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The map label for this gene is envZ [H]

Identifier: 83309647

GI number: 83309647

Start: 594395

End: 595720

Strand: Reverse

Name: envZ [H]

Synonym: amb0548

Alternate gene names: 83309647

Gene position: 595720-594395 (Counterclockwise)

Preceding gene: 83309648

Following gene: 83309646

Centisome position: 11.99

GC content: 67.5

Gene sequence:

>1326_bases
ATGTCTCATCTCGGGCGGTGGCTGAAGCGTCTGGCCCCCCAGGGTCTGCTGGGGCGATCCCTGCTGATCATCATCATGCC
ACTGGTGTTGCTGCAGTTGGTGTCCGCCTACGTATTTTACGGCAGTCACTGGGAATCGGTGGCCAAGCGCTTGGCCAAGG
GGTTGGCCGGCGACATCGGCACCATCATCGAATCGCTCCGCGCCTTTCCCGGGGAACAGGAGCGGAGCCTGATCCTGTCC
ATCGCCGCCAACAAGATGGAACTGGACACCCGCTTCCTGCCCGGCGCCATCCTGCCCAACCAGCCACGCGGCGCCCCCTC
GGGCCTGCTGGAACGCGCCCTGACCGAGGCCCTGGACGAGCGGGTCCAGCGCCCCTATCGCATCGACGCCGAATCCCTGG
AACGCGAGGTGGTCATCCGTGTCCAGCTCTCGGACGGGATGCTGGAGGTCTTCGCCCCCAAGAAGCGGCTGTTCAGCTCC
ACCACCTATGTCTTCATCCTGTGGATGCTGGGCACCGCCATGCTGCTGTTCGGCATCGCCACCTTGTTCATGCGTAATCA
GGTGCGCAGCGTGCGCAAGCTGGCGGTGGCCGCCGACCGCTTCGGCAAGGGCCAGGATGTGGCCGACTTCAAGCCCGAAG
GGGCGCAGGAGGTCCGGCAGGCCGCCCAGGCCTTCAACCTGATGCGCCACCGGGTCCAGCGCCAGATGCAGCAGCGCACC
GAGATGCTGGCCGGGGTCTCCCACGACCTGCGCACCCCGCTCACCCGCATGAAGCTGCAATTGGCCATCATGGGCGACAT
GGACGGCCGCGCCGAACTGGACGAGGACGTAGCCGAGATGGAGCGCATGGTCGAGGGCTATCTGGCCTTTGCCCGGGGCG
AAGGCAGCGAGCAGCCCGAGCAGGTGGACCTGCCGGCCCTGGTTGACGAGGTGGTCACCCGCTTTCGCCGCCAGGGCATG
GTCATCGACCTGCACCACGAGGGCGAGATCGTCATGCCGCTGCGTCCCGATTCCCTGGCCCGCGCCCTGGGTAACCTGAT
CGGTAACGCCTCGCGTTACGGTGGCCACGTCTGGGTCCGGGTCGGGCGGCGCGGCGAGGCGGCCGAGGTGCTGATCGATG
ACGACGGCCCCGGCATCCCTCCCGACCAGCGCGAGGAAGTGTTCAAGCCCTTCACCCGCCTGGAGACCTCGCGCAATCTG
GCCACCGGCGGCGTCGGCCTGGGCCTGACCATCGCCCGCGACATCGTGCGCACCCATGGCGGCGACCTGCTTTTAGAGGA
TTCGCCGCTGGGCGGATTGCGCGCGCGCGTTCGCCTGCCCTTGTGA

Upstream 100 bases:

>100_bases
CGACCCGAAAATGCCGCGCTATCTTCAGACAGTGCGCGGCATGGGCTATATGCTGCGACCCGACTGACCGGAAATTCCGG
CGTTTGAGAGGCCTTCTGGA

Downstream 100 bases:

>100_bases
TAGGCTTTGCCCGAGTTAAGGGGGGGGCTTTCGGCATGCGGACGGTACTGGTGGGAAATATCAAGGGCGGTTGCGGCAAG
ACGACGCTGGCCACCCATAT

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSHLGRWLKRLAPQGLLGRSLLIIIMPLVLLQLVSAYVFYGSHWESVAKRLAKGLAGDIGTIIESLRAFPGEQERSLILS
IAANKMELDTRFLPGAILPNQPRGAPSGLLERALTEALDERVQRPYRIDAESLEREVVIRVQLSDGMLEVFAPKKRLFSS
TTYVFILWMLGTAMLLFGIATLFMRNQVRSVRKLAVAADRFGKGQDVADFKPEGAQEVRQAAQAFNLMRHRVQRQMQQRT
EMLAGVSHDLRTPLTRMKLQLAIMGDMDGRAELDEDVAEMERMVEGYLAFARGEGSEQPEQVDLPALVDEVVTRFRRQGM
VIDLHHEGEIVMPLRPDSLARALGNLIGNASRYGGHVWVRVGRRGEAAEVLIDDDGPGIPPDQREEVFKPFTRLETSRNL
ATGGVGLGLTIARDIVRTHGGDLLLEDSPLGGLRARVRLPL

Sequences:

>Translated_441_residues
MSHLGRWLKRLAPQGLLGRSLLIIIMPLVLLQLVSAYVFYGSHWESVAKRLAKGLAGDIGTIIESLRAFPGEQERSLILS
IAANKMELDTRFLPGAILPNQPRGAPSGLLERALTEALDERVQRPYRIDAESLEREVVIRVQLSDGMLEVFAPKKRLFSS
TTYVFILWMLGTAMLLFGIATLFMRNQVRSVRKLAVAADRFGKGQDVADFKPEGAQEVRQAAQAFNLMRHRVQRQMQQRT
EMLAGVSHDLRTPLTRMKLQLAIMGDMDGRAELDEDVAEMERMVEGYLAFARGEGSEQPEQVDLPALVDEVVTRFRRQGM
VIDLHHEGEIVMPLRPDSLARALGNLIGNASRYGGHVWVRVGRRGEAAEVLIDDDGPGIPPDQREEVFKPFTRLETSRNL
ATGGVGLGLTIARDIVRTHGGDLLLEDSPLGGLRARVRLPL
>Mature_440_residues
SHLGRWLKRLAPQGLLGRSLLIIIMPLVLLQLVSAYVFYGSHWESVAKRLAKGLAGDIGTIIESLRAFPGEQERSLILSI
AANKMELDTRFLPGAILPNQPRGAPSGLLERALTEALDERVQRPYRIDAESLEREVVIRVQLSDGMLEVFAPKKRLFSST
TYVFILWMLGTAMLLFGIATLFMRNQVRSVRKLAVAADRFGKGQDVADFKPEGAQEVRQAAQAFNLMRHRVQRQMQQRTE
MLAGVSHDLRTPLTRMKLQLAIMGDMDGRAELDEDVAEMERMVEGYLAFARGEGSEQPEQVDLPALVDEVVTRFRRQGMV
IDLHHEGEIVMPLRPDSLARALGNLIGNASRYGGHVWVRVGRRGEAAEVLIDDDGPGIPPDQREEVFKPFTRLETSRNLA
TGGVGLGLTIARDIVRTHGGDLLLEDSPLGGLRARVRLPL

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=317, Percent_Identity=36.5930599369085, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=32.8519855595668, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1787894, Length=280, Percent_Identity=31.7857142857143, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788393, Length=267, Percent_Identity=29.2134831460674, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=26.510067114094, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=29.3617021276596, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=33.0396475770925, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=241, Percent_Identity=27.3858921161826, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=241, Percent_Identity=26.9709543568465, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789149, Length=342, Percent_Identity=25.1461988304094, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790551, Length=239, Percent_Identity=28.0334728033473, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=24.2914979757085, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788713, Length=257, Percent_Identity=22.1789883268482, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=25.531914893617, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87081816, Length=233, Percent_Identity=28.3261802575107, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49075; Mature: 48944

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLGRWLKRLAPQGLLGRSLLIIIMPLVLLQLVSAYVFYGSHWESVAKRLAKGLAGDIG
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHH
TIIESLRAFPGEQERSLILSIAANKMELDTRFLPGAILPNQPRGAPSGLLERALTEALDE
HHHHHHHCCCCCCHHHEEHHHHCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RVQRPYRIDAESLEREVVIRVQLSDGMLEVFAPKKRLFSSTTYVFILWMLGTAMLLFGIA
HHCCCCCCCHHHCCCEEEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLFMRNQVRSVRKLAVAADRFGKGQDVADFKPEGAQEVRQAAQAFNLMRHRVQRQMQQRT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EMLAGVSHDLRTPLTRMKLQLAIMGDMDGRAELDEDVAEMERMVEGYLAFARGEGSEQPE
HHHHCCCHHHHCHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QVDLPALVDEVVTRFRRQGMVIDLHHEGEIVMPLRPDSLARALGNLIGNASRYGGHVWVR
CCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCCHHCCCEEEEE
VGRRGEAAEVLIDDDGPGIPPDQREEVFKPFTRLETSRNLATGGVGLGLTIARDIVRTHG
ECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
GDLLLEDSPLGGLRARVRLPL
CCEEEECCCCCCCCCEEECCC
>Mature Secondary Structure 
SHLGRWLKRLAPQGLLGRSLLIIIMPLVLLQLVSAYVFYGSHWESVAKRLAKGLAGDIG
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHH
TIIESLRAFPGEQERSLILSIAANKMELDTRFLPGAILPNQPRGAPSGLLERALTEALDE
HHHHHHHCCCCCCHHHEEHHHHCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RVQRPYRIDAESLEREVVIRVQLSDGMLEVFAPKKRLFSSTTYVFILWMLGTAMLLFGIA
HHCCCCCCCHHHCCCEEEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLFMRNQVRSVRKLAVAADRFGKGQDVADFKPEGAQEVRQAAQAFNLMRHRVQRQMQQRT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EMLAGVSHDLRTPLTRMKLQLAIMGDMDGRAELDEDVAEMERMVEGYLAFARGEGSEQPE
HHHHCCCHHHHCHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QVDLPALVDEVVTRFRRQGMVIDLHHEGEIVMPLRPDSLARALGNLIGNASRYGGHVWVR
CCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCCHHCCCEEEEE
VGRRGEAAEVLIDDDGPGIPPDQREEVFKPFTRLETSRNLATGGVGLGLTIARDIVRTHG
ECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
GDLLLEDSPLGGLRARVRLPL
CCEEEECCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]