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The map label for this gene is msrA

Identifier: 83311052

GI number: 83311052

Start: 2106651

End: 2107286

Strand: Reverse

Name: msrA

Synonym: amb1953

Alternate gene names: 83311052

Gene position: 2107286-2106651 (Counterclockwise)

Preceding gene: 83311053

Following gene: 83311051

Centisome position: 42.42

GC content: 67.45

Gene sequence:

>636_bases
ATGTCGCTTTGGGGACCCAGCAAGACCGTGATGGTGAGCGCCGACAAGGCCCTGCCCGGCCGCGCCAGCGAAATCCGCGT
GCCCGAACGCCACTACGTGCTCGACACCCTCTTGAAGCCGCCCTTTCCCGTGGGAATGGAGGTGGCTTGCTTCGGCATGG
GCTGTTTCTGGGGTGCCGAGCGGCTGTTCTGGAAGACCGGCGGCGTCTATTCCACCTCCGTGGGCTATACGGGCGGCTTC
ACCCTCAACCCCACCTACGAGGAGGTGTGCTCGGCGCAGACCGGCCACACCGAGGCGGTGCTGGTGGCATTCGACCCGGC
GGAGGTCTCTTACACCGCGCTGCTGCGGCTGTTCTGGGAAGGACACAATCCGACCCAGGGCATGCGCCAGGGAAACGATA
TCGGCACCCAGTACCGCTCGGCCATCTACTGGACCACCCCGGAGCAGCAGGCGGCGGCCGAGGCCTCGGCCAAGGCCTAT
GGCGAAGCGCTGCGGCGGGCCGGCTTCGGCGCCATCACCACCGAGATCGCCCCGGCCGGGCGGTTCTACTGGGCCGAGGG
CTATCACCAGCAATATCTGGCCAAGGAACCGGGCGGCTATTGCGGCCTGGGCGGCACCGGAGTGCGTTACGGCTGA

Upstream 100 bases:

>100_bases
CGCCCTGGCCATCGTCGCCGCTTTGGCGCTGGCGGCCATCTCGCTACGCTGAGACCGCCTCCCCATATGGGAGGGGACGA
CTCGCTATGGAGACACGCTC

Downstream 100 bases:

>100_bases
CGCCACGCCCTGGAATTGTGCCCTCCCGCTTCCCATGTGAAGTCATGGCGGCGAAGTTTAGGGGACTGAAATGGCCACCT
GGCTTGATGAGCAGTGGAAA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MSLWGPSKTVMVSADKALPGRASEIRVPERHYVLDTLLKPPFPVGMEVACFGMGCFWGAERLFWKTGGVYSTSVGYTGGF
TLNPTYEEVCSAQTGHTEAVLVAFDPAEVSYTALLRLFWEGHNPTQGMRQGNDIGTQYRSAIYWTTPEQQAAAEASAKAY
GEALRRAGFGAITTEIAPAGRFYWAEGYHQQYLAKEPGGYCGLGGTGVRYG

Sequences:

>Translated_211_residues
MSLWGPSKTVMVSADKALPGRASEIRVPERHYVLDTLLKPPFPVGMEVACFGMGCFWGAERLFWKTGGVYSTSVGYTGGF
TLNPTYEEVCSAQTGHTEAVLVAFDPAEVSYTALLRLFWEGHNPTQGMRQGNDIGTQYRSAIYWTTPEQQAAAEASAKAY
GEALRRAGFGAITTEIAPAGRFYWAEGYHQQYLAKEPGGYCGLGGTGVRYG
>Mature_210_residues
SLWGPSKTVMVSADKALPGRASEIRVPERHYVLDTLLKPPFPVGMEVACFGMGCFWGAERLFWKTGGVYSTSVGYTGGFT
LNPTYEEVCSAQTGHTEAVLVAFDPAEVSYTALLRLFWEGHNPTQGMRQGNDIGTQYRSAIYWTTPEQQAAAEASAKAYG
EALRRAGFGAITTEIAPAGRFYWAEGYHQQYLAKEPGGYCGLGGTGVRYG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=204, Percent_Identity=57.3529411764706, Blast_Score=245, Evalue=2e-65,
Organism=Homo sapiens, GI208609995, Length=179, Percent_Identity=59.7765363128492, Blast_Score=228, Evalue=3e-60,
Organism=Homo sapiens, GI208609993, Length=205, Percent_Identity=42.4390243902439, Blast_Score=161, Evalue=5e-40,
Organism=Escherichia coli, GI1790665, Length=198, Percent_Identity=57.0707070707071, Blast_Score=214, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=38.7755102040816, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=33.1325301204819, Blast_Score=88, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24664627, Length=149, Percent_Identity=44.2953020134228, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24664631, Length=149, Percent_Identity=43.6241610738255, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=44.2857142857143, Blast_Score=97, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_MAGSA (Q2W5W8)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_421316.1
- ProteinModelPortal:   Q2W5W8
- SMR:   Q2W5W8
- STRING:   Q2W5W8
- GeneID:   3804470
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb1953
- NMPDR:   fig|342108.5.peg.1714
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   SAIYCTT
- PhylomeDB:   Q2W5W8
- BioCyc:   MMAG342108:AMB1953-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 22947; Mature: 22816

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 55-55

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLWGPSKTVMVSADKALPGRASEIRVPERHYVLDTLLKPPFPVGMEVACFGMGCFWGAE
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECHHHHCCC
RLFWKTGGVYSTSVGYTGGFTLNPTYEEVCSAQTGHTEAVLVAFDPAEVSYTALLRLFWE
EEEEECCCEEECCCCCCCCEEECCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHC
GHNPTQGMRQGNDIGTQYRSAIYWTTPEQQAAAEASAKAYGEALRRAGFGAITTEIAPAG
CCCCCCHHHCCCHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
RFYWAEGYHQQYLAKEPGGYCGLGGTGVRYG
CEEECCCHHHHHHHCCCCCEECCCCCCCCCC
>Mature Secondary Structure 
SLWGPSKTVMVSADKALPGRASEIRVPERHYVLDTLLKPPFPVGMEVACFGMGCFWGAE
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECHHHHCCC
RLFWKTGGVYSTSVGYTGGFTLNPTYEEVCSAQTGHTEAVLVAFDPAEVSYTALLRLFWE
EEEEECCCEEECCCCCCCCEEECCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHC
GHNPTQGMRQGNDIGTQYRSAIYWTTPEQQAAAEASAKAYGEALRRAGFGAITTEIAPAG
CCCCCCHHHCCCHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
RFYWAEGYHQQYLAKEPGGYCGLGGTGVRYG
CEEECCCHHHHHHHCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA