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The map label for this gene is fabH

Identifier: 82702201

GI number: 82702201

Start: 1238303

End: 1239262

Strand: Direct

Name: fabH

Synonym: Nmul_A1072

Alternate gene names: 82702201

Gene position: 1238303-1239262 (Clockwise)

Preceding gene: 82702200

Following gene: 82702202

Centisome position: 38.89

GC content: 55.94

Gene sequence:

>960_bases
ATGAAGTACGCCAGAGTCATTGGAACAGGCAGTTATTTGCCCGAGAAAATTCTCACCAATCATGATCTGGAGCGCATGGT
CGACACGAGCGACGAGTGGATCCGGACCCGTACCGGCATTGCACAACGGCACATCGCCGCCGACTCGGAAATGGCGAGCG
ATCTCGCCTTGAACGCGAGCCGTGAAGCAATAAAGGCAGGTGGGATCGACGCGCGGGAGATCGAGCTGGTAATTGTCGCC
ACCACTACGCCCGACATGATATTTCCCAGCACGGCGTGCATCCTGCAGGACAAGCTCGGTATCGGGGATTGCGCCGCATT
TGATGTACAGGCGGTATGCAGCGGTTTTATCTACGCGCTTGCCACTGCAGATATGTTCATTCGAGCCGGGAAATGCCAGA
CGGCGCTGGTTGTTGGGGCAGAAGTCTATTCACGTATATTGGACTGGAGCGACCGCAGCACTTGCGTATTGTTCGGTGAC
GGCGCCGGCGCTGTGCTGCTGACGGGCGATGAACGGCCCGGAGTCCTTTCAACGCATTTGCATGCGGACGGGAGCCAGAG
CAAGATTCTTTCCGCGCCGGCTAACATCTGTGGCGGCAAAGTACAAGGCAAACCCTTTGTCGTGATGGAGGGTAATACGG
TTTTCAAGTTTGCAGTAAAGGTTCTTGAAGAAGTCGTACACGAGGCTTTGACTGAAAACAATCTGGAGTCGTCGGATATC
GATTGGCTGATCCCGCACCAGGCCAATATCCGTATTATTGCTTCGACCGCAAAAAAACTCGGCATTCCCATGGATAAGGT
CGTTGCCACCGTGGATAAGCACGGCAACACTTCCGCCGCCTCGATTCCGCTTGCCCTCGACATCGCTGCCCGCGACGGAC
GCATCAAATCCGGCCAGCATGTGCTTCTGGAAGGCGTGGGGGGAGGTTTTACCTGGGGAGCGGCATTGATCCGCTGGTAA

Upstream 100 bases:

>100_bases
GCGGCATGTTGCGCCATATAAGCGAGCGGGTGGCGCAATTATCGCATCAATCCATGCAATCCTCCTCATACCGCCGGTCG
CTCCCGGAAGAGAGCCCGGT

Downstream 100 bases:

>100_bases
GCCAGTTCCTGCTGCTTGCCTCCTACATTTTAATTATTCTTGTTTCAGTTCCCTTTTCAGCCGGATTTTAACAACTTTTT
TTCTTCGGCTCGAAGGTTTT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKYARVIGTGSYLPEKILTNHDLERMVDTSDEWIRTRTGIAQRHIAADSEMASDLALNASREAIKAGGIDAREIELVIVA
TTTPDMIFPSTACILQDKLGIGDCAAFDVQAVCSGFIYALATADMFIRAGKCQTALVVGAEVYSRILDWSDRSTCVLFGD
GAGAVLLTGDERPGVLSTHLHADGSQSKILSAPANICGGKVQGKPFVVMEGNTVFKFAVKVLEEVVHEALTENNLESSDI
DWLIPHQANIRIIASTAKKLGIPMDKVVATVDKHGNTSAASIPLALDIAARDGRIKSGQHVLLEGVGGGFTWGAALIRW

Sequences:

>Translated_319_residues
MKYARVIGTGSYLPEKILTNHDLERMVDTSDEWIRTRTGIAQRHIAADSEMASDLALNASREAIKAGGIDAREIELVIVA
TTTPDMIFPSTACILQDKLGIGDCAAFDVQAVCSGFIYALATADMFIRAGKCQTALVVGAEVYSRILDWSDRSTCVLFGD
GAGAVLLTGDERPGVLSTHLHADGSQSKILSAPANICGGKVQGKPFVVMEGNTVFKFAVKVLEEVVHEALTENNLESSDI
DWLIPHQANIRIIASTAKKLGIPMDKVVATVDKHGNTSAASIPLALDIAARDGRIKSGQHVLLEGVGGGFTWGAALIRW
>Mature_319_residues
MKYARVIGTGSYLPEKILTNHDLERMVDTSDEWIRTRTGIAQRHIAADSEMASDLALNASREAIKAGGIDAREIELVIVA
TTTPDMIFPSTACILQDKLGIGDCAAFDVQAVCSGFIYALATADMFIRAGKCQTALVVGAEVYSRILDWSDRSTCVLFGD
GAGAVLLTGDERPGVLSTHLHADGSQSKILSAPANICGGKVQGKPFVVMEGNTVFKFAVKVLEEVVHEALTENNLESSDI
DWLIPHQANIRIIASTAKKLGIPMDKVVATVDKHGNTSAASIPLALDIAARDGRIKSGQHVLLEGVGGGFTWGAALIRW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=56.4668769716088, Blast_Score=371, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_NITMU (Q2YA46)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411767.1
- ProteinModelPortal:   Q2YA46
- SMR:   Q2YA46
- STRING:   Q2YA46
- GeneID:   3784686
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1072
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- PhylomeDB:   Q2YA46
- ProtClustDB:   PRK09352
- BioCyc:   NMUL323848:NMUL_A1072-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34015; Mature: 34015

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 246-246 ACT_SITE 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYARVIGTGSYLPEKILTNHDLERMVDTSDEWIRTRTGIAQRHIAADSEMASDLALNAS
CCCEEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
REAIKAGGIDAREIELVIVATTTPDMIFPSTACILQDKLGIGDCAAFDVQAVCSGFIYAL
HHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHH
ATADMFIRAGKCQTALVVGAEVYSRILDWSDRSTCVLFGDGAGAVLLTGDERPGVLSTHL
HHHHHHEECCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEE
HADGSQSKILSAPANICGGKVQGKPFVVMEGNTVFKFAVKVLEEVVHEALTENNLESSDI
ECCCCCCCEEECCHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DWLIPHQANIRIIASTAKKLGIPMDKVVATVDKHGNTSAASIPLALDIAARDGRIKSGQH
CEECCCCCCEEEEEECHHHHCCCHHHHHHHHHCCCCCCCEECEEEEEEEECCCCCCCCCE
VLLEGVGGGFTWGAALIRW
EEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MKYARVIGTGSYLPEKILTNHDLERMVDTSDEWIRTRTGIAQRHIAADSEMASDLALNAS
CCCEEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
REAIKAGGIDAREIELVIVATTTPDMIFPSTACILQDKLGIGDCAAFDVQAVCSGFIYAL
HHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHH
ATADMFIRAGKCQTALVVGAEVYSRILDWSDRSTCVLFGDGAGAVLLTGDERPGVLSTHL
HHHHHHEECCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEE
HADGSQSKILSAPANICGGKVQGKPFVVMEGNTVFKFAVKVLEEVVHEALTENNLESSDI
ECCCCCCCEEECCHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DWLIPHQANIRIIASTAKKLGIPMDKVVATVDKHGNTSAASIPLALDIAARDGRIKSGQH
CEECCCCCCEEEEEECHHHHCCCHHHHHHHHHCCCCCCCEECEEEEEEEECCCCCCCCCE
VLLEGVGGGFTWGAALIRW
EEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA