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The map label for this gene is hemD [H]

Identifier: 82703802

GI number: 82703802

Start: 3089378

End: 3090160

Strand: Reverse

Name: hemD [H]

Synonym: Nmul_A2689

Alternate gene names: 82703802

Gene position: 3090160-3089378 (Counterclockwise)

Preceding gene: 82703803

Following gene: 82703801

Centisome position: 97.05

GC content: 57.73

Gene sequence:

>783_bases
GTGAGCAAGCCGCTGACCGGGATCCATATCCTGGTCACGCGTCCTTCCCATCAGGCGGGGGGGCTCGCTGGGAAAATACG
AGCAGCAGGCGGAGAACCCTGCCTGTTTCCGGTCCTGGAGATTCAGGATATCTCTGACCCACGCCCATTGCTCGAATTGA
TCGAGCGCCTGGATGAATTCTATCTGGCGATTTTTGTCAGCCCCAACGCCGTCAATAAGGCGATGAGCGTCATATGCGCG
AAACGCGCATTGCCGTCCGATCTCAAAATTGCGACAGTCGGTCAGGGCACTGCCAGAACGCTGCGACGATTCGGCGTGAG
CGGAGTAATCGTGCCTGCGGTGCGGTTCGACAGCGAGGCCTTGCTCGATATGGCAGAATTGGATCGCATCAATGTAGCGG
GCAAGCGAATCATCATTTTTCGGGGCGACAACGGACGCGAACTGCTGGGGGAAACCCTGAGGAAACGCGGCGCTTCTGTC
GAATACGCGGAGTGTTACCGCCGGATACGGCCGGAAGCGGAAATTGGACCGCTTCTCGCAGCCTGGACGCGGGGTGAGAT
GAACGGGGTTACCGTCACCAGCAGTGAAGGTTTGCGCAATTTATGGGAGATGGTGGGCGACTCAGGCAGAACATGGCTTG
AAAATACGCCCTTGTTCGTTTCCCATGAGCGCATCGCGGGGGTGGCACGGAAATTGGGATTTAACCGCGTGATTGTTACC
GCTGCCGGGGACGATGGGCTGGTAGCGGGTTTGCAGGATTATTTTTCCGGCCACATGGGTTGA

Upstream 100 bases:

>100_bases
CTTCGATAGGAGCGCAGCTGGCAAAGAACCTGAAGGCAAAGGGTGCGGAAGAGATTCTGGTAGCGCTGGAATCGAAAGCG
GTTGACCCCGTGAGCCATCC

Downstream 100 bases:

>100_bases
AAGGTGACGGCAAAGGTAACAGCGGCGAAGGGCGCCAACACAATTTTGCTCCTACGCAATCATGGGCATGGAAACTCAGT
CTGCTGATATTGATCAACCG

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSKPLTGIHILVTRPSHQAGGLAGKIRAAGGEPCLFPVLEIQDISDPRPLLELIERLDEFYLAIFVSPNAVNKAMSVICA
KRALPSDLKIATVGQGTARTLRRFGVSGVIVPAVRFDSEALLDMAELDRINVAGKRIIIFRGDNGRELLGETLRKRGASV
EYAECYRRIRPEAEIGPLLAAWTRGEMNGVTVTSSEGLRNLWEMVGDSGRTWLENTPLFVSHERIAGVARKLGFNRVIVT
AAGDDGLVAGLQDYFSGHMG

Sequences:

>Translated_260_residues
MSKPLTGIHILVTRPSHQAGGLAGKIRAAGGEPCLFPVLEIQDISDPRPLLELIERLDEFYLAIFVSPNAVNKAMSVICA
KRALPSDLKIATVGQGTARTLRRFGVSGVIVPAVRFDSEALLDMAELDRINVAGKRIIIFRGDNGRELLGETLRKRGASV
EYAECYRRIRPEAEIGPLLAAWTRGEMNGVTVTSSEGLRNLWEMVGDSGRTWLENTPLFVSHERIAGVARKLGFNRVIVT
AAGDDGLVAGLQDYFSGHMG
>Mature_259_residues
SKPLTGIHILVTRPSHQAGGLAGKIRAAGGEPCLFPVLEIQDISDPRPLLELIERLDEFYLAIFVSPNAVNKAMSVICAK
RALPSDLKIATVGQGTARTLRRFGVSGVIVPAVRFDSEALLDMAELDRINVAGKRIIIFRGDNGRELLGETLRKRGASVE
YAECYRRIRPEAEIGPLLAAWTRGEMNGVTVTSSEGLRNLWEMVGDSGRTWLENTPLFVSHERIAGVARKLGFNRVIVTA
AGDDGLVAGLQDYFSGHMG

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=248, Percent_Identity=35.0806451612903, Blast_Score=121, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28264; Mature: 28133

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPLTGIHILVTRPSHQAGGLAGKIRAAGGEPCLFPVLEIQDISDPRPLLELIERLDEF
CCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHE
YLAIFVSPNAVNKAMSVICAKRALPSDLKIATVGQGTARTLRRFGVSGVIVPAVRFDSEA
EEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCEEEEEEECCHHH
LLDMAELDRINVAGKRIIIFRGDNGRELLGETLRKRGASVEYAECYRRIRPEAEIGPLLA
HHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHCCHHH
AWTRGEMNGVTVTSSEGLRNLWEMVGDSGRTWLENTPLFVSHERIAGVARKLGFNRVIVT
HHHCCCCCCEEEECCHHHHHHHHHHCCCCCEEECCCCEEEEHHHHHHHHHHCCCCEEEEE
AAGDDGLVAGLQDYFSGHMG
ECCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKPLTGIHILVTRPSHQAGGLAGKIRAAGGEPCLFPVLEIQDISDPRPLLELIERLDEF
CCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHE
YLAIFVSPNAVNKAMSVICAKRALPSDLKIATVGQGTARTLRRFGVSGVIVPAVRFDSEA
EEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCEEEEEEECCHHH
LLDMAELDRINVAGKRIIIFRGDNGRELLGETLRKRGASVEYAECYRRIRPEAEIGPLLA
HHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHCCHHH
AWTRGEMNGVTVTSSEGLRNLWEMVGDSGRTWLENTPLFVSHERIAGVARKLGFNRVIVT
HHHCCCCCCEEEECCHHHHHHHHHHCCCCCEEECCCCEEEEHHHHHHHHHHCCCCEEEEE
AAGDDGLVAGLQDYFSGHMG
ECCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3054815; 3320969; 3277628; 3040684; 1379743; 9278503 [H]