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The map label for this gene is prs [H]

Identifier: 83309689

GI number: 83309689

Start: 638226

End: 638798

Strand: Reverse

Name: prs [H]

Synonym: amb0590

Alternate gene names: 83309689

Gene position: 638798-638226 (Counterclockwise)

Preceding gene: 83309691

Following gene: 83309683

Centisome position: 12.86

GC content: 67.71

Gene sequence:

>573_bases
GTGGTGACGCTGGACCTGCACTCGGGCCAGATCCAGGGCTTCTTCGACATTCCGCTGGATAACCTCTACGCCGCCCCGGT
GTTCACCAACGACATCCGCGCCCGCTACCAGGGCGACGACGTCATGGTGGTGTCGCCCGACGTGGGCGGCGTGGTGCGCG
CCCGCGCCATCGCCAGCCGCATCGACGCCGATCTGGCCATCATCGACAAGCGCCGCGAAAAGGCTGGCGTGTCCGAGGTG
ATGAACATCATCGGCGACGTGCGCGGCCGCCGCTGCATCATGGTCGACGACATCGTCGATTCCGCCGGCACCCTGTGCAA
CGCCGCCGAGGCGCTGATGAAGGCCGGAGCCGTCTCCGTCGCCGCCTTCGTCACCCACGGCGTGCTGTCGGGCGGCGCGG
TGGCCCGCGTCACCGCTTCGCCCCTGGAAGAACTGGTGATCACCGATTCCATCCCCGCCACCGAGGCGGTGAAGATGGCC
CGCAACATCCGGCAGGTGACCATCGCCCCCCTGATGGCCGAATCCATCTCGCGCATCAGCGAGGAACGCTCGGTCTCCAG
CCTGTTCGACTAG

Upstream 100 bases:

>100_bases
CTATTTCGGCTATGCCCGCCAGGATCGCAAGTCCTCGCCCCGCTCGCCCATCTCGGCCAAGCTGGTGGCCAATCTGATCA
CCACCGCCGGCGCCGACCGC

Downstream 100 bases:

>100_bases
GGGATAACGGGGCTCACGCCCCGGCCCCGGTTGGAGGCTCAGCCTCCAAGCCTCCCATATTTTTGAAAATGGAAGGGGTC
TGGGGTCTGCCCCAGATGGG

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MVTLDLHSGQIQGFFDIPLDNLYAAPVFTNDIRARYQGDDVMVVSPDVGGVVRARAIASRIDADLAIIDKRREKAGVSEV
MNIIGDVRGRRCIMVDDIVDSAGTLCNAAEALMKAGAVSVAAFVTHGVLSGGAVARVTASPLEELVITDSIPATEAVKMA
RNIRQVTIAPLMAESISRISEERSVSSLFD

Sequences:

>Translated_190_residues
MVTLDLHSGQIQGFFDIPLDNLYAAPVFTNDIRARYQGDDVMVVSPDVGGVVRARAIASRIDADLAIIDKRREKAGVSEV
MNIIGDVRGRRCIMVDDIVDSAGTLCNAAEALMKAGAVSVAAFVTHGVLSGGAVARVTASPLEELVITDSIPATEAVKMA
RNIRQVTIAPLMAESISRISEERSVSSLFD
>Mature_190_residues
MVTLDLHSGQIQGFFDIPLDNLYAAPVFTNDIRARYQGDDVMVVSPDVGGVVRARAIASRIDADLAIIDKRREKAGVSEV
MNIIGDVRGRRCIMVDDIVDSAGTLCNAAEALMKAGAVSVAAFVTHGVLSGGAVARVTASPLEELVITDSIPATEAVKMA
RNIRQVTIAPLMAESISRISEERSVSSLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=190, Percent_Identity=43.1578947368421, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI84875539, Length=190, Percent_Identity=43.1578947368421, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI4506127, Length=190, Percent_Identity=43.6842105263158, Blast_Score=171, Evalue=2e-43,
Organism=Homo sapiens, GI28557709, Length=190, Percent_Identity=43.1578947368421, Blast_Score=167, Evalue=4e-42,
Organism=Homo sapiens, GI4506133, Length=223, Percent_Identity=31.8385650224215, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI194018537, Length=222, Percent_Identity=30.6306306306306, Blast_Score=85, Evalue=3e-17,
Organism=Escherichia coli, GI1787458, Length=191, Percent_Identity=50.261780104712, Blast_Score=200, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI25149168, Length=192, Percent_Identity=43.75, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17554704, Length=192, Percent_Identity=43.75, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17554702, Length=192, Percent_Identity=43.75, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71989924, Length=192, Percent_Identity=43.75, Blast_Score=167, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17570245, Length=219, Percent_Identity=32.4200913242009, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321776, Length=189, Percent_Identity=43.3862433862434, Blast_Score=164, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6319403, Length=190, Percent_Identity=44.2105263157895, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320946, Length=189, Percent_Identity=41.7989417989418, Blast_Score=161, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324511, Length=110, Percent_Identity=35.4545454545455, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322667, Length=115, Percent_Identity=31.304347826087, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45551540, Length=190, Percent_Identity=40, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21355239, Length=190, Percent_Identity=40, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24651458, Length=235, Percent_Identity=30.6382978723404, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24651456, Length=235, Percent_Identity=30.6382978723404, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281362873, Length=235, Percent_Identity=30.6382978723404, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24651454, Length=235, Percent_Identity=30.6382978723404, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24651462, Length=113, Percent_Identity=38.9380530973451, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24651464, Length=113, Percent_Identity=38.9380530973451, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45552010, Length=113, Percent_Identity=38.9380530973451, Blast_Score=83, Evalue=9e-17,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 20199; Mature: 20199

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLDLHSGQIQGFFDIPLDNLYAAPVFTNDIRARYQGDDVMVVSPDVGGVVRARAIASR
CEEEEECCCCCCEEEECCCCCEEECCEECCCHHHEECCCEEEEECCCCCHHHHHHHHHHH
IDADLAIIDKRREKAGVSEVMNIIGDVRGRRCIMVDDIVDSAGTLCNAAEALMKAGAVSV
HCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCHHHH
AAFVTHGVLSGGAVARVTASPLEELVITDSIPATEAVKMARNIRQVTIAPLMAESISRIS
HHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EERSVSSLFD
HHHHHHHHCC
>Mature Secondary Structure
MVTLDLHSGQIQGFFDIPLDNLYAAPVFTNDIRARYQGDDVMVVSPDVGGVVRARAIASR
CEEEEECCCCCCEEEECCCCCEEECCEECCCHHHEECCCEEEEECCCCCHHHHHHHHHHH
IDADLAIIDKRREKAGVSEVMNIIGDVRGRRCIMVDDIVDSAGTLCNAAEALMKAGAVSV
HCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCHHHH
AAFVTHGVLSGGAVARVTASPLEELVITDSIPATEAVKMARNIRQVTIAPLMAESISRIS
HHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EERSVSSLFD
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA