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The map label for this gene is hisG

Identifier: 82752257

GI number: 82752257

Start: 2710114

End: 2710728

Strand: Reverse

Name: hisG

Synonym: SAB2555c

Alternate gene names: 82752257

Gene position: 2710728-2710114 (Counterclockwise)

Preceding gene: 82752258

Following gene: 82752256

Centisome position: 98.84

GC content: 34.63

Gene sequence:

>615_bases
ATGTTAAGAATCGCCATTGCAAAAGGGCGCCTAATGGATAGTTTAATTAACTATTTAGATGCAATTGAATTTACGACATT
ATCAGAAACATTAAAAAATAGAGAACGCCAATTATTATTAAGTGTAGATAATATAGAATGCATTTTAGTAAAAGGGAGTG
ACGTGCCAATATATGTGGAACAAGGAATTGCAGATATTGGTATCGTTGGTAGCGACATTTTAGATGAGCGTCATTACAAT
GTTAATAATTTGTTGGATATGCCTTTTGGAGCATGTCATTTTGCGGTTGCAGCGAAACCTGAAACGACCAATTATCGTAA
AATCGCAACGAGTTATGTCCATACTGCCGAAGCATATTTTAAATCAAAAGGCATTGATGTCGAATTGATTAAATTGAATG
GTTCTGTTGAATTAGCTTGTGTCGTCGATATGGTAGACGGAATTGTCGACATCGTTCAAACAGGTACTACTCTAGAAGCG
AACGGACTGGTTGAAAAGCAACATATTAGTGATATCAATGCAAGATTAATCACTAATAAAGCTGCTTATTTTAAAAAATC
ACAATTAATTGAGCAATTTATTCGCTCTTTGGAGGTGTCTATAGCCAATGCTTAA

Upstream 100 bases:

>100_bases
TTGCTGAAAATGAATCTCGAGTTTTAACAGGTGGTTATTACAAAGGAAGCATCGAAGGGTTTGGATTAGGATTAACACTT
TAAGTAAGGGAGTATGCACT

Downstream 100 bases:

>100_bases
TGCACAACAATTTTTAAATCAATTTTCATTAGAAGCACCATTAGATGAGTCATTGTATCCAATTATTCGCGATATTTGTC
AGGAAGTTAAAGTTCATGGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLRIAIAKGRLMDSLINYLDAIEFTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGIADIGIVGSDILDERHYN
VNNLLDMPFGACHFAVAAKPETTNYRKIATSYVHTAEAYFKSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLEA
NGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA

Sequences:

>Translated_204_residues
MLRIAIAKGRLMDSLINYLDAIEFTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGIADIGIVGSDILDERHYN
VNNLLDMPFGACHFAVAAKPETTNYRKIATSYVHTAEAYFKSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLEA
NGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA
>Mature_204_residues
MLRIAIAKGRLMDSLINYLDAIEFTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGIADIGIVGSDILDERHYN
VNNLLDMPFGACHFAVAAKPETTNYRKIATSYVHTAEAYFKSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLEA
NGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=218, Percent_Identity=33.4862385321101, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320896, Length=196, Percent_Identity=30.6122448979592, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 22562; Mature: 22562

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAIAKGRLMDSLINYLDAIEFTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVE
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEECCCCEEEEE
QGIADIGIVGSDILDERHYNVNNLLDMPFGACHFAVAAKPETTNYRKIATSYVHTAEAYF
CCCCEECCCCHHHHHCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLEANGLVEKQHISDINARLITNK
HCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHCCCEEECCCCEEHHHHCCCHHEEEECH
AAYFKKSQLIEQFIRSLEVSIANA
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRIAIAKGRLMDSLINYLDAIEFTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVE
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEECCCCEEEEE
QGIADIGIVGSDILDERHYNVNNLLDMPFGACHFAVAAKPETTNYRKIATSYVHTAEAYF
CCCCEECCCCHHHHHCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLEANGLVEKQHISDINARLITNK
HCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHCCCEEECCCCEEHHHHCCCHHEEEECH
AAYFKKSQLIEQFIRSLEVSIANA
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA