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The map label for this gene is bioA [H]

Identifier: 82703481

GI number: 82703481

Start: 2690662

End: 2691984

Strand: Direct

Name: bioA [H]

Synonym: Nmul_A2364

Alternate gene names: 82703481

Gene position: 2690662-2691984 (Clockwise)

Preceding gene: 82703467

Following gene: 82703482

Centisome position: 84.5

GC content: 60.09

Gene sequence:

>1323_bases
ATGAGTCCCAAGAGTCCCCATGAAGCCTTGCGGCAACGCAGCCTGAAGTCGGTCTGGCATCCCTGCACCCAGATGAAGCG
GCATGAATCGCTGGCGCTCGTCACCATCGCGCGCGCCGAAGGCGTGTGGCTATACGATGGTGAGGGCAGGCGGTACCTCG
ATGCCATCGGTTCCTGGTGGGTCAATCTGTTCGGTCATGCCAACCCGCGCATCAACGCAGCCATTCGCGAGCAGCTCGAC
CGTCTGGAGCATGTCATGCTGGCCGGATTCACGCATGAACCGGTGGTGGAATTGTCCGAGCGCCTCAGCAAGCTGGTATC
GAACCAGCTGGGGCATTGCTTTTATGCGAGCGATGGTGCTTCCGCCACGGAAATTGCGCTGAAAATGAGTTTTCATTACT
GGCACAACCTCGGCCGCCCTGAAAAGAATCATTTCGTCAGCCTGCAGAACGACTACCATGGCGAAACGCTGGGAGCGCTT
TCGGTCACGGATGTAGCACTTTTCAAGGAAACCTATGCACCGCTCCTGCGGCCAGGCAGCCATGTTCCCACTCCGGACTG
GCGCTATGCCTCCGAGGGCGAGTCGCCTCAGGAGCATGCCCTGCGCGCCGCTGCGGCGCTCGAGGCGCACCTTGCAGCGC
ATCATGCGGAAACTGCTGCACTCATTCTGGAACCGCTGATTCAGGGAGCGGCCGGCATGGGCATGTATCATCCTGATTAT
CTCCGGCGCGCGCGCGAACTCTGCGACCGGTATCAGGTGCATCTCATCGCGGATGAAATCGCAGTCGGATTCGGCAGGAC
TGGGACCCTGTTTGCCTGTGAGCAGGCAGGCATCCTGCCGGATTTCCTCTGCATCGGTAAGGGTTTGACGGCAGGTTATC
TTCCTCTCTCGGTCGTGATGACTACCGAGGAAATCTACGCTGCCTTCTACGGCGACAACCCGGCGCGCGCCTTCCTGCAT
TCCCATACCCATTCCGGCAATGCGCTGGCCTGCCGGGCCGCGCTCGCGACGCTGGATATTTTCGAGCAGGACGGTATCAT
CGAGGCGAACCGTGGCAAGGCCCGCTATCTCAATCAGGCCTCCACACCCCTCGCAACGCATCCGCAGGTGCGGAACTTCC
GCAATTGCGGAATGATCTGGGCGTTCGAAGTCGAGACTTCCGATCCGTCGTTTCCGGGAAAATTTTTCCAGGCTGCGCTC
AGGCAGGAACTGTCCCTGCGGCCCTTGGGAAACACCGTCTACTTCATGCCGCCGTATGTCATCAACGAACAGGAAATGGA
CCTGCTGGTGGCGGGTACGCTGGCGGCGCTGGACGCATGGTGA

Upstream 100 bases:

>100_bases
TTCCACTGTTTTCCATTCCATTGCTTTCCGCTACCAGTTTCCCGCTTGCTTCCCCCATGATTGCCACCCGCAGATGAACG
ATGAGTCCCAATGAGTCCCA

Downstream 100 bases:

>100_bases
AAACCCCCCGGTGAGGAAACGACGGAGGCGATGAAGTGGCTGCGCCGAATGCCGGCAAGCCTCGCATTCATTTCGTTCAG
AGCGTCGTGGAGTCGATGCG

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSPKSPHEALRQRSLKSVWHPCTQMKRHESLALVTIARAEGVWLYDGEGRRYLDAIGSWWVNLFGHANPRINAAIREQLD
RLEHVMLAGFTHEPVVELSERLSKLVSNQLGHCFYASDGASATEIALKMSFHYWHNLGRPEKNHFVSLQNDYHGETLGAL
SVTDVALFKETYAPLLRPGSHVPTPDWRYASEGESPQEHALRAAAALEAHLAAHHAETAALILEPLIQGAAGMGMYHPDY
LRRARELCDRYQVHLIADEIAVGFGRTGTLFACEQAGILPDFLCIGKGLTAGYLPLSVVMTTEEIYAAFYGDNPARAFLH
SHTHSGNALACRAALATLDIFEQDGIIEANRGKARYLNQASTPLATHPQVRNFRNCGMIWAFEVETSDPSFPGKFFQAAL
RQELSLRPLGNTVYFMPPYVINEQEMDLLVAGTLAALDAW

Sequences:

>Translated_440_residues
MSPKSPHEALRQRSLKSVWHPCTQMKRHESLALVTIARAEGVWLYDGEGRRYLDAIGSWWVNLFGHANPRINAAIREQLD
RLEHVMLAGFTHEPVVELSERLSKLVSNQLGHCFYASDGASATEIALKMSFHYWHNLGRPEKNHFVSLQNDYHGETLGAL
SVTDVALFKETYAPLLRPGSHVPTPDWRYASEGESPQEHALRAAAALEAHLAAHHAETAALILEPLIQGAAGMGMYHPDY
LRRARELCDRYQVHLIADEIAVGFGRTGTLFACEQAGILPDFLCIGKGLTAGYLPLSVVMTTEEIYAAFYGDNPARAFLH
SHTHSGNALACRAALATLDIFEQDGIIEANRGKARYLNQASTPLATHPQVRNFRNCGMIWAFEVETSDPSFPGKFFQAAL
RQELSLRPLGNTVYFMPPYVINEQEMDLLVAGTLAALDAW
>Mature_439_residues
SPKSPHEALRQRSLKSVWHPCTQMKRHESLALVTIARAEGVWLYDGEGRRYLDAIGSWWVNLFGHANPRINAAIREQLDR
LEHVMLAGFTHEPVVELSERLSKLVSNQLGHCFYASDGASATEIALKMSFHYWHNLGRPEKNHFVSLQNDYHGETLGALS
VTDVALFKETYAPLLRPGSHVPTPDWRYASEGESPQEHALRAAAALEAHLAAHHAETAALILEPLIQGAAGMGMYHPDYL
RRARELCDRYQVHLIADEIAVGFGRTGTLFACEQAGILPDFLCIGKGLTAGYLPLSVVMTTEEIYAAFYGDNPARAFLHS
HTHSGNALACRAALATLDIFEQDGIIEANRGKARYLNQASTPLATHPQVRNFRNCGMIWAFEVETSDPSFPGKFFQAALR
QELSLRPLGNTVYFMPPYVINEQEMDLLVAGTLAALDAW

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=396, Percent_Identity=28.5353535353535, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI13994255, Length=333, Percent_Identity=28.5285285285285, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI37574042, Length=362, Percent_Identity=26.5193370165746, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI284507298, Length=311, Percent_Identity=28.2958199356913, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI226442705, Length=362, Percent_Identity=25.9668508287293, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI24119277, Length=400, Percent_Identity=25.25, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI226442709, Length=337, Percent_Identity=26.4094955489614, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=38.1861575178998, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=30.7692307692308, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789759, Length=395, Percent_Identity=28.1012658227848, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1789016, Length=400, Percent_Identity=30, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=28.9672544080605, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=32.0099255583127, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786349, Length=316, Percent_Identity=25.6329113924051, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=403, Percent_Identity=25.0620347394541, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=26.9320843091335, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=222, Percent_Identity=28.8288288288288, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=472, Percent_Identity=22.4576271186441, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=463, Percent_Identity=31.7494600431965, Blast_Score=219, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=27.3809523809524, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=415, Percent_Identity=27.4698795180723, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=28.7128712871287, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI161085790, Length=322, Percent_Identity=29.5031055900621, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI28574759, Length=322, Percent_Identity=28.8819875776398, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI21356575, Length=472, Percent_Identity=25, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48883; Mature: 48752

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPKSPHEALRQRSLKSVWHPCTQMKRHESLALVTIARAEGVWLYDGEGRRYLDAIGSWW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHH
VNLFGHANPRINAAIREQLDRLEHVMLAGFTHEPVVELSERLSKLVSNQLGHCFYASDGA
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCC
SATEIALKMSFHYWHNLGRPEKNHFVSLQNDYHGETLGALSVTDVALFKETYAPLLRPGS
CCEEEEEEEEHHHHHCCCCCCCCCEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHCCCC
HVPTPDWRYASEGESPQEHALRAAAALEAHLAAHHAETAALILEPLIQGAAGMGMYHPDY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LRRARELCDRYQVHLIADEIAVGFGRTGTLFACEQAGILPDFLCIGKGLTAGYLPLSVVM
HHHHHHHHHHHHEEEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHCCCCCCCCCEEEEEE
TTEEIYAAFYGDNPARAFLHSHTHSGNALACRAALATLDIFEQDGIIEANRGKARYLNQA
EHHHHHEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHCC
STPLATHPQVRNFRNCGMIWAFEVETSDPSFPGKFFQAALRQELSLRPLGNTVYFMPPYV
CCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCEE
INEQEMDLLVAGTLAALDAW
ECCCCCCEEEEHHHHHHCCC
>Mature Secondary Structure 
SPKSPHEALRQRSLKSVWHPCTQMKRHESLALVTIARAEGVWLYDGEGRRYLDAIGSWW
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHH
VNLFGHANPRINAAIREQLDRLEHVMLAGFTHEPVVELSERLSKLVSNQLGHCFYASDGA
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCC
SATEIALKMSFHYWHNLGRPEKNHFVSLQNDYHGETLGALSVTDVALFKETYAPLLRPGS
CCEEEEEEEEHHHHHCCCCCCCCCEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHCCCC
HVPTPDWRYASEGESPQEHALRAAAALEAHLAAHHAETAALILEPLIQGAAGMGMYHPDY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LRRARELCDRYQVHLIADEIAVGFGRTGTLFACEQAGILPDFLCIGKGLTAGYLPLSVVM
HHHHHHHHHHHHEEEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHCCCCCCCCCEEEEEE
TTEEIYAAFYGDNPARAFLHSHTHSGNALACRAALATLDIFEQDGIIEANRGKARYLNQA
EHHHHHEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHCC
STPLATHPQVRNFRNCGMIWAFEVETSDPSFPGKFFQAALRQELSLRPLGNTVYFMPPYV
CCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCEE
INEQEMDLLVAGTLAALDAW
ECCCCCCEEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]