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The map label for this gene is dacC [H]

Identifier: 82703482

GI number: 82703482

Start: 2692495

End: 2694141

Strand: Direct

Name: dacC [H]

Synonym: Nmul_A2367

Alternate gene names: 82703482

Gene position: 2692495-2694141 (Clockwise)

Preceding gene: 82703481

Following gene: 82703483

Centisome position: 84.56

GC content: 59.32

Gene sequence:

>1647_bases
ATGTCCCTGTTCACACGTTTGCAACGTTCCCTGGAAAACCCGCTGGAAAACCCGCAGAAAAACCTGCCCGGAAATCCATT
GAGAAACTCGCATCTCGTACCGCTATTACGCGCAATAAAGTGGGCATTATGCAGTCTGCTTGTCTTCCTGCCGCCGCCGG
CTTTGGCGCTCGACCTGCCTGACTCGGTAAAATACGCGCTCGCACGGGCGGGTATCCCCCGGTCTGCCGTCGGCATTTAC
GTGCATGAAACCGGTGCAGGACAGCCGCTGCTGGCTGTCAATGCTGGCGTCGGCATGAGCCCGGCTTCGGTGATGAAGCT
TCTGACCACATTTGCCGGACTGGAACTACTGGGGCCGGGATATGCCTGGAAGACGGAGCTGTATGCTGACGGGATTGTCC
GGGGGGATGCCCTTCACGGCAATCTGGTCATCAAGGGCTACGGCGATCCGAGGCTGAATCTGGAGAACTTCTGGTTGCTC
ACCCGACGGCTGCGCCAGACCGGATTGCGCGAAATCACCGGCGACCTGGTGCTCGACAGCAGCCATTTCGATCTCCCCGG
AAGCGACTCCGCCGCATTCGACGGCAGGCCCTATCGCGCATACAACGTCCTCCCCGAGGCGCTGATGGTGAATTACCGGA
CGCTCGCGCTGCGGCTGCTGCCGCAGCCGGAAAGCAGGAGCGTGCGCATTGTGGTGGACCCCCTGTTGCCCTCTCTCGAC
CTCAAAAACAGCCTGACGCTCACCAATGGTGCATGCAATGACTGGAAGGATGATCTTGGCACGGATATTCAGTTCGCCAC
GGGCCTCGACAGCCGCGTGTCCGTGACATTCAAGGGCAGCTATGCCCTGGCGTGCGGCGAAAAAACCCTGTTCCTCAGTG
TTCACGACACTGCCCGCTATACCTTCGATCTGTTCAGGCAGTTGTGGGAACAGCAAGGCGGTGTTCTTCGCGGGAGCGTG
CGCAGGAGTGCCGCTCCGGAAGGAATTGTGCCGCTGGAAACCCACCAGTCTCCTCCCTTGACGGATATCGTGCGCGATAT
CAACAAGTTCAGCAACAATACCGCGGCGCGGCAGCTCTATCTCACCCTGGGGCTGGGCAGTGGACCATTCAGGGAACCGC
AAGTAATGCCGGCTTCCTTCAACATCGGCTACGGAAATGATCGAACCGCCAAAAGCGGAACAATACTTTCCCTGGATGGA
ATCGGAGAAGATCCTGACCCGTCACGCGCAACCCTCGCCAAATCGGAAACCGCCATCCGGCAATGGCTCGCTTCCCGCCA
ACTGGTCTTTCCCGAGCTGATCCTGGAAAACGGGTCTGGCTTGTCGCGGAATGAACGCATCAGTGCCGGCCATATGGGCA
AACTGCTGCTCGCCGCATTCCAGAGTCATGTCATGCCCGAGTTTGTCTCCTCCCTGCCCATCGTCGCAGTGGACGGCACC
ATGAAGAAAAGACTCAACCGCAGTGCAATCGCCGGCCAGGCCCATATCAAGACAGGGCTGCTGGAGGGGGTAAAAACCAT
AGCGGGTTATGTGCGCGACAAGTCCGGCAGGCGCTCGGTCGTGGTTTTCTTCATCAACCACCCGCGCGCGGAGAACGGAC
AGGCTGCGATGGATGCGCTGCTCGATTGGGTCTACGAGGGGCGATAA

Upstream 100 bases:

>100_bases
TCACGCAGCCTTCAGCTTGCCCATTCTGGCCGACACCATCCGGCAGAAACCAAACTGGAATGCAAGTACCCTGTCCAACC
CTCATCCGTTGAGATATAGC

Downstream 100 bases:

>100_bases
CGCTATCAACGAAAGTTGTGCTCCGGGAAGCCGGATTAGCCCCGCCCAACGCTTTCTGATGCCTCATGCGGATCTCAATG
CTCCGCATCGGCGCACTGCC

Product: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 4a; PBP-4a [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MSLFTRLQRSLENPLENPQKNLPGNPLRNSHLVPLLRAIKWALCSLLVFLPPPALALDLPDSVKYALARAGIPRSAVGIY
VHETGAGQPLLAVNAGVGMSPASVMKLLTTFAGLELLGPGYAWKTELYADGIVRGDALHGNLVIKGYGDPRLNLENFWLL
TRRLRQTGLREITGDLVLDSSHFDLPGSDSAAFDGRPYRAYNVLPEALMVNYRTLALRLLPQPESRSVRIVVDPLLPSLD
LKNSLTLTNGACNDWKDDLGTDIQFATGLDSRVSVTFKGSYALACGEKTLFLSVHDTARYTFDLFRQLWEQQGGVLRGSV
RRSAAPEGIVPLETHQSPPLTDIVRDINKFSNNTAARQLYLTLGLGSGPFREPQVMPASFNIGYGNDRTAKSGTILSLDG
IGEDPDPSRATLAKSETAIRQWLASRQLVFPELILENGSGLSRNERISAGHMGKLLLAAFQSHVMPEFVSSLPIVAVDGT
MKKRLNRSAIAGQAHIKTGLLEGVKTIAGYVRDKSGRRSVVVFFINHPRAENGQAAMDALLDWVYEGR

Sequences:

>Translated_548_residues
MSLFTRLQRSLENPLENPQKNLPGNPLRNSHLVPLLRAIKWALCSLLVFLPPPALALDLPDSVKYALARAGIPRSAVGIY
VHETGAGQPLLAVNAGVGMSPASVMKLLTTFAGLELLGPGYAWKTELYADGIVRGDALHGNLVIKGYGDPRLNLENFWLL
TRRLRQTGLREITGDLVLDSSHFDLPGSDSAAFDGRPYRAYNVLPEALMVNYRTLALRLLPQPESRSVRIVVDPLLPSLD
LKNSLTLTNGACNDWKDDLGTDIQFATGLDSRVSVTFKGSYALACGEKTLFLSVHDTARYTFDLFRQLWEQQGGVLRGSV
RRSAAPEGIVPLETHQSPPLTDIVRDINKFSNNTAARQLYLTLGLGSGPFREPQVMPASFNIGYGNDRTAKSGTILSLDG
IGEDPDPSRATLAKSETAIRQWLASRQLVFPELILENGSGLSRNERISAGHMGKLLLAAFQSHVMPEFVSSLPIVAVDGT
MKKRLNRSAIAGQAHIKTGLLEGVKTIAGYVRDKSGRRSVVVFFINHPRAENGQAAMDALLDWVYEGR
>Mature_547_residues
SLFTRLQRSLENPLENPQKNLPGNPLRNSHLVPLLRAIKWALCSLLVFLPPPALALDLPDSVKYALARAGIPRSAVGIYV
HETGAGQPLLAVNAGVGMSPASVMKLLTTFAGLELLGPGYAWKTELYADGIVRGDALHGNLVIKGYGDPRLNLENFWLLT
RRLRQTGLREITGDLVLDSSHFDLPGSDSAAFDGRPYRAYNVLPEALMVNYRTLALRLLPQPESRSVRIVVDPLLPSLDL
KNSLTLTNGACNDWKDDLGTDIQFATGLDSRVSVTFKGSYALACGEKTLFLSVHDTARYTFDLFRQLWEQQGGVLRGSVR
RSAAPEGIVPLETHQSPPLTDIVRDINKFSNNTAARQLYLTLGLGSGPFREPQVMPASFNIGYGNDRTAKSGTILSLDGI
GEDPDPSRATLAKSETAIRQWLASRQLVFPELILENGSGLSRNERISAGHMGKLLLAAFQSHVMPEFVSSLPIVAVDGTM
KKRLNRSAIAGQAHIKTGLLEGVKTIAGYVRDKSGRRSVVVFFINHPRAENGQAAMDALLDWVYEGR

Specific function: Catalyzes DD-carboxypeptidase and transpeptidation reactions [H]

COG id: COG2027

COG function: function code M; D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)

Gene ontology:

Cell location: Secreted (Probable). Note=May be anchored in the membrane via a C-terminal amphiphatic alpha helix [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S13 family [H]

Homologues:

Organism=Escherichia coli, GI1789573, Length=459, Percent_Identity=24.6187363834423, Blast_Score=109, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR000667 [H]

Pfam domain/function: PF02113 Peptidase_S13 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 59836; Mature: 59705

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFTRLQRSLENPLENPQKNLPGNPLRNSHLVPLLRAIKWALCSLLVFLPPPALALDLP
CCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCC
DSVKYALARAGIPRSAVGIYVHETGAGQPLLAVNAGVGMSPASVMKLLTTFAGLELLGPG
HHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHCCCC
YAWKTELYADGIVRGDALHGNLVIKGYGDPRLNLENFWLLTRRLRQTGLREITGDLVLDS
CCEEHHHHHCCEEECCEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECC
SHFDLPGSDSAAFDGRPYRAYNVLPEALMVNYRTLALRLLPQPESRSVRIVVDPLLPSLD
CCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHEEEEEEECCCCCCCCEEEEEECCCCCCC
LKNSLTLTNGACNDWKDDLGTDIQFATGLDSRVSVTFKGSYALACGEKTLFLSVHDTARY
CCCCEEECCCCCCCCHHHHCCCEEEECCCCCEEEEEECCCEEEEECCEEEEEEECCHHHH
TFDLFRQLWEQQGGVLRGSVRRSAAPEGIVPLETHQSPPLTDIVRDINKFSNNTAARQLY
HHHHHHHHHHHCCCEEECCHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEEE
LTLGLGSGPFREPQVMPASFNIGYGNDRTAKSGTILSLDGIGEDPDPSRATLAKSETAIR
EEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHH
QWLASRQLVFPELILENGSGLSRNERISAGHMGKLLLAAFQSHVMPEFVSSLPIVAVDGT
HHHHHCCHHCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCH
MKKRLNRSAIAGQAHIKTGLLEGVKTIAGYVRDKSGRRSVVVFFINHPRAENGQAAMDAL
HHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHH
LDWVYEGR
HHHHHCCC
>Mature Secondary Structure 
SLFTRLQRSLENPLENPQKNLPGNPLRNSHLVPLLRAIKWALCSLLVFLPPPALALDLP
CHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCC
DSVKYALARAGIPRSAVGIYVHETGAGQPLLAVNAGVGMSPASVMKLLTTFAGLELLGPG
HHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHCCCC
YAWKTELYADGIVRGDALHGNLVIKGYGDPRLNLENFWLLTRRLRQTGLREITGDLVLDS
CCEEHHHHHCCEEECCEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECC
SHFDLPGSDSAAFDGRPYRAYNVLPEALMVNYRTLALRLLPQPESRSVRIVVDPLLPSLD
CCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHEEEEEEECCCCCCCCEEEEEECCCCCCC
LKNSLTLTNGACNDWKDDLGTDIQFATGLDSRVSVTFKGSYALACGEKTLFLSVHDTARY
CCCCEEECCCCCCCCHHHHCCCEEEECCCCCEEEEEECCCEEEEECCEEEEEEECCHHHH
TFDLFRQLWEQQGGVLRGSVRRSAAPEGIVPLETHQSPPLTDIVRDINKFSNNTAARQLY
HHHHHHHHHHHCCCEEECCHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEEE
LTLGLGSGPFREPQVMPASFNIGYGNDRTAKSGTILSLDGIGEDPDPSRATLAKSETAIR
EEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHH
QWLASRQLVFPELILENGSGLSRNERISAGHMGKLLLAAFQSHVMPEFVSSLPIVAVDGT
HHHHHCCHHCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCH
MKKRLNRSAIAGQAHIKTGLLEGVKTIAGYVRDKSGRRSVVVFFINHPRAENGQAAMDAL
HHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHH
LDWVYEGR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7711903; 9384377 [H]