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The map label for this gene is mutL [H]

Identifier: 82702273

GI number: 82702273

Start: 1315184

End: 1317034

Strand: Reverse

Name: mutL [H]

Synonym: Nmul_A1144

Alternate gene names: 82702273

Gene position: 1317034-1315184 (Counterclockwise)

Preceding gene: 82702274

Following gene: 82702272

Centisome position: 41.36

GC content: 57.27

Gene sequence:

>1851_bases
ATGAATGCAATCCAACCCCTGCCCGATCTTCTCATCAGCCAGATTGCGGCGGGAGAAGTCGTTGAACGTCCCGCTTCGGC
GCTCAAGGAACTACTGGAAAACAGCCTCGATGCGGGAGCAACCGAAGTAACGGTGCAGCTTTTCCAGGGCGGTGTCAAGC
TTGTGCGGGTGGCAGACAATGGCGCGGGAATTTCCGGAGAAGACCTGCCCCTTGCACTTGCCCGCCACGCCACCAGCAAG
ATAAGGACTCTGGAGGATTTGCAGAATGTGCCCAGTTTGGGTTTTCGCGGCGAAGCGCTTGCAAGCATCGCTTCCGTTTC
CCGGCTGGCTCTGGTAAGCCGCAGCGCGGGAGATAAGCACGCCTGGCGGATAGAGGCGGAAGCAGGACGGTTCACCCCGC
CTGAGCCTGCTGCGTTCGCCCAGGGAACAGCCGTGGAAATGCGCGATCTCTACTTCAACACTCCCGCCCGGCGGAAATTT
CTGAAAACAGAAGCTACCGAATTTGCGCATTGCGAGAGCGTGTTCAAGCGTATTGCCCTCTCACGGCCCAGCGTCGGTTT
CACCTTGCAGCACAATGGCACTGTACGCAGCCATTTGCGGACAGCGGATGCAAGACTGCGCATTGCTGCAGTATTAGGAG
ATGAATTCAGTCAGGCCTCGGTATTCGTCGATGATCAGGCAGCGGATCTACGGTTATGGGGCATGGCCGCACTCCCTGCC
TACAGCCGGTCTTCTGGCGATGCCCAATATTTCTTCGTCAATGGGCGTTTCGTACGTGACAAACTCGTTGCCCACGCCCT
GCGCGAAGCCTATCGCGACATCCTCCATCTGGATCGGCATCCGGCGTTTGTACTATTCCTGGAAATAAATGGGGGCGGTG
TGGACGTTAACGTGCACCCAAGCAAAACGGAGGTGAGATTCCGCGATCCGCGTGCGCTCCATCAATTCATCTTTCATACG
GTTGACAAGGCTCTGGCCATGCCGCACCTGACGGGTGGAGCAGCAGTACCTGTAGCCGGGAAACTTCCTGAATTCACCCG
GAAGGCAGCCGGAGAAGTATCCCTTGCACCTCCCGCTTATTCCCGGCAGGATGCGATTCCTTTTGCCTCGGCGGCGCCTC
AGATAAAAGCGGCTCAACCGCAGGCTTTCTACCAGGTGCTTTTCGGTTCCGATTCCAATGCCGGCACTCGTCAGACTGGA
TATCAGGCTGGGATCAATGGGCAATCTGCCTTCATGAAGCCGGAAGGGACTGTTCGGGAACCGGAAATCCCGCCATTGGG
ATTCGCGCTGGCGCAGCTTCTCGGCGTCTACATCCTGTCGCAGAATGAAAGAGGCCTGCTTATCGTGGATATGCACGCCG
CGCACGAACGCATCCTGTACGAGAAACTCAAGTCGGCGCTCGACAACCACACGCTCTCCATGCAGCCCCTGCTGATTCCG
GCCGCATTCCGGGCAGATAGCCAGGATATCGCCACGGCGGAAGAAAACAGTGCGGTTTTGCATGATATCGGATTCGAGAT
CTCCCCCTTCTCACCGGTGATGCTCGCGGTACGAGCCGTACCGGCCGCGCTCAAGGATGCCGATGTGGTGACCCTCGCGC
GTGACGTATTGAATGAAATCCGGGAATTTGGAGGGAGTCAGGTACTTGTCAGCAGGCGAAACGAACTCCTCGCCACCATG
GCCTGCCATGGAGCGATTCGGGCTAACCGTAGCCTGAGCATTCCGGAAATGAATGCACTGCTGCGTGAAATGGAAATCAC
TGAACGTTCCGGCCAGTGTAATCACGGCAGGCCCACATGGTTTGAGATCAGCCGCACTGACCTGGATAAGATGTTCATGC
GTGGCAGATAA

Upstream 100 bases:

>100_bases
CGCGACATACGAGCGACAGGCGAAATCTGCAGGAGACTTGTTCAGGGCTTTTCGGCTCCGGGCAGTATAATGAAGAGATG
CCCTGCCAATGTGATCAGCC

Downstream 100 bases:

>100_bases
AAGAATTGCTTGCATCCGGTTATCGCCGGAAAAGTCCGAAATGATTGCACCGTTGCCCCGCTGTATGTCGTGCAGCCATT
GTTACCTTCACCAAAACGCT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MNAIQPLPDLLISQIAAGEVVERPASALKELLENSLDAGATEVTVQLFQGGVKLVRVADNGAGISGEDLPLALARHATSK
IRTLEDLQNVPSLGFRGEALASIASVSRLALVSRSAGDKHAWRIEAEAGRFTPPEPAAFAQGTAVEMRDLYFNTPARRKF
LKTEATEFAHCESVFKRIALSRPSVGFTLQHNGTVRSHLRTADARLRIAAVLGDEFSQASVFVDDQAADLRLWGMAALPA
YSRSSGDAQYFFVNGRFVRDKLVAHALREAYRDILHLDRHPAFVLFLEINGGGVDVNVHPSKTEVRFRDPRALHQFIFHT
VDKALAMPHLTGGAAVPVAGKLPEFTRKAAGEVSLAPPAYSRQDAIPFASAAPQIKAAQPQAFYQVLFGSDSNAGTRQTG
YQAGINGQSAFMKPEGTVREPEIPPLGFALAQLLGVYILSQNERGLLIVDMHAAHERILYEKLKSALDNHTLSMQPLLIP
AAFRADSQDIATAEENSAVLHDIGFEISPFSPVMLAVRAVPAALKDADVVTLARDVLNEIREFGGSQVLVSRRNELLATM
ACHGAIRANRSLSIPEMNALLREMEITERSGQCNHGRPTWFEISRTDLDKMFMRGR

Sequences:

>Translated_616_residues
MNAIQPLPDLLISQIAAGEVVERPASALKELLENSLDAGATEVTVQLFQGGVKLVRVADNGAGISGEDLPLALARHATSK
IRTLEDLQNVPSLGFRGEALASIASVSRLALVSRSAGDKHAWRIEAEAGRFTPPEPAAFAQGTAVEMRDLYFNTPARRKF
LKTEATEFAHCESVFKRIALSRPSVGFTLQHNGTVRSHLRTADARLRIAAVLGDEFSQASVFVDDQAADLRLWGMAALPA
YSRSSGDAQYFFVNGRFVRDKLVAHALREAYRDILHLDRHPAFVLFLEINGGGVDVNVHPSKTEVRFRDPRALHQFIFHT
VDKALAMPHLTGGAAVPVAGKLPEFTRKAAGEVSLAPPAYSRQDAIPFASAAPQIKAAQPQAFYQVLFGSDSNAGTRQTG
YQAGINGQSAFMKPEGTVREPEIPPLGFALAQLLGVYILSQNERGLLIVDMHAAHERILYEKLKSALDNHTLSMQPLLIP
AAFRADSQDIATAEENSAVLHDIGFEISPFSPVMLAVRAVPAALKDADVVTLARDVLNEIREFGGSQVLVSRRNELLATM
ACHGAIRANRSLSIPEMNALLREMEITERSGQCNHGRPTWFEISRTDLDKMFMRGR
>Mature_616_residues
MNAIQPLPDLLISQIAAGEVVERPASALKELLENSLDAGATEVTVQLFQGGVKLVRVADNGAGISGEDLPLALARHATSK
IRTLEDLQNVPSLGFRGEALASIASVSRLALVSRSAGDKHAWRIEAEAGRFTPPEPAAFAQGTAVEMRDLYFNTPARRKF
LKTEATEFAHCESVFKRIALSRPSVGFTLQHNGTVRSHLRTADARLRIAAVLGDEFSQASVFVDDQAADLRLWGMAALPA
YSRSSGDAQYFFVNGRFVRDKLVAHALREAYRDILHLDRHPAFVLFLEINGGGVDVNVHPSKTEVRFRDPRALHQFIFHT
VDKALAMPHLTGGAAVPVAGKLPEFTRKAAGEVSLAPPAYSRQDAIPFASAAPQIKAAQPQAFYQVLFGSDSNAGTRQTG
YQAGINGQSAFMKPEGTVREPEIPPLGFALAQLLGVYILSQNERGLLIVDMHAAHERILYEKLKSALDNHTLSMQPLLIP
AAFRADSQDIATAEENSAVLHDIGFEISPFSPVMLAVRAVPAALKDADVVTLARDVLNEIREFGGSQVLVSRRNELLATM
ACHGAIRANRSLSIPEMNALLREMEITERSGQCNHGRPTWFEISRTDLDKMFMRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=310, Percent_Identity=35.4838709677419, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=27.6923076923077, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=27.6923076923077, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI4505913, Length=339, Percent_Identity=29.2035398230088, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI310128478, Length=339, Percent_Identity=29.2035398230088, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI189458896, Length=314, Percent_Identity=28.6624203821656, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI263191589, Length=216, Percent_Identity=30.5555555555556, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI310128480, Length=291, Percent_Identity=26.4604810996564, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992162, Length=326, Percent_Identity=25.1533742331288, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI91992160, Length=326, Percent_Identity=25.1533742331288, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790612, Length=557, Percent_Identity=39.6768402154399, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71991825, Length=326, Percent_Identity=37.4233128834356, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=348, Percent_Identity=24.1379310344828, Blast_Score=119, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=313, Percent_Identity=35.4632587859425, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=346, Percent_Identity=26.5895953757225, Blast_Score=134, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6325093, Length=188, Percent_Identity=29.2553191489362, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=356, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136968, Length=309, Percent_Identity=36.8932038834951, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17136970, Length=349, Percent_Identity=29.2263610315186, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67126; Mature: 67126

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIQPLPDLLISQIAAGEVVERPASALKELLENSLDAGATEVTVQLFQGGVKLVRVADN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEECC
GAGISGEDLPLALARHATSKIRTLEDLQNVPSLGFRGEALASIASVSRLALVSRSAGDKH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
AWRIEAEAGRFTPPEPAAFAQGTAVEMRDLYFNTPARRKFLKTEATEFAHCESVFKRIAL
EEEEEECCCCCCCCCCCHHCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
SRPSVGFTLQHNGTVRSHLRTADARLRIAAVLGDEFSQASVFVDDQAADLRLWGMAALPA
CCCCCCEEEECCCCHHHHHHHHCHHEEEEEECCCCCCCCEEEECCCCCCEEEECHHHCCC
YSRSSGDAQYFFVNGRFVRDKLVAHALREAYRDILHLDRHPAFVLFLEINGGGVDVNVHP
CCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECC
SKTEVRFRDPRALHQFIFHTVDKALAMPHLTGGAAVPVAGKLPEFTRKAAGEVSLAPPAY
CCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCEEECCCCC
SRQDAIPFASAAPQIKAAQPQAFYQVLFGSDSNAGTRQTGYQAGINGQSAFMKPEGTVRE
CCCCCCCCCCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEECCCCCCCC
PEIPPLGFALAQLLGVYILSQNERGLLIVDMHAAHERILYEKLKSALDNHTLSMQPLLIP
CCCCCHHHHHHHHHHEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEECCCEEEE
AAFRADSQDIATAEENSAVLHDIGFEISPFSPVMLAVRAVPAALKDADVVTLARDVLNEI
HHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
REFGGSQVLVSRRNELLATMACHGAIRANRSLSIPEMNALLREMEITERSGQCNHGRPTW
HHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCE
FEISRTDLDKMFMRGR
EEECHHHHHHHHHCCC
>Mature Secondary Structure
MNAIQPLPDLLISQIAAGEVVERPASALKELLENSLDAGATEVTVQLFQGGVKLVRVADN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEECC
GAGISGEDLPLALARHATSKIRTLEDLQNVPSLGFRGEALASIASVSRLALVSRSAGDKH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
AWRIEAEAGRFTPPEPAAFAQGTAVEMRDLYFNTPARRKFLKTEATEFAHCESVFKRIAL
EEEEEECCCCCCCCCCCHHCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
SRPSVGFTLQHNGTVRSHLRTADARLRIAAVLGDEFSQASVFVDDQAADLRLWGMAALPA
CCCCCCEEEECCCCHHHHHHHHCHHEEEEEECCCCCCCCEEEECCCCCCEEEECHHHCCC
YSRSSGDAQYFFVNGRFVRDKLVAHALREAYRDILHLDRHPAFVLFLEINGGGVDVNVHP
CCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECC
SKTEVRFRDPRALHQFIFHTVDKALAMPHLTGGAAVPVAGKLPEFTRKAAGEVSLAPPAY
CCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCEEECCCCC
SRQDAIPFASAAPQIKAAQPQAFYQVLFGSDSNAGTRQTGYQAGINGQSAFMKPEGTVRE
CCCCCCCCCCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEECCCCCCCC
PEIPPLGFALAQLLGVYILSQNERGLLIVDMHAAHERILYEKLKSALDNHTLSMQPLLIP
CCCCCHHHHHHHHHHEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEECCCEEEE
AAFRADSQDIATAEENSAVLHDIGFEISPFSPVMLAVRAVPAALKDADVVTLARDVLNEI
HHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
REFGGSQVLVSRRNELLATMACHGAIRANRSLSIPEMNALLREMEITERSGQCNHGRPTW
HHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCE
FEISRTDLDKMFMRGR
EEECHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA