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The map label for this gene is hisD

Identifier: 82752256

GI number: 82752256

Start: 2708871

End: 2710121

Strand: Reverse

Name: hisD

Synonym: SAB2554c

Alternate gene names: 82752256

Gene position: 2710121-2708871 (Counterclockwise)

Preceding gene: 82752257

Following gene: 82752255

Centisome position: 98.82

GC content: 35.81

Gene sequence:

>1251_bases
ATGCTTAATGCACAACAATTTTTAAATCAATTTTCATTAGAAGCACCATTAGATGAGTCATTGTATCCAATTATTCGCGA
TATTTGTCAGGAAGTTAAAGTTCATGGAGATAAGGCTTTGAAAATGTATAATCTAACATTCGATCATACGAAAACAGATC
ATTTAGAAATTAGTCATGAACAAATTAAAGCAGCATTTGACACATTAGATGAAAAAACAAAACAAGCATTACAACAAAGT
TATGAAAGAATTAAAGCATATCAAGAAAGTATTAAGCAGACGAATCAACAGTTAGAAAAATCAGTGGAGTGTTATGAAAT
ATACCATCCACTAGAAAGTGTGGGTATTTATGTGCCTGGTGGCAAAGCAAGTTATCCATCAACGGTTCTAATGACAGCGA
CTTTAGCACAAGTAGCGGGTGTAGAAAATATTGTTGTTGTGACACCACCTCAACCTAACGGAGTATCCCAAGAGGTATTA
GCTGCATGTTATATTACGCAAGTTAATCAAGTGTTTCAAGTTGGTGGTGCTCAAAGTATTGCTGCATTGACTTATGGAAC
AGAAACGATACCTAAAGTTGATAAGATTGTAGGTCCAGGTAACCAATTTGTTGCATATGCCAAAAAATATTTATTTGGAC
AGGTAGGTATTGATCAAATTGCAGGACCAACAGAAATAGCACTGATTATTGATGACACCGCAGATTTAGATGCCATCGTA
TATGATGTATTTGCGCAAGCAGAACATGATGAATTAGCACGTACATATGTCATTAGTGAAGATGCGCAAGTCCTTAAAGA
TTTAGAATCACGTATTACTAAAGCATTGCCTAATGTGGACAGATACGACATTGTTTCTAAAAGTATCGCTAATCAACACT
ACCTTATCCATGCTAGTAATTTTGATGACGCATGCCATGTCATGAATACAATCGCGCCTGAACATGCGTCGATTCAAACA
GTAAATCCTCAACCATATATTGAAAAAGTGAAATATGTGGGCGCATTGTTTATTGGACATTATTCGCCAGAGGTTATAGG
TGATTATGTCGCTGGACCTAGTCATGTATTACCTACAAATAGAACAGCTAGATTTACCAATGGGTTATCGGTCAATGATT
TCTTAACACGGAACACGGTCATCCATTTATCAAAAGATACGTTTGAACAAATTGCTGATTCAGCACAACATATTGCTCAT
GTTGAAGCATTATACAATCACCAACAGTCCATTTTAATACGTCAGTCTTAG

Upstream 100 bases:

>100_bases
AGTGATATCAATGCAAGATTAATCACTAATAAAGCTGCTTATTTTAAAAAATCACAATTAATTGAGCAATTTATTCGCTC
TTTGGAGGTGTCTATAGCCA

Downstream 100 bases:

>100_bases
GGGAGTGTAATTGAAATGATTTATATTGATAAAAACGAAAGCCCAGTTACGCCGTTGGATGAAAAAACAATGACGTCTAT
TATTAGTGCAACGCCATATA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQS
YERIKAYQESIKQTNQQLEKSVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVL
AACYITQVNQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIV
YDVFAQAEHDELARTYVISEDAQVLKDLESRITKALPNVDRYDIVSKSIANQHYLIHASNFDDACHVMNTIAPEHASIQT
VNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIAH
VEALYNHQQSILIRQS

Sequences:

>Translated_416_residues
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQS
YERIKAYQESIKQTNQQLEKSVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVL
AACYITQVNQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIV
YDVFAQAEHDELARTYVISEDAQVLKDLESRITKALPNVDRYDIVSKSIANQHYLIHASNFDDACHVMNTIAPEHASIQT
VNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIAH
VEALYNHQQSILIRQS
>Mature_416_residues
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQS
YERIKAYQESIKQTNQQLEKSVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVL
AACYITQVNQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIV
YDVFAQAEHDELARTYVISEDAQVLKDLESRITKALPNVDRYDIVSKSIANQHYLIHASNFDDACHVMNTIAPEHASIQT
VNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIAH
VEALYNHQQSILIRQS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=415, Percent_Identity=34.6987951807229, Blast_Score=265, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6319819, Length=420, Percent_Identity=33.0952380952381, Blast_Score=224, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46207; Mature: 46207

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHE
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEECCHH
QIKAAFDTLDEKTKQALQQSYERIKAYQESIKQTNQQLEKSVECYEIYHPLESVGIYVPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEECC
GKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVNQVFQVGGAQSI
CCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
AALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIV
EEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCHHHHH
YDVFAQAEHDELARTYVISEDAQVLKDLESRITKALPNVDRYDIVSKSIANQHYLIHASN
HHHHHCCCHHHHHHHHEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECC
FDDACHVMNTIAPEHASIQTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTN
CCHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCC
RTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIAHVEALYNHQQSILIRQS
CCCCCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHE
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEECCHH
QIKAAFDTLDEKTKQALQQSYERIKAYQESIKQTNQQLEKSVECYEIYHPLESVGIYVPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEECC
GKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVNQVFQVGGAQSI
CCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
AALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIV
EEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCHHHHH
YDVFAQAEHDELARTYVISEDAQVLKDLESRITKALPNVDRYDIVSKSIANQHYLIHASN
HHHHHCCCHHHHHHHHEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECC
FDDACHVMNTIAPEHASIQTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTN
CCHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCC
RTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIAHVEALYNHQQSILIRQS
CCCCCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA