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The map label for this gene is sucC [H]

Identifier: 82702208

GI number: 82702208

Start: 1245277

End: 1246467

Strand: Direct

Name: sucC [H]

Synonym: Nmul_A1079

Alternate gene names: 82702208

Gene position: 1245277-1246467 (Clockwise)

Preceding gene: 82702207

Following gene: 82702209

Centisome position: 39.11

GC content: 54.83

Gene sequence:

>1191_bases
TTGGATATACATGAGTATCAGGCAAAAGAAATTTTAATGAGGTATGGGGTCAAGATAGCGGAAGGGGGGTTGGCATATAC
GATAGAAGAAAGTGTGCAGCGTGCCAGGGAAATCGACGGCAATGTATGGGTGGTGAAGGCGCAGATCCATTCGGGGGGGC
GGGGCAAGGCGGGCGGCATCAAGGTATGCAGGACTCATGACGAAGTCCGGGCAGCCTCTGAGGAGTTGCTGGGAAAGATT
CTGGTGACCCGTCAGACCGGAGCCGTGGGGAAGGTGTGTACACGGGTATATGTGGAAGCGGGCACGCACATTGCCAGGGA
GATGTATCTCTGCTTTCTGATAGACAGGAGTTCGGAGCGCATCGTCATGATAGGCTCGGGGCAGGGTGGAATGGAAATCG
AGGAACTGGCTCACACAAATCCTCAGGCCATCAAGAAGATTTTTATCGAACCCGCAGTTGGGTTGCAGGATTTTCAAGCG
AGAGAGATGGCTTTTGCACTAGGGGTGGAAGCGGCACAACTGCCTCATGCCGTTAAAACCATTCGGGGGTGTTACCGCGC
CTTGCGTGATCTGGATGCGAACATGGTGGAAATCAACCCCCTCGTGATCACTGGGAGCGGCGAACTTCTTGCTCTTGACG
CAAAAATGAGCTTCGACGAAAACGCCTTGTTTCGCCGGCACGAGGTTGCCGAATTGCGTGATAAAACACAAGCCGATCCT
CGGGAGGTGGCAGCCTCCGATCATGGCTTGAGCTACATCGGATTGAACGGTGACATCGGATGCATGATAAACGGCGCCGG
GCTTGCCATGGCAACGATGGATATGATCAAGCTCGCGGGCGGCGAGCCGGCAAATTTCCTTGATGTGGGAGGAGGGGCGT
CCGCGGAGCGTACGGAAAAGGCGTTTCGCCTGGTTTTGGCTGATAAAGGAGTCAAGGCGATGCTGGTCAATATTTTTGCA
GGTATTAATCGCTGCGACTGGATTGCGCAAGGCGTCGTGCAGGCGGTAAGAAATATCGATATGAAAATCCCGCTGGTCGT
GCGCTTGTCCGGTACAAATGTCGAGGAGGGCCAGCGGATCATTGCCGAAAGCGGTTTGCCGATCATCACAGCGGGAACGC
TGGCGGAAGCAGCGGAGAAGGTTGTCCAGGCGCGCAATGGCGCGGTTGCGGAAGAGTGCAAAGGGATATAA

Upstream 100 bases:

>100_bases
TGTGCTTGAGCAATTCAAGGAATCCATGAAGCCTCCTGAATTGCGAGAGTCATGACCCCGGGGAATAGTGAAAATCATTG
TTGATAAATAAGGTGACGCA

Downstream 100 bases:

>100_bases
ATGGCGATTTTAATTGATGAGAACACACGGATCATAGTTCAGGGTTTCACCGGCAAGATCGGTACCTTTCATGCACAGGA
TATGATCAATTACGGTTCCA

Product: malate--CoA ligase subunit beta

Products: NA

Alternate protein names: MTK-beta; Malate thiokinase; Malyl-CoA synthetase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MDIHEYQAKEILMRYGVKIAEGGLAYTIEESVQRAREIDGNVWVVKAQIHSGGRGKAGGIKVCRTHDEVRAASEELLGKI
LVTRQTGAVGKVCTRVYVEAGTHIAREMYLCFLIDRSSERIVMIGSGQGGMEIEELAHTNPQAIKKIFIEPAVGLQDFQA
REMAFALGVEAAQLPHAVKTIRGCYRALRDLDANMVEINPLVITGSGELLALDAKMSFDENALFRRHEVAELRDKTQADP
REVAASDHGLSYIGLNGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEKAFRLVLADKGVKAMLVNIFA
GINRCDWIAQGVVQAVRNIDMKIPLVVRLSGTNVEEGQRIIAESGLPIITAGTLAEAAEKVVQARNGAVAEECKGI

Sequences:

>Translated_396_residues
MDIHEYQAKEILMRYGVKIAEGGLAYTIEESVQRAREIDGNVWVVKAQIHSGGRGKAGGIKVCRTHDEVRAASEELLGKI
LVTRQTGAVGKVCTRVYVEAGTHIAREMYLCFLIDRSSERIVMIGSGQGGMEIEELAHTNPQAIKKIFIEPAVGLQDFQA
REMAFALGVEAAQLPHAVKTIRGCYRALRDLDANMVEINPLVITGSGELLALDAKMSFDENALFRRHEVAELRDKTQADP
REVAASDHGLSYIGLNGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEKAFRLVLADKGVKAMLVNIFA
GINRCDWIAQGVVQAVRNIDMKIPLVVRLSGTNVEEGQRIIAESGLPIITAGTLAEAAEKVVQARNGAVAEECKGI
>Mature_396_residues
MDIHEYQAKEILMRYGVKIAEGGLAYTIEESVQRAREIDGNVWVVKAQIHSGGRGKAGGIKVCRTHDEVRAASEELLGKI
LVTRQTGAVGKVCTRVYVEAGTHIAREMYLCFLIDRSSERIVMIGSGQGGMEIEELAHTNPQAIKKIFIEPAVGLQDFQA
REMAFALGVEAAQLPHAVKTIRGCYRALRDLDANMVEINPLVITGSGELLALDAKMSFDENALFRRHEVAELRDKTQADP
REVAASDHGLSYIGLNGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEKAFRLVLADKGVKAMLVNIFA
GINRCDWIAQGVVQAVRNIDMKIPLVVRLSGTNVEEGQRIIAESGLPIITAGTLAEAAEKVVQARNGAVAEECKGI

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=390, Percent_Identity=43.3333333333333, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI157779135, Length=378, Percent_Identity=42.0634920634921, Blast_Score=304, Evalue=9e-83,
Organism=Homo sapiens, GI294862256, Length=363, Percent_Identity=41.0468319559229, Blast_Score=281, Evalue=7e-76,
Organism=Escherichia coli, GI1786948, Length=387, Percent_Identity=49.3540051679587, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17567829, Length=392, Percent_Identity=44.8979591836735, Blast_Score=325, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17539378, Length=393, Percent_Identity=41.9847328244275, Blast_Score=303, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6321683, Length=393, Percent_Identity=42.4936386768448, Blast_Score=330, Evalue=3e-91,
Organism=Drosophila melanogaster, GI21356231, Length=394, Percent_Identity=40.3553299492386, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI161078106, Length=390, Percent_Identity=40.2564102564103, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24645208, Length=390, Percent_Identity=40.2564102564103, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI281361397, Length=391, Percent_Identity=40.6649616368286, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI281361395, Length=391, Percent_Identity=40.6649616368286, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.9 [H]

Molecular weight: Translated: 42638; Mature: 42638

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIHEYQAKEILMRYGVKIAEGGLAYTIEESVQRAREIDGNVWVVKAQIHSGGRGKAGGI
CCCHHHHHHHHHHHCCCEEECCCEEEEHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCE
KVCRTHDEVRAASEELLGKILVTRQTGAVGKVCTRVYVEAGTHIAREMYLCFLIDRSSER
EEEECHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCHHHHHHEEEEEEEECCCCE
IVMIGSGQGGMEIEELAHTNPQAIKKIFIEPAVGLQDFQAREMAFALGVEAAQLPHAVKT
EEEEECCCCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
IRGCYRALRDLDANMVEINPLVITGSGELLALDAKMSFDENALFRRHEVAELRDKTQADP
HHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCH
REVAASDHGLSYIGLNGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEK
HHHHCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHH
AFRLVLADKGVKAMLVNIFAGINRCDWIAQGVVQAVRNIDMKIPLVVRLSGTNVEEGQRI
HHEEEHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHH
IAESGLPIITAGTLAEAAEKVVQARNGAVAEECKGI
HHHCCCCEEEECHHHHHHHHHHHHCCCCCHHHHCCC
>Mature Secondary Structure
MDIHEYQAKEILMRYGVKIAEGGLAYTIEESVQRAREIDGNVWVVKAQIHSGGRGKAGGI
CCCHHHHHHHHHHHCCCEEECCCEEEEHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCE
KVCRTHDEVRAASEELLGKILVTRQTGAVGKVCTRVYVEAGTHIAREMYLCFLIDRSSER
EEEECHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCHHHHHHEEEEEEEECCCCE
IVMIGSGQGGMEIEELAHTNPQAIKKIFIEPAVGLQDFQAREMAFALGVEAAQLPHAVKT
EEEEECCCCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
IRGCYRALRDLDANMVEINPLVITGSGELLALDAKMSFDENALFRRHEVAELRDKTQADP
HHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCH
REVAASDHGLSYIGLNGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEK
HHHHCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHH
AFRLVLADKGVKAMLVNIFAGINRCDWIAQGVVQAVRNIDMKIPLVVRLSGTNVEEGQRI
HHEEEHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHH
IAESGLPIITAGTLAEAAEKVVQARNGAVAEECKGI
HHHCCCCEEEECHHHHHHHHHHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961516 [H]