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The map label for this gene is uvrC

Identifier: 82702400

GI number: 82702400

Start: 1461466

End: 1463286

Strand: Direct

Name: uvrC

Synonym: Nmul_A1271

Alternate gene names: 82702400

Gene position: 1461466-1463286 (Clockwise)

Preceding gene: 82702399

Following gene: 82702401

Centisome position: 45.9

GC content: 54.64

Gene sequence:

>1821_bases
TTGCAGGCAGAACCGGCTTTCGATGCCAAGGCGTTTTGTGCGGGCCTTCCATCCCAGCCTGGAGTCTATCGCATGATGAA
CTCAGCCGGGCAGGTGATTTATGTCGGCAAGGCGATTGATCTCAAGAAGCGTGTTTCTTCCTATTTTCAGAAGAATGGCC
TGGCTCCCCGTACGCAACTCATGGTTTCCCAGATCGCGGGAATCGAGACCACCGTTACGCGATCCGAAGCAGAGGCCCTG
TTACTCGAAAACAACTTAATAAAGAGCTTAAATCCTCGCTATAACATACTATTCAGGGATGACAAATCATATCCCTACGT
GATCTTGAGCGGCCACAGGTTTCCCCGGCTTGGATTTCATCGCGGTCCGCTCGACAAGAAACATCATTATTTTGGTCCCT
TCCCGAATGCGGGAATGGTGCGAGAGAGTATCCAGTTGCTGCAAAAGGTATTCCGGATTCGCACTTGCGAAGACAGTGTT
TTCAGTAATCGTACACGCCCCTGCCTGCTCTACCAGATCAAACGCTGTAGCGGACCCTGCGTCGATCTGGTCAGCGAAGA
AGTTTACGCGGAAGACGCAAGGGATGCGGAGCTATTTCTCCAGGGCAAGCAAACGGAGGTTCTGAAAAGCATTACGAGAA
AAATGCATGAGGCCGCCGAGGAACAGGAATACGAGCAAGCGGCGCTGTTTCGCGACCAGATTCAGTCTCTGCGAAAGATT
TGCGAAAGGCAATTCGTGGATAGCGGGCGAGCGCTGGATGCCGATATCGTCGCCTGCGTGGCAGAGAATAACGGCGGCGG
ACGGGTGTGCGTCAACCTTGCCATGGTCAGGGGAGGACGCCACCTCGGGGACAAGAGTTTTTTTCCGCAAAACGCGGAAG
GATACGATCTCGCTACGGTGGCGGAAGCATTCCTGGCCCAGCACTACCTCAATCGCAGCATCCCAGATCTGATCATCGTG
GGCGAGAGAGTTCCGCGGGAATCTCTCCAGGCTCTGCTCACTCAGCAGGCTGGCCATAAAGTGATCATCAATGTGAATCC
GATAGGTAGCCGGCGTGTTTGGCTGGAAATGGCGACAGAAAATGCCGCCCTTGCCCTGGAACAAATGCTGGGCCGCCAGG
CGAGCCAGGAGGAGCGGCTGCTAGCCTTGCAGCAGGCGCTGGATATGACCGGGTTGAGCCGGATCGAATGTTTCGATATC
AGTCATACAATGGGCGAAGCCACCATCGCTTCCTGCGTGGTTTATGACAACTTCGGCATGCGCAATAGCGAGTACCGCCG
CTACAATATTACTGATATCACGCCGGGAGACGATTATGCGGCCATGCGCGATGTTCTGTCACGGCGCTACCATAAGATTG
CGGAAGGCGAGGGAAATCTGCCTGATCTGATCCTGATCGACGGGGGAAGAGGGCAGATCAACGCTGCTCTCGAGGTCATG
GTAGAGCTGGGGTTGAATGATGCCAACCTGGTAGGCGTGGCAAAAGGCGAGGAGCGCAAGCCGGGACTGGAGCAATTGAT
TTTCCCAGGGGTGAAAAAACCACTACAATTATCAAAGGATCATCCCGGATTGCATCTCATCCAGCAGATTCGGGATGAAG
CGCATCGCTTTGCAATTTACGGTCATCGCGCAAAACTCGGCAAGGCCCGCGTCAGTTCAAGCCTGGAGCAGATCGCCGGT
ATCGGCGCCAAGCGCCGGCAAAGTTTGCTGGCAAGGTTTGGCGGCCTGAAAGGCGTGCGCACTGCGAGCATCGAAGAATT
GCAGCAAGCTGACGGCATCAGCCGCGCGCTCGCAGAGAAAATTTACAGGGAACTGCATTGA

Upstream 100 bases:

>100_bases
CTCATAAGCCCAAATCCTATACGTATATCGCTTTCGATGAAATGCCTCATGAAAACTGGGCCATCGCGGGCACCCTGCTG
GGTGAGGAGGACTGAGCGCC

Downstream 100 bases:

>100_bases
ATCTTGCCCAGCCTGCAGGCTCAGTGGCTTGCAGCGGGACGCTTTCCAGATTCGTTTTTTAATAGCATATTCCCGATCCT
TATGCCTTTTAATCTGCCCA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MQAEPAFDAKAFCAGLPSQPGVYRMMNSAGQVIYVGKAIDLKKRVSSYFQKNGLAPRTQLMVSQIAGIETTVTRSEAEAL
LLENNLIKSLNPRYNILFRDDKSYPYVILSGHRFPRLGFHRGPLDKKHHYFGPFPNAGMVRESIQLLQKVFRIRTCEDSV
FSNRTRPCLLYQIKRCSGPCVDLVSEEVYAEDARDAELFLQGKQTEVLKSITRKMHEAAEEQEYEQAALFRDQIQSLRKI
CERQFVDSGRALDADIVACVAENNGGGRVCVNLAMVRGGRHLGDKSFFPQNAEGYDLATVAEAFLAQHYLNRSIPDLIIV
GERVPRESLQALLTQQAGHKVIINVNPIGSRRVWLEMATENAALALEQMLGRQASQEERLLALQQALDMTGLSRIECFDI
SHTMGEATIASCVVYDNFGMRNSEYRRYNITDITPGDDYAAMRDVLSRRYHKIAEGEGNLPDLILIDGGRGQINAALEVM
VELGLNDANLVGVAKGEERKPGLEQLIFPGVKKPLQLSKDHPGLHLIQQIRDEAHRFAIYGHRAKLGKARVSSSLEQIAG
IGAKRRQSLLARFGGLKGVRTASIEELQQADGISRALAEKIYRELH

Sequences:

>Translated_606_residues
MQAEPAFDAKAFCAGLPSQPGVYRMMNSAGQVIYVGKAIDLKKRVSSYFQKNGLAPRTQLMVSQIAGIETTVTRSEAEAL
LLENNLIKSLNPRYNILFRDDKSYPYVILSGHRFPRLGFHRGPLDKKHHYFGPFPNAGMVRESIQLLQKVFRIRTCEDSV
FSNRTRPCLLYQIKRCSGPCVDLVSEEVYAEDARDAELFLQGKQTEVLKSITRKMHEAAEEQEYEQAALFRDQIQSLRKI
CERQFVDSGRALDADIVACVAENNGGGRVCVNLAMVRGGRHLGDKSFFPQNAEGYDLATVAEAFLAQHYLNRSIPDLIIV
GERVPRESLQALLTQQAGHKVIINVNPIGSRRVWLEMATENAALALEQMLGRQASQEERLLALQQALDMTGLSRIECFDI
SHTMGEATIASCVVYDNFGMRNSEYRRYNITDITPGDDYAAMRDVLSRRYHKIAEGEGNLPDLILIDGGRGQINAALEVM
VELGLNDANLVGVAKGEERKPGLEQLIFPGVKKPLQLSKDHPGLHLIQQIRDEAHRFAIYGHRAKLGKARVSSSLEQIAG
IGAKRRQSLLARFGGLKGVRTASIEELQQADGISRALAEKIYRELH
>Mature_606_residues
MQAEPAFDAKAFCAGLPSQPGVYRMMNSAGQVIYVGKAIDLKKRVSSYFQKNGLAPRTQLMVSQIAGIETTVTRSEAEAL
LLENNLIKSLNPRYNILFRDDKSYPYVILSGHRFPRLGFHRGPLDKKHHYFGPFPNAGMVRESIQLLQKVFRIRTCEDSV
FSNRTRPCLLYQIKRCSGPCVDLVSEEVYAEDARDAELFLQGKQTEVLKSITRKMHEAAEEQEYEQAALFRDQIQSLRKI
CERQFVDSGRALDADIVACVAENNGGGRVCVNLAMVRGGRHLGDKSFFPQNAEGYDLATVAEAFLAQHYLNRSIPDLIIV
GERVPRESLQALLTQQAGHKVIINVNPIGSRRVWLEMATENAALALEQMLGRQASQEERLLALQQALDMTGLSRIECFDI
SHTMGEATIASCVVYDNFGMRNSEYRRYNITDITPGDDYAAMRDVLSRRYHKIAEGEGNLPDLILIDGGRGQINAALEVM
VELGLNDANLVGVAKGEERKPGLEQLIFPGVKKPLQLSKDHPGLHLIQQIRDEAHRFAIYGHRAKLGKARVSSSLEQIAG
IGAKRRQSLLARFGGLKGVRTASIEELQQADGISRALAEKIYRELH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=50.7389162561576, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1788037, Length=191, Percent_Identity=28.2722513089005, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_NITMU (Q2Y9J7)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411966.1
- ProteinModelPortal:   Q2Y9J7
- STRING:   Q2Y9J7
- GeneID:   3784286
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1271
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q2Y9J7
- ProtClustDB:   PRK00558
- BioCyc:   NMUL323848:NMUL_A1271-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 67635; Mature: 67635

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEPAFDAKAFCAGLPSQPGVYRMMNSAGQVIYVGKAIDLKKRVSSYFQKNGLAPRTQL
CCCCCCCCHHHHHCCCCCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHH
MVSQIAGIETTVTRSEAEALLLENNLIKSLNPRYNILFRDDKSYPYVILSGHRFPRLGFH
HHHHHCCCHHEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCC
RGPLDKKHHYFGPFPNAGMVRESIQLLQKVFRIRTCEDSVFSNRTRPCLLYQIKRCSGPC
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHCCCCH
VDLVSEEVYAEDARDAELFLQGKQTEVLKSITRKMHEAAEEQEYEQAALFRDQIQSLRKI
HHHHHHHHHHCCCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CERQFVDSGRALDADIVACVAENNGGGRVCVNLAMVRGGRHLGDKSFFPQNAEGYDLATV
HHHHHHCCCCCCCCEEEEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCHHHHH
AEAFLAQHYLNRSIPDLIIVGERVPRESLQALLTQQAGHKVIINVNPIGSRRVWLEMATE
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCC
NAALALEQMLGRQASQEERLLALQQALDMTGLSRIECFDISHTMGEATIASCVVYDNFGM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHEEEEECCCC
RNSEYRRYNITDITPGDDYAAMRDVLSRRYHKIAEGEGNLPDLILIDGGRGQINAALEVM
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHH
VELGLNDANLVGVAKGEERKPGLEQLIFPGVKKPLQLSKDHPGLHLIQQIRDEAHRFAIY
HHHCCCCCCEEEECCCCCCCCCHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHHHHEEEE
GHRAKLGKARVSSSLEQIAGIGAKRRQSLLARFGGLKGVRTASIEELQQADGISRALAEK
ECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHH
IYRELH
HHHHCC
>Mature Secondary Structure
MQAEPAFDAKAFCAGLPSQPGVYRMMNSAGQVIYVGKAIDLKKRVSSYFQKNGLAPRTQL
CCCCCCCCHHHHHCCCCCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHH
MVSQIAGIETTVTRSEAEALLLENNLIKSLNPRYNILFRDDKSYPYVILSGHRFPRLGFH
HHHHHCCCHHEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCC
RGPLDKKHHYFGPFPNAGMVRESIQLLQKVFRIRTCEDSVFSNRTRPCLLYQIKRCSGPC
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHCCCCH
VDLVSEEVYAEDARDAELFLQGKQTEVLKSITRKMHEAAEEQEYEQAALFRDQIQSLRKI
HHHHHHHHHHCCCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CERQFVDSGRALDADIVACVAENNGGGRVCVNLAMVRGGRHLGDKSFFPQNAEGYDLATV
HHHHHHCCCCCCCCEEEEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCHHHHH
AEAFLAQHYLNRSIPDLIIVGERVPRESLQALLTQQAGHKVIINVNPIGSRRVWLEMATE
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCC
NAALALEQMLGRQASQEERLLALQQALDMTGLSRIECFDISHTMGEATIASCVVYDNFGM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHEEEEECCCC
RNSEYRRYNITDITPGDDYAAMRDVLSRRYHKIAEGEGNLPDLILIDGGRGQINAALEVM
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHH
VELGLNDANLVGVAKGEERKPGLEQLIFPGVKKPLQLSKDHPGLHLIQQIRDEAHRFAIY
HHHCCCCCCEEEECCCCCCCCCHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHHHHEEEE
GHRAKLGKARVSSSLEQIAGIGAKRRQSLLARFGGLKGVRTASIEELQQADGISRALAEK
ECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHH
IYRELH
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA