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The map label for this gene is pyrG

Identifier: 82702356

GI number: 82702356

Start: 1410111

End: 1411811

Strand: Direct

Name: pyrG

Synonym: Nmul_A1227

Alternate gene names: 82702356

Gene position: 1410111-1411811 (Clockwise)

Preceding gene: 82702355

Following gene: 82702357

Centisome position: 44.28

GC content: 55.32

Gene sequence:

>1701_bases
ATGACAAAGTACGTGTTCGTGACCGGAGGGGTGGTTTCTTCTCTGGGGAAAGGCATCGCCGCCGCTTCTCTCGCGGCCAT
TCTCGAAACCCGCGGCATCAAAGTTACCCTGCTCAAGCTGGATCCTTATATCAACGTCGATCCGGGCACCATGAGTCCCT
TTCAGCATGGCGAGGTCTTCGTCACCGAAGATGGCGCGGAAACGGACCTCGACCTGGGGCACTACGAGCGCTTCATCAGT
GGCAAGATGACTCGGCGCAACAACTTTACCACAGGTCAGATTTACGAGAGCGTGATAAAGAAGGAGCGGCGCGGCGACTA
TCTGGGTGGCACCGTGCAAGTCATTCCGCATATCACGGACGAAATCAAGCATTACATCAGGGTGGGTGCCGGAGATGCCC
AGGTAGCCATCGTTGAAATCGGTGGAACCGTAGGGGATATTGAATCGCTGCCCTTTCTGGAAGCGATCCGGCAGATGGCT
GTTCAGCTCCCGCGGGAAGATACTTGTTTCATTCATCTCACATTGCTGCCCTATATCACCTCCGCCGGAGAACTTAAAAC
CAAGCCAACGCAGCACTCGGTAAAGGAGTTGCGCGAAATCGGCATTCAGCCGGATGTGCTGCTGTGCCGCGCCGACCGTG
CACTCCCCGCGGATGAACGCCGCAAAATCGCACTGTTCACCAATGTTCGGGAAGAGGCGGTGATTCTGGCGCTGGATGTG
GACAGCATCTATAAAATCCCCTCGCTGCTGCACGATCAGATGCTGGATGAAATCGTCTGCCATAAGCTGAACCTGCTTGC
CAAGGCCGCGGATCTCAGTACCTGGAAAAAACTGGTTCACGCGCTGGAGCATCCGGAGCGGGTGATAGAAATCGCGCTGG
TTGGAAAATATGTCGACTTGACGGAGTCTTACAAGTCTCTGTCGGAAGCGCTGATTCACGCGGGAATTCACACCCGCAGC
AAAATCAACATTCATTATGTGGATTCCGAGAGTATAGAAAAGGACGGTACGGGCTGTCTGGATGGCATGGATGCTATCCT
GGTGCCCGGGGGGTTTGGAAAACGTGGAGTAGAGGGCAAGATCATGGCCATCCATTTCGCGCGTACCAACCGCATTCCCT
ACCTCGGCATCTGCCTCGGCATGCAACTGGCTGTCATCGAATACGCGCGTAACAAGGCTGGCATGCAAGGGGCGCACAGT
ACCGAGTTTCATCCTGAGACAGCTTATCCCGTTATTGCACTGACTATCGAATGGCGCTCCCGTGAAGGCCAGTTGGAAAT
CAGGACTGCGGATTCCGACCTCGGAGGGACCATGCGTCTGGGCGGTCAGGAATGCTTGCTCAAAGAGGGGTCTCTTGCCC
GCAGAATTTACGGGTCCGACAAAATTATCGAACGGCATCGGCATCGTTACGAGGTTAATAATCAGTACATCCCCCGTCTG
GAACAGGCGGGGATGAGTATCAGCGCAGTATCGGCCGGAGAGGGGTTGTGCGAAATGGTCGAATTGCCACAAACCGAACA
TCCATGGTTTGTTGCCTCCCAGTTCCATCCTGAATTCACCTCGACTCCCCGCGCCGGACACCCTCTCTTTGCGGCATTCA
TCGAGGCGGCGGCTGTGTTCGCGGACAAGAGCCCTTCCAGCGAAGGGGCGATATCGGCTGATAAACCTGAACGCACCACA
ACGGGCGCCTATATCCAATAA

Upstream 100 bases:

>100_bases
CAAAGTACGCGTTGTGGCGATCTCCTTATGACGAAGTCGAATCGGCCGGAAGAGGCGCGTCGCTGGTTGGGGCAAAGGAC
GTATTTATGATCGGCCTCCA

Downstream 100 bases:

>100_bases
CTGTATTGTTGGAGGCGCCTTTCAAGATCGTTTCAGCCTCTAGTCCTCAGGCCGATTCTCCGGTAGTCCTCGGAGAGTGG
CAGAATCGTTTTCAATAACT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILETRGIKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
GKMTRRNNFTTGQIYESVIKKERRGDYLGGTVQVIPHITDEIKHYIRVGAGDAQVAIVEIGGTVGDIESLPFLEAIRQMA
VQLPREDTCFIHLTLLPYITSAGELKTKPTQHSVKELREIGIQPDVLLCRADRALPADERRKIALFTNVREEAVILALDV
DSIYKIPSLLHDQMLDEIVCHKLNLLAKAADLSTWKKLVHALEHPERVIEIALVGKYVDLTESYKSLSEALIHAGIHTRS
KINIHYVDSESIEKDGTGCLDGMDAILVPGGFGKRGVEGKIMAIHFARTNRIPYLGICLGMQLAVIEYARNKAGMQGAHS
TEFHPETAYPVIALTIEWRSREGQLEIRTADSDLGGTMRLGGQECLLKEGSLARRIYGSDKIIERHRHRYEVNNQYIPRL
EQAGMSISAVSAGEGLCEMVELPQTEHPWFVASQFHPEFTSTPRAGHPLFAAFIEAAAVFADKSPSSEGAISADKPERTT
TGAYIQ

Sequences:

>Translated_566_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILETRGIKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
GKMTRRNNFTTGQIYESVIKKERRGDYLGGTVQVIPHITDEIKHYIRVGAGDAQVAIVEIGGTVGDIESLPFLEAIRQMA
VQLPREDTCFIHLTLLPYITSAGELKTKPTQHSVKELREIGIQPDVLLCRADRALPADERRKIALFTNVREEAVILALDV
DSIYKIPSLLHDQMLDEIVCHKLNLLAKAADLSTWKKLVHALEHPERVIEIALVGKYVDLTESYKSLSEALIHAGIHTRS
KINIHYVDSESIEKDGTGCLDGMDAILVPGGFGKRGVEGKIMAIHFARTNRIPYLGICLGMQLAVIEYARNKAGMQGAHS
TEFHPETAYPVIALTIEWRSREGQLEIRTADSDLGGTMRLGGQECLLKEGSLARRIYGSDKIIERHRHRYEVNNQYIPRL
EQAGMSISAVSAGEGLCEMVELPQTEHPWFVASQFHPEFTSTPRAGHPLFAAFIEAAAVFADKSPSSEGAISADKPERTT
TGAYIQ
>Mature_565_residues
TKYVFVTGGVVSSLGKGIAAASLAAILETRGIKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFISG
KMTRRNNFTTGQIYESVIKKERRGDYLGGTVQVIPHITDEIKHYIRVGAGDAQVAIVEIGGTVGDIESLPFLEAIRQMAV
QLPREDTCFIHLTLLPYITSAGELKTKPTQHSVKELREIGIQPDVLLCRADRALPADERRKIALFTNVREEAVILALDVD
SIYKIPSLLHDQMLDEIVCHKLNLLAKAADLSTWKKLVHALEHPERVIEIALVGKYVDLTESYKSLSEALIHAGIHTRSK
INIHYVDSESIEKDGTGCLDGMDAILVPGGFGKRGVEGKIMAIHFARTNRIPYLGICLGMQLAVIEYARNKAGMQGAHST
EFHPETAYPVIALTIEWRSREGQLEIRTADSDLGGTMRLGGQECLLKEGSLARRIYGSDKIIERHRHRYEVNNQYIPRLE
QAGMSISAVSAGEGLCEMVELPQTEHPWFVASQFHPEFTSTPRAGHPLFAAFIEAAAVFADKSPSSEGAISADKPERTTT
GAYIQ

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI28559085, Length=560, Percent_Identity=43.9285714285714, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI28559083, Length=560, Percent_Identity=43.9285714285714, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI221316689, Length=560, Percent_Identity=43.9285714285714, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI148491070, Length=560, Percent_Identity=44.6428571428571, Blast_Score=474, Evalue=1e-133,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=63.2841328413284, Blast_Score=704, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=613, Percent_Identity=38.8254486133768, Blast_Score=420, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322563, Length=571, Percent_Identity=41.3309982486865, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319432, Length=569, Percent_Identity=40.0702987697715, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24664469, Length=559, Percent_Identity=44.0071556350626, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=42.8571428571429, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_NITMU (Q2Y9P1)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411922.1
- HSSP:   P17812
- ProteinModelPortal:   Q2Y9P1
- SMR:   Q2Y9P1
- STRING:   Q2Y9P1
- GeneID:   3785566
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1227
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- PhylomeDB:   Q2Y9P1
- ProtClustDB:   PRK05380
- BioCyc:   NMUL323848:NMUL_A1227-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 62378; Mature: 62247

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 378-378 ACT_SITE 516-516 ACT_SITE 518-518

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYVFVTGGVVSSLGKGIAAASLAAILETRGIKVTLLKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISGKMTRRNNFTTGQIYESVIKKERRGDYLGGTVQVIPHITD
EECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHH
EIKHYIRVGAGDAQVAIVEIGGTVGDIESLPFLEAIRQMAVQLPREDTCFIHLTLLPYIT
HHHHHHEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEHHHHC
SAGELKTKPTQHSVKELREIGIQPDVLLCRADRALPADERRKIALFTNVREEAVILALDV
CCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEH
DSIYKIPSLLHDQMLDEIVCHKLNLLAKAADLSTWKKLVHALEHPERVIEIALVGKYVDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEEECCHHHH
TESYKSLSEALIHAGIHTRSKINIHYVDSESIEKDGTGCLDGMDAILVPGGFGKRGVEGK
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCE
IMAIHFARTNRIPYLGICLGMQLAVIEYARNKAGMQGAHSTEFHPETAYPVIALTIEWRS
EEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEC
REGQLEIRTADSDLGGTMRLGGQECLLKEGSLARRIYGSDKIIERHRHRYEVNNQYIPRL
CCCEEEEEECCCCCCCEEEECCHHHHHCCCCHHHHHCCCHHHHHHHHHHEECCCCCCCCH
EQAGMSISAVSAGEGLCEMVELPQTEHPWFVASQFHPEFTSTPRAGHPLFAAFIEAAAVF
HHCCCEEEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
ADKSPSSEGAISADKPERTTTGAYIQ
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKYVFVTGGVVSSLGKGIAAASLAAILETRGIKVTLLKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISGKMTRRNNFTTGQIYESVIKKERRGDYLGGTVQVIPHITD
EECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHH
EIKHYIRVGAGDAQVAIVEIGGTVGDIESLPFLEAIRQMAVQLPREDTCFIHLTLLPYIT
HHHHHHEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEHHHHC
SAGELKTKPTQHSVKELREIGIQPDVLLCRADRALPADERRKIALFTNVREEAVILALDV
CCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEH
DSIYKIPSLLHDQMLDEIVCHKLNLLAKAADLSTWKKLVHALEHPERVIEIALVGKYVDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEEECCHHHH
TESYKSLSEALIHAGIHTRSKINIHYVDSESIEKDGTGCLDGMDAILVPGGFGKRGVEGK
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCE
IMAIHFARTNRIPYLGICLGMQLAVIEYARNKAGMQGAHSTEFHPETAYPVIALTIEWRS
EEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEC
REGQLEIRTADSDLGGTMRLGGQECLLKEGSLARRIYGSDKIIERHRHRYEVNNQYIPRL
CCCEEEEEECCCCCCCEEEECCHHHHHCCCCHHHHHCCCHHHHHHHHHHEECCCCCCCCH
EQAGMSISAVSAGEGLCEMVELPQTEHPWFVASQFHPEFTSTPRAGHPLFAAFIEAAAVF
HHCCCEEEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
ADKSPSSEGAISADKPERTTTGAYIQ
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA