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The map label for this gene is prlC [H]

Identifier: 82703598

GI number: 82703598

Start: 2834567

End: 2836678

Strand: Direct

Name: prlC [H]

Synonym: Nmul_A2483

Alternate gene names: 82703598

Gene position: 2834567-2836678 (Clockwise)

Preceding gene: 82703597

Following gene: 82703599

Centisome position: 89.02

GC content: 55.07

Gene sequence:

>2112_bases
ATGAACCCTTTGCTCGATTTTTCCGGATTGCCGCGCTTTGCCGAGATTCGTCCCGAACATATCACACCGGCTGTAAGTCA
ATTGCTGGGTGACAATCGCGCCCTCATTGGACGCGTACGGGAGGATACGGATGTGCCGACCTGGGACAACTTCGTTCAGC
CCATGGCGGATGCCAACGAGCGGCTCTCCCGTGCATGGGGACAGGTATCCCATTTGAATGCGGTGGTAAACACGCCGGAA
CTGCGGGAGGCTTATAATGCCAACCTGCCTCTTGTCACGCAGTATTATGCGGAACTGGCCCAGGATCAGGTGCTATTCGA
AAAATTCAAGGAATTGCGCGGCAGCAGGGAATTCGAAGGATTGAGTTCTGCGCGGAAAAAGGTCATCGAGAATGAGTTGC
GGGACTTCCGGCTGGGCGGGGCAGAACTGCCCGCCGAGAAGAAAGCGCGTTTCCTCCAGATTCAGGAAGAGCTGTCAGCG
CTGGGCTCACGCTTCAACGACAATCTTCTGGACGCCACCAACGCGTTTGTATTGCACGTGGAGGACGCCGGTGAGCTTTC
CGGTATTCCCGATGACGTATTGCAAACAGCGAGAGAAGTTGCGGCAAGAGATAATGCAAGTGGCTGGAAGTTCACCTTGC
ACGCGCCTTCGTATCTGCCTCTTATGCAATACGCGGACAACAGGAAGCTGCGTGAAAAAATGTACCGCGCTTATTCAACC
CGTGCCAGCGAACTGAACGCAGCCGCCCTTCCATCCGGGGATACAGGCAATCTGGATAATACCCCCCTCATTGCCCGAAT
ACTTGAACTGCGCAAGGAAGAATCGCAGCTACTTGGATTCGAATGCTATGCCGAAGTATCACTGGCGACGAAGATGGCTT
CGACTCCGGTCCAGGTGCTGGACTTTCTTGGCGAACTCGCCGACAAGGCCAGGCCGTATGCCGAACGCGACCTGAAGGAG
TTGAGCCAGTTTGCGGCCGAGAAGCTGCAACTGGATACCCTCGAAGCGTGGGATCTGGCGTACGTCAGCGAAAAGCTGCG
CCTGGAGCGTTATGCCTTCTCAGAACAGGAAGTAAAGCAGTATTTCCCGGAAACGAGCGTGCTGCCGGGTATGTTTGGTC
TGGTAGAGAATCTTTACGGCATCAACATCACTCCGGTGGAAGCAACCACGGTTCAACTCTGGCATGCGGATGCCAAGCTG
TTCAATATAGGCGACAGTGAGGGCAAGCTTCTCGGCCGGTTCTATCTCGATCTCTACGCCCGACCCGGCAAACGGGGAGG
AGGGTGGATGGATGATGCGATCAGCCGACGCCGCTATGTTGGAGGTGCGGACAACCGGGAATACGCGGTGCAAGCGCCCG
TCGCATACCTCAACTGTAACTTTTCCGGACCTGTCCCTCATGGAGAGAAAGTTCGCCCTGCCCTGTTCACTCATGATGAA
GTCATTACTCTGTTTCATGAATTCGGACATGGCCTCCATCACCTGTTAACCCAGGTGGACGATCTCGGCGTATCCGGCAT
CCATGGCGTAGAATGGGATGCGGTTGAGTTGCCCAGCCAGTTCATGGAAAACTTCTGCTGGGAATGGGAGGTAATCAGCA
GGATGGCAAGACATGTGGATACGGATGCATCCATGCCGCGTGAACTGTTCGACAAGATGCTGGCGGGGAAGAATTTCCAG
AGCGGCCTGCAGATGCTCAGGCAGCTCGAGTTTGCACTGTTCGACATGCATTTGCATTTCGATTTCGATCCGTATGGCCA
GAAAACCGCGCAGCAACTGCTCGATGAAGTCCGCGAGCAGGTTGCCGTCATCATTCCTCCCGCCTTCAACCGCTTTCCCA
ACAGTTTCTCGCATATCTTCGGCGGAGGCTATGCCGCCGGATATTACAGTTACAAATGGGCGGAAGTGTTGTCTGCGGAT
GCATACAGCATGTTCGAGGAAAACCCTGCGGGTACCGTAGTCGATTCCGAAACCGGACTACGCTTCTGGAAAGAAATCCT
CGCGGTAGGGGGAAGCCGGCCGACACTGGAATCTTTTATTGCGTTCCGGGGACGCGGGCCAGAAATAAATGCGCTTCTGC
GGCATAACGGCATGGCTCCAGCACCTGCATAA

Upstream 100 bases:

>100_bases
ATATACGCTGATCAACGGAAACGTTGTTTACGTGGACTAGGGTCGCAACACGGCATGCATTTTCGAGTTCTCTTCTTTCA
AACTGACTGAATTTCCATCA

Downstream 100 bases:

>100_bases
CCCGCCGAGAAAAAAGGTAATGAAGCTTAAATCAACTTCATCCTGCAACTGAATTTGGGAATCCAGAATACGAGGCTCAT
GCTTTCCCCTATACCGGTTA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 703; Mature: 703

Protein sequence:

>703_residues
MNPLLDFSGLPRFAEIRPEHITPAVSQLLGDNRALIGRVREDTDVPTWDNFVQPMADANERLSRAWGQVSHLNAVVNTPE
LREAYNANLPLVTQYYAELAQDQVLFEKFKELRGSREFEGLSSARKKVIENELRDFRLGGAELPAEKKARFLQIQEELSA
LGSRFNDNLLDATNAFVLHVEDAGELSGIPDDVLQTAREVAARDNASGWKFTLHAPSYLPLMQYADNRKLREKMYRAYST
RASELNAAALPSGDTGNLDNTPLIARILELRKEESQLLGFECYAEVSLATKMASTPVQVLDFLGELADKARPYAERDLKE
LSQFAAEKLQLDTLEAWDLAYVSEKLRLERYAFSEQEVKQYFPETSVLPGMFGLVENLYGINITPVEATTVQLWHADAKL
FNIGDSEGKLLGRFYLDLYARPGKRGGGWMDDAISRRRYVGGADNREYAVQAPVAYLNCNFSGPVPHGEKVRPALFTHDE
VITLFHEFGHGLHHLLTQVDDLGVSGIHGVEWDAVELPSQFMENFCWEWEVISRMARHVDTDASMPRELFDKMLAGKNFQ
SGLQMLRQLEFALFDMHLHFDFDPYGQKTAQQLLDEVREQVAVIIPPAFNRFPNSFSHIFGGGYAAGYYSYKWAEVLSAD
AYSMFEENPAGTVVDSETGLRFWKEILAVGGSRPTLESFIAFRGRGPEINALLRHNGMAPAPA

Sequences:

>Translated_703_residues
MNPLLDFSGLPRFAEIRPEHITPAVSQLLGDNRALIGRVREDTDVPTWDNFVQPMADANERLSRAWGQVSHLNAVVNTPE
LREAYNANLPLVTQYYAELAQDQVLFEKFKELRGSREFEGLSSARKKVIENELRDFRLGGAELPAEKKARFLQIQEELSA
LGSRFNDNLLDATNAFVLHVEDAGELSGIPDDVLQTAREVAARDNASGWKFTLHAPSYLPLMQYADNRKLREKMYRAYST
RASELNAAALPSGDTGNLDNTPLIARILELRKEESQLLGFECYAEVSLATKMASTPVQVLDFLGELADKARPYAERDLKE
LSQFAAEKLQLDTLEAWDLAYVSEKLRLERYAFSEQEVKQYFPETSVLPGMFGLVENLYGINITPVEATTVQLWHADAKL
FNIGDSEGKLLGRFYLDLYARPGKRGGGWMDDAISRRRYVGGADNREYAVQAPVAYLNCNFSGPVPHGEKVRPALFTHDE
VITLFHEFGHGLHHLLTQVDDLGVSGIHGVEWDAVELPSQFMENFCWEWEVISRMARHVDTDASMPRELFDKMLAGKNFQ
SGLQMLRQLEFALFDMHLHFDFDPYGQKTAQQLLDEVREQVAVIIPPAFNRFPNSFSHIFGGGYAAGYYSYKWAEVLSAD
AYSMFEENPAGTVVDSETGLRFWKEILAVGGSRPTLESFIAFRGRGPEINALLRHNGMAPAPA
>Mature_703_residues
MNPLLDFSGLPRFAEIRPEHITPAVSQLLGDNRALIGRVREDTDVPTWDNFVQPMADANERLSRAWGQVSHLNAVVNTPE
LREAYNANLPLVTQYYAELAQDQVLFEKFKELRGSREFEGLSSARKKVIENELRDFRLGGAELPAEKKARFLQIQEELSA
LGSRFNDNLLDATNAFVLHVEDAGELSGIPDDVLQTAREVAARDNASGWKFTLHAPSYLPLMQYADNRKLREKMYRAYST
RASELNAAALPSGDTGNLDNTPLIARILELRKEESQLLGFECYAEVSLATKMASTPVQVLDFLGELADKARPYAERDLKE
LSQFAAEKLQLDTLEAWDLAYVSEKLRLERYAFSEQEVKQYFPETSVLPGMFGLVENLYGINITPVEATTVQLWHADAKL
FNIGDSEGKLLGRFYLDLYARPGKRGGGWMDDAISRRRYVGGADNREYAVQAPVAYLNCNFSGPVPHGEKVRPALFTHDE
VITLFHEFGHGLHHLLTQVDDLGVSGIHGVEWDAVELPSQFMENFCWEWEVISRMARHVDTDASMPRELFDKMLAGKNFQ
SGLQMLRQLEFALFDMHLHFDFDPYGQKTAQQLLDEVREQVAVIIPPAFNRFPNSFSHIFGGGYAAGYYSYKWAEVLSAD
AYSMFEENPAGTVVDSETGLRFWKEILAVGGSRPTLESFIAFRGRGPEINALLRHNGMAPAPA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=632, Percent_Identity=30.5379746835443, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI14149738, Length=702, Percent_Identity=26.6381766381766, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI156105687, Length=632, Percent_Identity=24.3670886075949, Blast_Score=139, Evalue=1e-32,
Organism=Escherichia coli, GI1789913, Length=697, Percent_Identity=48.6370157819225, Blast_Score=660, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=719, Percent_Identity=32.9624478442281, Blast_Score=279, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71999758, Length=704, Percent_Identity=22.1590909090909, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32565901, Length=659, Percent_Identity=22.0030349013657, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319793, Length=700, Percent_Identity=27.1428571428571, Blast_Score=252, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322715, Length=581, Percent_Identity=23.7521514629948, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21356111, Length=567, Percent_Identity=28.2186948853616, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI20129717, Length=665, Percent_Identity=24.6616541353383, Blast_Score=137, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 79138; Mature: 79138

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLLDFSGLPRFAEIRPEHITPAVSQLLGDNRALIGRVREDTDVPTWDNFVQPMADANE
CCCCCCCCCCCHHHHCCCHHCCHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RLSRAWGQVSHLNAVVNTPELREAYNANLPLVTQYYAELAQDQVLFEKFKELRGSREFEG
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LSSARKKVIENELRDFRLGGAELPAEKKARFLQIQEELSALGSRFNDNLLDATNAFVLHV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEE
EDAGELSGIPDDVLQTAREVAARDNASGWKFTLHAPSYLPLMQYADNRKLREKMYRAYST
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHH
RASELNAAALPSGDTGNLDNTPLIARILELRKEESQLLGFECYAEVSLATKMASTPVQVL
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHH
DFLGELADKARPYAERDLKELSQFAAEKLQLDTLEAWDLAYVSEKLRLERYAFSEQEVKQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
YFPETSVLPGMFGLVENLYGINITPVEATTVQLWHADAKLFNIGDSEGKLLGRFYLDLYA
HCCCCCCCHHHHHHHHHHCCCCEECCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHC
RPGKRGGGWMDDAISRRRYVGGADNREYAVQAPVAYLNCNFSGPVPHGEKVRPALFTHDE
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCCCHHHCHHH
VITLFHEFGHGLHHLLTQVDDLGVSGIHGVEWDAVELPSQFMENFCWEWEVISRMARHVD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCC
TDASMPRELFDKMLAGKNFQSGLQMLRQLEFALFDMHLHFDFDPYGQKTAQQLLDEVREQ
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHH
VAVIIPPAFNRFPNSFSHIFGGGYAAGYYSYKWAEVLSADAYSMFEENPAGTVVDSETGL
EEEEECCCHHHCCCHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHH
RFWKEILAVGGSRPTLESFIAFRGRGPEINALLRHNGMAPAPA
HHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNPLLDFSGLPRFAEIRPEHITPAVSQLLGDNRALIGRVREDTDVPTWDNFVQPMADANE
CCCCCCCCCCCHHHHCCCHHCCHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RLSRAWGQVSHLNAVVNTPELREAYNANLPLVTQYYAELAQDQVLFEKFKELRGSREFEG
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LSSARKKVIENELRDFRLGGAELPAEKKARFLQIQEELSALGSRFNDNLLDATNAFVLHV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEE
EDAGELSGIPDDVLQTAREVAARDNASGWKFTLHAPSYLPLMQYADNRKLREKMYRAYST
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHH
RASELNAAALPSGDTGNLDNTPLIARILELRKEESQLLGFECYAEVSLATKMASTPVQVL
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHH
DFLGELADKARPYAERDLKELSQFAAEKLQLDTLEAWDLAYVSEKLRLERYAFSEQEVKQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
YFPETSVLPGMFGLVENLYGINITPVEATTVQLWHADAKLFNIGDSEGKLLGRFYLDLYA
HCCCCCCCHHHHHHHHHHCCCCEECCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHC
RPGKRGGGWMDDAISRRRYVGGADNREYAVQAPVAYLNCNFSGPVPHGEKVRPALFTHDE
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCCCHHHCHHH
VITLFHEFGHGLHHLLTQVDDLGVSGIHGVEWDAVELPSQFMENFCWEWEVISRMARHVD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCC
TDASMPRELFDKMLAGKNFQSGLQMLRQLEFALFDMHLHFDFDPYGQKTAQQLLDEVREQ
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHH
VAVIIPPAFNRFPNSFSHIFGGGYAAGYYSYKWAEVLSADAYSMFEENPAGTVVDSETGL
EEEEECCCHHHCCCHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHH
RFWKEILAVGGSRPTLESFIAFRGRGPEINALLRHNGMAPAPA
HHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]