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The map label for this gene is ypdF [H]

Identifier: 83309837

GI number: 83309837

Start: 799841

End: 801652

Strand: Reverse

Name: ypdF [H]

Synonym: amb0738

Alternate gene names: 83309837

Gene position: 801652-799841 (Counterclockwise)

Preceding gene: 83309839

Following gene: 83309830

Centisome position: 16.14

GC content: 70.81

Gene sequence:

>1812_bases
ATGAGCCCGCATCAGCCCGCCCCCTCCCCCACCGACCGCCTCGCCGACCTGCGTGCCGAACTGGCCCGCCTCAATCTGAC
GGGATTTGTCGTGCCTCGCGCCGACCAGCATCAGGGCGAGTACGTACCGCCGTCGGCCCAGCGCCTGGGCTGGCTGACCG
GCTTCACCGGCTCGGCGGGATCGGCCGTGGTGCTGCGCGACAAGGCCGCCATCTTCGTGGATGGCCGCTATACGCTGCAG
GTGCTGGCCGAGGTGAACACCCAGCTTTTCACGCCCCTGCATCTGGTCGAGCAGCCGCCGCATCGTTGGGCAGGCGAGGT
GCTGTCCAAGGGCGACAGGCTGGGGTTCGACCCCTGGCTGCATACCCACGATCAAGTCCAGAGCCTGACCGCCGCCTGCG
AGCGGGCCGGAGCCACCCTGGTTCCCTGCCCCGACAATCCCGTGGACGCGGTATGGGCCGGGCGGCCACCGGCCCCCGCC
ACCCCCATCTCCGCCCATCCCGAGCGCTTTGCCGGCCGGTCCGCCGCCGCCAAGCGTGGCGACATCGCCGCTGAACTGGC
GCGGGAGCGCCTGGACGCCGCCGTGCTGAGCGCCCCGGAATCCCTGGCCTGGCTGTTGAATATCCGGGCCGACGACGTGG
CCTATACGCCGCTGCCGCTGGGCTTTGCCGTCATTTACGCCGACGCCTCGGTGGATCTGTTCGTGCAGCCCGACCGCATC
GACGACACTGTCACCGCCCCGTGGGGCGACGCCGTCCGCGTGGCCGAGCCGGCCGCGTTCGAGGCGACGCTGCGCCTGCT
GGGACGCGGCGGAAAGCGCGTCAGGCTGGACTCGTCCTCCGCCCCCTTCCAGGTCTGGGAGACCCTGCGGGCCGCCGGCG
CCCGGGTGGAGCCCGGTTCCGACCCTTGTGCCCTGCCCCGCGCCTGCAAGAACGCCGTCGAGATGGCGGGCACCCGGGCC
GCCCATCTGCGCGACGGCGCCGCCATGGTCCGGTTCCTCGCCTGGCTGGACCGCACCACGCGAAGCGGAACGGTCAGCGA
AATGGAGGCGGCCGACGCCCTGGAAGGCTTCCGCCGCACCGGCGAGCATTTCCGCGGCCTGTCCTTTCCCACCATTTCCG
GGGCCGGCGCCAACGGCGCCATCGTCCACTACCATTCCACCGCCAAGACCAATCGTCCCCTGGCGGCCGGCGAGCTGTAT
CTGGTGGATTCCGGAGCCCAGTACCTGGACGGCACCACCGACATCACCCGCACCATCCTGGTGGGAGATGCCCCCCCGGA
CGAGGCGCGCCGGCGCTTCACCCTGGTGCTCAAGGGGCACATCGCCCTGGCGCGGGCGGTCTTTCCCATGGGCACCACCG
GCAGCCAGCTGGATATCCTGGCCCGCCGTCCGCTATGGTCGGCCGGGCTGGATTACGACCACGGCACCGGCCACGGCGTC
GGCAGCTTCCTGTCGGTGCACGAAGGGCCTCAGCGCATCTCCAAGGTGGGCAATTCCGTGGCTCTCAAGCCCGGAATGAT
CCTCTCCAACGAGCCCGGCTACTACAAGACCGGGGCCTACGGCATCCGCATCGAGAATCTGGTGATGGTGGAGCCCCGGC
CCGCCCCGGCTGGCGCCGAGCGGGATCTTCTGGAATTCGAGACCCTGACCCTGGTCCCCATCGACCGGGCCCTGGTGGCG
GAGGATCTGCTGGACCGGGACGAGCGGGACTGGCTGAACGCCTACCACGCCCGGGTCCGGGACGCGATCGTGCCGCAATT
GACCGAGGCCGCCGAGCGGGACTGGCTGGAGCAGGCGACCGCGACGCTGTAG

Upstream 100 bases:

>100_bases
TGCATATTCAACAGCCGGACCTGACAGCACCCTAACCATTCCGCGCGCCCAAAGCCAATTCCCCCTACCTGCCCCCGGCC
ATTTGAACTAGATTCCCAGG

Downstream 100 bases:

>100_bases
TTATTCCACCCAGCCGTGGTCAAGGGCGAAGCCCGAGGTGACGTAATCCATGGTCGCCCGGTGTTCCAGGAACCATTGCG
GCAGTTCGACCGTAAAGTAA

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MSPHQPAPSPTDRLADLRAELARLNLTGFVVPRADQHQGEYVPPSAQRLGWLTGFTGSAGSAVVLRDKAAIFVDGRYTLQ
VLAEVNTQLFTPLHLVEQPPHRWAGEVLSKGDRLGFDPWLHTHDQVQSLTAACERAGATLVPCPDNPVDAVWAGRPPAPA
TPISAHPERFAGRSAAAKRGDIAAELARERLDAAVLSAPESLAWLLNIRADDVAYTPLPLGFAVIYADASVDLFVQPDRI
DDTVTAPWGDAVRVAEPAAFEATLRLLGRGGKRVRLDSSSAPFQVWETLRAAGARVEPGSDPCALPRACKNAVEMAGTRA
AHLRDGAAMVRFLAWLDRTTRSGTVSEMEAADALEGFRRTGEHFRGLSFPTISGAGANGAIVHYHSTAKTNRPLAAGELY
LVDSGAQYLDGTTDITRTILVGDAPPDEARRRFTLVLKGHIALARAVFPMGTTGSQLDILARRPLWSAGLDYDHGTGHGV
GSFLSVHEGPQRISKVGNSVALKPGMILSNEPGYYKTGAYGIRIENLVMVEPRPAPAGAERDLLEFETLTLVPIDRALVA
EDLLDRDERDWLNAYHARVRDAIVPQLTEAAERDWLEQATATL

Sequences:

>Translated_603_residues
MSPHQPAPSPTDRLADLRAELARLNLTGFVVPRADQHQGEYVPPSAQRLGWLTGFTGSAGSAVVLRDKAAIFVDGRYTLQ
VLAEVNTQLFTPLHLVEQPPHRWAGEVLSKGDRLGFDPWLHTHDQVQSLTAACERAGATLVPCPDNPVDAVWAGRPPAPA
TPISAHPERFAGRSAAAKRGDIAAELARERLDAAVLSAPESLAWLLNIRADDVAYTPLPLGFAVIYADASVDLFVQPDRI
DDTVTAPWGDAVRVAEPAAFEATLRLLGRGGKRVRLDSSSAPFQVWETLRAAGARVEPGSDPCALPRACKNAVEMAGTRA
AHLRDGAAMVRFLAWLDRTTRSGTVSEMEAADALEGFRRTGEHFRGLSFPTISGAGANGAIVHYHSTAKTNRPLAAGELY
LVDSGAQYLDGTTDITRTILVGDAPPDEARRRFTLVLKGHIALARAVFPMGTTGSQLDILARRPLWSAGLDYDHGTGHGV
GSFLSVHEGPQRISKVGNSVALKPGMILSNEPGYYKTGAYGIRIENLVMVEPRPAPAGAERDLLEFETLTLVPIDRALVA
EDLLDRDERDWLNAYHARVRDAIVPQLTEAAERDWLEQATATL
>Mature_602_residues
SPHQPAPSPTDRLADLRAELARLNLTGFVVPRADQHQGEYVPPSAQRLGWLTGFTGSAGSAVVLRDKAAIFVDGRYTLQV
LAEVNTQLFTPLHLVEQPPHRWAGEVLSKGDRLGFDPWLHTHDQVQSLTAACERAGATLVPCPDNPVDAVWAGRPPAPAT
PISAHPERFAGRSAAAKRGDIAAELARERLDAAVLSAPESLAWLLNIRADDVAYTPLPLGFAVIYADASVDLFVQPDRID
DTVTAPWGDAVRVAEPAAFEATLRLLGRGGKRVRLDSSSAPFQVWETLRAAGARVEPGSDPCALPRACKNAVEMAGTRAA
HLRDGAAMVRFLAWLDRTTRSGTVSEMEAADALEGFRRTGEHFRGLSFPTISGAGANGAIVHYHSTAKTNRPLAAGELYL
VDSGAQYLDGTTDITRTILVGDAPPDEARRRFTLVLKGHIALARAVFPMGTTGSQLDILARRPLWSAGLDYDHGTGHGVG
SFLSVHEGPQRISKVGNSVALKPGMILSNEPGYYKTGAYGIRIENLVMVEPRPAPAGAERDLLEFETLTLVPIDRALVAE
DLLDRDERDWLNAYHARVRDAIVPQLTEAAERDWLEQATATL

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=604, Percent_Identity=39.4039735099338, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI93141226, Length=618, Percent_Identity=35.5987055016181, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI264681565, Length=604, Percent_Identity=37.2516556291391, Blast_Score=366, Evalue=1e-101,
Organism=Escherichia coli, GI1788728, Length=197, Percent_Identity=38.5786802030457, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17509539, Length=593, Percent_Identity=35.7504215851602, Blast_Score=331, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI25149105, Length=630, Percent_Identity=31.1111111111111, Blast_Score=280, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6322999, Length=659, Percent_Identity=32.9286798179059, Blast_Score=325, Evalue=1e-89,
Organism=Drosophila melanogaster, GI17137632, Length=602, Percent_Identity=34.3853820598007, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI161078230, Length=621, Percent_Identity=31.5619967793881, Blast_Score=267, Evalue=2e-71,
Organism=Drosophila melanogaster, GI21357287, Length=621, Percent_Identity=31.5619967793881, Blast_Score=267, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 65065; Mature: 64934

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPHQPAPSPTDRLADLRAELARLNLTGFVVPRADQHQGEYVPPSAQRLGWLTGFTGSAG
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHCEEEECCCCCCC
SAVVLRDKAAIFVDGRYTLQVLAEVNTQLFTPLHLVEQPPHRWAGEVLSKGDRLGFDPWL
CEEEEECCEEEEECCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCC
HTHDQVQSLTAACERAGATLVPCPDNPVDAVWAGRPPAPATPISAHPERFAGRSAAAKRG
CCHHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCHHHCCCHHHHHCC
DIAAELARERLDAAVLSAPESLAWLLNIRADDVAYTPLPLGFAVIYADASVDLFVQPDRI
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCEEEEEECCCEEEEECCCCC
DDTVTAPWGDAVRVAEPAAFEATLRLLGRGGKRVRLDSSSAPFQVWETLRAAGARVEPGS
CCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCC
DPCALPRACKNAVEMAGTRAAHLRDGAAMVRFLAWLDRTTRSGTVSEMEAADALEGFRRT
CCCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
GEHFRGLSFPTISGAGANGAIVHYHSTAKTNRPLAAGELYLVDSGAQYLDGTTDITRTIL
HHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCHHCCCCCCCEEEEE
VGDAPPDEARRRFTLVLKGHIALARAVFPMGTTGSQLDILARRPLWSAGLDYDHGTGHGV
ECCCCCHHHHCEEEEEEECHHHHHHHHCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCH
GSFLSVHEGPQRISKVGNSVALKPGMILSNEPGYYKTGAYGIRIENLVMVEPRPAPAGAE
HHHHHHCCCHHHHHHCCCCEEECCCEEECCCCCCEECCEEEEEEEEEEEECCCCCCCCCC
RDLLEFETLTLVPIDRALVAEDLLDRDERDWLNAYHARVRDAIVPQLTEAAERDWLEQAT
CCHHEEEEEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATL
HCC
>Mature Secondary Structure 
SPHQPAPSPTDRLADLRAELARLNLTGFVVPRADQHQGEYVPPSAQRLGWLTGFTGSAG
CCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHCEEEECCCCCCC
SAVVLRDKAAIFVDGRYTLQVLAEVNTQLFTPLHLVEQPPHRWAGEVLSKGDRLGFDPWL
CEEEEECCEEEEECCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCC
HTHDQVQSLTAACERAGATLVPCPDNPVDAVWAGRPPAPATPISAHPERFAGRSAAAKRG
CCHHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCHHHCCCHHHHHCC
DIAAELARERLDAAVLSAPESLAWLLNIRADDVAYTPLPLGFAVIYADASVDLFVQPDRI
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCEEEEEECCCEEEEECCCCC
DDTVTAPWGDAVRVAEPAAFEATLRLLGRGGKRVRLDSSSAPFQVWETLRAAGARVEPGS
CCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCC
DPCALPRACKNAVEMAGTRAAHLRDGAAMVRFLAWLDRTTRSGTVSEMEAADALEGFRRT
CCCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
GEHFRGLSFPTISGAGANGAIVHYHSTAKTNRPLAAGELYLVDSGAQYLDGTTDITRTIL
HHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCHHCCCCCCCEEEEE
VGDAPPDEARRRFTLVLKGHIALARAVFPMGTTGSQLDILARRPLWSAGLDYDHGTGHGV
ECCCCCHHHHCEEEEEEECHHHHHHHHCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCH
GSFLSVHEGPQRISKVGNSVALKPGMILSNEPGYYKTGAYGIRIENLVMVEPRPAPAGAE
HHHHHHCCCHHHHHHCCCCEEECCCEEECCCCCCEECCEEEEEEEEEEEECCCCCCCCCC
RDLLEFETLTLVPIDRALVAEDLLDRDERDWLNAYHARVRDAIVPQLTEAAERDWLEQAT
CCHHEEEEEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]