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The map label for this gene is mtlA

Identifier: 82751753

GI number: 82751753

Start: 2168491

End: 2170029

Strand: Direct

Name: mtlA

Synonym: SAB2036

Alternate gene names: 82751753

Gene position: 2168491-2170029 (Clockwise)

Preceding gene: 82751752

Following gene: 82751754

Centisome position: 79.07

GC content: 35.61

Gene sequence:

>1539_bases
ATGTCACAAACTGAAGAGAAAAAAGGAATTGGTCGTCGTGTTCAAGCATTTGGATCATTCTTAAGTAGTATGATCATGCC
AAACATTGGCGCTTTCATCGCTTGGGGTTTTATCGCGGCCATTTTTATAGATAATGGATGGTTACCTAACAAAGATTTAG
CTACTTTAGCAGGACCAATGATTACTTATTTAATCCCATTATTGATCGCATTTAGTGGTGGTCGTTTAATTTATGATTTA
CGTGGTGGTATCATCGCAGCAACAGCAACTATGGGTGTCATCGTTGCATTACCTGATACACCAATGTTACTTGGTGCAAT
GATTATGGGTCCACTTGTTGGTTGGTTAATGAAGAAGACCGACCAATTGATTCAACCTAGAACGTCGCAAGGTTTTGAAA
TGTTATTTAATAACTTTTCTGCTGGTATTTTAGGATTTATCATGACGATTGTTGGCTTTAAAGTGTTAGCTCCAGTCATG
AAATTCATCATGTACATTTTATCTGTAGCAGTTGAAAGTTTAGTACATGCGCATTTACTTCCAGTCGTAAGTATTTTAGT
AGAACCTGCTAAAATTTTATTCTTAAATAACGCAATCAACCATGGTGTATTTACACCACTAGGTACAGATCAAGTAGCTA
AAGTAGGACAATCAATTTTATACACAATTGAATCTAACCCTGGACCAGGTTTAGGTATCTTACTTGCTTATATGATTTTT
GGAAAAGGCACTGCAAAAGCGACGTCATATGGTGCTGGGATTATCCACTTCTTCGGTGGTATCCATGAAATTTATTTCCC
ATATGTATTAATGCGTCCATTACTATTTATCGCTGTTATTTTAGGTGGTATGACTGGCGTTGCAACTTATCAAGCTACTG
GATTTGGTTTTAAAACACCTGCTTCACCTGGTTCATTTATCGTTTATTGTTTAAATGCACCAAGAGGCGAATTCTTGCAC
ATGTTGCTCGGTGTATTCCTTTCTGCACTTGTATCATTCGTTGTAGCTGCTTTAATTATGAAGTTCACTAGAGAACCAAA
GCAGGATTTAGAAGCTGCGACAGCTCAAATGGAAAATACTAAAGGGAAAAAATCAAGCGTTGCTTCTAAGTTAGTATCTT
CTGATAAAAATGTTAATACAGAAGAAAATGCTAGTGGTAATGTTAGTGAAACATCTTCATCAGATGATGATCCTGAAGCG
TTATTGGATAATTACAACACTGAAGATGTTGATGCACACAATTACAATAATATAAATCATGTTATTTTTGCCTGCGATGC
GGGTATGGGTTCTAGTGCAATGGGTGCAAGCATGTTACGTAATAAATTTAAAAAAGCGGGCATTAATGATATTACAGTTA
CAAATACCGCGATTAATCAATTGCCAAAAGATGCTCAATTAGTTATCACTCAGAAAAAACTAACTGATCGTGCTATTAAA
CAAACACCAAATGCCATCCATATTTCAGTGGATAATTTCCTTAATTCACCAAGATATGAAGAACTTTTAAATAATCTAAA
AAAAGATGATCAAGCATAA

Upstream 100 bases:

>100_bases
CACATTTATTTTGACAAAGTTGATTTTTGTTTATATTGAGTAACAAGTATCGTCTCTATACACTATATATAGTCACATAT
ATTAAAAAAGAGGTGTAAAT

Downstream 100 bases:

>100_bases
TAATTAAATAAATTAAAAAATGGAGGATACCGCCATGTTATTGAGTACACGTGAAAAAGAAATGATAGCCCTATTGATTA
AGTACCACGGTCAATATATC

Product: PTS system mannitol-specific IIBC component

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDL
RGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTSQGFEMLFNNFSAGILGFIMTIVGFKVLAPVM
KFIMYILSVAVESLVHAHLLPVVSILVEPAKILFLNNAINHGVFTPLGTDQVAKVGQSILYTIESNPGPGLGILLAYMIF
GKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTPASPGSFIVYCLNAPRGEFLH
MLLGVFLSALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEA
LLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIK
QTPNAIHISVDNFLNSPRYEELLNNLKKDDQA

Sequences:

>Translated_512_residues
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDL
RGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTSQGFEMLFNNFSAGILGFIMTIVGFKVLAPVM
KFIMYILSVAVESLVHAHLLPVVSILVEPAKILFLNNAINHGVFTPLGTDQVAKVGQSILYTIESNPGPGLGILLAYMIF
GKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTPASPGSFIVYCLNAPRGEFLH
MLLGVFLSALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEA
LLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIK
QTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>Mature_511_residues
SQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLR
GGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTSQGFEMLFNNFSAGILGFIMTIVGFKVLAPVMK
FIMYILSVAVESLVHAHLLPVVSILVEPAKILFLNNAINHGVFTPLGTDQVAKVGQSILYTIESNPGPGLGILLAYMIFG
KGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTPASPGSFIVYCLNAPRGEFLHM
LLGVFLSALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEAL
LDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQ
TPNAIHISVDNFLNSPRYEELLNNLKKDDQA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=495, Percent_Identity=50.3030303030303, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1789301, Length=506, Percent_Identity=41.897233201581, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 55248; Mature: 55117

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPM
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKT
HHHHHHHHHHHCCCCEEEEECCCEEEEHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
DQLIQPRTSQGFEMLFNNFSAGILGFIMTIVGFKVLAPVMKFIMYILSVAVESLVHAHLL
HHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVVSILVEPAKILFLNNAINHGVFTPLGTDQVAKVGQSILYTIESNPGPGLGILLAYMIF
HHHHHHHCCHHHEEECCHHCCCCCCCCCCHHHHHHCHHEEEEEECCCCCCHHHHHHHHHH
GKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTP
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCCCCCC
ASPGSFIVYCLNAPRGEFLHMLLGVFLSALVSFVVAALIMKFTREPKQDLEAATAQMENT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
KGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINH
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCE
VIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIK
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCHHEEEEHHHHHHHHHH
QTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
CCCCEEEEEHHHHHCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPM
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKT
HHHHHHHHHHHCCCCEEEEECCCEEEEHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
DQLIQPRTSQGFEMLFNNFSAGILGFIMTIVGFKVLAPVMKFIMYILSVAVESLVHAHLL
HHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVVSILVEPAKILFLNNAINHGVFTPLGTDQVAKVGQSILYTIESNPGPGLGILLAYMIF
HHHHHHHCCHHHEEECCHHCCCCCCCCCCHHHHHHCHHEEEEEECCCCCCHHHHHHHHHH
GKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTP
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCCCCCC
ASPGSFIVYCLNAPRGEFLHMLLGVFLSALVSFVVAALIMKFTREPKQDLEAATAQMENT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
KGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINH
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCE
VIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIK
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCHHEEEEHHHHHHHHHH
QTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
CCCCEEEEEHHHHHCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA