Click here to switch to the map view.

The map label for this gene is nuoD

Identifier: 82702223

GI number: 82702223

Start: 1259407

End: 1260660

Strand: Direct

Name: nuoD

Synonym: Nmul_A1094

Alternate gene names: 82702223

Gene position: 1259407-1260660 (Clockwise)

Preceding gene: 82702222

Following gene: 82702224

Centisome position: 39.55

GC content: 54.47

Gene sequence:

>1254_bases
ATGGCTGAGATACGTAATTACACGATGAACTTCGGCCCGCAGCATCCGGCCGCCCACGGTGTCTTGCGACTGGTGCTGGA
GCTCGACGGGGAAGTCATACAACGTGCCGATCCGCACATCGGTCTGCTGCATCGTGCAACGGAAAAGCTTGCCGAGTACA
AGACATATATCCAGTCAGTCCCTTACATGGACAGATTGGACTACGTCTCCATGATGGCCAACGAGCACGCGTATGTGATG
GCGATCGAGAAGTTGCTTCAACTCGAAGTGCCCATACGCGCGCAGTATATCCGGGTGATGTTCGACGAAATCACGCGGAT
ACTCAATCATCTTCTGTGGCTGGGAGCACACGCGCTGGATGTGGGCGCGATGACGGTATTCCTTTACGCTTTCCGTGACC
GGGAAGACTTGATGGATGCCTACGAATCGGTTTCGGGCGCAAGGATGCATGCCGCTTACTATCGGCCTGGCGGCGTTTAT
CGGGACTTGCCGGATTCAATGCCGCAGTATAAGGCGTCAAAAATTCACGACGAAAAAACAACCAAGGCGCGCAATGAAAA
CCGCCAGGGTTCGCTGCTCGATTTCATCGAAGACTTCACCAACCGGTTTCCCACGTACGTCGATGAGTACGAGACCCTGC
TTACCGATAACCGTATCTGGAAACAGAGACTGGTAGGCATTGGAACGGTTTCGCCCGAGCGGGCCATGGCTCTGGGATTC
ACCGGCCCCATGCTGCGCGGGTCCGGCGTCGAATGGGATCTGCGGAAGAAGCAGCCCTATGAAGTTTATGATCAGCTCGA
TTTCGATATACCTGTCGGCGTCAATGGGGATTGCTACGACCGCTATCTGGTCCGGATCGAAGAATTCCGGCAGTCCAATC
GCATCATCAGGCAATGTGTCGACTGGCTTCGTAAAAATCCGGGGCCGGTCATAACGGATAACCACAAGGTCGCGCCGCCT
TCCCGTGTGAACATGAAGCAGAACATGGAGGAACTGATCCATCATTTCAAGCTTTTCACTGAAGGGTTTCACGTGCCGCC
CGGTGAAACCTATGCGGCAGTCGAGCACCCGAAAGGGGAATTCGGCATTTACCTGATATCGGATGGCGCCAACATGCCTT
ACCGCATGAAAATCCGCGCTCCCGGCTTTGCCCATCTGGCAGCGCTGGACGAGATGTCGCGCGGCCATATGATTGCCGAT
GTGGTTGCCATCATTGGTACCCAGGATATTGTGTTTGGTGAAATAGACAGATGA

Upstream 100 bases:

>100_bases
CTATCAGCCGGTCACCATAGAACCGCGCCAGATCACGCCGCGCGTTATCCGGGAAGAGCATTATGGGGACTCTGAATGAG
ATTTTTGTGGGCTGTTAACG

Downstream 100 bases:

>100_bases
CGTACTGAAGGTGAAACGGCTATCAACATGCTAAGCGCAGAGTCTCTGAAAAAAATCGATTACGAGTTGACCAAGTATCC
CGCAGACCAGAAGCAATCCG

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEYKTYIQSVPYMDRLDYVSMMANEHAYVM
AIEKLLQLEVPIRAQYIRVMFDEITRILNHLLWLGAHALDVGAMTVFLYAFRDREDLMDAYESVSGARMHAAYYRPGGVY
RDLPDSMPQYKASKIHDEKTTKARNENRQGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVGIGTVSPERAMALGF
TGPMLRGSGVEWDLRKKQPYEVYDQLDFDIPVGVNGDCYDRYLVRIEEFRQSNRIIRQCVDWLRKNPGPVITDNHKVAPP
SRVNMKQNMEELIHHFKLFTEGFHVPPGETYAAVEHPKGEFGIYLISDGANMPYRMKIRAPGFAHLAALDEMSRGHMIAD
VVAIIGTQDIVFGEIDR

Sequences:

>Translated_417_residues
MAEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEYKTYIQSVPYMDRLDYVSMMANEHAYVM
AIEKLLQLEVPIRAQYIRVMFDEITRILNHLLWLGAHALDVGAMTVFLYAFRDREDLMDAYESVSGARMHAAYYRPGGVY
RDLPDSMPQYKASKIHDEKTTKARNENRQGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVGIGTVSPERAMALGF
TGPMLRGSGVEWDLRKKQPYEVYDQLDFDIPVGVNGDCYDRYLVRIEEFRQSNRIIRQCVDWLRKNPGPVITDNHKVAPP
SRVNMKQNMEELIHHFKLFTEGFHVPPGETYAAVEHPKGEFGIYLISDGANMPYRMKIRAPGFAHLAALDEMSRGHMIAD
VVAIIGTQDIVFGEIDR
>Mature_416_residues
AEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEYKTYIQSVPYMDRLDYVSMMANEHAYVMA
IEKLLQLEVPIRAQYIRVMFDEITRILNHLLWLGAHALDVGAMTVFLYAFRDREDLMDAYESVSGARMHAAYYRPGGVYR
DLPDSMPQYKASKIHDEKTTKARNENRQGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVGIGTVSPERAMALGFT
GPMLRGSGVEWDLRKKQPYEVYDQLDFDIPVGVNGDCYDRYLVRIEEFRQSNRIIRQCVDWLRKNPGPVITDNHKVAPPS
RVNMKQNMEELIHHFKLFTEGFHVPPGETYAAVEHPKGEFGIYLISDGANMPYRMKIRAPGFAHLAALDEMSRGHMIADV
VAIIGTQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=61.1111111111111, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=60.2941176470588, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.0487804878049, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1789076, Length=419, Percent_Identity=28.4009546539379, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=27.2058823529412, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=57.8313253012048, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=57.1084337349398, Blast_Score=490, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=61.2048192771084, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI221459469, Length=414, Percent_Identity=56.280193236715, Blast_Score=481, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_NITMU (Q2YA24)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411789.1
- HSSP:   Q56220
- STRING:   Q2YA24
- GeneID:   3784709
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1094
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   MADVITI
- PhylomeDB:   Q2YA24
- ProtClustDB:   PRK06075
- BioCyc:   NMUL323848:NMUL_A1094-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 47988; Mature: 47856

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEYKTYIQSV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMANEHAYVMAIEKLLQLEVPIRAQYIRVMFDEITRILNHLLWLGAHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMTVFLYAFRDREDLMDAYESVSGARMHAAYYRPGGVYRDLPDSMPQYKASKIHDEKT
HHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCHHH
TKARNENRQGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVGIGTVSPERAMALGF
HHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHEEECC
TGPMLRGSGVEWDLRKKQPYEVYDQLDFDIPVGVNGDCYDRYLVRIEEFRQSNRIIRQCV
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLRKNPGPVITDNHKVAPPSRVNMKQNMEELIHHFKLFTEGFHVPPGETYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
FGIYLISDGANMPYRMKIRAPGFAHLAALDEMSRGHMIADVVAIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCC
>Mature Secondary Structure 
AEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEYKTYIQSV
CCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMANEHAYVMAIEKLLQLEVPIRAQYIRVMFDEITRILNHLLWLGAHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMTVFLYAFRDREDLMDAYESVSGARMHAAYYRPGGVYRDLPDSMPQYKASKIHDEKT
HHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCHHH
TKARNENRQGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVGIGTVSPERAMALGF
HHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHEEECC
TGPMLRGSGVEWDLRKKQPYEVYDQLDFDIPVGVNGDCYDRYLVRIEEFRQSNRIIRQCV
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLRKNPGPVITDNHKVAPPSRVNMKQNMEELIHHFKLFTEGFHVPPGETYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
FGIYLISDGANMPYRMKIRAPGFAHLAALDEMSRGHMIADVVAIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA