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The map label for this gene is hysA2

Identifier: 82751799

GI number: 82751799

Start: 2230263

End: 2232692

Strand: Direct

Name: hysA2

Synonym: SAB2082

Alternate gene names: 82751799

Gene position: 2230263-2232692 (Clockwise)

Preceding gene: 82751795

Following gene: 82751801

Centisome position: 81.32

GC content: 33.37

Gene sequence:

>2430_bases
ATGACATATAGAATGAAGAAATGGCAAAAATTATCCACCATTACGTTATTAATGGCCGGTGGGATTACTTTTAATGATAG
TGAATTCAGAAGTGTTGATAAACATCAAATCGCTGTGGCTGATACGAATGTTCAAACGCCAAATTATGAGAAATTGAAGA
ATACATGGCTGGACGTTAACTATGGTTATGATAAGTATGATGAGAGCAATCCAGACATGAAGAAAAAGTTTGAGGCTACG
GAGAAAGAGGCAAGGAAATTACTTAGTGAGATGAAAACTGAAAGTGATAGGAAATACTTGTGGGAAAACTCAAAAGATTT
AGATACGAAGTCTGCGGATATGACTCGTACCTATCGTAATATTGAGAAAATCGCAGAAGCGATGAAGCATCCTAAAACCA
CTTTAAAAAATGACGAAAATAAGAAGAAAGTGAAAGATGCCCTTGAGTGGCTGCATAAAAATGCATATGGAAAAGAACCA
GGTAAAAAAGTTGCTGATCTGAAAACTAATTTCTCAAAATCAGCACCTCAAAAGAATACCAATTTAAATTGGTGGGATTA
TGAAATTGGAACACCTAGAGCACTAACAAATACCCTTATACTCTTAAAAGAAGATTTTACTGATGAAGAAAAGAAAAAAT
ACACTGCCCCTATTAAAACTTTCGCCCCAAAAAGTGATGAAATATTATCTTCTGTAGGAAAAGCTGAACCTGCTAAAGGC
GGAAATTTAGTAGACATTTCTAAAGTAAAACTTTTAGAAAGTATTATCGAAGAAGATAAAGATATGATGAAAAATTCAAT
AGATTCATTTAATAAAGTCTTCACTTACGTTCAAGATTCTGCCACTGATAAAGAACGTAATGGATTTTATAAAGATGGTT
CATATATCGACCATAAAGATGTCCCATACACTGGTGCTTATGGCGTTGTACTCTTAGAGGGGATTTCTCAAATGATGCCG
ATGATAAAAGAAACACCTTTTAATGATAAAACCCAAAATAATACAACCTTAACATCATGGATTGACGACGGATTTATGCC
ACTCATTTATAAAGGTGAAATGATGGATTTATCACGTGGTAGAGCCATTAGCCGAGAAAATGAAACGAGTCACTCAGCAT
CTGCAACTGTAATGAAATCATTGTTGAGATTAAGTGATGCCATGGATGAGTCTACAAAAGCTAAATATAAACAAATTGTC
AAAAACTCTGTTAAATCTGATTCAAGTTACGGCCAAAATGATACATTAAGCTCTTATTCAGACATAGATAAAATGAAGTC
TTTAATGACAGATAGCACTATTTCTACTAACGGTTTAACACAACAACTTAAAATATATAATGCCATGGATCGTGTCACCT
ATCACAATAAAGACTTAGACTTTGCATTTGGCTTAAGTATGACGTCGAAAAACGTCGCACGTTACGAAAATATCAACGGA
GAGAACTTAAAAGGTTGGCATACTGGTGCTGGAATGTCTTATTTATACAATAGCGATGTGAGACACTACCGTGATAACTT
CTGGGCAACAGCTGATATGAAACGATTAGCAGATACTACAACTTTAGAAAATGAAGAACCTAAAGGTACGGATGTTAAAA
AGTCTAGTAAAACTTTTGTAGGCGGAACAAAATTTGATGACCAACATGCTAGTATTGGAATGGATTTTGAAAATCAGGAC
AAAACTTTAACTGCCAAAAAATCATATTTCATATTAAACGATAAAATTGTCTTCTTAGGAACTGGCATTAAAACTACTGA
TTCATCAAAGAATCCAGTTACAACGATTGAAAATCGCAAAGCGCATGGGTATACGTTATATACAGACGATAAACAAACAA
CCAATTCCAATAATCAGGAAACCAATTCAGTCTTTTTAGAATCAACGAATAGCACTCAAAACAATATAGGCTATCATTTT
TTAAACAAATCGAAAATAACTGTAAAAAAAGAAAGTCATACTGGTAAGTGGAGTGATATAAATAAAAGCCAAAAGGATAC
ACAAAAAACTGATGAGTATTATGAAGTAACTCAAAAGCATTCTAATACAGATGATAAATATGCATATGTGTTGTATCCAG
GAATAACAAAAGATAATTTTAAATCCAAAGCAAGCCAAGTAACTGTCGTTAAACAAGATGATGACTTCCACGTTGTGAAA
GATAATGAATCGGTTTGGGCTGGTGTTAATTACAGTGATAGCACTCAAACTTTTGACATTAATGGTACTAAAGTCGAAGT
TAAAGCCAAAGGAATGTTTATTCTTAAAAAGAAAGATGATAACACTTATGAATGTAGCTTCTATAATCCCGAATCTACAA
ATTCCGCTTCAGATATTGAATCTAAAATTTCAATGACTGGATACTCTATTACAAACAAAAATACGTCGAATACTAATGAA
TCCGGCGTGCGCTTTGAATTAACTAAATAA

Upstream 100 bases:

>100_bases
TAGAAAGTCATTTGTATACGTTAACAAATTTTGAAAAATTGAATCATTATTTAATCATAATATTCATTGCGCACGCGCAA
CACAAAAAGGAGACATGTCA

Downstream 100 bases:

>100_bases
GCAAGAAAATCTCGGCACTATACCATTTTTATAGTGTCGAGATTTTATAAGTATCGCCATCATTCACCTTGTAAACCGCA
GACCACATCACCCTTGATAA

Product: hyaluronate lyase

Products: NA

Alternate protein names: Hyaluronidase; HYase [H]

Number of amino acids: Translated: 809; Mature: 808

Protein sequence:

>809_residues
MTYRMKKWQKLSTITLLMAGGITFNDSEFRSVDKHQIAVADTNVQTPNYEKLKNTWLDVNYGYDKYDESNPDMKKKFEAT
EKEARKLLSEMKTESDRKYLWENSKDLDTKSADMTRTYRNIEKIAEAMKHPKTTLKNDENKKKVKDALEWLHKNAYGKEP
GKKVADLKTNFSKSAPQKNTNLNWWDYEIGTPRALTNTLILLKEDFTDEEKKKYTAPIKTFAPKSDEILSSVGKAEPAKG
GNLVDISKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKDVPYTGAYGVVLLEGISQMMP
MIKETPFNDKTQNNTTLTSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDESTKAKYKQIV
KNSVKSDSSYGQNDTLSSYSDIDKMKSLMTDSTISTNGLTQQLKIYNAMDRVTYHNKDLDFAFGLSMTSKNVARYENING
ENLKGWHTGAGMSYLYNSDVRHYRDNFWATADMKRLADTTTLENEEPKGTDVKKSSKTFVGGTKFDDQHASIGMDFENQD
KTLTAKKSYFILNDKIVFLGTGIKTTDSSKNPVTTIENRKAHGYTLYTDDKQTTNSNNQETNSVFLESTNSTQNNIGYHF
LNKSKITVKKESHTGKWSDINKSQKDTQKTDEYYEVTQKHSNTDDKYAYVLYPGITKDNFKSKASQVTVVKQDDDFHVVK
DNESVWAGVNYSDSTQTFDINGTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIESKISMTGYSITNKNTSNTNE
SGVRFELTK

Sequences:

>Translated_809_residues
MTYRMKKWQKLSTITLLMAGGITFNDSEFRSVDKHQIAVADTNVQTPNYEKLKNTWLDVNYGYDKYDESNPDMKKKFEAT
EKEARKLLSEMKTESDRKYLWENSKDLDTKSADMTRTYRNIEKIAEAMKHPKTTLKNDENKKKVKDALEWLHKNAYGKEP
GKKVADLKTNFSKSAPQKNTNLNWWDYEIGTPRALTNTLILLKEDFTDEEKKKYTAPIKTFAPKSDEILSSVGKAEPAKG
GNLVDISKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKDVPYTGAYGVVLLEGISQMMP
MIKETPFNDKTQNNTTLTSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDESTKAKYKQIV
KNSVKSDSSYGQNDTLSSYSDIDKMKSLMTDSTISTNGLTQQLKIYNAMDRVTYHNKDLDFAFGLSMTSKNVARYENING
ENLKGWHTGAGMSYLYNSDVRHYRDNFWATADMKRLADTTTLENEEPKGTDVKKSSKTFVGGTKFDDQHASIGMDFENQD
KTLTAKKSYFILNDKIVFLGTGIKTTDSSKNPVTTIENRKAHGYTLYTDDKQTTNSNNQETNSVFLESTNSTQNNIGYHF
LNKSKITVKKESHTGKWSDINKSQKDTQKTDEYYEVTQKHSNTDDKYAYVLYPGITKDNFKSKASQVTVVKQDDDFHVVK
DNESVWAGVNYSDSTQTFDINGTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIESKISMTGYSITNKNTSNTNE
SGVRFELTK
>Mature_808_residues
TYRMKKWQKLSTITLLMAGGITFNDSEFRSVDKHQIAVADTNVQTPNYEKLKNTWLDVNYGYDKYDESNPDMKKKFEATE
KEARKLLSEMKTESDRKYLWENSKDLDTKSADMTRTYRNIEKIAEAMKHPKTTLKNDENKKKVKDALEWLHKNAYGKEPG
KKVADLKTNFSKSAPQKNTNLNWWDYEIGTPRALTNTLILLKEDFTDEEKKKYTAPIKTFAPKSDEILSSVGKAEPAKGG
NLVDISKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKDVPYTGAYGVVLLEGISQMMPM
IKETPFNDKTQNNTTLTSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDESTKAKYKQIVK
NSVKSDSSYGQNDTLSSYSDIDKMKSLMTDSTISTNGLTQQLKIYNAMDRVTYHNKDLDFAFGLSMTSKNVARYENINGE
NLKGWHTGAGMSYLYNSDVRHYRDNFWATADMKRLADTTTLENEEPKGTDVKKSSKTFVGGTKFDDQHASIGMDFENQDK
TLTAKKSYFILNDKIVFLGTGIKTTDSSKNPVTTIENRKAHGYTLYTDDKQTTNSNNQETNSVFLESTNSTQNNIGYHFL
NKSKITVKKESHTGKWSDINKSQKDTQKTDEYYEVTQKHSNTDDKYAYVLYPGITKDNFKSKASQVTVVKQDDDFHVVKD
NESVWAGVNYSDSTQTFDINGTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIESKISMTGYSITNKNTSNTNES
GVRFELTK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide lyase 8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008929
- InterPro:   IPR011013
- InterPro:   IPR014718
- InterPro:   IPR011071
- InterPro:   IPR012970
- InterPro:   IPR004103
- InterPro:   IPR003159
- InterPro:   IPR012329 [H]

Pfam domain/function: PF02278 Lyase_8; PF02884 Lyase_8_C; PF08124 Lyase_8_N [H]

EC number: =4.2.2.1 [H]

Molecular weight: Translated: 92126; Mature: 91994

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRMKKWQKLSTITLLMAGGITFNDSEFRSVDKHQIAVADTNVQTPNYEKLKNTWLDVN
CCCCHHHHHHHHHEEEEEECCCEECCHHHHCCCCCEEEEEECCCCCCCHHHHHCCEEEEE
YGYDKYDESNPDMKKKFEATEKEARKLLSEMKTESDRKYLWENSKDLDTKSADMTRTYRN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHH
IEKIAEAMKHPKTTLKNDENKKKVKDALEWLHKNAYGKEPGKKVADLKTNFSKSAPQKNT
HHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCC
NLNWWDYEIGTPRALTNTLILLKEDFTDEEKKKYTAPIKTFAPKSDEILSSVGKAEPAKG
CCCEEEEECCCCHHHHHEEEEEECCCCCHHHHHHCCCHHHCCCCHHHHHHHHCCCCCCCC
GNLVDISKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKD
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VPYTGAYGVVLLEGISQMMPMIKETPFNDKTQNNTTLTSWIDDGFMPLIYKGEMMDLSRG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEECCEEECCCC
RAISRENETSHSASATVMKSLLRLSDAMDESTKAKYKQIVKNSVKSDSSYGQNDTLSSYS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
DIDKMKSLMTDSTISTNGLTQQLKIYNAMDRVTYHNKDLDFAFGLSMTSKNVARYENING
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCEEEECCCCCCCHHHHCCCCC
ENLKGWHTGAGMSYLYNSDVRHYRDNFWATADMKRLADTTTLENEEPKGTDVKKSSKTFV
CCCCCEECCCCCHHHCCCHHHHHHHCCEECHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
GGTKFDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKTTDSSKNPVTTIENRK
CCCCCCCCCCEECCCCCCCCCEEEECCEEEEEECEEEEEECCEECCCCCCCCCEEECCCC
AHGYTLYTDDKQTTNSNNQETNSVFLESTNSTQNNIGYHFLNKSKITVKKESHTGKWSDI
CCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCCCCCCCC
NKSQKDTQKTDEYYEVTQKHSNTDDKYAYVLYPGITKDNFKSKASQVTVVKQDDDFHVVK
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHCCCCEEEEEEECCCEEEEE
DNESVWAGVNYSDSTQTFDINGTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIE
CCCCEEEECCCCCCCEEEECCCCEEEEEECCEEEEEECCCCEEEEEEECCCCCCCHHHHH
SKISMTGYSITNKNTSNTNESGVRFELTK
HHHEECCEEEECCCCCCCCCCCEEEEECC
>Mature Secondary Structure 
TYRMKKWQKLSTITLLMAGGITFNDSEFRSVDKHQIAVADTNVQTPNYEKLKNTWLDVN
CCCHHHHHHHHHEEEEEECCCEECCHHHHCCCCCEEEEEECCCCCCCHHHHHCCEEEEE
YGYDKYDESNPDMKKKFEATEKEARKLLSEMKTESDRKYLWENSKDLDTKSADMTRTYRN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHH
IEKIAEAMKHPKTTLKNDENKKKVKDALEWLHKNAYGKEPGKKVADLKTNFSKSAPQKNT
HHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCC
NLNWWDYEIGTPRALTNTLILLKEDFTDEEKKKYTAPIKTFAPKSDEILSSVGKAEPAKG
CCCEEEEECCCCHHHHHEEEEEECCCCCHHHHHHCCCHHHCCCCHHHHHHHHCCCCCCCC
GNLVDISKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKD
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VPYTGAYGVVLLEGISQMMPMIKETPFNDKTQNNTTLTSWIDDGFMPLIYKGEMMDLSRG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEECCEEECCCC
RAISRENETSHSASATVMKSLLRLSDAMDESTKAKYKQIVKNSVKSDSSYGQNDTLSSYS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
DIDKMKSLMTDSTISTNGLTQQLKIYNAMDRVTYHNKDLDFAFGLSMTSKNVARYENING
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCEEEECCCCCCCHHHHCCCCC
ENLKGWHTGAGMSYLYNSDVRHYRDNFWATADMKRLADTTTLENEEPKGTDVKKSSKTFV
CCCCCEECCCCCHHHCCCHHHHHHHCCEECHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
GGTKFDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKTTDSSKNPVTTIENRK
CCCCCCCCCCEECCCCCCCCCEEEECCEEEEEECEEEEEECCEECCCCCCCCCEEECCCC
AHGYTLYTDDKQTTNSNNQETNSVFLESTNSTQNNIGYHFLNKSKITVKKESHTGKWSDI
CCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCCCCCCCC
NKSQKDTQKTDEYYEVTQKHSNTDDKYAYVLYPGITKDNFKSKASQVTVVKQDDDFHVVK
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHCCCCEEEEEEECCCEEEEE
DNESVWAGVNYSDSTQTFDINGTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIE
CCCCEEEECCCCCCCEEEECCCCEEEEEECCEEEEEECCCCEEEEEEECCCCCCCHHHHH
SKISMTGYSITNKNTSNTNESGVRFELTK
HHHEECCEEEECCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557301 [H]