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHH
GLDAARSVAIDPLFGLDSHRTVMTNPVTRAEIRDGAHGLLAGDEVAVSVIADSPGLVAQR
HHHHHHHEECCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHH
VVATIVNIGCDIAQQRIATPDDIDKAVTLGLGYPAGPLSWGDRIGAAKVVAILDTVLAIT
HHHHHHHHCHHHHHHHCCCCCHHHHHEEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHC
GDPRYRASLWLKRRAALGVSLLTSES
CCCCHHHHHHHHHHHHHCEEEEECCC
>Mature Secondary Structure 
SLDANRSDLILGLVGSGTMGRGIAQIAVASGVTVILVDALPGAAAKARDAVSAMLAKLA
CCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
EKGKLTAEACASATARLKLGESLADLAPCHVVVEAIVEDIKVKQALMKDLEAIVSKDCLI
HCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ASNTSSLSVTSIAAACQHPQRVGGFHFFNPVPLMKVVEVIDGVMTAPWVVETLTALARRM
ECCCCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GHTPVKAKDTPGFVVNHAGRGYGTEALKLVGEGVTDFFTADRILKGAAGFRMGPFELLDL
CCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
TALDVSHPVMESIYDQYYQEPRFRPSPITRSRLVAGLLGRKTGRGFYAYEGDKAVVPPAP
HHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEECCCCC
PVPAAWQGPVWVAPGEGSLAVAALVTKLGASLETGEKPGETALILIPVLGEDCTTAVVRL
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHH
GLDAARSVAIDPLFGLDSHRTVMTNPVTRAEIRDGAHGLLAGDEVAVSVIADSPGLVAQR
HHHHHHHEECCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHH
VVATIVNIGCDIAQQRIATPDDIDKAVTLGLGYPAGPLSWGDRIGAAKVVAILDTVLAIT
HHHHHHHHCHHHHHHHCCCCCHHHHHEEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHC
GDPRYRASLWLKRRAALGVSLLTSES
CCCCHHHHHHHHHHHHHCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]