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The map label for this gene is nuoH1

Identifier: 82702148

GI number: 82702148

Start: 1180884

End: 1181837

Strand: Direct

Name: nuoH1

Synonym: Nmul_A1019

Alternate gene names: 82702148

Gene position: 1180884-1181837 (Clockwise)

Preceding gene: 82702147

Following gene: 82702149

Centisome position: 37.09

GC content: 57.02

Gene sequence:

>954_bases
ATGAATGAGTGGACCCCCATCTGGGTGAACCTGATTTTGATCCTGGCCGTCTTGTTTGCTTTCGCGGCGATGCTGTCCTG
GATCGAGCGCCGCCTGCTCGGCTTGTGGCAGGATCGCTATGGGCCCAACCGAGTAGGGCCGTTCGGGGTTCTGCAAATTG
TCGCCGATTCGATCAAGCTTCTTACCAAGGAGGACTGGATACCTCCCTTTGCAGATAGGGCGGTGTTCGTGCTGGCGCCG
GCAATCGTTGCCGTCACCACGCTGCTTGCGTTTGCCGTCGTACCCATTGCGCCCGGCATCGGCGTGGTCGATCTGAACAT
CGGAGTTTTGTTTTTTCTTGCCATGTCTTCGCTGGGCGTCTATAGCATCGTGCTGGGCGGATGGGCGTCCAACAGCAAAT
ATCCGCTGCTCGGGGGATTGCGCGCCGCCGCCCAGATGTTGAGCTACGAGGTCTTCATGGGCTTGGCGCTCATGGGTGTT
GTCATGCTTGCAGGTTCATTCAACCTGCGCGATATCGTTGCCGCGCAGGAAAACCTCTGGTTCTGCATTCCCCAGATCCT
GGGCTTGGCAACTTTTGCCGTTGCCGGCATTGCTGAGGCGCGCAGGCTGCCTTTCGATCTGCCCGAGTCGGAGAACGAAC
TGGTCGCAGGCTTTCATACCGAATATTCCAGCATGAAGTTCGGGCTGTTTTTCATTGGCGAATACGTCGGGATCACCCTT
ATCTCAGCAATGATCGTCACATTATTCTTCGGGGGGTGGCTGGGACCCGTGCTGCCTCCACTCGCCTGGTTTCTGCTCAA
GACTTTTATCGTCATCATCTGCTTCGTCCTGCTGCGGGCGGCATTGCCACGCCCCCGTTACGATCAGCTGATGACCTACG
GCTGGAAAGTCATGCTGCCAGTCACGCTGGTCAATTTGTTGCTCACCGGCGCAGTCGTATTGTCAGTGGCATAA

Upstream 100 bases:

>100_bases
GAAGGTGTAAAGGGGAAAGGTGGGGAAGGGAAAGCAAATGGAAGGATAGATAGAGGAAAGAAGCCACGAATGGATTTAGC
CATGAGTAGTGGAGTCAGCC

Downstream 100 bases:

>100_bases
CTGCTCATATAGCTTCGGGAGAAGATTATGTGGAATTCTCTGAAGACAATGTGGATCGTTTTTCTGCACATGTTCCGCCG
CCGGGTAACCATTCAATACC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 1; NDH-1 subunit H 1

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MNEWTPIWVNLILILAVLFAFAAMLSWIERRLLGLWQDRYGPNRVGPFGVLQIVADSIKLLTKEDWIPPFADRAVFVLAP
AIVAVTTLLAFAVVPIAPGIGVVDLNIGVLFFLAMSSLGVYSIVLGGWASNSKYPLLGGLRAAAQMLSYEVFMGLALMGV
VMLAGSFNLRDIVAAQENLWFCIPQILGLATFAVAGIAEARRLPFDLPESENELVAGFHTEYSSMKFGLFFIGEYVGITL
ISAMIVTLFFGGWLGPVLPPLAWFLLKTFIVIICFVLLRAALPRPRYDQLMTYGWKVMLPVTLVNLLLTGAVVLSVA

Sequences:

>Translated_317_residues
MNEWTPIWVNLILILAVLFAFAAMLSWIERRLLGLWQDRYGPNRVGPFGVLQIVADSIKLLTKEDWIPPFADRAVFVLAP
AIVAVTTLLAFAVVPIAPGIGVVDLNIGVLFFLAMSSLGVYSIVLGGWASNSKYPLLGGLRAAAQMLSYEVFMGLALMGV
VMLAGSFNLRDIVAAQENLWFCIPQILGLATFAVAGIAEARRLPFDLPESENELVAGFHTEYSSMKFGLFFIGEYVGITL
ISAMIVTLFFGGWLGPVLPPLAWFLLKTFIVIICFVLLRAALPRPRYDQLMTYGWKVMLPVTLVNLLLTGAVVLSVA
>Mature_317_residues
MNEWTPIWVNLILILAVLFAFAAMLSWIERRLLGLWQDRYGPNRVGPFGVLQIVADSIKLLTKEDWIPPFADRAVFVLAP
AIVAVTTLLAFAVVPIAPGIGVVDLNIGVLFFLAMSSLGVYSIVLGGWASNSKYPLLGGLRAAAQMLSYEVFMGLALMGV
VMLAGSFNLRDIVAAQENLWFCIPQILGLATFAVAGIAEARRLPFDLPESENELVAGFHTEYSSMKFGLFFIGEYVGITL
ISAMIVTLFFGGWLGPVLPPLAWFLLKTFIVIICFVLLRAALPRPRYDQLMTYGWKVMLPVTLVNLLLTGAVVLSVA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=287, Percent_Identity=42.8571428571429, Blast_Score=218, Evalue=5e-57,
Organism=Escherichia coli, GI1788618, Length=303, Percent_Identity=61.3861386138614, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1789077, Length=287, Percent_Identity=29.2682926829268, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH1_NITMU (Q2YA99)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411714.1
- STRING:   Q2YA99
- GeneID:   3786544
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1019
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   MSWLTPE
- PhylomeDB:   Q2YA99
- ProtClustDB:   PRK06076
- BioCyc:   NMUL323848:NMUL_A1019-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 34716; Mature: 34716

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x114fa624)-; HASH(0x1259a980)-; HASH(0x11f63350)-; HASH(0x1300452c)-; HASH(0x11fef984)-; HASH(0x11e77f88)-; HASH(0x114e3b70)-; HASH(0x11f4ced8)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEWTPIWVNLILILAVLFAFAAMLSWIERRLLGLWQDRYGPNRVGPFGVLQIVADSIKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LTKEDWIPPFADRAVFVLAPAIVAVTTLLAFAVVPIAPGIGVVDLNIGVLFFLAMSSLGV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCH
YSIVLGGWASNSKYPLLGGLRAAAQMLSYEVFMGLALMGVVMLAGSFNLRDIVAAQENLW
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHH
FCIPQILGLATFAVAGIAEARRLPFDLPESENELVAGFHTEYSSMKFGLFFIGEYVGITL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
ISAMIVTLFFGGWLGPVLPPLAWFLLKTFIVIICFVLLRAALPRPRYDQLMTYGWKVMLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHH
VTLVNLLLTGAVVLSVA
HHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MNEWTPIWVNLILILAVLFAFAAMLSWIERRLLGLWQDRYGPNRVGPFGVLQIVADSIKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LTKEDWIPPFADRAVFVLAPAIVAVTTLLAFAVVPIAPGIGVVDLNIGVLFFLAMSSLGV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCH
YSIVLGGWASNSKYPLLGGLRAAAQMLSYEVFMGLALMGVVMLAGSFNLRDIVAAQENLW
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHH
FCIPQILGLATFAVAGIAEARRLPFDLPESENELVAGFHTEYSSMKFGLFFIGEYVGITL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
ISAMIVTLFFGGWLGPVLPPLAWFLLKTFIVIICFVLLRAALPRPRYDQLMTYGWKVMLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHH
VTLVNLLLTGAVVLSVA
HHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA