Click here to switch to the map view.

The map label for this gene is nuoI1

Identifier: 82702149

GI number: 82702149

Start: 1181865

End: 1182380

Strand: Direct

Name: nuoI1

Synonym: Nmul_A1020

Alternate gene names: 82702149

Gene position: 1181865-1182380 (Clockwise)

Preceding gene: 82702148

Following gene: 82702150

Centisome position: 37.12

GC content: 54.46

Gene sequence:

>516_bases
ATGTGGAATTCTCTGAAGACAATGTGGATCGTTTTTCTGCACATGTTCCGCCGCCGGGTAACCATTCAATACCCCGACGA
AATGCCTAATATCCCGCCGCGCTGGCGCGGACGCATCATTCTGAGCCGCGATCCGGATGGTGAGGAGCGCTGCGTCGCAT
GCTACCTCTGCGCGGCAGCCTGTCCAGTGGATTGCATCGCGCTTCAGGCCACCGAAGATGAACACGAACGCCGTTACCCC
GAGTTCTTTCGCATCAATTTTTCGCGCTGCATTTTTTGTGGATTTTGCGAAGAAGCCTGTCCTACCGACGCAATCCAGCT
TACGCCGGACTTTGAAATGGGCGAATACAACCGGAAAAACCTGGTGTATGAAAAAGAGGATCTGTTGATCGATGGTACCG
GCAAATACCCCGGCTATAACTTCTATCGGGTGGCGGGAGTCGCAATCGGAGGAAAAAACAAGGGCGGGGCCGAGAATGAA
GCTCCTCCGGTAGACCCGCATTCGCTGCTGCCTTGA

Upstream 100 bases:

>100_bases
CTGGAAAGTCATGCTGCCAGTCACGCTGGTCAATTTGTTGCTCACCGGCGCAGTCGTATTGTCAGTGGCATAACTGCTCA
TATAGCTTCGGGAGAAGATT

Downstream 100 bases:

>100_bases
TCCGTACCTTTGATTACTGATTCAGGAGGAGGTTATGGAAGCGACATTCTATTTGTCCGGGGCGGTTGCGGTCGCAGCCA
CCCTGATGGTCGTTACGCGG

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 1; NDH-1 subunit I 1

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MWNSLKTMWIVFLHMFRRRVTIQYPDEMPNIPPRWRGRIILSRDPDGEERCVACYLCAAACPVDCIALQATEDEHERRYP
EFFRINFSRCIFCGFCEEACPTDAIQLTPDFEMGEYNRKNLVYEKEDLLIDGTGKYPGYNFYRVAGVAIGGKNKGGAENE
APPVDPHSLLP

Sequences:

>Translated_171_residues
MWNSLKTMWIVFLHMFRRRVTIQYPDEMPNIPPRWRGRIILSRDPDGEERCVACYLCAAACPVDCIALQATEDEHERRYP
EFFRINFSRCIFCGFCEEACPTDAIQLTPDFEMGEYNRKNLVYEKEDLLIDGTGKYPGYNFYRVAGVAIGGKNKGGAENE
APPVDPHSLLP
>Mature_171_residues
MWNSLKTMWIVFLHMFRRRVTIQYPDEMPNIPPRWRGRIILSRDPDGEERCVACYLCAAACPVDCIALQATEDEHERRYP
EFFRINFSRCIFCGFCEEACPTDAIQLTPDFEMGEYNRKNLVYEKEDLLIDGTGKYPGYNFYRVAGVAIGGKNKGGAENE
APPVDPHSLLP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=133, Percent_Identity=41.3533834586466, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1788617, Length=169, Percent_Identity=69.8224852071006, Blast_Score=251, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17555194, Length=123, Percent_Identity=41.4634146341463, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17864306, Length=128, Percent_Identity=42.96875, Blast_Score=116, Evalue=7e-27,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI1_NITMU (Q2YA98)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411715.1
- ProteinModelPortal:   Q2YA98
- SMR:   Q2YA98
- STRING:   Q2YA98
- GeneID:   3786545
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1020
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   RYWSVAG
- PhylomeDB:   Q2YA98
- ProtClustDB:   PRK05888
- BioCyc:   NMUL323848:NMUL_A1020-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 19678; Mature: 19678

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWNSLKTMWIVFLHMFRRRVTIQYPDEMPNIPPRWRGRIILSRDPDGEERCVACYLCAAA
CCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
CPVDCIALQATEDEHERRYPEFFRINFSRCIFCGFCEEACPTDAIQLTPDFEMGEYNRKN
CCCEEEEEECCCCHHHHCCCCEEEECHHHEEEEECCHHCCCCCEEEECCCCCCCCCCCCC
LVYEKEDLLIDGTGKYPGYNFYRVAGVAIGGKNKGGAENEAPPVDPHSLLP
CEEECCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MWNSLKTMWIVFLHMFRRRVTIQYPDEMPNIPPRWRGRIILSRDPDGEERCVACYLCAAA
CCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
CPVDCIALQATEDEHERRYPEFFRINFSRCIFCGFCEEACPTDAIQLTPDFEMGEYNRKN
CCCEEEEEECCCCHHHHCCCCEEEECHHHEEEEECCHHCCCCCEEEECCCCCCCCCCCCC
LVYEKEDLLIDGTGKYPGYNFYRVAGVAIGGKNKGGAENEAPPVDPHSLLP
CEEECCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA