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The map label for this gene is adhA [H]

Identifier: 82703058

GI number: 82703058

Start: 2227666

End: 2228700

Strand: Reverse

Name: adhA [H]

Synonym: Nmul_A1937

Alternate gene names: 82703058

Gene position: 2228700-2227666 (Counterclockwise)

Preceding gene: 82703059

Following gene: 82703057

Centisome position: 69.99

GC content: 57.2

Gene sequence:

>1035_bases
ATGGCCATGCAAAACCAAGATGGCTTGATGCAGGCAATGGTGCTGGATGCGCCCCGAGAAAAGGTTCAAGTGCGCCGTAT
CCCGCGCCCCCGGCCGGGTCCTGATCAGTTATTGATCGAGATTGCAGCGTGTGCAGTCTGCCGCACCGACCTGCACGTAG
TGGACGGTGAACTGCCTCATCCGAAACTGCCTATTATCCCGGGGCATGAAATCGTTGGACGCGTAATTGCACGCGGAGCG
GATGTTCGGGATTTCGCAGTGGGAGACAGGATCGGTATTCCCTGGCTGGGCTGGACATGCGGTCATTGCCGCTATTGTCT
CGAGGGACGGGAAAACCTGTGCCCGAATGCCAGATTCACCGGTTATCAGATCGACGGCGGTTACGCGGAATATACGGTCG
CAGACGCCCGCTATTGTTTTCGCATTCCGGACCGTTATAGCGACCTGGAAGCTGCCCCGCTGCTGTGCGCCGGATTGATC
GGCTACCGCGCGCTCAAGATGACCGGCAATGCCGAACGGGTAGGTATCTACGGCTTTGGCGCCGCCGCCCACATTGTCGC
TCAAATTCTGCATTATCAAGGGTGCAGACTTTTTGCATTTACACGCCCCGGTGATGCGGCCGCCCAGGAATTCGCCCACA
AGATGGGCGCAGACTGGGTGGGCAGTTCGGATACGATGCCCCCGGAAGAACTCGATGCGGCGATCATCTTCGCTCCGGCA
GGAGCTCTTGTGCCTATCGCTCTGCGCGCTGTTTGTCCCGGTGGAATCGTCGTCTGCGGAGGAATTCACATGAGTGACAT
TCCCGCTTTTCCTTATGACATCCTGTGGCGGGAAAAACGTCTGGTTTCCGTTGCCAATCTTACCCGTCAGGATGGTGAGG
AATTTTTAAAGCTGGCAGCGCAAGTGCCAATCCACGTGACTACGGAATCCTTTCCGCTCGGCGAAGCGAATACGGCTTTG
ACAAGATTGCGGGAAGGAAAGCTGACAGGCGCGGCAGTGCTCATTCCGAAAAAAGGGAACGTTTCCCTCCCCTGA

Upstream 100 bases:

>100_bases
ATGGGCTTGAAGGGACGCATCCTTGTGCCACCACATTGGGTCGATAGAACTGCTACTGTAGGGGGAGGTTCAGCATCTTG
AGCTTTCTGTTTTTTTGAGA

Downstream 100 bases:

>100_bases
GGCGGAATGGATTTCTGGCGTTATGCTGGGTGGATACCGCTGCGAGTAGCGGGTATTGCTGCCCATACCGTCAGACGACC
TTTTGCCCCGTCCTCCCTAA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MAMQNQDGLMQAMVLDAPREKVQVRRIPRPRPGPDQLLIEIAACAVCRTDLHVVDGELPHPKLPIIPGHEIVGRVIARGA
DVRDFAVGDRIGIPWLGWTCGHCRYCLEGRENLCPNARFTGYQIDGGYAEYTVADARYCFRIPDRYSDLEAAPLLCAGLI
GYRALKMTGNAERVGIYGFGAAAHIVAQILHYQGCRLFAFTRPGDAAAQEFAHKMGADWVGSSDTMPPEELDAAIIFAPA
GALVPIALRAVCPGGIVVCGGIHMSDIPAFPYDILWREKRLVSVANLTRQDGEEFLKLAAQVPIHVTTESFPLGEANTAL
TRLREGKLTGAAVLIPKKGNVSLP

Sequences:

>Translated_344_residues
MAMQNQDGLMQAMVLDAPREKVQVRRIPRPRPGPDQLLIEIAACAVCRTDLHVVDGELPHPKLPIIPGHEIVGRVIARGA
DVRDFAVGDRIGIPWLGWTCGHCRYCLEGRENLCPNARFTGYQIDGGYAEYTVADARYCFRIPDRYSDLEAAPLLCAGLI
GYRALKMTGNAERVGIYGFGAAAHIVAQILHYQGCRLFAFTRPGDAAAQEFAHKMGADWVGSSDTMPPEELDAAIIFAPA
GALVPIALRAVCPGGIVVCGGIHMSDIPAFPYDILWREKRLVSVANLTRQDGEEFLKLAAQVPIHVTTESFPLGEANTAL
TRLREGKLTGAAVLIPKKGNVSLP
>Mature_343_residues
AMQNQDGLMQAMVLDAPREKVQVRRIPRPRPGPDQLLIEIAACAVCRTDLHVVDGELPHPKLPIIPGHEIVGRVIARGAD
VRDFAVGDRIGIPWLGWTCGHCRYCLEGRENLCPNARFTGYQIDGGYAEYTVADARYCFRIPDRYSDLEAAPLLCAGLIG
YRALKMTGNAERVGIYGFGAAAHIVAQILHYQGCRLFAFTRPGDAAAQEFAHKMGADWVGSSDTMPPEELDAAIIFAPAG
ALVPIALRAVCPGGIVVCGGIHMSDIPAFPYDILWREKRLVSVANLTRQDGEEFLKLAAQVPIHVTTESFPLGEANTALT
RLREGKLTGAAVLIPKKGNVSLP

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=228, Percent_Identity=25.4385964912281, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87082401, Length=305, Percent_Identity=29.5081967213115, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87081918, Length=319, Percent_Identity=32.2884012539185, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1786518, Length=209, Percent_Identity=39.2344497607655, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790045, Length=210, Percent_Identity=34.2857142857143, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1788073, Length=237, Percent_Identity=30.8016877637131, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=250, Percent_Identity=28, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI226510992, Length=123, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786825, Length=110, Percent_Identity=35.4545454545455, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790718, Length=154, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082125, Length=157, Percent_Identity=29.2993630573248, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=333, Percent_Identity=25.8258258258258, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=349, Percent_Identity=25.214899713467, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=344, Percent_Identity=26.7441860465116, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562876, Length=132, Percent_Identity=35.6060606060606, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=141, Percent_Identity=35.4609929078014, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=197, Percent_Identity=29.9492385786802, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=187, Percent_Identity=29.9465240641711, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=157, Percent_Identity=42.0382165605096, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324486, Length=157, Percent_Identity=39.4904458598726, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323729, Length=157, Percent_Identity=38.8535031847134, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319621, Length=354, Percent_Identity=29.3785310734463, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323980, Length=323, Percent_Identity=28.7925696594427, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319949, Length=343, Percent_Identity=26.530612244898, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=220, Percent_Identity=30, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=205, Percent_Identity=29.7560975609756, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=170, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737897, Length=177, Percent_Identity=29.3785310734463, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137530, Length=155, Percent_Identity=30.9677419354839, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37317; Mature: 37185

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMQNQDGLMQAMVLDAPREKVQVRRIPRPRPGPDQLLIEIAACAVCRTDLHVVDGELPH
CCCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCC
PKLPIIPGHEIVGRVIARGADVRDFAVGDRIGIPWLGWTCGHCRYCLEGRENLCPNARFT
CCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
GYQIDGGYAEYTVADARYCFRIPDRYSDLEAAPLLCAGLIGYRALKMTGNAERVGIYGFG
EEEECCCEEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEEECC
AAAHIVAQILHYQGCRLFAFTRPGDAAAQEFAHKMGADWVGSSDTMPPEELDAAIIFAPA
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCEEEEEECC
GALVPIALRAVCPGGIVVCGGIHMSDIPAFPYDILWREKRLVSVANLTRQDGEEFLKLAA
CHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVPIHVTTESFPLGEANTALTRLREGKLTGAAVLIPKKGNVSLP
CCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
AMQNQDGLMQAMVLDAPREKVQVRRIPRPRPGPDQLLIEIAACAVCRTDLHVVDGELPH
CCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCC
PKLPIIPGHEIVGRVIARGADVRDFAVGDRIGIPWLGWTCGHCRYCLEGRENLCPNARFT
CCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
GYQIDGGYAEYTVADARYCFRIPDRYSDLEAAPLLCAGLIGYRALKMTGNAERVGIYGFG
EEEECCCEEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEEECC
AAAHIVAQILHYQGCRLFAFTRPGDAAAQEFAHKMGADWVGSSDTMPPEELDAAIIFAPA
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCEEEEEECC
GALVPIALRAVCPGGIVVCGGIHMSDIPAFPYDILWREKRLVSVANLTRQDGEEFLKLAA
CHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVPIHVTTESFPLGEANTALTRLREGKLTGAAVLIPKKGNVSLP
CCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]