Click here to switch to the map view.

The map label for this gene is hemC [H]

Identifier: 82703803

GI number: 82703803

Start: 3090157

End: 3091122

Strand: Reverse

Name: hemC [H]

Synonym: Nmul_A2690

Alternate gene names: 82703803

Gene position: 3091122-3090157 (Counterclockwise)

Preceding gene: 82703806

Following gene: 82703802

Centisome position: 97.08

GC content: 57.35

Gene sequence:

>966_bases
ATGCCTAATTCATCCACTCCCAATAAAATAGTTATCGCGACACGGGAAAGCGCCCTTGCCCTGTGGCAGGCCAATTTCAT
CCGGGATCGACTGGCAGAATTATACCCGCAAATGGAGTTTCAAATATCCGGAATGACGACCCGGGGTGATCAGATTCTTG
ATGTGACGCTATCCAAAATCGGCGGAAAAGGTTTGTTCATCAAAGAACTGGAACAGGCGCTGGAGGACGGGCGGGCTGAC
ATCGCCGTGCATTCGATGAAGGATGTGCCGATGGATATGCCGGCCGGATTCGCGCTGGCAGCGATTACGGAGCGTGAAGA
TCCGCGGGATGCGTTTGTCTCCAACAAGTATGCGAGGCTGGATGCGCTTCCGCCGGGGAGCGTAGTGGGCACTTCCAGTC
TTCGCCGTGAAAGCCAGTTGCGCGCGCGCTTTCCCCATTTGCAGGTGCAGCCGTTGCGGGGCAACGTCCAGACGCGTTTG
CGCAAGCTGGATGAGGGTCAATTCGCAGCGATCATTCTGGCGGCAGCGGGATTGAAACGGCTGGGGCTTGCGGAGCGCAT
AACCGCCCTGCTAAGTCCCGATCTCAGTCTGCCCGCAGTAGGGCAAGGCGCTTTGGGTATTGAGTGTCGTGCAGATCGCT
CGGATTTGATCAAGCTCATGGAACCGCTGCATCATATTCCCACTGCACGCTGCGTCGAAGCCGAGCGCGCCATGAGTCGC
GCCCTGGGTGGCAGTTGCGAAGTGCCCTTGGGAGGCTTTGCTGAAATCGACGGACATGTGCTTAGGTTGCGCGGATTTGT
CGCCAGCCAGGATGGAATACGCATGGTAAGCGATGAGCTGAACGGGAGCCCTGATGATTGCGCTTCGATAGGAGCGCAGC
TGGCAAAGAACCTGAAGGCAAAGGGTGCGGAAGAGATTCTGGTAGCGCTGGAATCGAAAGCGGTTGACCCCGTGAGCCAT
CCGTGA

Upstream 100 bases:

>100_bases
AGTTTGGCACTTCAGTTTGCTACTTCAGTCCGGCTTTGGCATCCTCCATGGTAAAATAAGCACTGGCAGGATTTCCAAAC
TTTTGTTTATTTTAATAGGA

Downstream 100 bases:

>100_bases
GCAAGCCGCTGACCGGGATCCATATCCTGGTCACGCGTCCTTCCCATCAGGCGGGGGGGCTCGCTGGGAAAATACGAGCA
GCAGGCGGAGAACCCTGCCT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MPNSSTPNKIVIATRESALALWQANFIRDRLAELYPQMEFQISGMTTRGDQILDVTLSKIGGKGLFIKELEQALEDGRAD
IAVHSMKDVPMDMPAGFALAAITEREDPRDAFVSNKYARLDALPPGSVVGTSSLRRESQLRARFPHLQVQPLRGNVQTRL
RKLDEGQFAAIILAAAGLKRLGLAERITALLSPDLSLPAVGQGALGIECRADRSDLIKLMEPLHHIPTARCVEAERAMSR
ALGGSCEVPLGGFAEIDGHVLRLRGFVASQDGIRMVSDELNGSPDDCASIGAQLAKNLKAKGAEEILVALESKAVDPVSH
P

Sequences:

>Translated_321_residues
MPNSSTPNKIVIATRESALALWQANFIRDRLAELYPQMEFQISGMTTRGDQILDVTLSKIGGKGLFIKELEQALEDGRAD
IAVHSMKDVPMDMPAGFALAAITEREDPRDAFVSNKYARLDALPPGSVVGTSSLRRESQLRARFPHLQVQPLRGNVQTRL
RKLDEGQFAAIILAAAGLKRLGLAERITALLSPDLSLPAVGQGALGIECRADRSDLIKLMEPLHHIPTARCVEAERAMSR
ALGGSCEVPLGGFAEIDGHVLRLRGFVASQDGIRMVSDELNGSPDDCASIGAQLAKNLKAKGAEEILVALESKAVDPVSH
P
>Mature_320_residues
PNSSTPNKIVIATRESALALWQANFIRDRLAELYPQMEFQISGMTTRGDQILDVTLSKIGGKGLFIKELEQALEDGRADI
AVHSMKDVPMDMPAGFALAAITEREDPRDAFVSNKYARLDALPPGSVVGTSSLRRESQLRARFPHLQVQPLRGNVQTRLR
KLDEGQFAAIILAAAGLKRLGLAERITALLSPDLSLPAVGQGALGIECRADRSDLIKLMEPLHHIPTARCVEAERAMSRA
LGGSCEVPLGGFAEIDGHVLRLRGFVASQDGIRMVSDELNGSPDDCASIGAQLAKNLKAKGAEEILVALESKAVDPVSHP

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=339, Percent_Identity=43.6578171091445, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI66933009, Length=332, Percent_Identity=43.9759036144578, Blast_Score=235, Evalue=3e-62,
Organism=Escherichia coli, GI48994974, Length=301, Percent_Identity=57.4750830564784, Blast_Score=327, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=39.5569620253165, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20130425, Length=326, Percent_Identity=40.4907975460123, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34598; Mature: 34467

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNSSTPNKIVIATRESALALWQANFIRDRLAELYPQMEFQISGMTTRGDQILDVTLSKI
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
GGKGLFIKELEQALEDGRADIAVHSMKDVPMDMPAGFALAAITEREDPRDAFVSNKYARL
CCCCEEHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCEEEEEECCCCCCHHHHHCCCHHEE
DALPPGSVVGTSSLRRESQLRARFPHLQVQPLRGNVQTRLRKLDEGQFAAIILAAAGLKR
CCCCCCCEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHH
LGLAERITALLSPDLSLPAVGQGALGIECRADRSDLIKLMEPLHHIPTARCVEAERAMSR
HHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ALGGSCEVPLGGFAEIDGHVLRLRGFVASQDGIRMVSDELNGSPDDCASIGAQLAKNLKA
HCCCCCCCCCCCCHHCCCEEEEEEHHHCCCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHH
KGAEEILVALESKAVDPVSHP
CCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PNSSTPNKIVIATRESALALWQANFIRDRLAELYPQMEFQISGMTTRGDQILDVTLSKI
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
GGKGLFIKELEQALEDGRADIAVHSMKDVPMDMPAGFALAAITEREDPRDAFVSNKYARL
CCCCEEHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCEEEEEECCCCCCHHHHHCCCHHEE
DALPPGSVVGTSSLRRESQLRARFPHLQVQPLRGNVQTRLRKLDEGQFAAIILAAAGLKR
CCCCCCCEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHH
LGLAERITALLSPDLSLPAVGQGALGIECRADRSDLIKLMEPLHHIPTARCVEAERAMSR
HHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ALGGSCEVPLGGFAEIDGHVLRLRGFVASQDGIRMVSDELNGSPDDCASIGAQLAKNLKA
HCCCCCCCCCCCCHHCCCEEEEEEHHHCCCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHH
KGAEEILVALESKAVDPVSHP
CCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]