Click here to switch to the map view.

The map label for this gene is hssS [H]

Identifier: 82751957

GI number: 82751957

Start: 2370355

End: 2371728

Strand: Direct

Name: hssS [H]

Synonym: SAB2241

Alternate gene names: 82751957

Gene position: 2370355-2371728 (Clockwise)

Preceding gene: 82751956

Following gene: 82751958

Centisome position: 86.43

GC content: 31.3

Gene sequence:

>1374_bases
ATGTTTAAAACACTCTATGCTAGAATTGCGATTTATTCCATTACGGTTATTTTATTTAGTGCATTAATAAGTTTTGTATT
AACAAACGTTTACTATCATTATAATTTAAAAGCATCTAATGACGCGAAAATCATGAAGACGCTTAAAGAAGCAAGACAAT
ATGAACAATCGGCTAAACCAACGCACATTCAACAATATTTCAAACATTTAGGGCAAATGAATTACCAAATAATGACCGTT
GATCAAAAAGGTCATAAGACATTTTATGGAGAGCCTTTTAGAGAAGATACTTTATCACAAAATGCTATTAACAACGTGTT
AAATAATAAAGATTATCATGGTATTAAAGATAAACCATTCGCATTATTCGTAACTGGATTTTTCGACAATGTAACAGATA
ATACTGTTGGTATTAACTTTAAGACAAAAGACGGTTCAATAGCAGTATTCATGCGTCCAGATATTGGAGAAACATTTAGC
GAGTTTAGAACATTCTTAGCCGTCTTGTTAATGTTGTTATTATTTATCTCGATTTCATTAGTTATTGCATCAACCCATTC
AATCATTCGTCCAGTAAAAAAGTTAAAGCTTGCGACCGAACGCTTAATTGATGGTGATTTTAAAACACCTATCAAACAAA
CACGCAAAGATGAAATTGGAACATTACAGTATCACTTTAATAAGATGAGAGAGTCATTGGGACAAGTTGATCAAATGAGG
CAACATTTTGTACAAAATGTATCTCATGAAATCAAAACACCATTAACACATATTCATCATTTATTAAGCGAGTTACAACA
AACTTCTGATAAAACATTACGACAACAATATATAAATGATATTTATACCATTACAACGCAGCTGAGCGGATTAACAACTG
AATTGTTGCTCTTATCCGAATTAGATAATCACCAAAGTTTATTATTCGATGATAAGATTCAAGTCGATCAACTCATTAAA
GATATCATTCGACATGAACAATTTGCTGCTGATGAAAAGTCGTTAATCATTTTAGCTGACCTAGAATCAATCAATTTCCT
AGGAAATCAACGTTTGTTACATCAAGCATTGAGTAATTTATTAATAAATGCTATTAAATATACAGATGTTGGTGGTGCCA
TTGACATCGCTTTGCAACATAGTCACAACAACATCATTTTCACAATAAGTAATGATGGTTCACCAATTAGTCCACAAGTT
GAAGCACGTTTATTTGAACGTTTTTATAAAGTGAGCAAACATGATAATAGCAATGGTTTAGGTCTTGCAATTACAAAATC
CATCATTGAATTGCATCATGGTACAATCCAATTCACACAAAGTAACGAGTATATAACCACCTTTACTATTACACTGCCAA
ATAATTCACATTAA

Upstream 100 bases:

>100_bases
GTTGACGTTCATATTAAGCGACTACGCCAAAGATTAAAAAAATTAAATGCCACACTTACAATTGAAACAGTAAGAGGTCA
AGGCTATAAGGTGGAGAATC

Downstream 100 bases:

>100_bases
TCTCTACCTCCTGAAAAACATTTCTGTTTTTATTTCAGGAGGTATCTTTTATATTGATTAACGCTTTCTAGCCACTTAAC
ATTTAATTTCTACCATTCAA

Product: two-component sensor histidine kinase sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTV
DQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFS
EFRTFLAVLLMLLLFISISLVIASTHSIIRPVKKLKLATERLIDGDFKTPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQSLLFDDKIQVDQLIK
DIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQV
EARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYITTFTITLPNNSH

Sequences:

>Translated_457_residues
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTV
DQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFS
EFRTFLAVLLMLLLFISISLVIASTHSIIRPVKKLKLATERLIDGDFKTPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQSLLFDDKIQVDQLIK
DIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQV
EARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYITTFTITLPNNSH
>Mature_457_residues
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTV
DQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFS
EFRTFLAVLLMLLLFISISLVIASTHSIIRPVKKLKLATERLIDGDFKTPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQSLLFDDKIQVDQLIK
DIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQV
EARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYITTFTITLPNNSH

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=30.6859205776173, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786783, Length=296, Percent_Identity=28.0405405405405, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790346, Length=294, Percent_Identity=25.5102040816327, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788279, Length=274, Percent_Identity=28.1021897810219, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790861, Length=295, Percent_Identity=24.7457627118644, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787894, Length=290, Percent_Identity=25.5172413793103, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=23.2142857142857, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789403, Length=358, Percent_Identity=25.9776536312849, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=25.7918552036199, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=28.8537549407115, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=24.7967479674797, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=392, Percent_Identity=21.1734693877551, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=24.3362831858407, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52352; Mature: 52352

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCC
THIQQYFKHLGQMNYQIMTVDQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPF
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCE
ALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISL
EEEEEEHHCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VIASTHSIIRPVKKLKLATERLIDGDFKTPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LDNHQSLLFDDKIQVDQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNL
CCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHH
LINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQVEARLFERFYKVSKHDNSNGL
HHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
GLAITKSIIELHHGTIQFTQSNEYITTFTITLPNNSH
CHHHHHHHHHHHCCEEEEEECCCEEEEEEEECCCCCC
>Mature Secondary Structure
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCC
THIQQYFKHLGQMNYQIMTVDQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPF
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCE
ALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISL
EEEEEEHHCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VIASTHSIIRPVKKLKLATERLIDGDFKTPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LDNHQSLLFDDKIQVDQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNL
CCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHH
LINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQVEARLFERFYKVSKHDNSNGL
HHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
GLAITKSIIELHHGTIQFTQSNEYITTFTITLPNNSH
CHHHHHHHHHHHCCEEEEEECCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA