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The map label for this gene is trpE [H]

Identifier: 83310912

GI number: 83310912

Start: 1952872

End: 1954392

Strand: Reverse

Name: trpE [H]

Synonym: amb1813

Alternate gene names: 83310912

Gene position: 1954392-1952872 (Counterclockwise)

Preceding gene: 83310913

Following gene: 83310910

Centisome position: 39.35

GC content: 66.73

Gene sequence:

>1521_bases
ATGAGCCATCAGCCCGACTTCTCCGCCTTTGCCGCAGCCTATGACGATGGCAAGCCTCAGGTGGTCTGGCGGGTGTTGGT
GGCCGACCTGGAGACTCCAGTTTCCGCCTTCATGAAGCTGGCGGGCGGCCAGCCCAACGCCTTCCTGCTGGAATCGGTGG
AGGGCGGCGCGGTGCGCGGACGCTATTCCATCCTGGGCATGCGGCCGGATCTGCTGTGGAAATGCGTCGGCAACGAGGCC
TGGATCAACCGTAACGCCCGCTCCAAGACCAGCGAGTTCCTGCCCTGCCCGGTGGCGGCCAAGTCAGGCGCCCTCGACAG
CCTGCGAGCCCTGGTGGCGGAATGCGGCATCGAGACCCCGCCCCACCTGCCCCCCATGTCGGCCGGCTTGATCGGCTATA
TGAGCTACGACATGGTGCGGCTGGCGGAAAAGCTGCCCGATGCCAATCCCGACCCCATCAAGGTGCCCGACGGCATCTTC
ATGCGCCCAACCATCATGGCGGTGTTCGACAACGTCAACGGCACCCTGACCGCCGTCGCCCCCGTCTGGCCGCGGGCCGG
CATGGACGCCCAGGCGGCGTGGGACCTGGCCTGGGAGCGGCTCGAACACATCGTCGAGTCCCTGGAAAGCCCCCTGCCCC
ACACCTATCTCGGCTTCCCCCGCGACGAGCACCAGCCCATCCCGGTGCCCAGCGTGTCGCCCGAGCATTATTGCCGCATG
GTCGAGAAGGCCCAGGAATACATCGCCGCCGGCGATATCTTCCAGGTGGTGCTGTCCCAGCGCCTGGCGGTGCCGTTCCG
CCTGCCGCCGTTCTCGCTCTATCGCTCGCTGCGCCGGCTCAACCCTAGCCCGTTCCTGTTCTTCCTGGATCTGGGCGAGT
TCCAGCTGGTGGGCTCCAGCCCGGAAATCCTGGTGCGGCTGCGTGACGACAAGGTCACCATCCGCCCCATCGCCGGAACG
CGGCGCCGGGGCAAGACCCCCGCCGAGGACGAGGAACTGGCCGCCGACCTGCTGGCCGATCCCAAGGAACTGGCCGAACA
CCTGATGCTGCTGGATCTGGGCCGCAACGACGTGGGCCGGGTGGCCGCCATCGGCACGGTCGAAGTCACCAAGAAGATGA
CCGTGGAATACTATTCCCACGTCATGCACATCGTCTCCAACGTGGAAGGCAAGATCCGCGAGGGCTGCGACGCCATGGAC
GCCCTGATGGCCGGCTTCCCGGCCGGCACCACCTCGGGCGCCCCCAAGATCCGCGCCATGGAGATCATCGACGAGTTGGA
GACCGAGCGGCGCTCGTTCTATGCCGGCGCCATCGGCTATTTCGACGGCAACGGCAACATGGACACCTGCATCGCGCTGC
GCACCACCCTGGTCAAGGACGGCACCATGTATGTCCAGGCCGGGGCCGGCATCGTCGCCGATTCGGTGCCGCTGTCCGAG
CACGAGGAGTGCATGAACAAGGCCCGCGCCCTGGTGCGCGCCGCCGAGGATGCCATCGACTATACGCTGGTGAAGCAGTA
G

Upstream 100 bases:

>100_bases
GCCACCGACATTGCCGACCAGTACATCGCCGCCCTGAACGCCTCCATCGGCGTCAAGGTGGACCGTCCCCAACTGACCCG
CGAAGAGTAGCAGCGTCACC

Downstream 100 bases:

>100_bases
GGGGTGATTGGGGCTTTTGCCCCAAACCCCAATCGGGGCGATGCCCCGAACCCCCTTTTTGTTTATTGAGAAAATAAAAG
GGAAGGTTTGGGCGGCAGCC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSHQPDFSAFAAAYDDGKPQVVWRVLVADLETPVSAFMKLAGGQPNAFLLESVEGGAVRGRYSILGMRPDLLWKCVGNEA
WINRNARSKTSEFLPCPVAAKSGALDSLRALVAECGIETPPHLPPMSAGLIGYMSYDMVRLAEKLPDANPDPIKVPDGIF
MRPTIMAVFDNVNGTLTAVAPVWPRAGMDAQAAWDLAWERLEHIVESLESPLPHTYLGFPRDEHQPIPVPSVSPEHYCRM
VEKAQEYIAAGDIFQVVLSQRLAVPFRLPPFSLYRSLRRLNPSPFLFFLDLGEFQLVGSSPEILVRLRDDKVTIRPIAGT
RRRGKTPAEDEELAADLLADPKELAEHLMLLDLGRNDVGRVAAIGTVEVTKKMTVEYYSHVMHIVSNVEGKIREGCDAMD
ALMAGFPAGTTSGAPKIRAMEIIDELETERRSFYAGAIGYFDGNGNMDTCIALRTTLVKDGTMYVQAGAGIVADSVPLSE
HEECMNKARALVRAAEDAIDYTLVKQ

Sequences:

>Translated_506_residues
MSHQPDFSAFAAAYDDGKPQVVWRVLVADLETPVSAFMKLAGGQPNAFLLESVEGGAVRGRYSILGMRPDLLWKCVGNEA
WINRNARSKTSEFLPCPVAAKSGALDSLRALVAECGIETPPHLPPMSAGLIGYMSYDMVRLAEKLPDANPDPIKVPDGIF
MRPTIMAVFDNVNGTLTAVAPVWPRAGMDAQAAWDLAWERLEHIVESLESPLPHTYLGFPRDEHQPIPVPSVSPEHYCRM
VEKAQEYIAAGDIFQVVLSQRLAVPFRLPPFSLYRSLRRLNPSPFLFFLDLGEFQLVGSSPEILVRLRDDKVTIRPIAGT
RRRGKTPAEDEELAADLLADPKELAEHLMLLDLGRNDVGRVAAIGTVEVTKKMTVEYYSHVMHIVSNVEGKIREGCDAMD
ALMAGFPAGTTSGAPKIRAMEIIDELETERRSFYAGAIGYFDGNGNMDTCIALRTTLVKDGTMYVQAGAGIVADSVPLSE
HEECMNKARALVRAAEDAIDYTLVKQ
>Mature_505_residues
SHQPDFSAFAAAYDDGKPQVVWRVLVADLETPVSAFMKLAGGQPNAFLLESVEGGAVRGRYSILGMRPDLLWKCVGNEAW
INRNARSKTSEFLPCPVAAKSGALDSLRALVAECGIETPPHLPPMSAGLIGYMSYDMVRLAEKLPDANPDPIKVPDGIFM
RPTIMAVFDNVNGTLTAVAPVWPRAGMDAQAAWDLAWERLEHIVESLESPLPHTYLGFPRDEHQPIPVPSVSPEHYCRMV
EKAQEYIAAGDIFQVVLSQRLAVPFRLPPFSLYRSLRRLNPSPFLFFLDLGEFQLVGSSPEILVRLRDDKVTIRPIAGTR
RRGKTPAEDEELAADLLADPKELAEHLMLLDLGRNDVGRVAAIGTVEVTKKMTVEYYSHVMHIVSNVEGKIREGCDAMDA
LMAGFPAGTTSGAPKIRAMEIIDELETERRSFYAGAIGYFDGNGNMDTCIALRTTLVKDGTMYVQAGAGIVADSVPLSEH
EECMNKARALVRAAEDAIDYTLVKQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=380, Percent_Identity=38.6842105263158, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1788114, Length=457, Percent_Identity=31.9474835886214, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI87082077, Length=350, Percent_Identity=27.1428571428571, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1786809, Length=265, Percent_Identity=28.3018867924528, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=481, Percent_Identity=38.2536382536383, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6324361, Length=400, Percent_Identity=26.75, Blast_Score=111, Evalue=3e-25,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55539; Mature: 55408

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHQPDFSAFAAAYDDGKPQVVWRVLVADLETPVSAFMKLAGGQPNAFLLESVEGGAVRG
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEC
RYSILGMRPDLLWKCVGNEAWINRNARSKTSEFLPCPVAAKSGALDSLRALVAECGIETP
EEEEEECCHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PHLPPMSAGLIGYMSYDMVRLAEKLPDANPDPIKVPDGIFMRPTIMAVFDNVNGTLTAVA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEECCCCEEEEECCCCEEEEEE
PVWPRAGMDAQAAWDLAWERLEHIVESLESPLPHTYLGFPRDEHQPIPVPSVSPEHYCRM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VEKAQEYIAAGDIFQVVLSQRLAVPFRLPPFSLYRSLRRLNPSPFLFFLDLGEFQLVGSS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEEECCC
PEILVRLRDDKVTIRPIAGTRRRGKTPAEDEELAADLLADPKELAEHLMLLDLGRNDVGR
CEEEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
VAAIGTVEVTKKMTVEYYSHVMHIVSNVEGKIREGCDAMDALMAGFPAGTTSGAPKIRAM
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHCCCCCCCCCCCCHHHH
EIIDELETERRSFYAGAIGYFDGNGNMDTCIALRTTLVKDGTMYVQAGAGIVADSVPLSE
HHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCHH
HEECMNKARALVRAAEDAIDYTLVKQ
HHHHHHHHHHHHHHHHHHHCEEEECC
>Mature Secondary Structure 
SHQPDFSAFAAAYDDGKPQVVWRVLVADLETPVSAFMKLAGGQPNAFLLESVEGGAVRG
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEC
RYSILGMRPDLLWKCVGNEAWINRNARSKTSEFLPCPVAAKSGALDSLRALVAECGIETP
EEEEEECCHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PHLPPMSAGLIGYMSYDMVRLAEKLPDANPDPIKVPDGIFMRPTIMAVFDNVNGTLTAVA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEECCCCEEEEECCCCEEEEEE
PVWPRAGMDAQAAWDLAWERLEHIVESLESPLPHTYLGFPRDEHQPIPVPSVSPEHYCRM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VEKAQEYIAAGDIFQVVLSQRLAVPFRLPPFSLYRSLRRLNPSPFLFFLDLGEFQLVGSS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEEECCC
PEILVRLRDDKVTIRPIAGTRRRGKTPAEDEELAADLLADPKELAEHLMLLDLGRNDVGR
CEEEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
VAAIGTVEVTKKMTVEYYSHVMHIVSNVEGKIREGCDAMDALMAGFPAGTTSGAPKIRAM
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHCCCCCCCCCCCCHHHH
EIIDELETERRSFYAGAIGYFDGNGNMDTCIALRTTLVKDGTMYVQAGAGIVADSVPLSE
HHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCHH
HEECMNKARALVRAAEDAIDYTLVKQ
HHHHHHHHHHHHHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA