Click here to switch to the map view.

The map label for this gene is hemH [H]

Identifier: 82703539

GI number: 82703539

Start: 2761954

End: 2763066

Strand: Direct

Name: hemH [H]

Synonym: Nmul_A2424

Alternate gene names: 82703539

Gene position: 2761954-2763066 (Clockwise)

Preceding gene: 82703538

Following gene: 82703554

Centisome position: 86.74

GC content: 56.24

Gene sequence:

>1113_bases
GTGATTTCCCCTGGGTCTGCTCTCCATCAGGACATATCCAGCCGGACTGGAGTCCTGCTGATCAATCTCGGCACGCCGGA
TGCGCCCACTCCAGAGGCGCTACGGCCTTATCTCAAGCAGTTCCTCAGTAATCCCCGCGTTATAGAATTGCCACAGTGGC
TGTGGTGGCCGATACTCAACGGCATCATACTCAACACCCGACCGAAAAAATCGGCGGAAAAGTATGCGCAGGTGTGGATG
CCGGAAGGCTCACCGCTCAAGGTGCACACTGCCCGCCAGACCCGGCTACTCCAGGATTTCCTGGGAAAACGCCTTCATTC
CGCGCCGGTGGTGCAATATGCAATGAACATAGGCAATCCTTCGGTAGCTGAAATGCTGGAGCGCTTCCGGGAACAGGGTT
GCGACCGACTGCTCGTACTGCCGCTCTATCCCCAATACGCTGCCAGCAGTACTGCTTCAGCCTTCGATGAGATATTCGCG
CAACTGGCGAAGCTGCGAAATATTCCCGCTGTGCGCACAGTGAAACACTATCACGATCATCCAGGATACATCGCCGCGCT
CGCGAATAACGTGCGCGACCACTGGGCGAGAGCGGGCAGGCCGGATAAACTCGTGATGAGCTTTCATGGCATACCCCGAG
CGTCGGTGGACAAAGGAGACCCGTACCAGGATGAATGCCGGAAAACGGGCCTCTTACTGGCGGAGGCGCTGGAACTGGAC
GCAAATCAGTATCAACTCTGCTTTCAGTCCCGCTTTGGCAGAGCGGAATGGCTGAGGCCTTACACAGCGGACACCTTGGA
GCAGCTAGGCAGGCAAGGAACACGGCGCATCGATGTCGTCTGCCCCGGTTTTGTCTCCGACTGCCTTGAAACACTTGAAG
AAATCGCCATGGAGGGCAAAAACATTTTTATCCAGGCCGGGGGACACGAGTTCCATTACATTCCCTGCCTGAATGAACGC
GATGACTGGATACACGCCCTAGGTGACATTACCCTTGCCAATCTGCAGGGATGGATGGGCCCGGGTTTTGAGGAGAAAGG
GTCCGACAAGGATGGGGAGGTTATCGGCTTATCGCAAGGGGAGGCATCCCCGACCGATAAAAATACCGATTGA

Upstream 100 bases:

>100_bases
TGGCTTACGAGCGTGTCATTCCTGTCGTGGATATGACGGCAAGGCTGCTGTCGAGCGCATTGTCCCTGCATTAATTAAGA
ATCTTCGGAATCCTCCCGCC

Downstream 100 bases:

>100_bases
TGTGACAACCCTTTCCATTCCTTCTGCCTTTCTGAAGCATCCGCAAATCGGGTTCCGATTTGTCCGCTTGCGGTCTCTCT
AGCGCGAACGGGCTGCAGCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MISPGSALHQDISSRTGVLLINLGTPDAPTPEALRPYLKQFLSNPRVIELPQWLWWPILNGIILNTRPKKSAEKYAQVWM
PEGSPLKVHTARQTRLLQDFLGKRLHSAPVVQYAMNIGNPSVAEMLERFREQGCDRLLVLPLYPQYAASSTASAFDEIFA
QLAKLRNIPAVRTVKHYHDHPGYIAALANNVRDHWARAGRPDKLVMSFHGIPRASVDKGDPYQDECRKTGLLLAEALELD
ANQYQLCFQSRFGRAEWLRPYTADTLEQLGRQGTRRIDVVCPGFVSDCLETLEEIAMEGKNIFIQAGGHEFHYIPCLNER
DDWIHALGDITLANLQGWMGPGFEEKGSDKDGEVIGLSQGEASPTDKNTD

Sequences:

>Translated_370_residues
MISPGSALHQDISSRTGVLLINLGTPDAPTPEALRPYLKQFLSNPRVIELPQWLWWPILNGIILNTRPKKSAEKYAQVWM
PEGSPLKVHTARQTRLLQDFLGKRLHSAPVVQYAMNIGNPSVAEMLERFREQGCDRLLVLPLYPQYAASSTASAFDEIFA
QLAKLRNIPAVRTVKHYHDHPGYIAALANNVRDHWARAGRPDKLVMSFHGIPRASVDKGDPYQDECRKTGLLLAEALELD
ANQYQLCFQSRFGRAEWLRPYTADTLEQLGRQGTRRIDVVCPGFVSDCLETLEEIAMEGKNIFIQAGGHEFHYIPCLNER
DDWIHALGDITLANLQGWMGPGFEEKGSDKDGEVIGLSQGEASPTDKNTD
>Mature_370_residues
MISPGSALHQDISSRTGVLLINLGTPDAPTPEALRPYLKQFLSNPRVIELPQWLWWPILNGIILNTRPKKSAEKYAQVWM
PEGSPLKVHTARQTRLLQDFLGKRLHSAPVVQYAMNIGNPSVAEMLERFREQGCDRLLVLPLYPQYAASSTASAFDEIFA
QLAKLRNIPAVRTVKHYHDHPGYIAALANNVRDHWARAGRPDKLVMSFHGIPRASVDKGDPYQDECRKTGLLLAEALELD
ANQYQLCFQSRFGRAEWLRPYTADTLEQLGRQGTRRIDVVCPGFVSDCLETLEEIAMEGKNIFIQAGGHEFHYIPCLNER
DDWIHALGDITLANLQGWMGPGFEEKGSDKDGEVIGLSQGEASPTDKNTD

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=335, Percent_Identity=27.1641791044776, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI60499021, Length=340, Percent_Identity=27.0588235294118, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=45, Blast_Score=289, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6324750, Length=334, Percent_Identity=25.1497005988024, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=25.5131964809384, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24651774, Length=262, Percent_Identity=25.5725190839695, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 41480; Mature: 41480

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPGSALHQDISSRTGVLLINLGTPDAPTPEALRPYLKQFLSNPRVIELPQWLWWPILN
CCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHC
GIILNTRPKKSAEKYAQVWMPEGSPLKVHTARQTRLLQDFLGKRLHSAPVVQYAMNIGNP
CEEECCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCH
SVAEMLERFREQGCDRLLVLPLYPQYAASSTASAFDEIFAQLAKLRNIPAVRTVKHYHDH
HHHHHHHHHHHCCCCEEEEEECCCHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
PGYIAALANNVRDHWARAGRPDKLVMSFHGIPRASVDKGDPYQDECRKTGLLLAEALELD
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
ANQYQLCFQSRFGRAEWLRPYTADTLEQLGRQGTRRIDVVCPGFVSDCLETLEEIAMEGK
CHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCC
NIFIQAGGHEFHYIPCLNERDDWIHALGDITLANLQGWMGPGFEEKGSDKDGEVIGLSQG
EEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCC
EASPTDKNTD
CCCCCCCCCC
>Mature Secondary Structure
MISPGSALHQDISSRTGVLLINLGTPDAPTPEALRPYLKQFLSNPRVIELPQWLWWPILN
CCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHC
GIILNTRPKKSAEKYAQVWMPEGSPLKVHTARQTRLLQDFLGKRLHSAPVVQYAMNIGNP
CEEECCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCH
SVAEMLERFREQGCDRLLVLPLYPQYAASSTASAFDEIFAQLAKLRNIPAVRTVKHYHDH
HHHHHHHHHHHCCCCEEEEEECCCHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
PGYIAALANNVRDHWARAGRPDKLVMSFHGIPRASVDKGDPYQDECRKTGLLLAEALELD
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
ANQYQLCFQSRFGRAEWLRPYTADTLEQLGRQGTRRIDVVCPGFVSDCLETLEEIAMEGK
CHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCC
NIFIQAGGHEFHYIPCLNERDDWIHALGDITLANLQGWMGPGFEEKGSDKDGEVIGLSQG
EEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCC
EASPTDKNTD
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]