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The map label for this gene is ubiB [H]

Identifier: 83309729

GI number: 83309729

Start: 678420

End: 679961

Strand: Reverse

Name: ubiB [H]

Synonym: amb0630

Alternate gene names: 83309729

Gene position: 679961-678420 (Counterclockwise)

Preceding gene: 83309730

Following gene: 83309727

Centisome position: 13.69

GC content: 66.93

Gene sequence:

>1542_bases
ATGATCAGGTCGTTTCGCAACCTCAACCGCCTGCTGACCATCGGCCGCGTCCTGGCTCGCCACGACGCCTTGTTCCTGCT
GGAAGACTATCTGCCCATCGCGCGCTTCGGCTCGAAGCTGCTGCGCGGCGGCCGCCGTCCGGCCAGTTCGGGGCGGCCGG
GCGAGCGCCTCGCCGCCGCCCTGGCCGAGCTGGGACCGTCCTTCATCAAGCTGGGCCAGGCCCTGTCCACCCGCGCCGAC
CTGCTGGGCGAGGAAATGGCCGCCGATCTGTCGGGGCTGCAAGACAAGCTGCCCCCCTTCCCGCCCGAGGATGCCCGGCG
CATCATCGAGGAGGAACTGGGCGGGCCGCTGTCCAATTTCTATTCCGCCTTCGACGACATCCCCGTGGCCGCCGCCTCTA
TCGCCCAAGTGCACTTCGCCACCACCCGCGAAGGCCGCGAAGTGGCGGTCAAGGTGCTGCGCCCCGGGGTCGAGGCCAAG
TTCCACCGCGACATCGACCTGCTGTACTGGCTGGCCGAGTGGGCGGAGCTGGCCGTTCCCCGGCTGCGCCGCCTCAAGCC
GGTGGAAACGGTCAAGACCTTCGAGGAATCCGTCACCCTGGAGATGGATCTCCGCTTCGAGGCCGCCGCCGCCTCGGAAC
TGGCCGAGAACTTCCGCGGCGATGACAATTTCAAGGTGCCCGAAGTCGACTGGCTGCGCACCGGTAAGCGCCTTTTGACC
CTGGAACGGGTCTCGGGCATTCCGGTGGACGAGGTGGACCGCATGCGGGCGGCGGGCATCGACCCCGTCGACGTGCTGGC
CAAGGCCGCCGAAGCCATGTTCAACCAGGTGTTCCGCGACGGCTTCTTCCACGCCGACATGCATCCGGGCAACCTGTTCA
TCGGCAAGGGCGGTCAGCTGATCGCCATGGATTTCGGCATCATGGGCCGTGTCGACAAAAGCACGCGGCGCTTCCTGGGC
GAGATGCTGCTGGGTTTCCTGTCGGGCGATTACCGCAAGGTGGCCGAAGTACACTTCGCCGCCGGCTATGTGCCCGCCGA
CCAGTCCCTGGACACCTTCACCCAGGCCTGTCGCTCCATCGCCGAGCCCATCCTGGGCCGTCCGCTGCACGAAATCTCCA
TCGCCAAGCTGCTGGGCCAGCTGTTCCAGGTCACCGAGACCTTCGCCATGGAAACCCAGCCGCAATTGCTGCTGCTGCAA
AAGAGCATGCTGGTGGCCGAGGGCGTCGGGCGCATCCTCGACCCCAACATCAATATGTGGCATCTGGCCCAGCCGCTGAT
CGAAGGCTGGATGCGCGAGAATCTCGGCCCCGAGGCCCGGGTGCGCGAAACCTTCAGCAGCGTGGTCGGCTCGCTGGAGC
GCCTGCCCCGCCTGCTGGCCGAGACCGAGAAGACCTATTCCATGCTGGTCAATCAGGGGCTCAAGCTGCACCCCGACACG
GTCAAGGCCATGTTCCCCGACCAGGGCCGCCTGCGCCGCCCCTCGCCCCTGCTGGCCTGGGTCATCGCCGCCGGTCTGGC
GGTGGCGCTGTATCTGAAATAG

Upstream 100 bases:

>100_bases
GTCCTGATCCGGCGGTTCCGAATCGGACCCGGCAGTCCAAGCGGAGATCCCTCGCTATCGCTCGGGATGACAATGCAAGA
CAGGTCGAAGGCCTGTCGCC

Downstream 100 bases:

>100_bases
GGGGCGATGCGGGGCTCCCGCCCCGTAACCCCGGTTGGAGGCGATGCCTCCAAACCTCCCTTTGATTTATAAATAGAAAT
GGGGCCGGGGCATTGGCCCC

Product: protein kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MIRSFRNLNRLLTIGRVLARHDALFLLEDYLPIARFGSKLLRGGRRPASSGRPGERLAAALAELGPSFIKLGQALSTRAD
LLGEEMAADLSGLQDKLPPFPPEDARRIIEEELGGPLSNFYSAFDDIPVAAASIAQVHFATTREGREVAVKVLRPGVEAK
FHRDIDLLYWLAEWAELAVPRLRRLKPVETVKTFEESVTLEMDLRFEAAAASELAENFRGDDNFKVPEVDWLRTGKRLLT
LERVSGIPVDEVDRMRAAGIDPVDVLAKAAEAMFNQVFRDGFFHADMHPGNLFIGKGGQLIAMDFGIMGRVDKSTRRFLG
EMLLGFLSGDYRKVAEVHFAAGYVPADQSLDTFTQACRSIAEPILGRPLHEISIAKLLGQLFQVTETFAMETQPQLLLLQ
KSMLVAEGVGRILDPNINMWHLAQPLIEGWMRENLGPEARVRETFSSVVGSLERLPRLLAETEKTYSMLVNQGLKLHPDT
VKAMFPDQGRLRRPSPLLAWVIAAGLAVALYLK

Sequences:

>Translated_513_residues
MIRSFRNLNRLLTIGRVLARHDALFLLEDYLPIARFGSKLLRGGRRPASSGRPGERLAAALAELGPSFIKLGQALSTRAD
LLGEEMAADLSGLQDKLPPFPPEDARRIIEEELGGPLSNFYSAFDDIPVAAASIAQVHFATTREGREVAVKVLRPGVEAK
FHRDIDLLYWLAEWAELAVPRLRRLKPVETVKTFEESVTLEMDLRFEAAAASELAENFRGDDNFKVPEVDWLRTGKRLLT
LERVSGIPVDEVDRMRAAGIDPVDVLAKAAEAMFNQVFRDGFFHADMHPGNLFIGKGGQLIAMDFGIMGRVDKSTRRFLG
EMLLGFLSGDYRKVAEVHFAAGYVPADQSLDTFTQACRSIAEPILGRPLHEISIAKLLGQLFQVTETFAMETQPQLLLLQ
KSMLVAEGVGRILDPNINMWHLAQPLIEGWMRENLGPEARVRETFSSVVGSLERLPRLLAETEKTYSMLVNQGLKLHPDT
VKAMFPDQGRLRRPSPLLAWVIAAGLAVALYLK
>Mature_513_residues
MIRSFRNLNRLLTIGRVLARHDALFLLEDYLPIARFGSKLLRGGRRPASSGRPGERLAAALAELGPSFIKLGQALSTRAD
LLGEEMAADLSGLQDKLPPFPPEDARRIIEEELGGPLSNFYSAFDDIPVAAASIAQVHFATTREGREVAVKVLRPGVEAK
FHRDIDLLYWLAEWAELAVPRLRRLKPVETVKTFEESVTLEMDLRFEAAAASELAENFRGDDNFKVPEVDWLRTGKRLLT
LERVSGIPVDEVDRMRAAGIDPVDVLAKAAEAMFNQVFRDGFFHADMHPGNLFIGKGGQLIAMDFGIMGRVDKSTRRFLG
EMLLGFLSGDYRKVAEVHFAAGYVPADQSLDTFTQACRSIAEPILGRPLHEISIAKLLGQLFQVTETFAMETQPQLLLLQ
KSMLVAEGVGRILDPNINMWHLAQPLIEGWMRENLGPEARVRETFSSVVGSLERLPRLLAETEKTYSMLVNQGLKLHPDT
VKAMFPDQGRLRRPSPLLAWVIAAGLAVALYLK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=291, Percent_Identity=30.2405498281787, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI41393593, Length=279, Percent_Identity=29.0322580645161, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI217035081, Length=231, Percent_Identity=29.4372294372294, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI32261307, Length=342, Percent_Identity=25.4385964912281, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI34147522, Length=273, Percent_Identity=26.7399267399267, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI27363457, Length=259, Percent_Identity=25.4826254826255, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI217416386, Length=206, Percent_Identity=27.6699029126214, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI2367309, Length=413, Percent_Identity=41.4043583535109, Blast_Score=321, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI17559152, Length=311, Percent_Identity=30.8681672025724, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI32565180, Length=326, Percent_Identity=27.9141104294479, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325148, Length=463, Percent_Identity=21.5982721382289, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323282, Length=287, Percent_Identity=25.7839721254355, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=325, Percent_Identity=24.3076923076923, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24662575, Length=308, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI22024280, Length=279, Percent_Identity=27.9569892473118, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18859849, Length=284, Percent_Identity=26.056338028169, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57057; Mature: 57057

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSFRNLNRLLTIGRVLARHDALFLLEDYLPIARFGSKLLRGGRRPASSGRPGERLAAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LAELGPSFIKLGQALSTRADLLGEEMAADLSGLQDKLPPFPPEDARRIIEEELGGPLSNF
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHH
YSAFDDIPVAAASIAQVHFATTREGREVAVKVLRPGVEAKFHRDIDLLYWLAEWAELAVP
HHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHH
RLRRLKPVETVKTFEESVTLEMDLRFEAAAASELAENFRGDDNFKVPEVDWLRTGKRLLT
HHHHCCHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHH
LERVSGIPVDEVDRMRAAGIDPVDVLAKAAEAMFNQVFRDGFFHADMHPGNLFIGKGGQL
HHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCE
IAMDFGIMGRVDKSTRRFLGEMLLGFLSGDYRKVAEVHFAAGYVPADQSLDTFTQACRSI
EEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AEPILGRPLHEISIAKLLGQLFQVTETFAMETQPQLLLLQKSMLVAEGVGRILDPNINMW
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHCCCCCCHH
HLAQPLIEGWMRENLGPEARVRETFSSVVGSLERLPRLLAETEKTYSMLVNQGLKLHPDT
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
VKAMFPDQGRLRRPSPLLAWVIAAGLAVALYLK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRSFRNLNRLLTIGRVLARHDALFLLEDYLPIARFGSKLLRGGRRPASSGRPGERLAAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LAELGPSFIKLGQALSTRADLLGEEMAADLSGLQDKLPPFPPEDARRIIEEELGGPLSNF
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHH
YSAFDDIPVAAASIAQVHFATTREGREVAVKVLRPGVEAKFHRDIDLLYWLAEWAELAVP
HHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHH
RLRRLKPVETVKTFEESVTLEMDLRFEAAAASELAENFRGDDNFKVPEVDWLRTGKRLLT
HHHHCCHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHH
LERVSGIPVDEVDRMRAAGIDPVDVLAKAAEAMFNQVFRDGFFHADMHPGNLFIGKGGQL
HHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCE
IAMDFGIMGRVDKSTRRFLGEMLLGFLSGDYRKVAEVHFAAGYVPADQSLDTFTQACRSI
EEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AEPILGRPLHEISIAKLLGQLFQVTETFAMETQPQLLLLQKSMLVAEGVGRILDPNINMW
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHCCCCCCHH
HLAQPLIEGWMRENLGPEARVRETFSSVVGSLERLPRLLAETEKTYSMLVNQGLKLHPDT
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
VKAMFPDQGRLRRPSPLLAWVIAAGLAVALYLK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA