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The map label for this gene is clpA [H]

Identifier: 82703366

GI number: 82703366

Start: 2553022

End: 2555280

Strand: Direct

Name: clpA [H]

Synonym: Nmul_A2248

Alternate gene names: 82703366

Gene position: 2553022-2555280 (Clockwise)

Preceding gene: 82703365

Following gene: 82703370

Centisome position: 80.18

GC content: 53.74

Gene sequence:

>2259_bases
ATGATTGCTCAAGAATTAGAGGTAAGTCTGCATATGGCATTCGTGGAATCGCGTCAGAAGCGCCACGAGTTCATTACGGT
CGAGCATCTGTTACTGGCCCTGCTCGATAATCCGACTGCCGCAGAGGTATTGCGCGCCTGCTCGGTTGATATGGACGATC
TACGCCGGCTGCTGACTGAGCATGTCACCGAAAACACGCCGACTGTGGGAGGAAGTGGAGAGGTAGATACGCAGCCTACT
CTTGGTTTTCAGCGCGTTATCCAGCGTGCGATTCTGCATGTGCAGTCCTCCGGGAAAAAAGAGGTTACGGGTGCAAACGT
ACTGGTAGCAATATTTGGCGAAAAGGATTCGCACGCAGTTTATTTTCTTCATCAAAAGGGGGTAACCCGGCTCGATGTCG
TGAACTATATTTCTCACGGCATCAGCAAAGTTCCGCAGGGAACCAACGCCAAAACCGAAAGCGAAGGGGATACCGAGCAG
GAAATGAATGCAGGGGGCGCGCTGGAAAGTTATGCGGTCAATCTCAACGCCCAAGCACTGGCAGGCAAGATCGATCCGTT
GATCGGACGGGAGCGCGAGCTGGAGCGCCTGATACAGACGCTGTGTCGCCGGCGCAAGAACAACCCGTTATTGGTGGGGG
AAGCAGGAGTAGGCAAAACAGCTATTGCTGAAGGTCTGGCACGGCGAATCATCGAGAACGACGTCCCCGAGATCCTTGCA
CATCATCAGGTTTATGCCCTGGATATGGGAGCGCTGCTGGCGGGTACCAAATACCGGGGTGATTTCGAGCAACGCCTGAA
GGCCGTACTCAAACAGTTGCTCGAGAGCTCGAATGCCATACTATTCATCGACGAAATTCACACCCTGATCGGGGCTGGCG
CAGCTTCCGGAGGCACGCTGGATGCCTCCAATCTATTGAAACCGATACTGAATACCGGACAGCTGAAATGCATTGGCGCC
ACGACTTACAGCGAATATCGCGGAATCTTCGAAAAGGATCATGCGCTTTCACGGCGCTTCCAGAAGATCGATGTGCTCGA
ACCGAGCGTGGATGAAACGGTTTCCATACTGCGTGGCTTGAAAGCGCGTTATGAGGCCCATCATGGTGTCAAATATACCG
CTACCGCGCTTACGACCGCCGCCGAGTTGTCGGCACGCTTTATCAACGACCGGCACTTGCCTGACAAGGCAATCGATGTG
ATCGATGAAGCCGGCGCAGCACAGCGTGTTTTACCCAAATCGAAGCAGCGCAAGGTAATCAGCAGGCATGAGATAGAGGT
CATCATTGCCAAGATTGCGCGTATTCCGGCGCAGAATATTTCCAGTGACGATCGCAACACGTTGAAGACGCTTGATCGTG
ACCTGAAAGCGGTTGTGTTCGGTCAGGACAAGGCCATCAACGCGCTGACAGCCTCGATCAAGATGGCGAGAAGTGGTCTC
GGGAATCCACAAAAGCCGGTTGGCTCTTTCCTTTTTTCCGGCCCGACCGGAGTCGGCAAAACCGAGGTTGCACGGCAGCT
GGCCTATGCGCTTGGTATTCACCTGCACCGTTTCGACATGTCTGAATATATGGAACGGCACGCTGTTTCGCGTTTGATCG
GCGCGCCGCCCGGGTATGTCGGATTTGATCAGGGTGGTTTGCTCACCGAAGCCATTATCAAGCAACCCTATTCCGTGCTG
CTGCTGGACGAAATTGAAAAGGCGCATCCCGATATTTTCAATATCCTGCTGCAAGTGATGGATCACGGCACATTGACGGA
CAATAACGGCCGCAAGGCGGATTTCCGTAATGTCGTCATCATCATGACGACCAATGCCGGAGCGGAAGCGTTGAGCAAGG
CTACCATGGGCTTCACCAAGGCCGCGCAGGCAGGGGATGAGATGGCCGATATCAAGCGGATGTTCACGCCTGAGTTCCGC
AATCGGCTGGATGCGATCATTTCCTTTGCGCCGCTAGAGAGAGAAGTGATTCTGCGCGTAGTGGATAAATTCCTGATGCA
GCTTGAAGCCCAGTTGCAGGAAAAGAAAGTGGATGCGATATTCACCGACGCACTGAGAGAGTATCTTGCCAATAATGGTG
TGGATCCTCTCATGGGCGCACGACCGATGGCGCGTCTCATTCAGGACACCATACGCAGCGCTCTGGCGGATGAATTACTG
TTCGGACGTCTGGCCAATGGCGGCAGAGTGACAGTGGATATCGATACCGATAACAAGGTGAAGCTTCAGTTTGAGGAAGA
GGCGGCGACAGCGATATAA

Upstream 100 bases:

>100_bases
GTTTATCCCAATGATGTGGCTTCCACAAAAGTCGAACAGGTGGTTGCATTTGCAAGGCAGCATCAGCATCCGCTACAGTG
CGTGATGGAGGAGAACTGAA

Downstream 100 bases:

>100_bases
CTCGGCTTTCAGGGTAGAAAACAAGGAAGGCGCGAATTTCCGCGCCTTTTTTGTTTTTGTCTTTTTTACTTTGCCTCGGA
TGCTGTTCCGATTATTCCCC

Product: ATPase with chaperone activity

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 752

Protein sequence:

>752_residues
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPTAAEVLRACSVDMDDLRRLLTEHVTENTPTVGGSGEVDTQPT
LGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLHQKGVTRLDVVNYISHGISKVPQGTNAKTESEGDTEQ
EMNAGGALESYAVNLNAQALAGKIDPLIGRERELERLIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIIENDVPEILA
HHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLLESSNAILFIDEIHTLIGAGAASGGTLDASNLLKPILNTGQLKCIGA
TTYSEYRGIFEKDHALSRRFQKIDVLEPSVDETVSILRGLKARYEAHHGVKYTATALTTAAELSARFINDRHLPDKAIDV
IDEAGAAQRVLPKSKQRKVISRHEIEVIIAKIARIPAQNISSDDRNTLKTLDRDLKAVVFGQDKAINALTASIKMARSGL
GNPQKPVGSFLFSGPTGVGKTEVARQLAYALGIHLHRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAIIKQPYSVL
LLDEIEKAHPDIFNILLQVMDHGTLTDNNGRKADFRNVVIIMTTNAGAEALSKATMGFTKAAQAGDEMADIKRMFTPEFR
NRLDAIISFAPLEREVILRVVDKFLMQLEAQLQEKKVDAIFTDALREYLANNGVDPLMGARPMARLIQDTIRSALADELL
FGRLANGGRVTVDIDTDNKVKLQFEEEAATAI

Sequences:

>Translated_752_residues
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPTAAEVLRACSVDMDDLRRLLTEHVTENTPTVGGSGEVDTQPT
LGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLHQKGVTRLDVVNYISHGISKVPQGTNAKTESEGDTEQ
EMNAGGALESYAVNLNAQALAGKIDPLIGRERELERLIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIIENDVPEILA
HHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLLESSNAILFIDEIHTLIGAGAASGGTLDASNLLKPILNTGQLKCIGA
TTYSEYRGIFEKDHALSRRFQKIDVLEPSVDETVSILRGLKARYEAHHGVKYTATALTTAAELSARFINDRHLPDKAIDV
IDEAGAAQRVLPKSKQRKVISRHEIEVIIAKIARIPAQNISSDDRNTLKTLDRDLKAVVFGQDKAINALTASIKMARSGL
GNPQKPVGSFLFSGPTGVGKTEVARQLAYALGIHLHRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAIIKQPYSVL
LLDEIEKAHPDIFNILLQVMDHGTLTDNNGRKADFRNVVIIMTTNAGAEALSKATMGFTKAAQAGDEMADIKRMFTPEFR
NRLDAIISFAPLEREVILRVVDKFLMQLEAQLQEKKVDAIFTDALREYLANNGVDPLMGARPMARLIQDTIRSALADELL
FGRLANGGRVTVDIDTDNKVKLQFEEEAATAI
>Mature_752_residues
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPTAAEVLRACSVDMDDLRRLLTEHVTENTPTVGGSGEVDTQPT
LGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLHQKGVTRLDVVNYISHGISKVPQGTNAKTESEGDTEQ
EMNAGGALESYAVNLNAQALAGKIDPLIGRERELERLIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIIENDVPEILA
HHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLLESSNAILFIDEIHTLIGAGAASGGTLDASNLLKPILNTGQLKCIGA
TTYSEYRGIFEKDHALSRRFQKIDVLEPSVDETVSILRGLKARYEAHHGVKYTATALTTAAELSARFINDRHLPDKAIDV
IDEAGAAQRVLPKSKQRKVISRHEIEVIIAKIARIPAQNISSDDRNTLKTLDRDLKAVVFGQDKAINALTASIKMARSGL
GNPQKPVGSFLFSGPTGVGKTEVARQLAYALGIHLHRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAIIKQPYSVL
LLDEIEKAHPDIFNILLQVMDHGTLTDNNGRKADFRNVVIIMTTNAGAEALSKATMGFTKAAQAGDEMADIKRMFTPEFR
NRLDAIISFAPLEREVILRVVDKFLMQLEAQLQEKKVDAIFTDALREYLANNGVDPLMGARPMARLIQDTIRSALADELL
FGRLANGGRVTVDIDTDNKVKLQFEEEAATAI

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=332, Percent_Identity=28.0120481927711, Blast_Score=148, Evalue=2e-35,
Organism=Escherichia coli, GI1787109, Length=747, Percent_Identity=62.516733601071, Blast_Score=967, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=397, Percent_Identity=45.3400503778337, Blast_Score=306, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6320464, Length=250, Percent_Identity=56.8, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6323002, Length=429, Percent_Identity=38.6946386946387, Blast_Score=273, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 82538; Mature: 82538

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2 ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPTAAEVLRACSVDMDDLRRLLTE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
HVTENTPTVGGSGEVDTQPTLGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAV
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YFLHQKGVTRLDVVNYISHGISKVPQGTNAKTESEGDTEQEMNAGGALESYAVNLNAQAL
EEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCHHHHEECCCHHHH
AGKIDPLIGRERELERLIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIIENDVPEILA
HCCCCHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHH
HHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLLESSNAILFIDEIHTLIGAGAASGGTL
HCHHEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCC
DASNLLKPILNTGQLKCIGATTYSEYRGIFEKDHALSRRFQKIDVLEPSVDETVSILRGL
CHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KARYEAHHGVKYTATALTTAAELSARFINDRHLPDKAIDVIDEAGAAQRVLPKSKQRKVI
HHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCHHHHHHH
SRHEIEVIIAKIARIPAQNISSDDRNTLKTLDRDLKAVVFGQDKAINALTASIKMARSGL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCC
GNPQKPVGSFLFSGPTGVGKTEVARQLAYALGIHLHRFDMSEYMERHAVSRLIGAPPGYV
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
GFDQGGLLTEAIIKQPYSVLLLDEIEKAHPDIFNILLQVMDHGTLTDNNGRKADFRNVVI
CCCCCCHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
IMTTNAGAEALSKATMGFTKAAQAGDEMADIKRMFTPEFRNRLDAIISFAPLEREVILRV
EEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
VDKFLMQLEAQLQEKKVDAIFTDALREYLANNGVDPLMGARPMARLIQDTIRSALADELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FGRLANGGRVTVDIDTDNKVKLQFEEEAATAI
HHHCCCCCEEEEEECCCCEEEEEECHHHCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFVESRQKRHEFITVEHLLLALLDNPTAAEVLRACSVDMDDLRRLLTE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
HVTENTPTVGGSGEVDTQPTLGFQRVIQRAILHVQSSGKKEVTGANVLVAIFGEKDSHAV
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YFLHQKGVTRLDVVNYISHGISKVPQGTNAKTESEGDTEQEMNAGGALESYAVNLNAQAL
EEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCHHHHEECCCHHHH
AGKIDPLIGRERELERLIQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIIENDVPEILA
HCCCCHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHH
HHQVYALDMGALLAGTKYRGDFEQRLKAVLKQLLESSNAILFIDEIHTLIGAGAASGGTL
HCHHEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCC
DASNLLKPILNTGQLKCIGATTYSEYRGIFEKDHALSRRFQKIDVLEPSVDETVSILRGL
CHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KARYEAHHGVKYTATALTTAAELSARFINDRHLPDKAIDVIDEAGAAQRVLPKSKQRKVI
HHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCHHHHHHH
SRHEIEVIIAKIARIPAQNISSDDRNTLKTLDRDLKAVVFGQDKAINALTASIKMARSGL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCC
GNPQKPVGSFLFSGPTGVGKTEVARQLAYALGIHLHRFDMSEYMERHAVSRLIGAPPGYV
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
GFDQGGLLTEAIIKQPYSVLLLDEIEKAHPDIFNILLQVMDHGTLTDNNGRKADFRNVVI
CCCCCCHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
IMTTNAGAEALSKATMGFTKAAQAGDEMADIKRMFTPEFRNRLDAIISFAPLEREVILRV
EEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
VDKFLMQLEAQLQEKKVDAIFTDALREYLANNGVDPLMGARPMARLIQDTIRSALADELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FGRLANGGRVTVDIDTDNKVKLQFEEEAATAI
HHHCCCCCEEEEEECCCCEEEEEECHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]