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The map label for this gene is ccmA

Identifier: 82702346

GI number: 82702346

Start: 1401359

End: 1401979

Strand: Reverse

Name: ccmA

Synonym: Nmul_A1217

Alternate gene names: 82702346

Gene position: 1401979-1401359 (Counterclockwise)

Preceding gene: 82702347

Following gene: 82702345

Centisome position: 44.03

GC content: 59.1

Gene sequence:

>621_bases
ATGCCCACGCTGGAAGGAATTGACCTGACATGCATCCGCGGTGACCGCAAGCTGTTCAGTGGCGTCAATTTTTTGCTCGA
ATCCGGGGGGTTGATGCAGGTTCAGGGCCCCAACGGCAGCGGTAAAACGAGTCTTCTACGCATGTTGTGCGGACTGGCTT
CGCCGGCCGAGGGCGAAATCCGCTGGGATGGTACCCAGATTCGCTCTCTTGGCGGAGATTATTTTGGTGCGATGACCTAT
CTCGGCCATTTAGGCGGGGTAAAAGACGATCTGACTGCCATCGAGAATTTGCGCATCTCCAGCGCACTGGGCGGGGTTGA
TCTGGATGAACGCAAGGCCCATGACGCCTTGCAGCACATGGGATTGGGCGGACGCGAACTGTTGCCTGCCAAGGTGTTGT
CGCAGGGACAGCGCCGCCGGGTGACGCTGGCGCGCCTGCTGGTATGCGGTACCGTGCTCTGGATACTGGATGAGCCCCTG
ACTGCACTCGATACGAGTGCAGTCAAGCTGGTACAAGGTTTGATAGAGCGGCACCTGGAACACGGGGGCATGATCGTGAT
GACCACCCACCAGGAAATCGAGATAGCAGGCGCCGCCATCCAGCGGCTGCAGCTCACCTGA

Upstream 100 bases:

>100_bases
TACTGATTTCCAGCAGTACTGCCGCAGAAACTGGAAGATCAATCCAAAGGCCATCGGCCTTATCGTTACGCTATAATGCT
GACTTTTTTGGCGACTGATA

Downstream 100 bases:

>100_bases
CATGTTTTTCTGGATCCTCCGCCGAGATCTTCTGCTTGCGGCAAGACGCCGCTCCGATGTCCTGACGACGCTGTTTTTTT
TCATCATCGTCGTCAGTCTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MPTLEGIDLTCIRGDRKLFSGVNFLLESGGLMQVQGPNGSGKTSLLRMLCGLASPAEGEIRWDGTQIRSLGGDYFGAMTY
LGHLGGVKDDLTAIENLRISSALGGVDLDERKAHDALQHMGLGGRELLPAKVLSQGQRRRVTLARLLVCGTVLWILDEPL
TALDTSAVKLVQGLIERHLEHGGMIVMTTHQEIEIAGAAIQRLQLT

Sequences:

>Translated_206_residues
MPTLEGIDLTCIRGDRKLFSGVNFLLESGGLMQVQGPNGSGKTSLLRMLCGLASPAEGEIRWDGTQIRSLGGDYFGAMTY
LGHLGGVKDDLTAIENLRISSALGGVDLDERKAHDALQHMGLGGRELLPAKVLSQGQRRRVTLARLLVCGTVLWILDEPL
TALDTSAVKLVQGLIERHLEHGGMIVMTTHQEIEIAGAAIQRLQLT
>Mature_205_residues
PTLEGIDLTCIRGDRKLFSGVNFLLESGGLMQVQGPNGSGKTSLLRMLCGLASPAEGEIRWDGTQIRSLGGDYFGAMTYL
GHLGGVKDDLTAIENLRISSALGGVDLDERKAHDALQHMGLGGRELLPAKVLSQGQRRRVTLARLLVCGTVLWILDEPLT
ALDTSAVKLVQGLIERHLEHGGMIVMTTHQEIEIAGAAIQRLQLT

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI116734710, Length=188, Percent_Identity=31.3829787234043, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4505771, Length=184, Percent_Identity=28.804347826087, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI9961250, Length=184, Percent_Identity=28.804347826087, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI9961252, Length=184, Percent_Identity=28.804347826087, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87082064, Length=206, Percent_Identity=42.2330097087379, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1787105, Length=185, Percent_Identity=29.1891891891892, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786563, Length=187, Percent_Identity=33.1550802139037, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1786698, Length=201, Percent_Identity=27.8606965174129, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI87081782, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI87081709, Length=167, Percent_Identity=30.5389221556886, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788761, Length=207, Percent_Identity=28.0193236714976, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787041, Length=190, Percent_Identity=27.3684210526316, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081834, Length=196, Percent_Identity=28.0612244897959, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787029, Length=205, Percent_Identity=29.2682926829268, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789032, Length=180, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789873, Length=185, Percent_Identity=28.1081081081081, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1788225, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787712, Length=200, Percent_Identity=27.5, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786703, Length=183, Percent_Identity=30.6010928961749, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788165, Length=191, Percent_Identity=30.3664921465969, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788897, Length=190, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1786253, Length=175, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786345, Length=189, Percent_Identity=29.6296296296296, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786872, Length=180, Percent_Identity=29.4444444444444, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=184, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17565586, Length=189, Percent_Identity=28.042328042328, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71992290, Length=185, Percent_Identity=26.4864864864865, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24666092, Length=188, Percent_Identity=31.9148936170213, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19920532, Length=182, Percent_Identity=27.4725274725275, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24580930, Length=182, Percent_Identity=27.4725274725275, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574533, Length=186, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85724864, Length=182, Percent_Identity=27.4725274725275, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24580555, Length=182, Percent_Identity=27.4725274725275, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI85816269, Length=182, Percent_Identity=27.4725274725275, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24580553, Length=182, Percent_Identity=27.4725274725275, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_NITMU (Q2Y9Q1)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411912.1
- ProteinModelPortal:   Q2Y9Q1
- SMR:   Q2Y9Q1
- STRING:   Q2Y9Q1
- GeneID:   3786148
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1217
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   MTYLGHL
- PhylomeDB:   Q2Y9Q1
- ProtClustDB:   PRK13538
- BioCyc:   NMUL323848:NMUL_A1217-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 22163; Mature: 22032

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLEGIDLTCIRGDRKLFSGVNFLLESGGLMQVQGPNGSGKTSLLRMLCGLASPAEGEI
CCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE
RWDGTQIRSLGGDYFGAMTYLGHLGGVKDDLTAIENLRISSALGGVDLDERKAHDALQHM
EECHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GLGGRELLPAKVLSQGQRRRVTLARLLVCGTVLWILDEPLTALDTSAVKLVQGLIERHLE
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
HGGMIVMTTHQEIEIAGAAIQRLQLT
CCCEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTLEGIDLTCIRGDRKLFSGVNFLLESGGLMQVQGPNGSGKTSLLRMLCGLASPAEGEI
CCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE
RWDGTQIRSLGGDYFGAMTYLGHLGGVKDDLTAIENLRISSALGGVDLDERKAHDALQHM
EECHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GLGGRELLPAKVLSQGQRRRVTLARLLVCGTVLWILDEPLTALDTSAVKLVQGLIERHLE
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
HGGMIVMTTHQEIEIAGAAIQRLQLT
CCCEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA