Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 82703363

GI number: 82703363

Start: 2550786

End: 2552039

Strand: Direct

Name: icd [H]

Synonym: Nmul_A2245

Alternate gene names: 82703363

Gene position: 2550786-2552039 (Clockwise)

Preceding gene: 82703360

Following gene: 82703365

Centisome position: 80.11

GC content: 52.63

Gene sequence:

>1254_bases
ATGTATCAGCACATCAGCATACCAGCGGAAGGCTCGAAGATCAGCGTAAATGCGGATTATTCCCTGAATGTGCCGGACAA
CCCGGTCATACCCTATATAGAAGGCGACGGAATCGGGGTGGATATTACTCCGGTAATGAGGAAAGTGGTGGATTCCGCCG
TAGAAAAGGCTTATGAAGGCAAACGCAGGATTTCCTGGATGGAAATCTATGCCGGAGAGAAATCGACGCGTATTTACGGC
GAAAATGTCTGGTTACCCGAGGAAACCCTGCAGGCGGCGAAAGAGTATGTGGTTTCGATCAAGGGTCCGTTGACCACACC
GGTGGGAGGCGGCATCCGCTCCATCAATGTGGCTTTGCGCCAGGAGCTGGATTTGTATGTATGCCTTCGTCCTGTTCGCT
ATTTTCAGGGGGTACCTAGCCCCTTGAAAAATCCGGAGAAAACCGACATGGTCATTTTTCGCGAGAATTCGGAGGACATC
TACGCCGGTATTGAATGGGAAGCCGGGTCGGAAGGCGCTAAAAAAGTTATCGATTTTCTGATGAACGACATGAGCGTCAC
CAAGATACGCTTTCCCCAAACCGCAGGGATCGGCGTAAAGCCGGTATCCCGCGAAGGTACCGAGAGGCTGGTACGCAAGG
CAATTCAATATGCGATAGATAACGGACGGCGCTCGGTAACCCTGGTGCATAAAGGCAACATCATGAAATTTACCGAAGGT
GCGTTCAAGAACTGGGGCTATCAGCTTGCAGCAAAAGAGTTTGGAGCAAGCCTGCTCGACGGCGGACCATGGATGAAGCT
GCCTGAGGATAAAGGCGGTATAGTGATCAAGGATGTGATCGCGGACGCTTTTCTTCAGCAGATTCTGCTGCGGCCGGAGG
AATACGATGTCATCGCCACGTTGAATCTGAACGGCGATTATGTTTCCGATGCTTTGGCTGCGCAGGTAGGCGGCATCGGG
ATCGCCCCCGGCGCAAACATGAGCGACTCGATAGCCATTTTCGAGGCAACCCATGGAACCGCTCCCAAGTATGCCGGCAA
GGACCAGGTCAATCCAGGCTCCATCATTCTGTCCGCGGAGATGATGCTGAGGCATATGGGCTGGGCAGAAGCTGCTGATC
TCATCACGCAGTCGATGGAAAAAACCATTCAGGATAAAACCGTAACTTATGACTTCGCCCGCCTGATGGCCGGTGCGCAA
AAAGTCTCCTGTTCAGCATTTGGGCAGGCCTTGATCGAAAACATGGCCCGTTGA

Upstream 100 bases:

>100_bases
TCTATCCGAAACGCGGTTAAAATATATGAATTTTTTGCCGATCCGGTTCCGGCTTGTTCCGGATTATGGAACCAAGCCCT
GCTCAACAAATGGAGATAGC

Downstream 100 bases:

>100_bases
AAAGATGGCACATCGAAAATCTGCTGCCTTGGGGGCGGAAGGGTAAGCAAGCGGTAAAAGTATTGATGGGTTTGCTGCTT
ATCCTCGACAAGAAAAAGCC

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MYQHISIPAEGSKISVNADYSLNVPDNPVIPYIEGDGIGVDITPVMRKVVDSAVEKAYEGKRRISWMEIYAGEKSTRIYG
ENVWLPEETLQAAKEYVVSIKGPLTTPVGGGIRSINVALRQELDLYVCLRPVRYFQGVPSPLKNPEKTDMVIFRENSEDI
YAGIEWEAGSEGAKKVIDFLMNDMSVTKIRFPQTAGIGVKPVSREGTERLVRKAIQYAIDNGRRSVTLVHKGNIMKFTEG
AFKNWGYQLAAKEFGASLLDGGPWMKLPEDKGGIVIKDVIADAFLQQILLRPEEYDVIATLNLNGDYVSDALAAQVGGIG
IAPGANMSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAEMMLRHMGWAEAADLITQSMEKTIQDKTVTYDFARLMAGAQ
KVSCSAFGQALIENMAR

Sequences:

>Translated_417_residues
MYQHISIPAEGSKISVNADYSLNVPDNPVIPYIEGDGIGVDITPVMRKVVDSAVEKAYEGKRRISWMEIYAGEKSTRIYG
ENVWLPEETLQAAKEYVVSIKGPLTTPVGGGIRSINVALRQELDLYVCLRPVRYFQGVPSPLKNPEKTDMVIFRENSEDI
YAGIEWEAGSEGAKKVIDFLMNDMSVTKIRFPQTAGIGVKPVSREGTERLVRKAIQYAIDNGRRSVTLVHKGNIMKFTEG
AFKNWGYQLAAKEFGASLLDGGPWMKLPEDKGGIVIKDVIADAFLQQILLRPEEYDVIATLNLNGDYVSDALAAQVGGIG
IAPGANMSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAEMMLRHMGWAEAADLITQSMEKTIQDKTVTYDFARLMAGAQ
KVSCSAFGQALIENMAR
>Mature_417_residues
MYQHISIPAEGSKISVNADYSLNVPDNPVIPYIEGDGIGVDITPVMRKVVDSAVEKAYEGKRRISWMEIYAGEKSTRIYG
ENVWLPEETLQAAKEYVVSIKGPLTTPVGGGIRSINVALRQELDLYVCLRPVRYFQGVPSPLKNPEKTDMVIFRENSEDI
YAGIEWEAGSEGAKKVIDFLMNDMSVTKIRFPQTAGIGVKPVSREGTERLVRKAIQYAIDNGRRSVTLVHKGNIMKFTEG
AFKNWGYQLAAKEFGASLLDGGPWMKLPEDKGGIVIKDVIADAFLQQILLRPEEYDVIATLNLNGDYVSDALAAQVGGIG
IAPGANMSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAEMMLRHMGWAEAADLITQSMEKTIQDKTVTYDFARLMAGAQ
KVSCSAFGQALIENMAR

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=388, Percent_Identity=31.701030927835, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI28178816, Length=353, Percent_Identity=27.4787535410765, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI28178821, Length=353, Percent_Identity=27.4787535410765, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI28178838, Length=366, Percent_Identity=25.6830601092896, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI4758582, Length=364, Percent_Identity=25.5494505494505, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI28178819, Length=179, Percent_Identity=31.8435754189944, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=73.8609112709832, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=27.0557029177719, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI87081683, Length=396, Percent_Identity=24.2424242424242, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71986051, Length=358, Percent_Identity=31.5642458100559, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25144293, Length=303, Percent_Identity=32.013201320132, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17505779, Length=295, Percent_Identity=30.5084745762712, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17550882, Length=396, Percent_Identity=25.2525252525253, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324709, Length=391, Percent_Identity=30.1790281329923, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6322097, Length=366, Percent_Identity=30.327868852459, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324291, Length=367, Percent_Identity=28.3378746594005, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24643270, Length=381, Percent_Identity=32.8083989501312, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24643268, Length=381, Percent_Identity=32.8083989501312, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=32.133676092545, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI161078635, Length=276, Percent_Identity=30.4347826086957, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI161078639, Length=278, Percent_Identity=30.2158273381295, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161078633, Length=276, Percent_Identity=30.0724637681159, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24650122, Length=276, Percent_Identity=30.0724637681159, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161078637, Length=276, Percent_Identity=30.0724637681159, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI20130355, Length=388, Percent_Identity=24.2268041237113, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281362242, Length=411, Percent_Identity=26.7639902676399, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648872, Length=411, Percent_Identity=26.7639902676399, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45692; Mature: 45692

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHISIPAEGSKISVNADYSLNVPDNPVIPYIEGDGIGVDITPVMRKVVDSAVEKAYEG
CCCEECCCCCCCEEEEECCEEECCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHH
KRRISWMEIYAGEKSTRIYGENVWLPEETLQAAKEYVVSIKGPLTTPVGGGIRSINVALR
HHCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHH
QELDLYVCLRPVRYFQGVPSPLKNPEKTDMVIFRENSEDIYAGIEWEAGSEGAKKVIDFL
HCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHH
MNDMSVTKIRFPQTAGIGVKPVSREGTERLVRKAIQYAIDNGRRSVTLVHKGNIMKFTEG
HCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCC
AFKNWGYQLAAKEFGASLLDGGPWMKLPEDKGGIVIKDVIADAFLQQILLRPEEYDVIAT
HHHHCCEEEEHHHHCCHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEE
LNLNGDYVSDALAAQVGGIGIAPGANMSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAE
EECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEHH
MMLRHMGWAEAADLITQSMEKTIQDKTVTYDFARLMAGAQKVSCSAFGQALIENMAR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYQHISIPAEGSKISVNADYSLNVPDNPVIPYIEGDGIGVDITPVMRKVVDSAVEKAYEG
CCCEECCCCCCCEEEEECCEEECCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHH
KRRISWMEIYAGEKSTRIYGENVWLPEETLQAAKEYVVSIKGPLTTPVGGGIRSINVALR
HHCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHH
QELDLYVCLRPVRYFQGVPSPLKNPEKTDMVIFRENSEDIYAGIEWEAGSEGAKKVIDFL
HCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHH
MNDMSVTKIRFPQTAGIGVKPVSREGTERLVRKAIQYAIDNGRRSVTLVHKGNIMKFTEG
HCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCC
AFKNWGYQLAAKEFGASLLDGGPWMKLPEDKGGIVIKDVIADAFLQQILLRPEEYDVIAT
HHHHCCEEEEHHHHCCHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEE
LNLNGDYVSDALAAQVGGIGIAPGANMSDSIAIFEATHGTAPKYAGKDQVNPGSIILSAE
EECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEHH
MMLRHMGWAEAADLITQSMEKTIQDKTVTYDFARLMAGAQKVSCSAFGQALIENMAR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]