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The map label for this gene is galK [H]

Identifier: 82703059

GI number: 82703059

Start: 2228720

End: 2229829

Strand: Reverse

Name: galK [H]

Synonym: Nmul_A1938

Alternate gene names: 82703059

Gene position: 2229829-2228720 (Counterclockwise)

Preceding gene: 82703060

Following gene: 82703058

Centisome position: 70.03

GC content: 55.86

Gene sequence:

>1110_bases
GTGAGCAGTTTCGAGTCTGTATTTGGAGATTCGCCTGAGTTTGTGGCACGCGCCCCAGGCCGCGTTAACCTGCTGGGAGA
GCATACTGACTACAACGGAGGTTATGTACTGCCGATTGCAATCGAGCAGCAGACGAGTGTCAGCATGAGCCATAGCAACA
GCAAGCAATACGCATTGTATTCGGAAATGCTCGATGACATCGTTTACTTTACTCTCGGCAAATCTCCAACTGAGCACTTC
GCCACCTACGTATATGGATGTTTGATGGAAGCTCGCGCGGTTGGGATGAAGGTGCCGGTGCTGGATATCTACATTCAATC
AGATGTGCCGATGGGAGCAGGGCTATCCTCCAGTGCAGCGCTTGAGGTAGCGACGTTGCGAGTCCTGCGTGCGCTGACCG
GTTTCCCCCTGGATGATGTGCAAATCGCACAACTTGCTCAGCGCGCAGAAATCCAGTACGCAGGAGTGCGCTGTGGCATC
ATGGATCAGATGGCATCGAGCCTTGCGGGAACCAGAGAGGCCTTGCTGCTGGATACCCTTACGCTTGAGCGGCGCCTGGT
TCCCTTACCGCCTGCTTCGGCTGTGCTGGTACTTGATTCAGGCGTTGTCCGCACGCTTGCGACAAGCGGTTACAATCAGC
GCCGGACAGAGTGTGAAGAGGCGGCACATCAACTTGGAGTGCAATCACTTCGCGAAGTCCATGACATTTCACTGGCGGAC
GCTTTGCCTGAGCCGCTGGGCCGCCGGGTACGCCATATCGTAAGCGAGAACGCGCGCGTGCTGCGGGCGGCGGAATGCAA
CAACGCCGCGGAGTTCGGGATGCTGATGAACGCATCCCATACCAGTTTGCGCGACGATTATGAGGTCTCGGTTCCCCAAC
TTGATCAATTGGTGACCCTGCTTCAGGCTCATCCTGATGTTTATGGAGCGCGCTTGACAGGAGCAGGCTTTGGAGGCGCG
TGCGTCGCCTTATGCAAGCCGGAGTCCTTGCATCAGATTTCCGAAGCGGTGCTGCAAGATTATTCAAGCATGGGCTTGAA
GGGACGCATCCTTGTGCCACCACATTGGGTCGATAGAACTGCTACTGTAGGGGGAGGTTCAGCATCTTGA

Upstream 100 bases:

>100_bases
TGAATATATTCCGCCGTTCTTCCGGCAATCGATCCGGAATTTGCTTTGAGGCTCGAAATCGGAGAGACAGGCAACGCAAC
CCGGATTTTATGGAGGCGGG

Downstream 100 bases:

>100_bases
GCTTTCTGTTTTTTTGAGAATGGCCATGCAAAACCAAGATGGCTTGATGCAGGCAATGGTGCTGGATGCGCCCCGAGAAA
AGGTTCAAGTGCGCCGTATC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSSFESVFGDSPEFVARAPGRVNLLGEHTDYNGGYVLPIAIEQQTSVSMSHSNSKQYALYSEMLDDIVYFTLGKSPTEHF
ATYVYGCLMEARAVGMKVPVLDIYIQSDVPMGAGLSSSAALEVATLRVLRALTGFPLDDVQIAQLAQRAEIQYAGVRCGI
MDQMASSLAGTREALLLDTLTLERRLVPLPPASAVLVLDSGVVRTLATSGYNQRRTECEEAAHQLGVQSLREVHDISLAD
ALPEPLGRRVRHIVSENARVLRAAECNNAAEFGMLMNASHTSLRDDYEVSVPQLDQLVTLLQAHPDVYGARLTGAGFGGA
CVALCKPESLHQISEAVLQDYSSMGLKGRILVPPHWVDRTATVGGGSAS

Sequences:

>Translated_369_residues
MSSFESVFGDSPEFVARAPGRVNLLGEHTDYNGGYVLPIAIEQQTSVSMSHSNSKQYALYSEMLDDIVYFTLGKSPTEHF
ATYVYGCLMEARAVGMKVPVLDIYIQSDVPMGAGLSSSAALEVATLRVLRALTGFPLDDVQIAQLAQRAEIQYAGVRCGI
MDQMASSLAGTREALLLDTLTLERRLVPLPPASAVLVLDSGVVRTLATSGYNQRRTECEEAAHQLGVQSLREVHDISLAD
ALPEPLGRRVRHIVSENARVLRAAECNNAAEFGMLMNASHTSLRDDYEVSVPQLDQLVTLLQAHPDVYGARLTGAGFGGA
CVALCKPESLHQISEAVLQDYSSMGLKGRILVPPHWVDRTATVGGGSAS
>Mature_368_residues
SSFESVFGDSPEFVARAPGRVNLLGEHTDYNGGYVLPIAIEQQTSVSMSHSNSKQYALYSEMLDDIVYFTLGKSPTEHFA
TYVYGCLMEARAVGMKVPVLDIYIQSDVPMGAGLSSSAALEVATLRVLRALTGFPLDDVQIAQLAQRAEIQYAGVRCGIM
DQMASSLAGTREALLLDTLTLERRLVPLPPASAVLVLDSGVVRTLATSGYNQRRTECEEAAHQLGVQSLREVHDISLADA
LPEPLGRRVRHIVSENARVLRAAECNNAAEFGMLMNASHTSLRDDYEVSVPQLDQLVTLLQAHPDVYGARLTGAGFGGAC
VALCKPESLHQISEAVLQDYSSMGLKGRILVPPHWVDRTATVGGGSAS

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=354, Percent_Identity=43.5028248587571, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI48527957, Length=420, Percent_Identity=32.1428571428571, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4503897, Length=420, Percent_Identity=32.1428571428571, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1786972, Length=362, Percent_Identity=41.1602209944751, Blast_Score=241, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71989053, Length=386, Percent_Identity=26.9430051813472, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319494, Length=202, Percent_Identity=31.6831683168317, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320212, Length=261, Percent_Identity=28.3524904214559, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24661292, Length=437, Percent_Identity=25.858123569794, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355577, Length=437, Percent_Identity=25.858123569794, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24661285, Length=437, Percent_Identity=25.858123569794, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 39751; Mature: 39620

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFESVFGDSPEFVARAPGRVNLLGEHTDYNGGYVLPIAIEQQTSVSMSHSNSKQYALY
CCCHHHHHCCCCHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCEEECCCCCCHHHHH
SEMLDDIVYFTLGKSPTEHFATYVYGCLMEARAVGMKVPVLDIYIQSDVPMGAGLSSSAA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHH
LEVATLRVLRALTGFPLDDVQIAQLAQRAEIQYAGVRCGIMDQMASSLAGTREALLLDTL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCEECCHHHHHHHHHCCCHHHHHHHHH
TLERRLVPLPPASAVLVLDSGVVRTLATSGYNQRRTECEEAAHQLGVQSLREVHDISLAD
HHHCCCCCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALPEPLGRRVRHIVSENARVLRAAECNNAAEFGMLMNASHTSLRDDYEVSVPQLDQLVTL
HCCHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHH
LQAHPDVYGARLTGAGFGGACVALCKPESLHQISEAVLQDYSSMGLKGRILVPPHWVDRT
HHHCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
ATVGGGSAS
EECCCCCCC
>Mature Secondary Structure 
SSFESVFGDSPEFVARAPGRVNLLGEHTDYNGGYVLPIAIEQQTSVSMSHSNSKQYALY
CCHHHHHCCCCHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCEEECCCCCCHHHHH
SEMLDDIVYFTLGKSPTEHFATYVYGCLMEARAVGMKVPVLDIYIQSDVPMGAGLSSSAA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHH
LEVATLRVLRALTGFPLDDVQIAQLAQRAEIQYAGVRCGIMDQMASSLAGTREALLLDTL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCEECCHHHHHHHHHCCCHHHHHHHHH
TLERRLVPLPPASAVLVLDSGVVRTLATSGYNQRRTECEEAAHQLGVQSLREVHDISLAD
HHHCCCCCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALPEPLGRRVRHIVSENARVLRAAECNNAAEFGMLMNASHTSLRDDYEVSVPQLDQLVTL
HCCHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHH
LQAHPDVYGARLTGAGFGGACVALCKPESLHQISEAVLQDYSSMGLKGRILVPPHWVDRT
HHHCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
ATVGGGSAS
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA