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The map label for this gene is mcl1 [H]

Identifier: 82702207

GI number: 82702207

Start: 1244109

End: 1245059

Strand: Direct

Name: mcl1 [H]

Synonym: Nmul_A1078

Alternate gene names: 82702207

Gene position: 1244109-1245059 (Clockwise)

Preceding gene: 82702206

Following gene: 82702208

Centisome position: 39.07

GC content: 54.68

Gene sequence:

>951_bases
ATGAGTCATACACTATATGAAGCCTCTGTCATTCGTGTGCAACGATGCGAACTGGCTGTTCCCGGTTCAAATCCTGGCAT
GTTCGAGAAAGCCCTGAAAAGCGGGGTAGATTTCGTTTTTCTCGATCTCGAAGACGCCGTTGCCCCGGATGACAAGCTGA
CTGCGCGAAAAAACGTTATCGAGGCGCTCAACGACCTGGATTGGAGAGGTCACGGGGTGACTGTTTCAGTACGGATAAAC
GGTCTGGATACCCAGTTCATGGTTCGTGATGTGGTGGATGTGGTCGAAAAAGCAGGCCATAAACTGGATACCATACTGAT
CCCGAAGGTGGGAGTATATTCTGATGTCTATATGGTTGAAGCCATGCTCAACCAGCTGGAGATGCAGCAGGGATTGAAAA
ACCGGATAGGCATTGAAGCATTGATTGAAACGGCCCTGGGTATGGCGAATGTGGAAGACATCGCGCGCCATGGTGTGCGC
GGACGGCTGGAGGCGCTCCACTTCGGGGTGGCGGATTACGCGGCCAGCAATCGCGCCAGAACGACAAATATCGGCGGCCT
CAATCCGGACTATCCTGGGGACCAGTGGCATGCCGCCATCAGCCGGATGACTGTCGCCTGCCGTGCCTATGGTTTAAGGC
CGATAGATGGTCCTTTTGGCGATATCCAGGATCCGGAAGGCTATAAAGCGGCGGCCCGACGAGCTGCCGCTTTGGGCTGT
GAAGGTAAATGGGCTATCCATCCGTCGCAAATCGATCTTGCCAACGAGGTTTTCACGCCACCTCCATCCGAAGTTGAAAA
AGCACAACGTATCCTTGCGGCATTGCAGGAAGCGGCAGCTCAAGGGAAAGGGGCAGCTGCGCTGGACGGGCGCCTGATCG
ATGCCGCATCCGCAAGAATGGCCAATAACGTGGTAAAAATGGCAGAGGCGATAGGCGCAACCGCGACATAG

Upstream 100 bases:

>100_bases
GATAAGCAGAGCTGAGCCGGATGTCTTCAGCCATCCGGGCCGCGCCAGTTCCCCTCCCCATCAGTCTCCAAAATTAAATA
ACTCAATCAGGAAGGAGCAA

Downstream 100 bases:

>100_bases
CCTTCCGACCGCATCGAGCGGTCTTTCTTTTTCTCCTGATCCTGCCGGTGGAGACACTCAGGTTGGCCGGTACATTACTG
TGAAGTGTGAAGCCGTTTCC

Product: citrate lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSHTLYEASVIRVQRCELAVPGSNPGMFEKALKSGVDFVFLDLEDAVAPDDKLTARKNVIEALNDLDWRGHGVTVSVRIN
GLDTQFMVRDVVDVVEKAGHKLDTILIPKVGVYSDVYMVEAMLNQLEMQQGLKNRIGIEALIETALGMANVEDIARHGVR
GRLEALHFGVADYAASNRARTTNIGGLNPDYPGDQWHAAISRMTVACRAYGLRPIDGPFGDIQDPEGYKAAARRAAALGC
EGKWAIHPSQIDLANEVFTPPPSEVEKAQRILAALQEAAAQGKGAAALDGRLIDAASARMANNVVKMAEAIGATAT

Sequences:

>Translated_316_residues
MSHTLYEASVIRVQRCELAVPGSNPGMFEKALKSGVDFVFLDLEDAVAPDDKLTARKNVIEALNDLDWRGHGVTVSVRIN
GLDTQFMVRDVVDVVEKAGHKLDTILIPKVGVYSDVYMVEAMLNQLEMQQGLKNRIGIEALIETALGMANVEDIARHGVR
GRLEALHFGVADYAASNRARTTNIGGLNPDYPGDQWHAAISRMTVACRAYGLRPIDGPFGDIQDPEGYKAAARRAAALGC
EGKWAIHPSQIDLANEVFTPPPSEVEKAQRILAALQEAAAQGKGAAALDGRLIDAASARMANNVVKMAEAIGATAT
>Mature_315_residues
SHTLYEASVIRVQRCELAVPGSNPGMFEKALKSGVDFVFLDLEDAVAPDDKLTARKNVIEALNDLDWRGHGVTVSVRING
LDTQFMVRDVVDVVEKAGHKLDTILIPKVGVYSDVYMVEAMLNQLEMQQGLKNRIGIEALIETALGMANVEDIARHGVRG
RLEALHFGVADYAASNRARTTNIGGLNPDYPGDQWHAAISRMTVACRAYGLRPIDGPFGDIQDPEGYKAAARRAAALGCE
GKWAIHPSQIDLANEVFTPPPSEVEKAQRILAALQEAAAQGKGAAALDGRLIDAASARMANNVVKMAEAIGATAT

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=305, Percent_Identity=28.1967213114754, Blast_Score=114, Evalue=9e-26,
Organism=Escherichia coli, GI87081764, Length=302, Percent_Identity=30.4635761589404, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17557458, Length=307, Percent_Identity=28.0130293159609, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 33969; Mature: 33838

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTLYEASVIRVQRCELAVPGSNPGMFEKALKSGVDFVFLDLEDAVAPDDKLTARKNVI
CCCCHHHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCEEEEECHHHCCCCHHHHHHHHHH
EALNDLDWRGHGVTVSVRINGLDTQFMVRDVVDVVEKAGHKLDTILIPKVGVYSDVYMVE
HHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
AMLNQLEMQQGLKNRIGIEALIETALGMANVEDIARHGVRGRLEALHFGVADYAASNRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
TTNIGGLNPDYPGDQWHAAISRMTVACRAYGLRPIDGPFGDIQDPEGYKAAARRAAALGC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
EGKWAIHPSQIDLANEVFTPPPSEVEKAQRILAALQEAAAQGKGAAALDGRLIDAASARM
CCCEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHH
ANNVVKMAEAIGATAT
HHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SHTLYEASVIRVQRCELAVPGSNPGMFEKALKSGVDFVFLDLEDAVAPDDKLTARKNVI
CCCHHHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCEEEEECHHHCCCCHHHHHHHHHH
EALNDLDWRGHGVTVSVRINGLDTQFMVRDVVDVVEKAGHKLDTILIPKVGVYSDVYMVE
HHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
AMLNQLEMQQGLKNRIGIEALIETALGMANVEDIARHGVRGRLEALHFGVADYAASNRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
TTNIGGLNPDYPGDQWHAAISRMTVACRAYGLRPIDGPFGDIQDPEGYKAAARRAAALGC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
EGKWAIHPSQIDLANEVFTPPPSEVEKAQRILAALQEAAAQGKGAAALDGRLIDAASARM
CCCEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHH
ANNVVKMAEAIGATAT
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA