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The map label for this gene is hrcA

Identifier: 82703538

GI number: 82703538

Start: 2760908

End: 2761927

Strand: Direct

Name: hrcA

Synonym: Nmul_A2423

Alternate gene names: 82703538

Gene position: 2760908-2761927 (Clockwise)

Preceding gene: 82703535

Following gene: 82703539

Centisome position: 86.71

GC content: 53.63

Gene sequence:

>1020_bases
ATGCTGAACAAACGCGCACAGATTTTGCTTAAGACCCTGGTGGAACGCTATATAAGCGAAGGCCAGCCGGTGGGGTCGCG
CTCGCTCTCAAAATTTTCCGGGCTGGACCTCAGCGCGGCCACGATTCGAAATGTAATGGCGGATCTCGAGGACATGGGCC
TGGTTGCCAGCCCCCATGCCTCTGCCGGCCGCATACCTACTCATCAGGGCTATCGCTTTTTTGTGGATACGCTGCTGGTG
GTCAAACCTCTGGATGTCATCGAGATTCATCAATTGCAGGATCAACTCCATCCGGATAATCCTTCACGGTTGATCAACTC
CGCCTCGCAATTGCTCGCCGAACTCACCCGCTTTGCCGGAGTAGTAGTCAGCCCCAAGCGCAATAGCGCCATATTCCGTT
ATATAGAATTCATGTCGCTGTCGGAAAAACGCGTTCTGCTCATCATTGTCACCCCGGAAGGAGACGTTCAAAATCGCGTG
CTTTTCACCGACAGGAATTACAGTCAGTCTGAACTGACGGAAGCGGCGAATTTCATCAACCACAATTATGCCGGTTGCGC
CATTGATGAGATCCGCACCCGCCTGCAAAGTGAACTCAAGCAGTTGCGCCAGGACATGACCTCGTTGATGACCGCCGCCA
TCGATGCGGGCGATGCGGCAATCAGAGAAAACAGCGAGGCTGTAATAGTGGCTGGTGAGCGCAAGCTTCTGGATGTGCAG
GATTTATCCAGCAATATGGCAAGCCTGAAAAAGCTGTTCGACTTGTTCGAACGCAAGACCGCGTTGCTGCAGTTGCTGGA
ATTCAGCCGCAAGGCGGAAGGTGTGCAAATCTTTATCGGGGAAGAATGCGGAGTCGTCACCATGGATGAATTCAGCGTTG
TTACGGCACCTTACAGGGTGGATGGGAAAATGGTCGGTACGGTTGCCGTCATCGGCCCTACCCGGATGGCTTACGAGCGT
GTCATTCCTGTCGTGGATATGACGGCAAGGCTGCTGTCGAGCGCATTGTCCCTGCATTAA

Upstream 100 bases:

>100_bases
TATGGAATCTTTTCACTCGATTGAAGCTCAAAAGATGAGGTGCTGTTCCTTTTCGCGGGAACAGAAGGCTTAAAATGAAA
TCCTGGTGTAGAATATCCGA

Downstream 100 bases:

>100_bases
TTAAGAATCTTCGGAATCCTCCCGCCGTGATTTCCCCTGGGTCTGCTCTCCATCAGGACATATCCAGCCGGACTGGAGTC
CTGCTGATCAATCTCGGCAC

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLNKRAQILLKTLVERYISEGQPVGSRSLSKFSGLDLSAATIRNVMADLEDMGLVASPHASAGRIPTHQGYRFFVDTLLV
VKPLDVIEIHQLQDQLHPDNPSRLINSASQLLAELTRFAGVVVSPKRNSAIFRYIEFMSLSEKRVLLIIVTPEGDVQNRV
LFTDRNYSQSELTEAANFINHNYAGCAIDEIRTRLQSELKQLRQDMTSLMTAAIDAGDAAIRENSEAVIVAGERKLLDVQ
DLSSNMASLKKLFDLFERKTALLQLLEFSRKAEGVQIFIGEECGVVTMDEFSVVTAPYRVDGKMVGTVAVIGPTRMAYER
VIPVVDMTARLLSSALSLH

Sequences:

>Translated_339_residues
MLNKRAQILLKTLVERYISEGQPVGSRSLSKFSGLDLSAATIRNVMADLEDMGLVASPHASAGRIPTHQGYRFFVDTLLV
VKPLDVIEIHQLQDQLHPDNPSRLINSASQLLAELTRFAGVVVSPKRNSAIFRYIEFMSLSEKRVLLIIVTPEGDVQNRV
LFTDRNYSQSELTEAANFINHNYAGCAIDEIRTRLQSELKQLRQDMTSLMTAAIDAGDAAIRENSEAVIVAGERKLLDVQ
DLSSNMASLKKLFDLFERKTALLQLLEFSRKAEGVQIFIGEECGVVTMDEFSVVTAPYRVDGKMVGTVAVIGPTRMAYER
VIPVVDMTARLLSSALSLH
>Mature_339_residues
MLNKRAQILLKTLVERYISEGQPVGSRSLSKFSGLDLSAATIRNVMADLEDMGLVASPHASAGRIPTHQGYRFFVDTLLV
VKPLDVIEIHQLQDQLHPDNPSRLINSASQLLAELTRFAGVVVSPKRNSAIFRYIEFMSLSEKRVLLIIVTPEGDVQNRV
LFTDRNYSQSELTEAANFINHNYAGCAIDEIRTRLQSELKQLRQDMTSLMTAAIDAGDAAIRENSEAVIVAGERKLLDVQ
DLSSNMASLKKLFDLFERKTALLQLLEFSRKAEGVQIFIGEECGVVTMDEFSVVTAPYRVDGKMVGTVAVIGPTRMAYER
VIPVVDMTARLLSSALSLH

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_NITMU (Q2Y6A9)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_413104.1
- ProteinModelPortal:   Q2Y6A9
- SMR:   Q2Y6A9
- STRING:   Q2Y6A9
- GeneID:   3785515
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2423
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   NMUL323848:NMUL_A2423-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 37597; Mature: 37597

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKRAQILLKTLVERYISEGQPVGSRSLSKFSGLDLSAATIRNVMADLEDMGLVASPHA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCCC
SAGRIPTHQGYRFFVDTLLVVKPLDVIEIHQLQDQLHPDNPSRLINSASQLLAELTRFAG
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
VVVSPKRNSAIFRYIEFMSLSEKRVLLIIVTPEGDVQNRVLFTDRNYSQSELTEAANFIN
EEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHC
HNYAGCAIDEIRTRLQSELKQLRQDMTSLMTAAIDAGDAAIRENSEAVIVAGERKLLDVQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCCCEEEHH
DLSSNMASLKKLFDLFERKTALLQLLEFSRKAEGVQIFIGEECGVVTMDEFSVVTAPYRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCEEEECCEEE
DGKMVGTVAVIGPTRMAYERVIPVVDMTARLLSSALSLH
CCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNKRAQILLKTLVERYISEGQPVGSRSLSKFSGLDLSAATIRNVMADLEDMGLVASPHA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCCC
SAGRIPTHQGYRFFVDTLLVVKPLDVIEIHQLQDQLHPDNPSRLINSASQLLAELTRFAG
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
VVVSPKRNSAIFRYIEFMSLSEKRVLLIIVTPEGDVQNRVLFTDRNYSQSELTEAANFIN
EEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHC
HNYAGCAIDEIRTRLQSELKQLRQDMTSLMTAAIDAGDAAIRENSEAVIVAGERKLLDVQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCCCEEEHH
DLSSNMASLKKLFDLFERKTALLQLLEFSRKAEGVQIFIGEECGVVTMDEFSVVTAPYRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCEEEECCEEE
DGKMVGTVAVIGPTRMAYERVIPVVDMTARLLSSALSLH
CCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA