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The map label for this gene is pgm [H]

Identifier: 83309673

GI number: 83309673

Start: 621446

End: 623074

Strand: Reverse

Name: pgm [H]

Synonym: amb0574

Alternate gene names: 83309673

Gene position: 623074-621446 (Counterclockwise)

Preceding gene: 83309675

Following gene: 83309672

Centisome position: 12.54

GC content: 66.73

Gene sequence:

>1629_bases
ATGGCCGCAGTGAAGACGATCCCCACCACCCCCTTTTCCGGCCAGAAGCCCGGGACCTCGGGTCTTCGCAAGAAGGTCAA
GGTCTTCGCCCAGCCCCACTACCTGGAAAACTTCGTCCAGGCGGTGTTCGACTCCATTGGAGACCTGGGGGGCAAGACCC
TGGTGGTGGGCGGCGACGGCCGCTATCACAACCGCACCGCCATCCAGACCATCCTGAAGATGGCTGCCGCCAGCGGCTTC
GCCAAGGTGATGGTGGGCCGGGGCGGCATCCTGTCCACCCCGGCGGCGTCCTGCGTCATCCGCAAGTACAAGACCTTCGG
CGGCATCATCCTGTCAGCCAGCCACAATCCCGGCGGCCCGGACGAGGATTTCGGCATCAAGTACAACATCCCGGCCGGCG
GCCCGGCGCCCGAGGCCATCACCGAGGCCATCTACGCCCGCACCCAGGAAATCTCGTCCTACAAGATCATCGAAGCGGCG
GATGTGGATCTGGACACCATCGGCGAGCGCGGCCTGGGCGGCATGACGGTGCAGGTCTTCGACCCCGTCGCCGATTATGC
CGAGCTGATGGAAAGCCTGTTCGACTTCGGCGCCATCCGGGCGGCCTTCGCCGCCGGGTTCCGCATGAAGTTCGACGCCA
TGCACGCGGTGACCGGCCCCTATGCCACCGAGATCCTGGAGAATCGCCTGGGCGCCCCCAAAGGCACCGTGATGAACGGC
GTGCCGCTGGAAGATTTCGGCCACGGCCATCCCGACCCCAATCTGGTCCATGCCCATGATCTGGTGGAGGCCCTGACCGG
TGCCGGCGCCCCCGATTTCGGCGCGGCCTCGGATGGCGACGGCGACCGCAACATGATTCTGGGCCGCGACTTCTATGTGA
CGCCGTCGGATTCCCTGGCGGTGCTGGCCGCCAATGCCACCCTGTGTCCCGGCTATGCCCGGGGCCTGAAAGGCATCGCC
CGGTCCATGCCCACCAGCGCCGCGCCCGACCGGGTGGCGGCCAAGCTGGGCATTCCCGCCTGGGAGACTCCCACCGGCTG
GAAATTCTTCGGTACCCTGCTGGACGCGGGCAAGGCCACCTTCTGCGGCGAGGAAAGCTTCGGCACCGGCTCGGACCATG
TGCGCGAGAAGGACGGGCTGTGGGCGGTGCTGGCCTGGCTGAACGTGCTGGCCGTGCGCAAGCAAAGCGTCGCCGACATC
GTTACCGCCCATTGGCGGGAATACGGCCGCAACGTCTATTCCCGCCATGATTACGAGGGCATCGATTCCGCCGCCGCCGA
AGGGCTGATGGAGCATCTGCGCGGCCTGTCCCTGAAGGGCGAGCGGCTCGGGACCTACACCGTCGCCTTCAACGACGACT
TCGCCTATACCGACCCCGTTGACGGCTCTGTCTCGAAGAAGCAGGGCATCCGCGTGGTATTCGAGGACGGCTCCCGCGTG
GTCTTCCGCCTGTCGGGCACCGGCACCGAGGGCGCCACGCTGCGCGTCTACATCGAGCGCTTTGAACCCGACGCCACCAA
GCACCATCTGGACCCCCAGGTGGCCCTGGCCGACCTCATCACAATCGCCCGCGACCTGGCCCAGATCGAGGCCCGGACCG
GACGGACCGAACCGACGGTGATTACCTGA

Upstream 100 bases:

>100_bases
CTTATCTCGTAAAATTTGCCGCCTTTCCTGCGCCATTGACACCTGCCCCGCCATCGGCCATCAACGCCGAAGCAGTTTTG
TCGGAAGGGAGCCCCGCGCC

Downstream 100 bases:

>100_bases
CATGACCCACATCTTCCACCCCACCATCCTGCGCGAATACGACATCCGCGGCATTATCGGCGAGACGCTGTTCGCCGCCG
ACGCCGAGGCCATCGGCCGG

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAAVKTIPTTPFSGQKPGTSGLRKKVKVFAQPHYLENFVQAVFDSIGDLGGKTLVVGGDGRYHNRTAIQTILKMAAASGF
AKVMVGRGGILSTPAASCVIRKYKTFGGIILSASHNPGGPDEDFGIKYNIPAGGPAPEAITEAIYARTQEISSYKIIEAA
DVDLDTIGERGLGGMTVQVFDPVADYAELMESLFDFGAIRAAFAAGFRMKFDAMHAVTGPYATEILENRLGAPKGTVMNG
VPLEDFGHGHPDPNLVHAHDLVEALTGAGAPDFGAASDGDGDRNMILGRDFYVTPSDSLAVLAANATLCPGYARGLKGIA
RSMPTSAAPDRVAAKLGIPAWETPTGWKFFGTLLDAGKATFCGEESFGTGSDHVREKDGLWAVLAWLNVLAVRKQSVADI
VTAHWREYGRNVYSRHDYEGIDSAAAEGLMEHLRGLSLKGERLGTYTVAFNDDFAYTDPVDGSVSKKQGIRVVFEDGSRV
VFRLSGTGTEGATLRVYIERFEPDATKHHLDPQVALADLITIARDLAQIEARTGRTEPTVIT

Sequences:

>Translated_542_residues
MAAVKTIPTTPFSGQKPGTSGLRKKVKVFAQPHYLENFVQAVFDSIGDLGGKTLVVGGDGRYHNRTAIQTILKMAAASGF
AKVMVGRGGILSTPAASCVIRKYKTFGGIILSASHNPGGPDEDFGIKYNIPAGGPAPEAITEAIYARTQEISSYKIIEAA
DVDLDTIGERGLGGMTVQVFDPVADYAELMESLFDFGAIRAAFAAGFRMKFDAMHAVTGPYATEILENRLGAPKGTVMNG
VPLEDFGHGHPDPNLVHAHDLVEALTGAGAPDFGAASDGDGDRNMILGRDFYVTPSDSLAVLAANATLCPGYARGLKGIA
RSMPTSAAPDRVAAKLGIPAWETPTGWKFFGTLLDAGKATFCGEESFGTGSDHVREKDGLWAVLAWLNVLAVRKQSVADI
VTAHWREYGRNVYSRHDYEGIDSAAAEGLMEHLRGLSLKGERLGTYTVAFNDDFAYTDPVDGSVSKKQGIRVVFEDGSRV
VFRLSGTGTEGATLRVYIERFEPDATKHHLDPQVALADLITIARDLAQIEARTGRTEPTVIT
>Mature_541_residues
AAVKTIPTTPFSGQKPGTSGLRKKVKVFAQPHYLENFVQAVFDSIGDLGGKTLVVGGDGRYHNRTAIQTILKMAAASGFA
KVMVGRGGILSTPAASCVIRKYKTFGGIILSASHNPGGPDEDFGIKYNIPAGGPAPEAITEAIYARTQEISSYKIIEAAD
VDLDTIGERGLGGMTVQVFDPVADYAELMESLFDFGAIRAAFAAGFRMKFDAMHAVTGPYATEILENRLGAPKGTVMNGV
PLEDFGHGHPDPNLVHAHDLVEALTGAGAPDFGAASDGDGDRNMILGRDFYVTPSDSLAVLAANATLCPGYARGLKGIAR
SMPTSAAPDRVAAKLGIPAWETPTGWKFFGTLLDAGKATFCGEESFGTGSDHVREKDGLWAVLAWLNVLAVRKQSVADIV
TAHWREYGRNVYSRHDYEGIDSAAAEGLMEHLRGLSLKGERLGTYTVAFNDDFAYTDPVDGSVSKKQGIRVVFEDGSRVV
FRLSGTGTEGATLRVYIERFEPDATKHHLDPQVALADLITIARDLAQIEARTGRTEPTVIT

Specific function: This enzyme participates in both the breakdown and synthesis of glucose. Required for the synthesis of capsular polysaccharide and normal lipopolysaccharide [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI290463102, Length=558, Percent_Identity=55.5555555555556, Blast_Score=618, Evalue=1e-177,
Organism=Homo sapiens, GI21361621, Length=563, Percent_Identity=53.8188277087034, Blast_Score=608, Evalue=1e-174,
Organism=Homo sapiens, GI133922562, Length=561, Percent_Identity=49.3761140819964, Blast_Score=550, Evalue=1e-156,
Organism=Homo sapiens, GI290463104, Length=366, Percent_Identity=56.2841530054645, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI239743670, Length=132, Percent_Identity=44.6969696969697, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI239741729, Length=132, Percent_Identity=46.2121212121212, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786904, Length=508, Percent_Identity=26.7716535433071, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17535441, Length=571, Percent_Identity=52.0140105078809, Blast_Score=551, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322722, Length=568, Percent_Identity=45.2464788732394, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6323752, Length=570, Percent_Identity=44.9122807017544, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17864244, Length=560, Percent_Identity=50.3571428571429, Blast_Score=548, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 57829; Mature: 57698

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVKTIPTTPFSGQKPGTSGLRKKVKVFAQPHYLENFVQAVFDSIGDLGGKTLVVGGDG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCC
RYHNRTAIQTILKMAAASGFAKVMVGRGGILSTPAASCVIRKYKTFGGIILSASHNPGGP
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCC
DEDFGIKYNIPAGGPAPEAITEAIYARTQEISSYKIIEAADVDLDTIGERGLGGMTVQVF
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCEEEEEE
DPVADYAELMESLFDFGAIRAAFAAGFRMKFDAMHAVTGPYATEILENRLGAPKGTVMNG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHCCHHHHHHHHHHCCCCCCCEECC
VPLEDFGHGHPDPNLVHAHDLVEALTGAGAPDFGAASDGDGDRNMILGRDFYVTPSDSLA
CCHHHCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCEEEECCCCCEE
VLAANATLCPGYARGLKGIARSMPTSAAPDRVAAKLGIPAWETPTGWKFFGTLLDAGKAT
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCE
FCGEESFGTGSDHVREKDGLWAVLAWLNVLAVRKQSVADIVTAHWREYGRNVYSRHDYEG
ECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCC
IDSAAAEGLMEHLRGLSLKGERLGTYTVAFNDDFAYTDPVDGSVSKKQGIRVVFEDGSRV
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCEE
VFRLSGTGTEGATLRVYIERFEPDATKHHLDPQVALADLITIARDLAQIEARTGRTEPTV
EEEEECCCCCCCEEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IT
EC
>Mature Secondary Structure 
AAVKTIPTTPFSGQKPGTSGLRKKVKVFAQPHYLENFVQAVFDSIGDLGGKTLVVGGDG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCC
RYHNRTAIQTILKMAAASGFAKVMVGRGGILSTPAASCVIRKYKTFGGIILSASHNPGGP
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCC
DEDFGIKYNIPAGGPAPEAITEAIYARTQEISSYKIIEAADVDLDTIGERGLGGMTVQVF
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCEEEEEE
DPVADYAELMESLFDFGAIRAAFAAGFRMKFDAMHAVTGPYATEILENRLGAPKGTVMNG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHCCHHHHHHHHHHCCCCCCCEECC
VPLEDFGHGHPDPNLVHAHDLVEALTGAGAPDFGAASDGDGDRNMILGRDFYVTPSDSLA
CCHHHCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCEEEECCCCCEE
VLAANATLCPGYARGLKGIARSMPTSAAPDRVAAKLGIPAWETPTGWKFFGTLLDAGKAT
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCE
FCGEESFGTGSDHVREKDGLWAVLAWLNVLAVRKQSVADIVTAHWREYGRNVYSRHDYEG
ECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCC
IDSAAAEGLMEHLRGLSLKGERLGTYTVAFNDDFAYTDPVDGSVSKKQGIRVVFEDGSRV
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCEE
VFRLSGTGTEGATLRVYIERFEPDATKHHLDPQVALADLITIARDLAQIEARTGRTEPTV
EEEEECCCCCCCEEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IT
EC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7959036; 2307661 [H]