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The map label for this gene is tpiA

Identifier: 82750482

GI number: 82750482

Start: 803059

End: 803820

Strand: Direct

Name: tpiA

Synonym: SAB0730

Alternate gene names: 82750482

Gene position: 803059-803820 (Clockwise)

Preceding gene: 82750481

Following gene: 82750483

Centisome position: 29.28

GC content: 37.01

Gene sequence:

>762_bases
ATGAGAACACCAATTATAGCTGGTAACTGGAAAATGAACAAAACAGTACAAGAAGCAAAAGACTTCGTCAATGCATTGCC
AACATTACCAGATTCAAAAGAAGTAGAATCAGTAATTTGTGGACCAGCAATTCAATTAGATGCATTAACTACTGCAGTTA
AAGAAGGAAAAGCACAAGGTTTAGAAATCGGTGCTCAAAATACGTATTTCGAAGATAATGGTGCGTTCACAGGTGAAACG
TCTCCAGTTGCGTTAGCAGATTTAGGCGTTAAATACGTTGTTATCGGTCATTCTGAACGTCGTGAATTATTCCACGAAAC
AGATGAAGAAATTAACAAAAAAGCGCACGCTATTTTCAAACATGGTATGACACCAATTATTTGTGTTGGTGAAACAGATG
AAGAGCGTGAAAGTGGTAAAGCTAACGATGTTGTAGGTGAGCAAGTTAAGAAAGCTGTTGCAGGTTTATCTGAAGAGCAA
CTTAAATCAGTTGTAATTGCTTATGAACCAATCTGGGCAATCGGAACTGGTAAATCATCAACATCTGAAGATGCGAATGA
AATGTGTACATTTGTACGTCAAACTATTGCTGACTTATCAAGCAAAGAAGTATCAGAAGCAACTCGTATTCAATATGGTG
GTAGTGTTAAACCTAACAACATTAAAGAATACATGGCACAAACTGATATTGATGGGGCATTAGTAGGTGGCGCATCACTT
AAAGTTGAAGATTTCGTACAATTGTTAGAAGGTGCAAAATAA

Upstream 100 bases:

>100_bases
TGTGGCATGTTTGTTTAACATTGTTACGGGAAAACAGTCACAAGATGACATCGTGTTTCATCACTTTTTAAAAATATTTA
CAAAACAAGGAGTGTCTTTA

Downstream 100 bases:

>100_bases
TCATGGCTAAGAAACCAACTGCGTTAATTATTTTAGATGGTTTTGCGAACCGCGAAAGCGAACATGGTAATGCGGTAAAA
TTAGCAAACAAGCCTAATTT

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICGPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGET
SPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEEQ
LKSVVIAYEPIWAIGTGKSSTSEDANEMCTFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL
KVEDFVQLLEGAK

Sequences:

>Translated_253_residues
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICGPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGET
SPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEEQ
LKSVVIAYEPIWAIGTGKSSTSEDANEMCTFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL
KVEDFVQLLEGAK
>Mature_253_residues
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICGPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGET
SPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEEQ
LKSVVIAYEPIWAIGTGKSSTSEDANEMCTFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL
KVEDFVQLLEGAK

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=248, Percent_Identity=41.1290322580645, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI4507645, Length=248, Percent_Identity=41.1290322580645, Blast_Score=171, Evalue=7e-43,
Organism=Escherichia coli, GI1790353, Length=259, Percent_Identity=41.3127413127413, Blast_Score=198, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17536593, Length=249, Percent_Identity=42.1686746987952, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6320255, Length=248, Percent_Identity=41.5322580645161, Blast_Score=185, Evalue=5e-48,
Organism=Drosophila melanogaster, GI28572008, Length=248, Percent_Identity=44.3548387096774, Blast_Score=193, Evalue=8e-50,
Organism=Drosophila melanogaster, GI28572006, Length=248, Percent_Identity=44.3548387096774, Blast_Score=193, Evalue=8e-50,
Organism=Drosophila melanogaster, GI28572004, Length=248, Percent_Identity=44.3548387096774, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27292; Mature: 27292

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICGPAIQLDALTTAVKEGKAQG
CCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCC
LEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFK
EEECCCCCEECCCCCCCCCCCCEEHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
HGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEEQLKSVVIAYEPIWAIGTGKSS
CCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEECCEEEEECCCCC
TSEDANEMCTFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEECCCCC
KVEDFVQLLEGAK
CHHHHHHHHHCCC
>Mature Secondary Structure
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICGPAIQLDALTTAVKEGKAQG
CCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCC
LEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFK
EEECCCCCEECCCCCCCCCCCCEEHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
HGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEEQLKSVVIAYEPIWAIGTGKSS
CCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEECCEEEEECCCCC
TSEDANEMCTFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEECCCCC
KVEDFVQLLEGAK
CHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA