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The map label for this gene is nuoM [H]

Identifier: 82702232

GI number: 82702232

Start: 1269813

End: 1271300

Strand: Direct

Name: nuoM [H]

Synonym: Nmul_A1103

Alternate gene names: 82702232

Gene position: 1269813-1271300 (Clockwise)

Preceding gene: 82702231

Following gene: 82702233

Centisome position: 39.88

GC content: 53.63

Gene sequence:

>1488_bases
ATGTTGTTTGGTTTCCCCCTGTTAAGTCTGGTTATCTGGCTGCCTATCCTCGCCGGTGTTGCTGTACTCGCTACCGGTGG
AGATCGTAATGCTCCCCTTGCGCGCATGATCGCCCTCGTCGGATCTATTGCGGGTTTTCTGGTGGCGATTCCGCTTTATA
CCAGCTTCGATCCGTCGACGAGCACTATGCAATTTGTCGAGAGCCATGTGTGGATCGAACGCTTCAACGTCCACTATCAC
CTCGGGGTGGATGGAATCGCCATGCCCCTGATACTGCTGAATGCTTTTACCACCCCTCTGGTAGTGATCGCGGGATGGGA
AGTGATTACCCGGCGCGTATCGCAGTATATGGGGGCCTTTCTCATCATGTCCGGCATCGTCAACGGTGTTTTTTCGTCGC
TGGATGCAATTCTCTTCTATGTCTTCTGGGAAGCTTCCCTCATTCCGATGTTTCTTATCATTGGCGTGTGGGGGGGACCC
AACCGGGTTTATGCGGCAATCAAGTTTTTCCTTTATACGCTGCTCGGTTCACTGCTGATGCTGGTGGCATTCATCTATCT
TTACCAGGTTTCCGAGGGTAGCTTCTCGATACTTGAATATCATAAACTGCCGTTGTCGATGGCATCGCAGATCCTGATAT
TCATCGCCTTCCTGCTGGCTTTTGCTGTCAAAGTCCCCATGTGGCCCGTCCATACGTGGCTACCCGACGCGCACGTGGAA
GCGCCGACCGGAGGTTCGGTGGTGCTTGCCGCTATCCTGCTGAAAATGGGAGGCTACGGGTTCCTGCGGTTTTCGCTGCC
GATCCTGCCGGATGCGAGTCACCAGCTCGCGGGCATGATGATCGCATTGTCGCTGATCGCGGTCGTCTATATCGGCCTGG
TTGCCCTGGTGCAGGCGGACATGAAAAAGCTGATCGCCTACTCATCGGTGGCACATATGGGTTTCGTCACCCTCGGTTTT
TTCCTGTTCAATAATTACGGCCTCGAAGGCGCCATGGTCCAGATGGTTTCACATGGTTTTATTTCGGCTGCAATGTTTCT
TTGTATTGGCGTCATGTATGACAGGCTGCATTCCCGCCAGATCGTGGATTATGGGGGAGTGGCGCACCGCATGCCTGCCT
TTGCCGCTTTTTTCATGCTGTTTGCCATGGCTAACTCCGGGTTGCCCGGCACCAGCGGTTTCGTCGGCGAGTTCATGGTC
ATCATGGCATCGATGAAAGTGAATTTCTGGTATGCGTTTCTGGCCGCCACGACGCTCATCACAGGCGCAGCTTATACCCT
GTGGATGTACAAGCGCGTGATATTCGGCGCCGTTGTACATCCCGCAGTGGAGGAAATGAAAGATATCGGCGCGCGCGAGA
TTCTTGTATTGACCGTACTCGCGGTGGCGGTATTGGGGATGGGACTATATCCGCTACCCTTGACGGAAGTCATGCATACC
ACAGTTGATGATTTACTTGCGCATGTTGCTCGCAGCAAATTGCAGTGA

Upstream 100 bases:

>100_bases
GTGGTTGTTCTGGTAATGGGACAACGAAAAATACAATAAAAATGTTAGTTGTGGGACCCTCCCGCATCCGCTGCACGCTA
ATGAAAAAAATGGAATAGAC

Downstream 100 bases:

>100_bases
GTGAAGCGCTCCGACTCGGCTAAGGATGATAAATGAATTTTATGCTGCCTAATTTCGCGCCAGCCTATCCGGAAATATTC
CTTCTGGTGATGGTGTGCGG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MLFGFPLLSLVIWLPILAGVAVLATGGDRNAPLARMIALVGSIAGFLVAIPLYTSFDPSTSTMQFVESHVWIERFNVHYH
LGVDGIAMPLILLNAFTTPLVVIAGWEVITRRVSQYMGAFLIMSGIVNGVFSSLDAILFYVFWEASLIPMFLIIGVWGGP
NRVYAAIKFFLYTLLGSLLMLVAFIYLYQVSEGSFSILEYHKLPLSMASQILIFIAFLLAFAVKVPMWPVHTWLPDAHVE
APTGGSVVLAAILLKMGGYGFLRFSLPILPDASHQLAGMMIALSLIAVVYIGLVALVQADMKKLIAYSSVAHMGFVTLGF
FLFNNYGLEGAMVQMVSHGFISAAMFLCIGVMYDRLHSRQIVDYGGVAHRMPAFAAFFMLFAMANSGLPGTSGFVGEFMV
IMASMKVNFWYAFLAATTLITGAAYTLWMYKRVIFGAVVHPAVEEMKDIGAREILVLTVLAVAVLGMGLYPLPLTEVMHT
TVDDLLAHVARSKLQ

Sequences:

>Translated_495_residues
MLFGFPLLSLVIWLPILAGVAVLATGGDRNAPLARMIALVGSIAGFLVAIPLYTSFDPSTSTMQFVESHVWIERFNVHYH
LGVDGIAMPLILLNAFTTPLVVIAGWEVITRRVSQYMGAFLIMSGIVNGVFSSLDAILFYVFWEASLIPMFLIIGVWGGP
NRVYAAIKFFLYTLLGSLLMLVAFIYLYQVSEGSFSILEYHKLPLSMASQILIFIAFLLAFAVKVPMWPVHTWLPDAHVE
APTGGSVVLAAILLKMGGYGFLRFSLPILPDASHQLAGMMIALSLIAVVYIGLVALVQADMKKLIAYSSVAHMGFVTLGF
FLFNNYGLEGAMVQMVSHGFISAAMFLCIGVMYDRLHSRQIVDYGGVAHRMPAFAAFFMLFAMANSGLPGTSGFVGEFMV
IMASMKVNFWYAFLAATTLITGAAYTLWMYKRVIFGAVVHPAVEEMKDIGAREILVLTVLAVAVLGMGLYPLPLTEVMHT
TVDDLLAHVARSKLQ
>Mature_495_residues
MLFGFPLLSLVIWLPILAGVAVLATGGDRNAPLARMIALVGSIAGFLVAIPLYTSFDPSTSTMQFVESHVWIERFNVHYH
LGVDGIAMPLILLNAFTTPLVVIAGWEVITRRVSQYMGAFLIMSGIVNGVFSSLDAILFYVFWEASLIPMFLIIGVWGGP
NRVYAAIKFFLYTLLGSLLMLVAFIYLYQVSEGSFSILEYHKLPLSMASQILIFIAFLLAFAVKVPMWPVHTWLPDAHVE
APTGGSVVLAAILLKMGGYGFLRFSLPILPDASHQLAGMMIALSLIAVVYIGLVALVQADMKKLIAYSSVAHMGFVTLGF
FLFNNYGLEGAMVQMVSHGFISAAMFLCIGVMYDRLHSRQIVDYGGVAHRMPAFAAFFMLFAMANSGLPGTSGFVGEFMV
IMASMKVNFWYAFLAATTLITGAAYTLWMYKRVIFGAVVHPAVEEMKDIGAREILVLTVLAVAVLGMGLYPLPLTEVMHT
TVDDLLAHVARSKLQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=329, Percent_Identity=36.4741641337386, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI251831117, Length=328, Percent_Identity=25.609756097561, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788613, Length=431, Percent_Identity=36.8909512761021, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1788827, Length=278, Percent_Identity=28.7769784172662, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788831, Length=290, Percent_Identity=26.8965517241379, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788829, Length=252, Percent_Identity=30.1587301587302, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI145693160, Length=349, Percent_Identity=24.6418338108883, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788614, Length=418, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI2367154, Length=355, Percent_Identity=23.943661971831, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54107; Mature: 54107

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFGFPLLSLVIWLPILAGVAVLATGGDRNAPLARMIALVGSIAGFLVAIPLYTSFDPST
CCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
STMQFVESHVWIERFNVHYHLGVDGIAMPLILLNAFTTPLVVIAGWEVITRRVSQYMGAF
HHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIMSGIVNGVFSSLDAILFYVFWEASLIPMFLIIGVWGGPNRVYAAIKFFLYTLLGSLLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LVAFIYLYQVSEGSFSILEYHKLPLSMASQILIFIAFLLAFAVKVPMWPVHTWLPDAHVE
HHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
APTGGSVVLAAILLKMGGYGFLRFSLPILPDASHQLAGMMIALSLIAVVYIGLVALVQAD
CCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKKLIAYSSVAHMGFVTLGFFLFNNYGLEGAMVQMVSHGFISAAMFLCIGVMYDRLHSRQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
IVDYGGVAHRMPAFAAFFMLFAMANSGLPGTSGFVGEFMVIMASMKVNFWYAFLAATTLI
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGAAYTLWMYKRVIFGAVVHPAVEEMKDIGAREILVLTVLAVAVLGMGLYPLPLTEVMHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
TVDDLLAHVARSKLQ
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MLFGFPLLSLVIWLPILAGVAVLATGGDRNAPLARMIALVGSIAGFLVAIPLYTSFDPST
CCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
STMQFVESHVWIERFNVHYHLGVDGIAMPLILLNAFTTPLVVIAGWEVITRRVSQYMGAF
HHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIMSGIVNGVFSSLDAILFYVFWEASLIPMFLIIGVWGGPNRVYAAIKFFLYTLLGSLLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LVAFIYLYQVSEGSFSILEYHKLPLSMASQILIFIAFLLAFAVKVPMWPVHTWLPDAHVE
HHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
APTGGSVVLAAILLKMGGYGFLRFSLPILPDASHQLAGMMIALSLIAVVYIGLVALVQAD
CCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKKLIAYSSVAHMGFVTLGFFLFNNYGLEGAMVQMVSHGFISAAMFLCIGVMYDRLHSRQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
IVDYGGVAHRMPAFAAFFMLFAMANSGLPGTSGFVGEFMVIMASMKVNFWYAFLAATTLI
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGAAYTLWMYKRVIFGAVVHPAVEEMKDIGAREILVLTVLAVAVLGMGLYPLPLTEVMHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
TVDDLLAHVARSKLQ
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]