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The map label for this gene is isdA

Identifier: 82750736

GI number: 82750736

Start: 1073523

End: 1075412

Strand: Reverse

Name: isdA

Synonym: SAB0993c

Alternate gene names: 82750736

Gene position: 1075412-1073523 (Counterclockwise)

Preceding gene: 82750737

Following gene: 82750733

Centisome position: 39.21

GC content: 32.75

Gene sequence:

>1890_bases
ATGAACAAACAGCAAAAAGAATTTAAATCATTTTATTCAATTAGAAAGTCATCACTAGGCGTTGCATCTGTAGCGATTAG
TACACTTTTATTATTAATGTCAAATGGCGAAGCACAAGCAGCTGAGGAAACAGGTGGTACAAATACAGAAGCACAACCAA
AAACTGAAGCAGTTGCAAGTCCATCAACAACAACTGAAAAAGCTCCAGAAGCTAAATCAGTAGCCAATGCTGTCTCAGTA
TCTAATAAAGAAGTTGAGGCCCCTACTTCTGAAACAAAAGAAGTTAAACCAGCAGCAAAATCCGATAACAATACATATCC
TATTTTGAATCAGGAACTAAGAGAAGCGATTAAAAACCCTGCAATAAAAGATAAAGATCATAGCGCACCAAACTCTCGTC
CAATTGATTTTGAAATGAAAAAAGAAAACGGGGAGCAACAATTTTATCATTATGCAAGCTCTGTTAAACCAGCTAGAGTT
ATTTTCACTGATTCAAAACCAGAAATAGAATTAGGTTTACAATCAGGGCAATTTTGGAGAAAATTTGAAGTTTATGAAGG
TGACAAAAAGTTGCCAATTAAATTAGTATCATACGATACTGTTAAAGATTATGCTTACATTCGCTTCTCTGTTTCAAATG
GAACAAAAGCCGTTAAAATTGTAAGTTCAACTCACTTCAATAACAAAGAAGAAAAATACGATTACACATTAATGGAATTC
GCACAACCAATTTATAACAGTGCAGATAAATTCAAAACTGAAGAAGATTATAAAGCTGAAAAATTATTAGCGCCATATAA
AAAAGCGAAAACACTAGAAAGACAAGTTTATGAATTAAATAAAATTCAAGATAAACTTCCTGAAAAATTGAAAGCTGAAT
ACAAGAAGAAATTAGAAGAGACGAAAAAAGCTTTAGATGAACAAGTGAAATCTGCGATAACTGAATTCCAAAATGTACAA
CCAACAAATGAAAAAATGACTGATTTACAAGATACAAAATATGTTGTTTATGAAAGTGTTGAGAATAACGAATCTATGAT
GGATACTTTTGTTAAACACCCTATTAAAACAGGTATGCTTAACGGCAAAAAATATATGGTAATGGAAACTACTAATGACG
ATTACTGGAAAGATTTCATGGTTGAAGGTCAACGTGTTAGAACAATTAGCAAAGATGCTAAAAATAACACTAGAACGATT
ATTTTCCCATATGTTGAAGGTAAAACTCTATATGATGCTATCGTTAAAGTTCATGTAAAAACTATTGATTATGATGGACA
ATACCATGTCAGAATCGTTGATAAAGAAGCATTTACTAAAGCCAATGCCGATAAAACTAATAAAAAGGAACAACAAGATA
ACTCAGCTAAGAAGGAAACTACTCCAGCTACGCCTAGCAAACCAACAACACCACCTGTTGAAAAAGAATCACAAAAACAA
GACAGCCAAAAAGATGACAATAAACAATCACCAAGTGTTGAAAAAGAAAATGACGCATCTAGTGAGTCAGGTAAAGACAA
AACGCCTGCTACAAAACCAGCTAAAGGTGAAGTAGAATCAAGTAGTACAACTCCAACTAAGGTAGTATCTACGACTCAAA
ATGCTGCAAAACCAACAACTGCTTCATCAGAAACAACAAAAGATGTTGTTCAAACTTCAGCAGGTTCTAGCGAAGCAAAA
GATAGTGCTCCATTACAAAAAGCAAACATTAAAAACACAAATGATGGACACACTCAAAGCGAAAACAATAAAAATACACA
AGAAAATAAAGCAAAATCATTACCACAAACTGGTGAAGAATCAAATAAAGATATGACATTACCATTAATGTCATTATTAG
CTTTAAGTAGCATCATTGCATTCGTATTACCTAGAAAACGTAAAAACTAA

Upstream 100 bases:

>100_bases
AATAACGTTGCAATTAACTACCATTTCAATGTACAATACAAGTAATCAATTGATAATGATTATCAGTTGATAATATACAA
TTAGGAGTTGTTTCTACAAC

Downstream 100 bases:

>100_bases
TTAATCGTCTTTATATTTAATTATTAAATTAACAAATTTTAATTGGTGGATGAGGTAGCCTGTTACTTCGTTCGCCAATT
ATTTTTTGCAATATAAAAAG

Product: iron-regulated cell wall-anchored protein

Products: NA

Alternate protein names: Fur-regulated protein B; Staphylococcal iron-regulated protein H; Staphylococcus aureus surface protein J

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAEETGGTNTEAQPKTEAVASPSTTTEKAPEAKSVANAVSV
SNKEVEAPTSETKEVKPAAKSDNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKENGEQQFYHYASSVKPARV
IFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEF
AQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEETKKALDEQVKSAITEFQNVQ
PTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTI
IFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANADKTNKKEQQDNSAKKETTPATPSKPTTPPVEKESQKQ
DSQKDDNKQSPSVEKENDASSESGKDKTPATKPAKGEVESSSTTPTKVVSTTQNAAKPTTASSETTKDVVQTSAGSSEAK
DSAPLQKANIKNTNDGHTQSENNKNTQENKAKSLPQTGEESNKDMTLPLMSLLALSSIIAFVLPRKRKN

Sequences:

>Translated_629_residues
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAEETGGTNTEAQPKTEAVASPSTTTEKAPEAKSVANAVSV
SNKEVEAPTSETKEVKPAAKSDNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKENGEQQFYHYASSVKPARV
IFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEF
AQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEETKKALDEQVKSAITEFQNVQ
PTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTI
IFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANADKTNKKEQQDNSAKKETTPATPSKPTTPPVEKESQKQ
DSQKDDNKQSPSVEKENDASSESGKDKTPATKPAKGEVESSSTTPTKVVSTTQNAAKPTTASSETTKDVVQTSAGSSEAK
DSAPLQKANIKNTNDGHTQSENNKNTQENKAKSLPQTGEESNKDMTLPLMSLLALSSIIAFVLPRKRKN
>Mature_629_residues
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAEETGGTNTEAQPKTEAVASPSTTTEKAPEAKSVANAVSV
SNKEVEAPTSETKEVKPAAKSDNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKENGEQQFYHYASSVKPARV
IFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEF
AQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEETKKALDEQVKSAITEFQNVQ
PTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTI
IFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANADKTNKKEQQDNSAKKETTPATPSKPTTPPVEKESQKQ
DSQKDDNKQSPSVEKENDASSESGKDKTPATKPAKGEVESSSTTPTKVVSTTQNAAKPTTASSETTKDVVQTSAGSSEAK
DSAPLQKANIKNTNDGHTQSENNKNTQENKAKSLPQTGEESNKDMTLPLMSLLALSSIIAFVLPRKRKN

Specific function: Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also requ

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 NEAT domains

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISDB_STAAB (Q2YX96)

Other databases:

- EMBL:   AJ938182
- RefSeq:   YP_416477.1
- ProteinModelPortal:   Q2YX96
- STRING:   Q2YX96
- EnsemblBacteria:   EBSTAT00000012221
- GeneID:   3795267
- GenomeReviews:   AJ938182_GR
- KEGG:   sab:SAB0993c
- NMPDR:   fig|273036.3.peg.1226
- GeneTree:   EBGT00050000023708
- HOGENOM:   HBG215818
- OMA:   ANADKTN
- ProtClustDB:   CLSK885152
- BioCyc:   SAUR273036:SAB0993C-MONOMER
- GO:   GO:0016020
- GO:   GO:0009405
- InterPro:   IPR005877
- InterPro:   IPR019948
- InterPro:   IPR019929
- InterPro:   IPR019931
- InterPro:   IPR006635
- InterPro:   IPR001899
- SMART:   SM00725
- TIGRFAMs:   TIGR03657
- TIGRFAMs:   TIGR01167
- TIGRFAMs:   TIGR01168

Pfam domain/function: PF00746 Gram_pos_anchor; PF05031 NEAT; PF04650 YSIRK_signal

EC number: NA

Molecular weight: Translated: 70433; Mature: 70433

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS50847 GRAM_POS_ANCHORING; PS50978 NEAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAEETGGTNTEAQPKTEAVAS
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHCCC
PSTTTEKAPEAKSVANAVSVSNKEVEAPTSETKEVKPAAKSDNNTYPILNQELREAIKNP
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHCC
AIKDKDHSAPNSRPIDFEMKKENGEQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWR
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCEE
KFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEF
EEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHH
AQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEE
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGML
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHHCCC
NGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVK
CCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHEEEEE
TIDYDGQYHVRIVDKEAFTKANADKTNKKEQQDNSAKKETTPATPSKPTTPPVEKESQKQ
EEECCCEEEEEEECHHHHHHCCCCCCCCHHHHHCCHHCCCCCCCCCCCCCCCCCCHHHHH
DSQKDDNKQSPSVEKENDASSESGKDKTPATKPAKGEVESSSTTPTKVVSTTQNAAKPTT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEECCCCCCCCCC
ASSETTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSENNKNTQENKAKSLPQTGEE
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCC
SNKDMTLPLMSLLALSSIIAFVLPRKRKN
CCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAEETGGTNTEAQPKTEAVAS
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHCCC
PSTTTEKAPEAKSVANAVSVSNKEVEAPTSETKEVKPAAKSDNNTYPILNQELREAIKNP
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHCC
AIKDKDHSAPNSRPIDFEMKKENGEQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWR
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCEE
KFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEF
EEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHH
AQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEE
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGML
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHHCCC
NGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVK
CCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHEEEEE
TIDYDGQYHVRIVDKEAFTKANADKTNKKEQQDNSAKKETTPATPSKPTTPPVEKESQKQ
EEECCCEEEEEEECHHHHHHCCCCCCCCHHHHHCCHHCCCCCCCCCCCCCCCCCCHHHHH
DSQKDDNKQSPSVEKENDASSESGKDKTPATKPAKGEVESSSTTPTKVVSTTQNAAKPTT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEECCCCCCCCCC
ASSETTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSENNKNTQENKAKSLPQTGEE
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCC
SNKDMTLPLMSLLALSSIIAFVLPRKRKN
CCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA