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The map label for this gene is nuoN [H]

Identifier: 82702233

GI number: 82702233

Start: 1271333

End: 1272778

Strand: Direct

Name: nuoN [H]

Synonym: Nmul_A1104

Alternate gene names: 82702233

Gene position: 1271333-1272778 (Clockwise)

Preceding gene: 82702232

Following gene: 82702238

Centisome position: 39.93

GC content: 53.8

Gene sequence:

>1446_bases
ATGAATTTTATGCTGCCTAATTTCGCGCCAGCCTATCCGGAAATATTCCTTCTGGTGATGGTGTGCGGAGTATTAATGGC
TGATCTTGCCTGGGGCGACAAGAAGCCCGGCACTGCCTATCTTTTAGCCCAACTGACGTTGTTCGGCTGCATGCTGATCA
CCTTCGGTACCTTGCAACCCGACACAGTCCATACGTTTTCCGGCATGTTTGTCGATGACAGGCTCGCCGACATTCTCAAG
ATGCTGGTTTATATCACCGTCTCCATAGTCCTGGTTTATTCCCGTACTTATATTTCGGAGCGGGGAATACTCAGCGGAGA
ATTCTTCAGCCTGGCGCTGTTCGCGACCCTCGGAATGATGGTCATGATTTCCGCCACCCACTTCATGACACTCTACCTGG
GGTTGGAACTCCTTTCCTTGTCCCTCTATGCGATGGTTGCGTTGAGGCGTGACTCGGCAGGAGCCACGGAGGCCGCAATA
AAGTTTTTTGTCCTGGGTGCTCTGGCATCCGGCTTTCTGCTGTATGGCATGTCGATGATTTATGGGGCCACTGGCTCGCT
TGATATCGCCAGTGTGACAAAAGCGATCGAAGGCGGAATCATCAGCCGGGGTGTGCTGGTTGTCGGTCTGGTTTTCATTG
TGGCCGGCATTAGTTTCAAGCTGAGCGCAGCGCCTTTCCATATGTGGGCGCCCGATGTTTATGAAGGAGCGTCTTCAGCA
GTGGTGCTGTTTGTCGGTTCAGCGCCGAAGCTCGCGGCATTCGGTTTTGTCATGCGCCTGCTGGTGGAAGGCCTGGGTGC
AATGTCCGGCGACTGGCAGGGCATGCTGATCATACTTGCAATCACGTCAATGGTGATCGGCAATATTGCCGCTATCGCCC
AGAGCAACATCAAGCGCATGCTGGCCTATTCCACCATCTCGCACATGGGGTTCATGCTGCTTGGCCTTATCGGCGCGAAT
GAAAACGGCTACAGTGCCGCAATGTTTTACGTCGTGGTCTACGTGCTCATGACAATGGGTACGTTCGGCATTATCATGCT
TCTCTCGCGCGCGGGTTTTGAAGCCGACAAACTGGATGATTACAAAGGGCTCAACCGGCGCAATCCATGGTATGCTTTTA
TCATGCTGCTGCTGATGTTCTCCATGGCTGGCATCCCCCCCACCGTGGGCATTTATGCCAAGCTGTCAGTGCTTCAGGCC
GTGCTGAACGCAGGGTACACCTGGCTCGCCGTGCTGGCTGTGCTCCTTTCGCTGATCGGGGTATTCTATTACCTGCGTAT
CGTCAAGCTCATGTATTTCGACGAGCCTGAAACCGATGCGGTCATCGCACCAAAAGGTGACGTAAAGGTATTGCTGAGCG
CCAACGGCCTCGCAATACTCGCATTCGGCATCTTCCCCCAGTCGCTTATTGCCCTCTGCACCTACGCGATACAGCAATCT
GCTTGA

Upstream 100 bases:

>100_bases
TGACGGAAGTCATGCATACCACAGTTGATGATTTACTTGCGCATGTTGCTCGCAGCAAATTGCAGTGAGTGAAGCGCTCC
GACTCGGCTAAGGATGATAA

Downstream 100 bases:

>100_bases
TCCGCCTTTCCGCATCACAAGCCGCCTATTCCTGCATAAGGGACAGGCGGCGCTTGCAGACGATTCCGTATCTGGACGCG
TGAAGAGGTTTCCATTTATT

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNFMLPNFAPAYPEIFLLVMVCGVLMADLAWGDKKPGTAYLLAQLTLFGCMLITFGTLQPDTVHTFSGMFVDDRLADILK
MLVYITVSIVLVYSRTYISERGILSGEFFSLALFATLGMMVMISATHFMTLYLGLELLSLSLYAMVALRRDSAGATEAAI
KFFVLGALASGFLLYGMSMIYGATGSLDIASVTKAIEGGIISRGVLVVGLVFIVAGISFKLSAAPFHMWAPDVYEGASSA
VVLFVGSAPKLAAFGFVMRLLVEGLGAMSGDWQGMLIILAITSMVIGNIAAIAQSNIKRMLAYSTISHMGFMLLGLIGAN
ENGYSAAMFYVVVYVLMTMGTFGIIMLLSRAGFEADKLDDYKGLNRRNPWYAFIMLLLMFSMAGIPPTVGIYAKLSVLQA
VLNAGYTWLAVLAVLLSLIGVFYYLRIVKLMYFDEPETDAVIAPKGDVKVLLSANGLAILAFGIFPQSLIALCTYAIQQS
A

Sequences:

>Translated_481_residues
MNFMLPNFAPAYPEIFLLVMVCGVLMADLAWGDKKPGTAYLLAQLTLFGCMLITFGTLQPDTVHTFSGMFVDDRLADILK
MLVYITVSIVLVYSRTYISERGILSGEFFSLALFATLGMMVMISATHFMTLYLGLELLSLSLYAMVALRRDSAGATEAAI
KFFVLGALASGFLLYGMSMIYGATGSLDIASVTKAIEGGIISRGVLVVGLVFIVAGISFKLSAAPFHMWAPDVYEGASSA
VVLFVGSAPKLAAFGFVMRLLVEGLGAMSGDWQGMLIILAITSMVIGNIAAIAQSNIKRMLAYSTISHMGFMLLGLIGAN
ENGYSAAMFYVVVYVLMTMGTFGIIMLLSRAGFEADKLDDYKGLNRRNPWYAFIMLLLMFSMAGIPPTVGIYAKLSVLQA
VLNAGYTWLAVLAVLLSLIGVFYYLRIVKLMYFDEPETDAVIAPKGDVKVLLSANGLAILAFGIFPQSLIALCTYAIQQS
A
>Mature_481_residues
MNFMLPNFAPAYPEIFLLVMVCGVLMADLAWGDKKPGTAYLLAQLTLFGCMLITFGTLQPDTVHTFSGMFVDDRLADILK
MLVYITVSIVLVYSRTYISERGILSGEFFSLALFATLGMMVMISATHFMTLYLGLELLSLSLYAMVALRRDSAGATEAAI
KFFVLGALASGFLLYGMSMIYGATGSLDIASVTKAIEGGIISRGVLVVGLVFIVAGISFKLSAAPFHMWAPDVYEGASSA
VVLFVGSAPKLAAFGFVMRLLVEGLGAMSGDWQGMLIILAITSMVIGNIAAIAQSNIKRMLAYSTISHMGFMLLGLIGAN
ENGYSAAMFYVVVYVLMTMGTFGIIMLLSRAGFEADKLDDYKGLNRRNPWYAFIMLLLMFSMAGIPPTVGIYAKLSVLQA
VLNAGYTWLAVLAVLLSLIGVFYYLRIVKLMYFDEPETDAVIAPKGDVKVLLSANGLAILAFGIFPQSLIALCTYAIQQS
A

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=236, Percent_Identity=24.1525423728814, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI145693160, Length=384, Percent_Identity=38.8020833333333, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI1788827, Length=341, Percent_Identity=27.8592375366569, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788614, Length=341, Percent_Identity=21.9941348973607, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788613, Length=295, Percent_Identity=26.1016949152542, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788831, Length=293, Percent_Identity=23.2081911262799, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 51897; Mature: 51897

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFMLPNFAPAYPEIFLLVMVCGVLMADLAWGDKKPGTAYLLAQLTLFGCMLITFGTLQP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DTVHTFSGMFVDDRLADILKMLVYITVSIVLVYSRTYISERGILSGEFFSLALFATLGMM
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VMISATHFMTLYLGLELLSLSLYAMVALRRDSAGATEAAIKFFVLGALASGFLLYGMSMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YGATGSLDIASVTKAIEGGIISRGVLVVGLVFIVAGISFKLSAAPFHMWAPDVYEGASSA
HCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHCCCCCE
VVLFVGSAPKLAAFGFVMRLLVEGLGAMSGDWQGMLIILAITSMVIGNIAAIAQSNIKRM
EEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYSTISHMGFMLLGLIGANENGYSAAMFYVVVYVLMTMGTFGIIMLLSRAGFEADKLDD
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHH
YKGLNRRNPWYAFIMLLLMFSMAGIPPTVGIYAKLSVLQAVLNAGYTWLAVLAVLLSLIG
HCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VFYYLRIVKLMYFDEPETDAVIAPKGDVKVLLSANGLAILAFGIFPQSLIALCTYAIQQS
HHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHCC
A
C
>Mature Secondary Structure
MNFMLPNFAPAYPEIFLLVMVCGVLMADLAWGDKKPGTAYLLAQLTLFGCMLITFGTLQP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DTVHTFSGMFVDDRLADILKMLVYITVSIVLVYSRTYISERGILSGEFFSLALFATLGMM
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VMISATHFMTLYLGLELLSLSLYAMVALRRDSAGATEAAIKFFVLGALASGFLLYGMSMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YGATGSLDIASVTKAIEGGIISRGVLVVGLVFIVAGISFKLSAAPFHMWAPDVYEGASSA
HCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHCCCCCE
VVLFVGSAPKLAAFGFVMRLLVEGLGAMSGDWQGMLIILAITSMVIGNIAAIAQSNIKRM
EEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYSTISHMGFMLLGLIGANENGYSAAMFYVVVYVLMTMGTFGIIMLLSRAGFEADKLDD
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHH
YKGLNRRNPWYAFIMLLLMFSMAGIPPTVGIYAKLSVLQAVLNAGYTWLAVLAVLLSLIG
HCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VFYYLRIVKLMYFDEPETDAVIAPKGDVKVLLSANGLAILAFGIFPQSLIALCTYAIQQS
HHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]