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The map label for this gene is ilvA

Identifier: 82751664

GI number: 82751664

Start: 2073311

End: 2074579

Strand: Direct

Name: ilvA

Synonym: SAB1946

Alternate gene names: 82751664

Gene position: 2073311-2074579 (Clockwise)

Preceding gene: 82751663

Following gene: 82751681

Centisome position: 75.6

GC content: 32.07

Gene sequence:

>1269_bases
ATGACAGTCAAAACAACAGTTTCTACGAAAGATATCGATGAAGCATTTTTAAGACTTAAAGATATTGTCAAAGAAACACC
TTTACAATTAGACCATTACTTATCTCAAAAGTATGATTGTAAAGTTTATTTAAAACGAGAAGATTTACAATGGGTACGTT
CTTTTAAATTAAGAGGTGCTTACAACGCTATTTCTGTTTTATCAGATGAAGCTAAAAGTAAAGGTATTACATGTGCGAGT
GCAGGTAATCATGCTCAAGGTGTTGTCTATACAGCTAAAAAACTTAATTTAAACGCTGTTATCTTTATGCCAGTCACTAC
ACCTTTACAAAAGGTAAATCAAGTAAAGTTCTTTGGAAATAGTAACGTTGAAGTTGTACTCACTGGTGATACATTTGATC
ACTGTTTAGCTGAAGCTTTAACTTATACAAGTGAACATCAAATGAACTTTATAGACCCATTCAATAATGTTCATACAATT
TCTGGACAAGGTACGCTTGCTAAAGAAATGCTAGAACAATCAAAGTCTGACAATGTTAACTTTGATTATCTATTTGCCGC
AATTGGTGGTGGTGGTTTAATTTCAGGTATCAGTACCTATTTTAAATCCTATTCTCCCAACACAAAAATTATCGGAGTTG
AACCTTCAGGTGCTAGTAGTATGTATGAATCTGTTGTCGTAAACAATCAGGTTATCACATTACCTAATATCGATAAATTT
GTCGATGGAGCTTCTGTAGCCAGAGTTGGCGATATTACTTTTGAAATTGCCAAAAAAAATGTAGATAACTACGTACAAGT
AGATGAAGGTGCTGTATGTTCAACAATTTTGGATATGTATTCAAAACAAGCAATAGTAGCAGAACCCGCTGGCGCTTTAA
GTGTAAGTGCGCTTGAAAACTATAAAGATCATATTAAAGGTAAAACAGTGGTTTGTGTCATTAGTGGTGGTAATAATGAT
ATTAATCGAATGAAAGAAATTGAAGAACGTTCATTACTATACGAAGAAATGAAGCATTACTTTATCTTAAATTTCCCTCA
ACGTCCAGGTGCATTGAGAGAATTTGTAAATGACGTGTTAGGACCTCAAGACGATATTACTAAATTTGAATACTTAAAAA
AATCTTCTCAAAATACAGGTACTGTCATTATTGGTATTCAACTTAAAGATCATGATGATTTAATACAACTCAAACAACGT
GTAAATCATTTCGATCCTTCCAATATTTATATTAATGAAAATAAGATGTTACATTCATTGTTAATTTAA

Upstream 100 bases:

>100_bases
AGAATAAACTTGTAAATGGCTTAGATGACATTGCAATCACCCTACAATATGAATCATTAATAGAAAAATATGAAAAATCA
CTTTAAGGGAGTTGAATATT

Downstream 100 bases:

>100_bases
TATATATTAAGAAAAGCTGTCATAAATTGATTTCTAATTGAAATCATCTTATGACTGCTTTTTATTATGCTTTACATTAT
TTAGGTTGCACGCTTTGTAT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGAYNAISVLSDEAKSKGITCAS
AGNHAQGVVYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGNSNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTI
SGQGTLAKEMLEQSKSDNVNFDYLFAAIGGGGLISGISTYFKSYSPNTKIIGVEPSGASSMYESVVVNNQVITLPNIDKF
VDGASVARVGDITFEIAKKNVDNYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALENYKDHIKGKTVVCVISGGNND
INRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVLGPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQR
VNHFDPSNIYINENKMLHSLLI

Sequences:

>Translated_422_residues
MTVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGAYNAISVLSDEAKSKGITCAS
AGNHAQGVVYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGNSNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTI
SGQGTLAKEMLEQSKSDNVNFDYLFAAIGGGGLISGISTYFKSYSPNTKIIGVEPSGASSMYESVVVNNQVITLPNIDKF
VDGASVARVGDITFEIAKKNVDNYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALENYKDHIKGKTVVCVISGGNND
INRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVLGPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQR
VNHFDPSNIYINENKMLHSLLI
>Mature_421_residues
TVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGAYNAISVLSDEAKSKGITCASA
GNHAQGVVYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGNSNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTIS
GQGTLAKEMLEQSKSDNVNFDYLFAAIGGGGLISGISTYFKSYSPNTKIIGVEPSGASSMYESVVVNNQVITLPNIDKFV
DGASVARVGDITFEIAKKNVDNYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALENYKDHIKGKTVVCVISGGNNDI
NRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVLGPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQRV
NHFDPSNIYINENKMLHSLLI

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=331, Percent_Identity=29.3051359516616, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1790207, Length=365, Percent_Identity=34.2465753424658, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1789505, Length=329, Percent_Identity=34.3465045592705, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789235, Length=271, Percent_Identity=23.6162361623616, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=350, Percent_Identity=31.7142857142857, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=411, Percent_Identity=28.7104622871046, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17508781, Length=322, Percent_Identity=26.7080745341615, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320930, Length=375, Percent_Identity=38.1333333333333, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=33.5463258785943, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319788, Length=332, Percent_Identity=25, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21355833, Length=350, Percent_Identity=31.7142857142857, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24645328, Length=254, Percent_Identity=29.9212598425197, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 46967; Mature: 46836

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGA
CEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCC
YNAISVLSDEAKSKGITCASAGNHAQGVVYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGN
HHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEECCCEEEEEEECCCHHHHCCEEEEECC
SNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTISGQGTLAKEMLEQSKSDNVN
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCC
FDYLFAAIGGGGLISGISTYFKSYSPNTKIIGVEPSGASSMYESVVVNNQVITLPNIDKF
EEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCEEEECCCHHHH
VDGASVARVGDITFEIAKKNVDNYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALEN
HCCCCCEEECCEEEEEECCCCCCEEEECCCHHHHHHHHHHCCCEEEECCCCCEEHHHHHH
YKDHIKGKTVVCVISGGNNDINRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVL
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHC
GPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQRVNHFDPSNIYINENKMLHSL
CCCCHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCEEECCCHHHHHH
LI
CC
>Mature Secondary Structure 
TVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGA
EEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCC
YNAISVLSDEAKSKGITCASAGNHAQGVVYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGN
HHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEECCCEEEEEEECCCHHHHCCEEEEECC
SNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTISGQGTLAKEMLEQSKSDNVN
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCC
FDYLFAAIGGGGLISGISTYFKSYSPNTKIIGVEPSGASSMYESVVVNNQVITLPNIDKF
EEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCEEEECCCHHHH
VDGASVARVGDITFEIAKKNVDNYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALEN
HCCCCCEEECCEEEEEECCCCCCEEEECCCHHHHHHHHHHCCCEEEECCCCCEEHHHHHH
YKDHIKGKTVVCVISGGNNDINRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVL
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHC
GPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQRVNHFDPSNIYINENKMLHSL
CCCCHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCEEECCCHHHHHH
LI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA