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The map label for this gene is nuoE [H]

Identifier: 82702224

GI number: 82702224

Start: 1260688

End: 1261164

Strand: Direct

Name: nuoE [H]

Synonym: Nmul_A1095

Alternate gene names: 82702224

Gene position: 1260688-1261164 (Clockwise)

Preceding gene: 82702223

Following gene: 82702225

Centisome position: 39.59

GC content: 51.36

Gene sequence:

>477_bases
ATGCTAAGCGCAGAGTCTCTGAAAAAAATCGATTACGAGTTGACCAAGTATCCCGCAGACCAGAAGCAATCCGCGGTAAT
GTCGGCGCTCGCCATCGCCCAGGATGAGAAAGGGTGGCTGACCACCGAAACGATGGATTTTGTGGCGGAGTACTTGGGCA
TGCCGTCGATCGCCGTATACGAAGTGGCTACTTTCTACACCATGTACAATTTGCAGCCCATCGGAAAATACAAGATCACG
GTCTGCACGAATCTTCCATGTGCGCTGTCCGGCGCAAACGAGGCAGTCGCCCATTTCCGGGAAAAGCTGGGAATAGGCTT
CAACGAAACCACTGCGGACGGAAAATTTACCTTGAAAGAAGGGGAGTGTATGGGTGCATGTGGAGATGCGCCGGTTCTCC
TGGTCAATAACAAACGCATGTGCAGTTTCATGTCCAACGACAAGATCGACCAGTTGCTGGAGGATTTGAGCAAATGA

Upstream 100 bases:

>100_bases
CGGCCATATGATTGCCGATGTGGTTGCCATCATTGGTACCCAGGATATTGTGTTTGGTGAAATAGACAGATGACGTACTG
AAGGTGAAACGGCTATCAAC

Downstream 100 bases:

>100_bases
ACCAGCCTGCCCAGATACTGCTGGCCGGATTGAATCCATCGGATCCCAACGATTGGCGGCTGAATAATTACGAACAGCGT
GAAGGATATGCTGCGCTCAG

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MLSAESLKKIDYELTKYPADQKQSAVMSALAIAQDEKGWLTTETMDFVAEYLGMPSIAVYEVATFYTMYNLQPIGKYKIT
VCTNLPCALSGANEAVAHFREKLGIGFNETTADGKFTLKEGECMGACGDAPVLLVNNKRMCSFMSNDKIDQLLEDLSK

Sequences:

>Translated_158_residues
MLSAESLKKIDYELTKYPADQKQSAVMSALAIAQDEKGWLTTETMDFVAEYLGMPSIAVYEVATFYTMYNLQPIGKYKIT
VCTNLPCALSGANEAVAHFREKLGIGFNETTADGKFTLKEGECMGACGDAPVLLVNNKRMCSFMSNDKIDQLLEDLSK
>Mature_158_residues
MLSAESLKKIDYELTKYPADQKQSAVMSALAIAQDEKGWLTTETMDFVAEYLGMPSIAVYEVATFYTMYNLQPIGKYKIT
VCTNLPCALSGANEAVAHFREKLGIGFNETTADGKFTLKEGECMGACGDAPVLLVNNKRMCSFMSNDKIDQLLEDLSK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=155, Percent_Identity=42.5806451612903, Blast_Score=137, Evalue=5e-33,
Organism=Escherichia coli, GI1788621, Length=153, Percent_Identity=32.0261437908497, Blast_Score=93, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17561328, Length=155, Percent_Identity=41.2903225806452, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI18859877, Length=155, Percent_Identity=43.2258064516129, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21355353, Length=136, Percent_Identity=38.9705882352941, Blast_Score=113, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 17420; Mature: 17420

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSAESLKKIDYELTKYPADQKQSAVMSALAIAQDEKGWLTTETMDFVAEYLGMPSIAVY
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCHHHH
EVATFYTMYNLQPIGKYKITVCTNLPCALSGANEAVAHFREKLGIGFNETTADGKFTLKE
HHHHHHHHHCCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEC
GECMGACGDAPVLLVNNKRMCSFMSNDKIDQLLEDLSK
CCEECCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MLSAESLKKIDYELTKYPADQKQSAVMSALAIAQDEKGWLTTETMDFVAEYLGMPSIAVY
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCHHHH
EVATFYTMYNLQPIGKYKITVCTNLPCALSGANEAVAHFREKLGIGFNETTADGKFTLKE
HHHHHHHHHCCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEC
GECMGACGDAPVLLVNNKRMCSFMSNDKIDQLLEDLSK
CCEECCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]